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Huperzine A High CAS 102518-79-6

Molecular Formula: C15H18N2O

Formula Weight: 242.32

ZSpharmac: Huperzine A High Supplier

Product Name: Huperzine A High
CAS No: 102518-79-6
Purity: 99%

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Basic Info

Product Name:Huperzine A High
Other Names:(-)-Huperzine A
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Neat
EINECS No.:600-320-6
Storage:Keep in Dark Place,Inert Atmosphere,2-8°C
Provide:Huperzine A High MSDS;
Huperzine A High COA

What is Huperzine A High?

Huperzine A High is an all-natural plant alkaloid extracted from the traditional Chinese medication Huperzine genus Melaleuca. It is a powerful, relatively easy to fix in addition to highly critical second-generation acetylcholinesterase avoidance. Its look is light yellow to white crystalline powder, easily soluble in chloroform, soluble in methanol in addition to ethanol, slightly soluble in water, has high fat solubility, tiny particle, can go through the blood-brain challenge well, and also after getting in the central nerves, it is much more dispersed in the frontal wattle, Temporal lobe, hippocampus and also various other mind areas that are very carefully related to finding out along with memory have a strong inhibitory effect on acetylcholinesterase (DISCOMFORT) at minimized dosages,which substantially raises the material of acetylcholine (Ach) in the synaptic void in the distribution location, so regarding improve the excitatory transmission of nerve cells, enhance the excitatory result of discovering and also memory brain regions, as well as play a role in boosting cognitive function, improving memory retention and also advertising memory recreation. It is presently one of the most effective drug for the therapy of Alzheimer’s condition (senile dementia) developed in China.

Huperzine A High Property

Melting point 211-216oC
alpha D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point 505.0±50.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility insoluble in H2O; ≥12.12 mg/mL in DMSO; ≥23.13 mg/mL in EtOH
form neat
color White to Almost white


Huperzine A High Indications

Huperzine A High is a relatively easy to fix and also potent cholinesterase prevention, stronger than physostigmine, neostigmine and Tacrine. For myasthenia gravis, the efficient price is 99%.
Professional trials have actually shown that this item appropriates for benign memory problems, and can improve the capability of clients to point to memory, associative understanding, picture recall, acknowledgment of worthless graphics as well as portrait recall, as well as it can also improve the learning and memory of normal people; this product is effective for mental deterioration patients. It can additionally boost the memory impairment brought on by brain natural condition.
Clinically, huperzine A can be applied to the treatment of the following signs:
1. Huperzine A High is utilized to deal with as well as improve amnesia in middle-aged as well as senior individuals, as well as boost associative recall function; it is utilized for memory loss brought on by extreme use the brain, and also improves knowing and also job effectiveness;
2. Used for amnesia related to neurasthenia;
3. Huperzine A High is used for memory loss triggered by cerebrovascular conditions;
4. It is utilized to boost the memory of Alzheimer’s condition, as well as it has noticeable alleviative effect on enhancing and also bring back the cognition, memory function and also unusual emotional behavior of individuals;
5. Huperzine A High is utilized to treat myasthenia gravis;
6. Huperzine A can improve organization problems, cognitive disability as well as memory loss associated with schizophrenia;
7. It can improve the memory loss related to different mind conditions and physical diseases.

Neuroprotective Effects of Huperzine A High

1 Anti-inflammatory effect and protection of rat neural stem cells
The ratio of pro-apoptotic and anti-apoptotic proteins in the Bcl-2 protein family determines whether cells undergo apoptosis after being stimulated by apoptotic signals. When the Bcl-2/Bax value decreases, Bax forms a homodimer to induce cell apoptosis; when the Bcl-2/Bax value increases, Bax and Bcl-2 form a heterodimer to achieve Bcl-2 inhibition of cell death. Apoptotic function. Zhu Ning et al. found in rat experiments that under the stimulation of Aβ1-42-mediated inflammatory response in neural stem cells, the expression levels of Bcl-2 and Bax were the highest in each group, while the Bcl-2/Bax value was the highest in each group. lowest. After Hup A pretreated microglia, liquid chip detection showed that the secretion of inflammatory factors was reduced, and at the same time, the Bcl-2/Bax value was significantly higher than that of the Aβ group, which inhibited the apoptosis of neural stem cells. The results of Western blotting and flow cytometry both suggested that Hup A could inhibit the apoptosis of neural stem cells.

2 Against the neurotoxicity of organophosphates
The main mechanism of Huperzine A High against organophosphate poisoning is: the reversible combination of Hup A with acetylcholinesterase in advance of administration, thus preventing the irreversible combination of organophosphorus compounds and acetylcholinesterase. Compared with other reversible cholinesterase inhibitors such as pyridostigmine bromide, Hup A has two advantages: On the one hand, Huperzine A High can pass through the blood-brain barrier, thereby protecting the acetylcholinesterase in the brain . On the other hand, butyrylcholinesterase and carboxylesterase may be endogenous organophosphate scavengers, Hup A can selectively inhibit plasma erythrocyte acetylcholinesterase, but has no inhibitory effect on butyrylcholinesterase, So the selectivity of Hup A is helpful for the prevention of organophosphate poisoning.

3 Fight against glutamate toxicity
Glutamate is an agonist of N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are stimulated to increase the influx of calcium ions into neurons, and excessive calcium ions can lead to cell death . Huperzine A High can reduce the toxicity of glutamate to nerve cells and increase the cell survival rate, especially for mature neuron cells, because there are more NMDA receptors in mature neuron cells. The mechanism of anti-glutamate may be that after the NMDA receptor is stimulated, Hup A blocks somewhere downstream of its signal transduction channel, thereby preventing cell death caused by glutamate. In addition, the protective effect of Hup A on nerve cells may also be Involvement mediated by glutamate receptors.

4 Fights Oxidative Stress
Huperzine A High protects neuronal cells against the toxicity of β-amyloid production and increases the production of superoxide dismutase (SOD). Rat primary cortical cells cultured in vitro were incubated under the condition of Aβ25-35 (the 25th to 35th amino acid residues of β-amyloid protein fragments), and the apoptosis of the cells could be observed, the viability of the cells decreased significantly, and the morphology of neurons Alteration and its DNA fragmentation. Pre-administration of Hup A can significantly improve cell survival and prevent nuclear fragmentation. The mechanism is that Hup A inhibits the formation of reactive oxygen species (ROS reactive oxygen species) and the activity of caspase-3 enzyme.

5 Inhibition of neurotoxicity of NO
Studies have shown that NO can inhibit the growth of human neuroblastoma SK-N-SH line cells and induce cell apoptosis. Huperzine A High, ginkgolides A and B can block the apoptosis and growth inhibition of sodium nitroprusside (NO donor) on SK-N-SH cells. In addition, Hup A and ginkgolides A and B can also inhibit the production of NO in mouse glial cells and the production of NO in human and mouse astrocytes.

Production Method of Huperzine A High

CN1781907A discloses a kind of production method of high-purity huperzine A, comprises the steps:

(1) The pretreatment adopts conventional methods to fully soak the dry powder of Melaleuca tower with 1.2% tartaric acid solution, adjust the pH value of the solution to weak alkalinity with ammonia water, repeatedly extract with chloroform, concentrate and evaporate the extract to dryness, and obtain huperzine A crude product; the crude product can be used for sample injection after being dissolved with an appropriate amount of stationary phase solution;

(2) Preparative high-speed countercurrent chromatography separates and selects a solvent system, and adopts a preparative high-speed countercurrent chromatographic system for separation;

(3) Aftertreatment Concentrate the collected solution of huperzine A under reduced pressure and evaporate to dryness to obtain an off-white solid, then dissolve it with an appropriate amount of acetone, crystallize at 0-10°C, and dry the crystal to obtain a white powdery solid That is the finished product.

About Products:
If you need Huperzine A High, this cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Huperzine A High, ZSpharmac will provide Huperzine A High raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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