Zhishang Chemical

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Zhishang Chemical

Hydrolyzed Keratin CAS 69430-36-0

Molecular Formula: C2H2BrClO2

Formula Weight: 173.39308

ZSpharmac: Hydrolyzed Keratin Supplement

Product Name: Hydrolyzed Keratin
CAS No: 69430-36-0
Purity: 99%

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Basic Info

Product Name:Hydrolyzed Keratin
Other Names:BCAA
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:274-001-1
Provide:Hydrolyzed Keratin MSDS;
Hydrolyzed Keratin COA

What is Hydrolyzed Keratin?

Hydrolyzed keratin is stemmed from wool as well as is a light yellow to amber clear fluid with a certain smell. It should take on unique organic therapy to find to be brief peptides before it can be biologically made use of. Treated keratin is a recognized prospective source of state-of-the-art healthy and balanced protein with high nutritional well worth as well as also constant quality.

Pet healthy and balanced protein is called overall healthy protein, i.e. healthy protein consisting of 9 vital amino acids. However, it has the drawbacks of high fat, high calorie as well as additionally high cholesterol. So, consist of! Supplement in small amounts. Plant protein is an inadequate healthy and balanced protein, yet it does not have the unfavorable facets of pet healthy protein. Animal healthy protein primarily stems from meat, eggs as well as additionally milk of poultry, livestock as well as fish. Its healthy and balanced protein cosmetics is typically casein (78-85%), which can be better absorbed as well as additionally made use of by adults. A great deal much more significantly, pet protein has an overall variety of important amino acids and a reasonable proportion, so it is much less complicated to absorb, soak up and utilize than fundamental plant healthy protein, as well as its dietary value is relatively high.

Hydrolyzed Keratin Product Properties

Hydrolyzed keratin has a protective effect on hair and also hair, properly protects broken hair, and can properly repair split hair, lower and also protect against split ends.
The main concepts as a repairing representative as well as a nutrient:
Hair contains a huge quantity of keratin, accounting for regarding 65%-95% of the hair. Lots of natural active proteins have high affinity for the hair, are conveniently absorbed by the hair, have nutrition as well as film-forming effects, as well as are excellent hair conditioners representative. The feature of healthy protein in conditioning is closely related to its own architectural composition as well as molecular weight. The key is that it forms hydrogen bonds with keratin in the hair. Water-soluble protein has a particular repairing impact on damaged hair. This is because of the damage of the hair cuticle of the damaged hair, that makes the healthy protein exposed, the hydrophilicity of the hair is raised, as well as the water-soluble healthy protein is easily integrated to create a protein film, that makes the hair simple to brush as well as have radiance.

Main Clinical Applications of Hydrolyzed Keratin

When the body is in a state of stress due to trauma, surgery, severe infection, etc., it can show a negative ammonia balance, which is mainly caused by the increase of skeletal muscle protein decomposition, and the degree of decomposition depends on the severity and duration of the stress. A metabolic feature of stress is that muscle and plasma glutamine concentrations decrease, but glutamine release from skeletal muscle increases.} In addition, the activity of glutamine synthase can be increased by 50% in stressed animals. Accordingly, it has been suggested that the increased rate of muscle protein degradation provides BCAAs, which in turn provide the ammonia required for muscle synthesis of glutamine. In vivo studies have also found that the use of BCAA can reduce the negative nitrogen balance associated with trauma, surgery and other stress.

Under normal circumstances, the composition of various amino acids in plasma remains basically constant. The liver is the main organ in the body to decompose and convert amino acids other than BCAA, so it plays a major role in the balance of amino acid metabolism in the body. Most reports still show that BCAA treatment of hepatic encephalopathy has a certain effect, at least not worse than the traditional treatment.


1) After the infusion of BCAA increases the plasma concentration, it can reduce the accumulation of AAA and other neutral amino acids in brain cells through the competitive transport with AAA and other neutral amino acids, which can reduce the generation of pseudo-neurotransmitters and the harm to neural activity.

2) BCAA, especially leucine, can increase protein synthesis and reduce protein degradation such as muscle, thereby reducing plasma AAA concentration and preventing severe negative nitrogen balance.

3) BCAA can help improve the nutritional status of the body when liver insufficiency occurs, that is, provide energy through the special metabolic type of BCAA. Therefore, it shows that long-term oral BCAA can effectively improve the survival rate and quality of life of patients.

Similar to portal venous encephalopathy, the plasma BCAA and its ketoacid concentrations are below normal values ​​in patients with chronic renal failure. Some people supplemented patients with chronic renal failure with essential amino acids or supplemented with solutions containing a high proportion of BCAA and found that although the clinical symptoms improved, However, plasma BCAA levels were not significantly elevated.

The innate immune response was recovered to some extent after BCAA supplementation. Naka-mura et al [6] reported. Neutrophil phagocytosis and NK cell activity and Fischer’s ratio were significantly improved in patients with decompensated cirrhosis after taking 12 g BCAA daily for 3 months. The mechanism may be that BCAA supplementation promotes albumin synthesis by activating the mTOR signal transduction system, and also enhances the synthesis of hepatocyte growth factor [7]. Therefore, BCAA not only improves the poor nutritional status of patients with liver cirrhosis, but also restores the inherent immunity of patients.

BCAA inhibits the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, not only by promoting the mammalian target of rapamycin complex 1. mTORC 1/ Negative feedback from S6 kinase 1 to the PI3K/Akt pathway and also inhibits mTORC2 kinase activity. It is suggested that supplementation of BCAA may be effective in inhibiting the progression of liver cancer by inhibiting insulin-mediated PI3K/Akt and subsequent anti-apoptotic pathways. It also suggests that BCAA supplementation is important in diabetic patients with advanced liver disease.

Features of Hydrolyzed Keratin

Hydrolyzed Keratin acts as a nitrogen carrier and assists in the synthesis of other amino acids required for muscle synthesis. Simply put, it is a process in which simple amino acids synthesize complex and complete muscle tissue. Thus, branched-chain amino acids stimulate the production of insulin, the primary role of which is to allow peripheral blood glucose to be taken up by muscles and used as a source of energy.

The production of insulin also promotes the absorption of amino acids by the muscles. Hydrolyzed Keratin is both anabolic and anti-catabolic, as they can significantly increase protein synthesis, promote the release of related hormones such as growth hormone (GH), IGF-1 (insulin-like growth factor-1) and insulin and contribute to Maintain a reasonable testosterone/cortisol ratio.

Hydrolyzed Keratin is also very anti-catabolic as they help prevent protein breakdown and muscle loss, which is very important for those who are in the pre-competition diet phase.

When the calorie intake is relatively low, Hydrolyzed Keratin is strongly recommended, because at this time, the rate of protein synthesis decreases and the protein breakdown increases, just like when the ingested protein is digested and absorbed, the protein is hydrolyzed and decomposed into simple, Soluble substances, such as peptides and amino acids, otherwise risk losing muscle.

Hydrolyzed Keratin Metabolic Profile

1. Basic process
BCAA is transported to cells by an intracellular specific carrier (Ly-system), and forms branched-chain keto acids (BCKA) via two transaminases, and its catalytic process is close to an equilibrium reaction. Then each BCKA undergoes its own oxidative decarboxylation, which is a single-enzyme-catalyzed process that presents a non-equilibrium reaction. The product of this process is acyl-CoA (acyl-CoA), the subsequent metabolic pathway is very similar to fatty acid oxidation, and its tail product can enter the tricarboxylic acid cycle. The tail product of valine and isoleucine metabolism is succinyl-CoA|leucine to generate acetoacetate and acetyl-CoA. BCAA aminotransferase (BCAAT) is widely distributed in tissues, and the enzyme activity per gram of tissue is highest in heart and kidney, intermediate in bone and muscle, and lowest in liver. After BCAA is deaminated and its resulting ketoacid, oxidative decarboxylation is carried out by means of a mitochondrial enzyme, alpha- isoleucine dehydrogenase, and the subsequent reaction proceeds via a specific catabolic pathway.

2. BCAA metabolism in muscle tissue
Muscle is the main site of BCAA metabolism, and BCAA is also an important energy source for muscle tissue. At present, it is known that the key enzyme regulating the catalytic pathway in muscle is α-isoleucine dehydrogenase, which exists in two forms, active and inactive, and is converted into each other by phosphorylation and dephosphorylation. This enzyme in rat skeletal muscle is almost always inactive. The BCAA released from the bloodstream or endogenously released from muscle protein is deaminated, and most of the ketoacids are subsequently released into the bloodstream, which is a reactive form. Metabolized by other tissues (liver, kidney, brain) by dehydrogenase.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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