Zhishang Chemical

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Zhishang Chemical

Huperzine a Gnc CAS 102518-79-6

Molecular Formula: C15H18N2O

Formula Weight: 242.32

ZSpharmac: Huperzine a Gnc Supplement

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Product Name: Huperzine a Gnc
CAS No: 102518-79-6
Purity: 99%

Basic Info

Product Name:Huperzine a Gnc
Other Names:(-)-Huperzine A
CAS:102518-79-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Yellow to White Crystalline Powder
EINECS No.:600-320-6
Storage:Keep in Dark Place,Inert Atmosphere,2-8°C
Provide:Huperzine a Gnc MSDS;
Huperzine a Gnc COA

What is Huperzine a Gnc?

Huperzine a Gnc is a natural plant alkaloid drawn out from the conventional Chinese medicine Huperzina Melaleuca.have a solid inhibitory impact on acetylcholinesterase (PAIN) at reduced dosages, which dramatically raises the content of acetylcholine (Ach) in the synaptic cleft of the distribution location. High, therefore improving neuronal excitatory transmission, enhancing the excitatory result of discovering and also memory brain areas, and enhancing cognitive function, boosting memory retention as well as promoting memory recreation.

Huperzine a Gnc Properties:

Melting point 211-216oC
alpha D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point 505.0±50.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
pka12.25±0.60(Predicted)

 

Huperzine a Gnc Uses

  1. Huperzine a Gnc is a new drug for the treatment of benign memory disorders.
  2. Huperzine a Gnc Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier .A potential thera peutic agent for Alzheimer disease. It reduces cell death induced by glutamate inprimary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
  3. Huperzine a Gnc has a selective inhibitory effect on true cholinesterase, and the inhibitory intensity is thousands of times that of false cholinesterase; the inhibition mode is a mixture of competitive and non-competitive inhibition, which is different from that of pure competitive inhibitors. There are significant differences; it is easy to enter the center through the blood-brain barrier, and has both central and peripheral therapeutic effects; long effective time; good absorption from the gastrointestinal tract; high safety index; good stability. The comparison results of the inhibitory intensity of different drugs on acetylcholinesterase (AChE) were: huperzine A > physostigmine > neostigmine > huperzine B > galantamine > galanin. The order of inhibitory intensity to human butyrylcholinesterase (BuChE) was: physostigmine>neostigmine>huperzine A>huperzine B. This product is stronger than physostigmine in enhancing the amplitude of muscle contraction caused by indirect electrical stimulation of nerves and enhancing the memory function of rats, but its toxicity is lower than that of physostigmine, and its effect lasts for a long time.

Pharmacological effects of Huperzine a Gnc

1 Anti-inflammatory effect and protection of rat neural stem cells
The ratio of pro-apoptotic and anti-apoptotic proteins in the Bcl-2 protein family determines whether cells undergo apoptosis after being stimulated by apoptotic signals. When the Bcl-2/Bax value decreases, Bax forms a homodimer to induce apoptosis; while when the Bcl-2/Bax value increases, Bax and Bcl-2 form a heterodimer to achieve Bcl-2 inhibition of cells function of apoptosis. Zhu Ning et al¹ found in a rat experiment that when neural stem cells were stimulated by Aβ1-42-mediated inflammatory response, the expression levels of Bcl-2 and Bax were the highest in each group, while the Bcl-2/Bax value was the highest in each group. lowest. After Hup A pretreated microglia, liquid chip detection showed that the secretion of inflammatory factors was reduced, and the Bcl-2/Bax value was significantly higher than that of Aβ group, which inhibited the apoptosis of neural stem cells. Both Western blotting and flow cytometry results indicated that Huperzine a Gnc could inhibit the apoptosis of neural stem cells.

2 Against organophosphorus neurotoxicity
The main mechanism of Huperzine a Gnc against organophosphorus poisoning is: Huperzine a Gnc is reversibly combined with acetylcholinesterase when administered in advance, thereby preventing the irreversible combination of organophosphorus compounds and acetylcholinesterase. Compared with other reversible cholinesterase inhibitors such as pyridostigmine bromide that have been used, Huperzine a Gnc has two major advantages: On the one hand, Huperzine a Gnc can pass through the blood-brain barrier, thereby protecting acetylcholinesterase in the brain. On the other hand, butyrylcholinesterase and carboxylesterase may be endogenous organophosphate scavengers. Huperzine a Gnc can selectively inhibit plasma erythrocyte acetylcholinesterase, but has no inhibitory effect on butyrylcholinesterase. Therefore, the selectivity of Huperzine a Gnc contributes to the prevention of organophosphorus poisoning.

3 Fight against glutamate toxicity
Glutamate is an agonist of N-methyl-D-aspartate (NMDA) receptors, which can increase the influx of calcium ions into neurons when NMDA receptors are stimulated, and high concentrations of calcium ions can lead to cell death . Huperzine a Gnc can reduce the toxicity of glutamate to neuronal cells and improve cell survival, especially for mature neuronal cells, which have the strongest protective effect because the number of NMDA receptors in mature neuronal cells is high. The anti-glutamate mechanism may be that after the NMDA receptor is activated, Huperzine a Gnc blocks its signal transduction channel somewhere downstream, thereby preventing the cell death caused by glutamate. In addition, the protective effect of Huperzine a Gncon nerve cells may also be There is glutamate receptor-mediated involvement.

4 Fight against oxidative stress
Huperzine a Gnc protects neuronal cells against the toxicity of beta-amyloid production and increases superoxide dismutase (SOD) production. Rat primary cortical cells cultured in vitro were incubated under the conditions of Aβ25-35 (amino acid residues 25-35 of β-amyloid fragments), and apoptosis of the cells could be observed, the cell viability was significantly decreased, and the neuronal cell morphology was changed. Alterations and their DNA fragments. Pre-administration of Huperzine a Gnc can significantly improve cell viability and prevent nuclear fragmentation. The mechanism is that Huperzine a Gnc inhibits the formation of reactive oxygen species (ROS reactive oxygen species) and the activity of caspase-3.

5 Inhibits the neurotoxicity of NO
Studies have shown that NO can inhibit the growth of human neurocytoma SK-N-SH cells and induce cell apoptosis. Huperzine a Gnc, ginkgolide A and B could block the apoptosis and growth inhibition of SK-N-SH cells by sodium nitroprusside (NO donor). In addition, Huperzine a Gnc and ginkgolides A and B also inhibited NO production in mouse glial cells and NO production in human and murine astrocytes.

Huperzine a Gnc Indications

Huperzine a Gnc is a powerful and relatively easy to fix cholinesterase prevention, more powerful than physostigmine, neostigmine and also Tacrine. For myasthenia gravis, the effective price is 99%. Clinical tests have actually shown that this product appropriates for benign memory problems, which can enhance individuals’ capability of aiming memory, associative learning, picture recall, meaningless number acknowledgment and also picture recall, as well as also improves the discovering and memory of typical people; this product works for mental deterioration people. It also boosts memory impairment caused by organic mind lesions. Clinically, Huperzine a Gnccan be used for the treatment of the following symptoms:

1. It is utilized to deal with and also improve amnesia in middle-aged and senior people, and also to improve associative memory feature; it is made use of for amnesia caused by too much mind usage, and to boost knowing and also work effectiveness;

2. It is used for memory loss associated with neurasthenia;

3, Huperzine a Gnc is utilized for amnesia brought on by cerebrovascular problems;

4, it is utilized for memory enhancement in senile dementia, to enhance and restore the cognition of individuals

5. It is made use of to treat myasthenia gravis;

6. Huperzine A has an enhancement effect on associative conditions, cognitive disability, as well as amnesia connected with schizophrenia;

7. It can boost the memory function related to a range of brain illness and also somatic diseases.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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