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Hydrocortisone Acetate Cream CAS 50-03-3

Molecular Formula: C23H32O6

Formula Weight: 404.5

ZSpharmac: Hydrocortisone Acetate Cream Cosmetic Raw Material Suppliers

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Product Name: Hydrocortisone Acetate Cream
CAS No: 50-03-3
Purity: 99%

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Basic Info

Product Name:Hydrocortisone Acetate Cream
Other Names:Hydrocortisone Acetate
CAS:50-03-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:200-004-4
Storage:0-6°C
Provide:Hydrocortisone Acetate Cream MSDS;
Hydrocortisone Acetate Cream COA

What is Hydrocortisone Acetate Cream?

Hydrocortisone acetate (11β, 17α, 21-trihydroxypregnant-4-ene-3,20-dione-21-acetate) is an adrenocortical hormone medicine with anti-inflammatory, immunosuppressive, anti-toxic and anti-shock residential or commercial properties as well as other pharmacological impacts. The 11β-hydroxyl group in the steroidal compound framework is an essential group for anti-inflammatory drugs. Exactly how to present the 11β-hydroxyl group throughout the prep work of hydrocortisone acetate is a vital step in the entire procedure. The existing processes mostly consist of microbial makeover methods and chemical Two approaches.

Hydrocortisone Acetate Cream Property

Melting point 223 °C (dec.)(lit.)
Boiling point 446.1°C (rough estimate)
alpha D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
density d420 1.289
refractive index 1.4593 (estimate)
Fp 223°C
storage temp. 0-6°C
solubility Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
pka12.42±0.70(Predicted)
form Solid
color White to Off-White
Water Solubility Insoluble in water.

 

Hydrocortisone Acetate Cream Applications

Hydrocortisone Acetate Lotion is mainly made use of to deal with rheumatoid joint inflammation, rheumatic fever, gout pain, bronchial asthma, and so on. Injections can be used for tuberculous or purulent meningitis, tuberculous pleurisy, empyema, joint inflammation, tenosynovitis, ligament pressure, sprains, nodular prurigo, lichen planus, and so on. Eye drops are used for numerous types of ophthalmia. Creams are used for allergic or seborrheic dermatitis, pruritus, and so on. Due to environmental pollution, fast job speed, absence of workout and also other reasons, the number of people suffering from rheumatoid arthritis or rheumatoid arthritis is boosting as well as is trending younger. In my nation, the incidence rate of rheumatoid arthritis is 0.2%-0.4%. For that reason, the variety of individuals with rheumatoid arthritis in my nation has gotten to 5 million. Additionally, in our nation, the incidence of rheumatoid joint inflammation is raising year by year. As a commonly utilized medicine for the treatment of rheumatoid arthritis, the demand for Hydrocortisone Acetate Cream is bound to be really high.

Hydrocortisone Acetate Cream Preparation

(a) Ketal reaction: Prepare “16α, 17α-epoxy-4-pregnene-11-one-3,20-diethylene glycol ketal”. In the reaction bottle, add 50g of Platt’s oxide, Mix 100 ml of methylene chloride, 100 ml of ethylene glycol and 80 ml of triethyl orthoformate, stir, add 2 g of boron trifluoride-diethyl ether, stir and react at 20~28°C for more than 8 hours; after the reaction is completed, concentrate under reduced pressure, filter, and use Wash the material with a small amount of methanol, pump it dry, and dry to obtain 60.8g of formula 16α, 17 α-epoxy-4-pregnantene-11-one-3, 20-diethylene glycol ketal;

(b) Reduction reaction: Prepare the formula “11β, 17α-dihydroxy-4-pregnene-3, 20-diethylene glycol ketal”, put it into the reaction bottle and put the formula II 16α, 17α-hydroxy-4-pregnene into the reaction bottle. Stelen-11-one-3,20-dihexanediol ketal 50g, tetrahydrofuran 500ml, methanol 50ml, stir, slowly add 15g lithium aluminum hydride, stir and react at 30~40°C for 4 hours; concentrate under reduced pressure to recover the solvent, add water 1500ml of water was separated, filtered, washed with water until neutral, drained, and dried to obtain 44.8g of formula 11β, 17 α-dihydroxy-4-pregnantene-3, 20-diethylene glycol ketal;

(c) Hydrolysis reaction: Prepare “11β, 17α-dihydroxy-4-pregnene-3,20-dione” and put the formula 11β, 17α-dihydroxy-4-pregnene-3 into the reaction bottle. , 50g of 20-diethylene glycol ketal, 15ml of hydrochloric acid, 200ml of water, stir and react for 2 hours at 20~22°C, add 1500ml of water for precipitation, filter, wash, drain, and dry to obtain formula 11β, 17 α-dihydroxy -4-Pregnene-3,20-dione 38.4g;

(d) Iodine reaction: Prepare “21-iodine-11β,17α-dihydroxy-4-pregnene-3,20-dione”, dissolve 6g of calcium chloride in 60ml of methanol, and take 2/3 The amount is used to dissolve 18g of iodine in the bath, and the remaining 1/3 is put into the reaction bottle, and 20g of formula IV 11β, 17 α-dihydroxy-4-pregnene-3,20-dione and 100ml of chloroform are stirred and dissolved. Add 12g of calcium oxide, adjust the temperature to 0~5℃, add iodine-calcium chloride-methanol solution dropwise, complete the addition, react at 0~5℃ for 2 hours, when the reaction is completed, add 100ml of 20% ammonium chloride aqueous solution (containing chlorine 20g of ammonium chloride), filtered, the water layer was extracted with chlorotetralane, combined, concentrated under reduced pressure to recover the solvent, concentrated to dryness, to obtain 21-iodine-1β, 17 α-dihydroxy-4-pregnene-3, 20 -Diketone 28g;

(e) Acetylation reaction: Prepare hydrocortisone acetate. In the reaction bottle, put 28g of formula V21-iodine-11β, 17 α-dihydroxy-4-pregnantene-3,20-dione and 40ml of DMF into the reaction bottle. 16g of potassium acetate, 2ml of glacial acetic acid, adjust the temperature to reflux for 3 hours. After the reaction is completed, cool to -5°C, filter, wash, drain, and dry to obtain 21.9g of hydrocortisone acetate.

Adrenocortical Hormone Drugs

Hydrocortisone acetate is an adrenocortical hormonal agent medicine, furthermore called cortisol acetate. It is a white crystalline powder, odorless as well as bitter in preference. The melting point is 216 ~ 222 ℃, showing best optical turning. Somewhat soluble in ethanol, ether, chloroform, acetone, insoluble in water. Manufactured from 17α-hydroxyprogesterone.
Hydrocortisone acetate has essential exercises, such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, and also decreasing inflammatory exudation. It is frequently used clinically for adrenocortical insufficiency as well as autoimmune conditions. Prep work contain shots, tablets, ointments as well as eye decreases. Adding a portion of hydrocortisone acetate to some cosmetics can improve the anti-allergic outcome and improve skin lightening, yet lasting use this material can trigger skin hormonal representative dependancy. my nation’s cosmetics plans stipulate that hormone representative compounds are not enabled to be included in cosmetics.

About Products:
If you need the cosmetic raw material Hydrocortisone Acetate Cream, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced Hydrocortisone Acetate Cream manufacturer and supplier, ZSpharmac will provide Hydrocortisone Acetate Cream raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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