Hp Beta Cyclodextrin is a non-reducing cyclic oligosaccharide. It is a white crystalline powder, non-hygroscopic, with a melting point of 300-350 ° C. It is hydrophilic and also hydrophobic in liquid remedy. At 20 ° C, the solubility in 100 mL of water is 18.5 g. It is an amphiphilic molecule with a hydrophobic internal tooth cavity and a hydrophilic external surface area, 2 circles of H (H-3 and also H-5) and one circle of glycosidic oxygen atoms inside the dental caries, 21 hydrophilic OH exists on the outer surface as well as extends to create a hydrophobic chemical environment in the ring that is fairly hydrophilic outside the ring. When there are both hydrophobic and also hydrophilic substances in the aqueous solution, the hydrophobic compound is preferentially adsorbed in the ring. The number of hydrogen bonds formed in between the hydroxyl groups outside the tooth cavity and also the vicinal water particles identifies the water solubility of cyclodextrin. The reason is that intramolecular hydrogen bonds are quickly created between C2-OH and also C3-OH, and the communication with water molecules Hp Beta Cyclodextrin solubility in water is decreased when using hydrophilic groups to damage intramolecular hydrogen bonds, as well as can lower when hydrophobic teams are made use of to damage hydrogen bonds its solubility in water. The stability of Hp Beta Cyclodextrin in water depends upon the pH of the system. It is reasonably stable under alkaline conditions, however partly hydrolyzed to glucose or different oligosaccharides under acidic problems. The concentration of Hp Beta Cyclodextrin in water additionally influences its stability in water. When the focus is high, the intermolecular hydrogen bonding pressure of Hp Beta Cyclodextrin is strong, and also it can self-aggregate in water, even at high pH conditions. It can likewise be carried out under low temperature level, which is additionally the reason for its low solubility. Some variables that stop the development of intermolecular hydrogen bonds, such as temperature level and the influence of existing together materials in solution, such as urea, citric acid, polyvinylpyrrolidone, NaCl, etc, will impact the framework, size and also dispersion of β-cyclodextrin self-polymers. When β-cyclodextrin kinds complexes with other compounds, it will certainly also promote the development of nano-aggregates. The concentration of Hp Beta Cyclodextrin itself affects its complexation performance. Hp Beta Cyclodextrin forms nanoaggregates with lipophilic substances. Substitution of groups such as methyl and hydroxypropyl will certainly interfere with the crystal latticework of Hp Beta Cyclodextrin, leading to the formation of amorphous cyclodextrin by-products.