Zhishang Chemical

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Zhishang Chemical

Hydroxypropyl Beta Cyclodextrin CAS 128446-35-5

Molecular Formula: C63H112O42

Formula Weight: 1541.54

ZSpharmac: Hydroxypropyl Beta Cyclodextrin Supplier

Product Name: Hydroxypropyl Beta Cyclodextrin
CAS No: 128446-35-5
Purity: 99%

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Basic Info

Product Name:Hydroxypropyl Beta Cyclodextrin
Other Names:2-Hydroxypropyl-β-cyclodextrin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Slightly Yellow Solution
EINECS No.:420-920-1
Storage:Room Temp
Provide:Hydroxypropyl Beta Cyclodextrin MSDS;
Hydroxypropyl Beta Cyclodextrin COA

What is Hydroxypropyl Beta Cyclodextrin?

Hydroxypropyl Beta Cyclodextrin is currently among the most intensively investigated and commonly utilized cyclodextrin by-products. It is primarily made use of in food, medicine as well as cosmetic industries.

Hydroxypropyl Beta Cyclodextrin Property

Melting point 278 °C (dec.)
Boiling point 400℃
density 1.05 at 20.3℃
refractive index 125 ° (C=1, H2O)
storage temp. room temp
solubility H2O: 45 % (w/v)
form solution (clear, colorless)
color White to slightly yellow
optical activity[α]26/D +139°, c = 1 in H2O
Water Solubility Soluble in water.


Hydroxypropyl Beta Cyclodextrin Uses

  1. Hydroxypropyl Beta Cyclodextrin is a widely used modified cyclodextrin consisting of 7 glucose units forming a lipophilic cavity. After the drug is complexed with hydroxypropyl-β-cyclodextrin, the water solubility will be greatly enhanced. The number of 2-hydroxypropyl groups is between 5 and 14.

Hydroxypropyl Beta Cyclodextrin Application

Hydroxypropyl Beta Cyclodextrin is an excellent shot solubilizer and also pharmaceutical excipient, which can improve the water solubility of improperly soluble medications, rise medicine security, improve medication bioavailability, boost the efficiency of the medicine or decrease the dose, and can be readjusted or Control the launch price of the medicine and reduce the side effects of the medication.
1. In the field of food as well as seasonings, it can enhance the security and lasting effect of dietary particles, cover up or correct the poor odor as well as taste of food dietary molecules, and also boost the production process as well as item quality. The product has great solubility in water, and also can be miscible with water in any kind of proportion if the level of substitution is 4 as well as above, and can additionally be dissolved in 50% ethanol and also methanol.
2. Made use of as a stabilizer, emulsifier, deodorant, and so on in cosmetic basic materials, which can reduce the stimulation of organic particles in cosmetics to skin and mucous membrane tissues, enhance the security of energetic ingredients, and also avoid the volatilization as well as oxidation of nutrients. It has a particular family member hygroscopicity.
3. In the pharmaceutical industry, it is a suitable shot solubilizer and also pharmaceutical excipient due to its fairly reduced surface task and also hemolytic task and also no irritability to muscles.

Hydroxypropyl Beta Cyclodextrin In Vitro Study

cell treatment with (2-Hydroxypropyl)– cyclodextrin cause the activation of the tanscription variable EB, a master regulatory authority of lysosomal feature as well as autophagy, and improvement of the cellular autophagic clearance ability. (2-Hydroxypropyl)-B-cylodextrin treatment minimizes intracellular cholesterol causing significant leukemiccell development restraint through G2/M cell-cycle arrest as well as apoptosis. The IC 50 valuesor (2-Hydroxypropyl)– cyclodextrin after 72 hours exposure remain in the series of 3.8-10.09 mM.(2-Hydroxypropyl)-B-cyclodextrin also shows anticancer effects againstCML cells revealing a T3151 BCR-ABL mutation (that offers resistance to most ABLyrosine kinase inhibitors), and also hypoxia-adapted CML cells that have qualities oleukemic stem cells.n addition, nest developing ability of human primary AML andML cells is inhibited by (2-Hydroxypropyl)-B-cyclodextrin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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