Zhishang Chemical

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Zhishang Chemical

Hydrocinnamic Acid CAS 501-52-0

Molecular Formula: C9H10O2

Formula Weight: 150.17

ZSpharmac: Hydrocinnamic Acid Supplier

Product Name: Hydrocinnamic Acid
CAS No: 501-52-0
Purity: 99%

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Basic Info

Product Name:Hydrocinnamic Acid
Other Names:3-Phenylpropionic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Yellow to Yellow-Green Liquid
EINECS No.:207-924-5
Storage:Sealed in Dry,Room Temperature
Provide:Hydrocinnamic Acid MSDS;
Hydrocinnamic Acid COA

What is Hydrocinnamic Acid?

Hydrocinnamic Acid, additionally called hydrogenated cinnamon acid, is naturally existing in raspberry and also cistus. It is separated from ethanol and water as colorless needle crystals, and also from ether as colorless prismatic crystals. There are elegant coumarin, vanilla bean-like aromas, as well as hyacinth as well as rose-like scents. White crystal, molecular weight 150.18, melting point 48.5 ° C, boiling point 280 ° C, family member density 1.071. Soluble in hot water, alcohol, benzene, chloroform, ether, antarctic acetic acid, oil ether and carbon dichloride. A little soluble in cold water. With water vapor can be volatile. Hydrocinnamic Acid is used as a fixative for scents.

If Hydrocinnamic Acid is inhaled, get rid of patient to fresh air; if touching skin, remove polluted apparel, wash skin completely with soap and also water, seek clinical attention if discomfort takes place; in case of eye get in touch with, separate eyelids, Wash with running water or regular saline, and look for clinical interest instantly; if ingested, rinse mouth instantly, restrict throwing up, as well as look for clinical interest instantly. Advice to shield rescuers is as follows: move the person to a refuge, get in touch with a medical professional, and also ideally, please program this chemical safety data sheet to the medical professional on site. In case of leakage, if a percentage of leak takes place, accumulate the leak liquid in a sealable container as much as feasible, absorb it with sand, turned on carbon or other inert products, as well as transfer it to a refuge. For containment, close the drain pipeline, cover it with foam to subdue evaporation, transfer it to a storage tank vehicle or a special collection agency with an explosion-proof pump, as well as reuse it or transfer it to a waste therapy site for disposal.

Hydrocinnamic Acid Property

Melting point 

45-48 °C (lit.)

Boiling point 

280 °C (lit.)


1.071 g/mL at 25 °C (lit.)

vapor pressure 

0.356Pa at 25℃

refractive index 

1.5408 (estimate)


>230 °F

storage temp. 

Sealed in dry,Room Temperature


ethanol: soluble50mg/mL, clear, colorless to faintly yellow




4.66(at 25℃)


Clear yellow to yellow-green

Specific Gravity


Water Solubility 

Soluble in water



Application of Hydrocinnamic Acid

Hydrocinnamic Acid is a fixative for spices, and can also be used as a pharmaceutical intermediate and organic synthesis. Its application examples are as follows: for the synthesis of Hydrocinnamic Acid. The oil field will use pickling to remove the salt scale formed on the inner wall of the pipeline, and it will also cause certain corrosion on the inner wall of the pipeline. Therefore, in order to suppress the acid corrosion of pipelines and prolong the life of pipelines, oil and gas fields generally adopt the method of adding corrosion inhibitors. Among many corrosion inhibitors, imidazoline corrosion inhibitors have been widely used in oil and gas fields at home and abroad because of their special structural composition, high efficiency, low toxicity and easy biodegradability.

Imidazoline derivatives are generally five-membered nitrogen-containing heterocyclic compounds obtained by the dehydration reaction of organic carboxylic acids and polyethylene polyamines, in which the N atom contains unshared electron pairs and can form a coordination bond with the empty 3d orbital of the Fe atom. , so that the molecules are adsorbed on the metal surface to form a corrosion inhibitor adsorption film, which separates the metal from the corrosive medium, so as to achieve the purpose of corrosion inhibition. Imidazoline corrosion inhibitors have good corrosion inhibition performance in acidic environments, are low in toxicity and easy to degrade, and have high application value in inhibiting pipeline corrosion.

The preparation method of Hydrocinnamic Acid: Take 15g of 3-phenylpropionic acid, 15mL of diethylenetriamine, and 7mL of xylene and mix them, then carry out magnetic stirring and start heating; raise the temperature to 170°C, carry out amidation reaction for 5h, and then raise the temperature to 220°C, carry out cyclization reaction for 3 hours; after the reaction is completed, transfer it to a rotary evaporator for vacuum distillation to evaporate excess diethylenetriamine and xylene, and then dry it in a vacuum drying oven at room temperature to obtain dark brown Viscous Hydrocinnamic Acid creature.

Preparation of Hydrocinnamic Acid

1. Using cinnamic acid as raw material, Hydrocinnamic Acid can be prepared by the following two methods.

(1) Mix cinnamic acid with sodium hydroxide solution at 80-90°C to form sodium salt, add Raney nickel to the solution, and then slowly add hydrazine hydrate dropwise. Cool to 20°C, add hydrochloric acid to pH = 1, and then Hydrocinnamic Acid will precipitate.

(2) Under stirring, slowly add 2.5% sodium amalgam into the mixture of cinnamic acid and sodium hydroxide solution, and the cinnamic acid is reduced to phenylpropionic acid by the generated hydrogen. The reaction mixture is acidified with hydrochloric acid, and the phenylpropionic acid is precipitated in the form of oil, and solidifies quickly, and recrystallized with hot water to obtain the finished product Hydrocinnamic Acid.

2. Add 1g of cinnamic acid and 15mL of absolute ethanol to the hydrogenation reaction flask at normal pressure, and stir to dissolve. Add 1 g of Rany Ni catalyst, vacuum out the air, fill with nitrogen, repeat twice, and then replace the nitrogen with hydrogen. Start the magnetic stirrer and carry out hydrogenation at normal pressure until no hydrogen is absorbed, about 2 hours. Suction filtration, the filtrate was distilled off the solvent under normal pressure, and when about 1-2 mL remained, pour it into a watch glass while hot, and after cooling, 0.8 g of white (slightly green) waxy solid 3-phenylpropionic acid was obtained, mp46-48 °C, the yield is 80%.

Enzymatic Basis of Hydrocinnamic Acid

Hydrocinnamic Acid is completion product of microbial degradation of unabsorbed phenylalanine in the intestinal tract lumen. As a CoA ester, this metabolite is thought about a certain substrate for medium-chain acyl-CoA dehydrogenase (MCAD). Its glycine conjugate, 3-phenylpropionylglycine, has now been determined as a characteristic marker in the urine of clients impacted by MCAD shortage. However, to day, no methodical researches have been executed to examine the sensitivity of 3-phenylpropionyl-CoA with other well-known acyl-CoA dehydrogenases to establish the uniqueness of this substratum for MCAD. We examined the in vitro sensitivity of 3-phenylpropionyl-CoA with 5 rat and human liver acyl-CoA dehydrogenases making use of purified preparations. We demonstrate that MCAD efficiently dehydrogenates 3-phenylpropionyl-CoA which no other acyl-CoA dehydrogenases exhibit any substantial activity versus this substrate. Human MCAD has a Km of 50 microM for 3-phenylpropionyl-CoA under steady-state conditions. Gas chromatography/mass spectrometry evaluation of the assay blend determined trans-cinnamoyl-CoA as the response product. Moreover, we determined response items making use of gas chromatography/mass spectrometry chosen ion monitoring to show that 3-phenylpropionyl-CoA is slowly but significantly dehydrogenated by MCAD under cardio problems in the lack of a primary electron acceptor. These information suggest that MCAD can use an alternate electron acceptor to oxidize 3-phenylpropionyl-CoA in vivo to produce trans-cinnamoyl-CoA.

About That Product:
If you need Hydrocinnamic Acid as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Hydrocinnamic Acid, ZSpharmac will provide Hydrocinnamic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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