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Hydroxylamine Hydrochloride CAS 5470-11-1

Molecular Formula: NH2OH·HCl

Formula Weight: 69.49

ZSpharmac: Hydroxylamine Hydrochloride Supplement

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Product Name: Hydroxylamine Hydrochloride
CAS No: 5470-11-1
Purity: 99%

Basic Info

Product Name:Hydroxylamine Hydrochloride
Other Names:Hydroxylammonium Chloride
CAS:5470-11-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White to Off-White Liquid
EINECS No.:226-798-2
Storage:Store at +15°C to +25°C.
Provide:Hydroxylamine Hydrochloride MSDS;
Hydroxylamine Hydrochloride COA

What is Hydroxylamine Hydrochloride?

Hydroxylamine hydrochloride is colorless monoclinic crystal, easily soluble in water, soluble in ethanol, glycerol, and insoluble in ether. It has strong hygroscopicity and gradually decomposes after being wet. It also decomposes when heated to above 151°C.

Hydroxylamine Hydrochloride Properties:

Melting point 155-157 °C (dec.)(lit.)
density 1.67 g/mL at 25 °C(lit.)
vapor pressure 0.054 Pa (50 °C)
storage temp. Store at +15°C to +25°C.
solubility 470g/l
form Liquid
color White to off-white
PH2.5-3.5 (25℃, 50mg/mL in H2O)
Water Solubility 560 g/L (20 ºC)

 

Hydroxylamine Hydrochloride Uses

  1. Hydroxylamine hydrochloride is used as logical reagent and also reducing representative, and likewise utilized in organic synthesis as well as color film printing.
  2. Hydroxylamine hydrochloride is made use of as a basic material for medication and organic synthesis, as a minimizing representative and also an imaging representative, etc.
  3. Hydroxylamine hydrochloride pharmaceutical industry is utilized for the production of sulfamethoxazole intermediates and the raw materials for the synthesis of anticancer medications (hydroxyurea) as well as sulfonamides. Prep work of dye isatin intermediates. Also made use of in fats as well as soaps as anti-oxidants.
  4. Hydroxylamine hydrochloride In the natural synthesis sector, it is made use of as a reducing representative to prepare oximes, as well as it is likewise utilized in the production of medications, dyes, and also in shade photography and movie printing. It is utilized as a non-coloring temporary suspending agent in the artificial rubber market, in analytical chemistry for the examination of aldehydes as well as ketones organic substances as well as for the trace evaluation of sulfonic acids, as a depolarizer in electroanalysis, as well as in pharmaceutical manufacturing.
  5. Hydroxylamine hydrochloride is utilized to prepare oximes, anticancer medicines and also sulfonamides. In medication, it is additionally utilized to generate cotrimoxazole, danazol, ethinyl estradiol, norethisterone, methyl testosterone, hydroxyurea, chlordiazepoxide, etc. In the artificial rubber sector, it is used as a non-coloring temporary quit.
  6. Hydroxylamine hydrochloride is primarily made use of as a lowering agent and an imaging agent.
  7. Hydroxylamine hydrochloride is made use of as reducing agent as well as imaging representative; utilized in natural synthesis to prepare oxime; made use of as depolarizer in electroanalysis; minimizing representative in not natural analysis; anti-oxidant of fatty acid as well as soap; analysis of formaldehyde, camphor and sugar, and so on; organic Analytical screening of aldehydes and also ketones; trace analysis of sulfonic acids; decision of magnesium in iron and steel.

Preparation of Hydroxylamine Hydrochloride

report one,
The first step, ketoxime synthesis: 5 kg of Ti-MWW molecular sieve, 36 kg of butanone, and 100 kg of water were added to the reactor together, heated to 60 °C in a water bath, and then 75 kg of ammonia water and 68 kg of hydrogen peroxide were added to the reactor. The uniform rate was added to the reactor within 90 minutes, keeping the water bath temperature and stirring speed unchanged throughout the process. After the reaction was completed, the unreacted ammonia was absorbed under reduced pressure. The butanone oxime is extracted, and the obtained butanone oxime is mixed with the oil phase to obtain a crude butanone oxime.

The second step, the preparation of hydroxylamine hydrochloride: take 45 kilograms of water, add 13.5 kilograms of ammonium chloride, add 43 kilograms of crude butanone oxime obtained in the first step, heat it to 70 ° C to make it react, depressurize to a vacuum degree of 100KPa and absorb the reaction to generate The ammonia and methyl ethyl ketone were kept at 70°C for 6 hours, and after cooling to 0°C, the lower water phase was released with a separating funnel after standing, and the unreacted butanone oxime was extracted with ether, and the obtained aqueous phase was Hydroxylamine hydrochloride aqueous solution. The hydroxylamine hydrochloride aqueous solution is frozen and precipitated at -10°C, filtered and suctioned to obtain hydroxylamine hydrochloride crystals, and then the filtrate is evaporated and concentrated under negative pressure, and then subjected to cold precipitation, repeated several times, and the obtained hydroxylamine hydrochloride crystals are weighed together. 16 kg of hydroxylamine hydrochloride crystals, the yield is 92% based on ammonium chloride.

The unreacted ammonia gas absorbed in the first step under reduced pressure, the ammonia gas and butanone generated by the reaction under reduced pressure absorption in the second step can be reused in the first step. In the second step, the diethyl ether extract was evaporated to remove diethyl ether, and then combined with the upper oil as unreacted crude butanone oxime for reuse in the second step.

report two,
A green synthesis process for preparing hydroxylamine hydrochloride without solvent, taking 0.36g of Ti-MWW catalyst, 8.35g of ammonia water (28wt.%), and 4.5g of butanone in a reaction flask, and controlling the temperature at 65° C.; Then, 21.25 g of hydrogen peroxide (concentration of 10%) was dropped into the flask with a peristaltic pump, and the residence time was controlled at 2 h. Subsequently, the reaction solution is passed through the membrane filter, and the catalyst mother liquor and the crude product are separated, and the catalyst mother liquor is recycled by using a circulating pump. 36%) to the reaction device, the mol ratio of hydrochloric acid and butanone is 1.2:1, the butanone obtained by hydrolysis is recycled to the amidoxime chemical section through distillation to continue the reaction, and the reaction mother liquor is concentrated and crystallized to obtain hydroxylamine hydrochloride product. The conversion rate of butanone=99.1%, the selectivity of butanone oxime reaches 100%, the recovery rate of butanone=95%, the yield of hydroxylamine hydrochloride=96%, and the product purity=99.3%.

Hydroxylamine Hydrochloride Applications

Application 1.
CN201510189160.X discloses a method for preparing and purifying erythromycin oxime. The reaction product of erythromycin oxime is prepared by reacting methanol, hydroxylamine hydrochloride and erythromycin thiocyanate to prepare the filtered mother liquor of the reaction product in erythromycin oxime, and red thiocyanate is added to it. Mycin, methanol and hydroxylamine hydrochloride, the added amount of hydroxylamine hydrochloride is 0.1-10 times the molar amount of erythromycin thiocyanate, the amount of methanol added is 0.1-0.5 times the volume of the mother liquor, and the amount of erythromycin thiocyanate is 0.1-0.5 times. The amount of addition is 0.5-1 times of the volume of the mother liquor, then the pH of ammonium bicarbonate is added to 6-7, and then the oximation reaction is carried out. Obtain the wet product of erythromycin oxime salt, then add alkali to free erythromycin oxime, repeat the above steps, and recycle the reaction mother liquor 1-10 times, so as to maximize the utilization of erythromycin thiocyanate and hydroxylamine hydrochloride, improve yield, reduce waste discharge, and reduce costs.

Application 2.
CN201911070018.8 reported a preparation method of octanoyl hydroxamic acid, comprising the following steps: Step 1: mix hydroxylamine hydrochloride and methanol to prepare a methanol solution of hydroxylamine hydrochloride with a certain concentration; Hydroxylamine hydrochloride methanol solution, liquid sodium methoxide, and methyl octanoate are added to the reactor, and under normal pressure and a reaction temperature of 60 to 75 ° C, the oximation reaction is carried out for 300 seconds to 3 hours; Step 3: The solution after step 2 is reacted The temperature is lowered to 15-30° C., hydrogen chloride gas is introduced into the solution until the pH value of the solution is 2-4, and then the octanoylhydroxamic acid product is obtained after centrifugation, concentration, crystallization, centrifugation and drying. The invention adopts liquid sodium methoxide as the raw material for synthesizing octanoyl hydroxamic acid, which not only greatly improves the yield of the product, but also has high product purity and few impurities, and no waste water is generated in the synthesis process, thus reducing the production cost and being more environmentally friendly.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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