Zhishang Chemical

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Zhishang Chemical

Hydroquinone 4 CAS 123-31-9

Molecular Formula: C6H6O2

Formula Weight: 110.11

ZSpharmac: Hydroquinone 4 Supplement

Product Name: Hydroquinone 4
CAS No: 123-31-9
Purity: 99%

Basic Info

Product Name:Hydroquinone 4
Other Names:Hydroquinone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White Crystal Powder
EINECS No.:204-617-8
Storage:Store Below +30°C.
Provide:Hydroquinone 4 MSDS;
Hydroquinone 4 COA

What is Hydroquinone 4?

Hydroquinone 4, additionally called hydroquinone, is a vital chemical basic material. In recent times, the residential need for it has shown an expanding fad, and the intake area has increased year by year. 1,4-Diphenol is extensively used as well as is a crucial basic material, intermediate and also complementary for medication, chemical, dye and also rubber, etc. It is generally used in designer, anthraquinone dye, azo dye, rubber anti-oxidant and also monomer prevention. Polymerization agent, food stabilizer as well as coating antioxidant, oil anticoagulant, artificial ammonia stimulant, and so on.

Hydroquinone 4 Properties:

Melting point 172-175 °C(lit.)
Boiling point 285 °C(lit.)
density 1.32
vapor density 3.81 (vs air)
vapor pressure 1 mm Hg ( 132 °C)
refractive index 1.6320
Fp 165 °C
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL, clear
form Needle-Like Crystals or Crystalline Powder
pka10.35(at 20℃)
color White to off-white
Water Solubility 70 g/L (20 ºC)


Hydroquinone 4 Uses

  1. Hydroquinone 4 is used as imaging agent, dyestuff and pharmaceutical raw material.
  2. Hydroquinone 4 hydroquinone is the intermediate of herbicides quizalofop, diflufenapyr, thiazoxapyr, oxaflufen, diflufenox, and oxflufen body.
  3. Hydroquinone 4 is mostly utilized as a developer in digital photography. Hydroquinone and also its alkylates are commonly made use of as polymerization preventions included throughout the storage space and also transportation of monomers, as well as the generally made use of focus is about 200ppm. Hydroquinone is also used to prepare N,N’-diphenyl-p-phenylenediamine, which is an antioxidant and deodorant for rubber and gasoline.
  4. Hydroquinone 4 is used as analytical reagent, reducing agent and developer for copper and gold.
  5. Hydroquinone 4 is used for photometric determination of phosphorus, magnesium, niobium, copper, silicon and arsenic, etc.; polarographic and volumetric determination of iridium; reducing agent for heteropolyacids; reducing agent for copper and gold; testing phosphate, tungstate , nitrate, nitrite, selenium and tellurium, etc.; developer; antioxidant; chemical fertilizer industry desulfurizer; urea synergist.

Preparation of Hydroquinone 4

1.1 Traditional methods
1.1.1 Reppe method
The Reppe method is an early preparation method, and the reaction process is roughly under the catalyst of Ru and Rh. At a temperature of 100-300°C and a pressure of 100-350 MPa, acetylene reacts with carbon monoxide to form 1,4-benzenediol. The process of this method is simple, but the required catalyst is expensive and difficult to recover.
1.1.2 Aniline oxidation method
Aniline oxidation is a traditional synthesis process. At present, some manufacturers in my country still use this method to produce 1,4-benzenediol. The reaction process of this method is as follows: Step 1. Under acidic conditions in the presence of sulfuric acid, aniline is oxidized to p-benzoquinone with manganese dioxide or sodium dichromate; in the second step, p-benzoquinone is under acidic conditions. It is reduced to 1,4-benzenediol with iron powder; step 3. The finished product is obtained by filtration, crystallization and decolorization. The reaction equation is as follows:

This method is mature, easy to control, and has a high yield, but generates a large amount of manganese salt, iron salt and ammonium sulfate waste liquid, etc., with low recovery rate, environmental pollution, large consumption of raw materials, and high cost of production equipment.
1.1.4 Phenol and acetone method
Phenol and acetone method (bisphenol A method) prepares 1,4-diphenol production method The reaction scheme is roughly: the 1st step, under the hydrochloric acid catalysis condition, phenol and acetone react to generate bisphenol A; the 2nd step, in the alkali Under the action of a natural catalyst, bisphenol A is decomposed into phenol and p-isopropyl phenol; in the third step, p-isopropyl phenol is oxidized to 1,4-benzenediphenol and acetone.
1.1.5 Benzene and Propylene Process
The process is roughly as follows: Benzene is alkylated with propylene to generate para-cumene and meta-cumene. Separation and oxidation of para-cumene to dicumene oxide, catalytic decomposition of 1,4-benzenediol and acetone.

1.2 Clean and environmentally friendly methods
with the development of economy. The requirements for environmental protection are also getting higher and higher, and the new environmental protection process has challenged the traditional synthesis process, and gradually matured.
1.2.1 Hydroxylation of phenol with hydrogen peroxide
The method was developed in the 1970s and is now industrialized. The reaction process is as follows: in the presence of a catalyst, phenol reacts with hydrogen peroxide to generate 1,4-benzenediol; dehydration and separation to obtain crude 1,4-benzenediol; finally, through dissolution, decolorization and recrystallization to obtain 1,4-benzenediol 4-Benzenediol.

1.2.2 Phenol hydroxylation-peroxyacid, peroxyketone oxidation
This method, also known as the Ube method, is the first example of the successful application of El Ben Ube Company. The reaction process is as follows: sulfuric acid, a certain amount of hydrogen peroxide and methyl isobutyl ketone are reacted to generate peroxyketone as a catalyst. Catalytic oxidation of phenol to produce 1,4-benzenediol and catechol: finally, the items are obtained by separation and purification.

"Hydroquinone 4" in the Whitening World

The name hydroquinone may be unfamiliar to everyone. If you have a deeper understanding of whitening products and ingredients, you should have heard of “hydroquinone”. Hydroquinone 4 is hydroquinone. The status of hydroquinone in whitening and lightening, just like VA in anti-aging, is the gold standard that can be proved at present.
Sounds awesome is there? Put a pound of it on your face, will you immediately turn into an egg shell! NO! Why do we rarely hear the name of Hydroquinone 4 when the ingredients are hot and niacinamide and VC whitening products are flying all over the sky?
Simply because it is poisonous.
Hydroquinone has a strong inhibitory effect on the formation of melanin, but at the same time, it is accompanied by serious side effects and irritation, and it is also unstable. Hydroquinone 4 is cytotoxic. Improper use will “kill” melanocytes and cause depigmentation, resulting in white spots similar to vitiligo, which is much more difficult to treat than whitening and lightening.
However, in Japan and the United States, the control of Hydroquinone 4 is relatively loose. As long as the content of Hydroquinone 4 in the United States does not exceed 2%, it can be used as an OTC (over-the-counter drug) or added to skin care products. In Japan, there is also a 4% concentration of whitening essence!
Although the brand has a lot of data to express absolute safety, there is technology to stabilize Hydroquinone 4! However, I would not dare to sell it, nor would I recommend normal and healthy people to buy a whitening essence containing Hydroquinone 4 on a daily basis! 
Although we can’t control Hydroquinone 4 yet, we have discovered that hydroquinone’s brother, resorcinol, can retain most of the “power” of Hydroquinone 4, and at the same time, it has less stimulation, but it is still fierce and not good for consumers.” Brainless” use.
Therefore, various resorcinol derivatives were developed, which were optimized again in terms of irritation and stability, in order to be more easily tolerated by most skins and can be used for a long time. The more common resorcinol derivatives The substances are: phenethyl resorcinol, 4-butyl resorcinol, dimethoxytolyl-4-propyl resorcinol, hexyl resorcinol. So today’s theme officially debuts, what are these whitening essences that use resorcinol derivatives as the main ingredient!
For example, Hydroquinone 4 is like A acid, and it is not allowed to be added to skin care products because of too many side effects! But resorcinol derivatives are like A-alcohol, which not only has the powerful effects of the mother’s family, but also is safe and reliable, so for this kind of whitening essence, feel free to use it! Benjia’s selection of products is very rigorous. The whitening essence on the shelves will never contain any Hydroquinone 4 ingredients. It is not recommended for everyone to buy hydroquinone whitening essence. This position must be stated!

Hydroquinone 4 Precautions

Path of entry: breathing, ingestion, percutaneous absorption.
Harm: It is extra toxic than phenol, has a solid destructive effect on the skin as well as mucous membranes, can prevent the central nervous system or damages the liver and skin functions.
Severe poisoning: Inhalation of high-concentration vapor can create migraine, lightheadedness, tiredness, blurred vision, pulmonary edema, etc.
Chronic results: Long-lasting inhalation of reduced concentrations can create headache, wooziness, cough, loss of appetite, nausea or vomiting, as well as throwing up.
Irritant: Human skin: 250mg (24 hours), mild irritation.
Subacute and Chronic Toxicity: Subacute poisoning in animals manifests as hemolytic jaundice, anemia, leukocytosis, increased red blood cell fragility, hypoglycemia, dull coat and marked cachexia.
Sex chromosome deletion and non-segregation: human lymphocytes 6 mg/kg. DNA damage: human bone marrow 500mol/L.
Reproductive toxicity: Rat oral minimum toxic dose (TDL0): 2500mg/kg (1-22 days of pregnancy), resulting in post-implantation mortality (51 days, male), affecting testis, epididymis, vas deferens, prostate, seminal vesicles, etc.
Carcinogenicity: IARC Carcinogenicity Review: Unclear in animals, no reliable data in humans.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Value
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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