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Hovid Ginkgo Biloba Extract CAS 90045-36-6

Molecular Formula: NULL

Formula Weight: 0

ZSpharmac: Hovid Ginkgo Biloba Extract Supplement

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Product Name: Hovid Ginkgo Biloba Extract
CAS No: 90045-36-6
Purity: 99%

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Basic Info

Product Name:Hovid Ginkgo Biloba Extract
Other Names:Ginkgo Biloba P.E.
CAS:90045-36-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Brown powder
EINECS No.:0
Storage:Low Temperature Drying
Provide:Hovid Ginkgo Biloba Extract MSDS;
Hovid Ginkgo Biloba Extract COA

What is Hovid Ginkgo Biloba Extract?

Hovid Ginkgo Biloba Extract is a famous supplement in addition to amongst the very successful herbs. The healing property or commercial buildings of Hovid Ginkgo Biloba Eliminate are mentioned to consist of blood problems and likewise memory difficulties, enhanced cardio function and also improved eye health and wellness.The major elements are flavonoids in addition to terpene lactones. It has numerous health care functions and is typically used in food and additionally cosmetics.

Hovid Ginkgo Biloba Extract Pharmacokinetics

1. Pharmacokinetics of flavonoids
Ginkgo biloba flavonoids are mostly absorbed in the form of aglycones, and the glycoside or aglycone forms of ginkgo flavonoids are barely detected in plasma and pee, and also their main kinds are glucuronic acid conjugates or sulfuric acid conjugates of aglycones. At the same time, there are also literary works records that ginkgo flavonoids can be detected after hydrolysis in plasma or pee. The different conclusions may be brought on by the level of sensitivity of analytical instruments as well as techniques, but also disclosed that the bioavailability of ginkgo flavonoids is low. Ginkgo flavonoid glycosides are mainly metabolized in two parts in the body: one is the liver, which undertakes a series of responses under the action of CYP450 in the liver to generate more water-soluble metabolites that are eliminated; the other is the intestine, which plays a role in the intestinal tract flora Following, it is hydrolyzed to aglycone. Unlike the activation of CYP3A enzyme by ginkgo terpene lactones, ginkgo flavonoids exhibit an inhibitory effect on the activity of CYP3A enzyme. Quercetin and kaempferol can lower the activity of rat and also human liver microsomes CYP1A1, CYP1A2, and CYP3A4.
2. Pharmacokinetics of terpene lactones
Throughout the phase I metabolic rate of ginkgolides, the impacts of various lactones on CYP450 enzymes were tissue-specific, and also different substances had various effects on them. Ginkgolide A can generate the expression of CYP3A23, while Ginkgolide An and B have no effect on the transcription of CYP3A4; bilobalide can generate the expression of CYP3A4 and also CYP2B1. The result of ginkgolide on CYP450 enzyme system may be the basis of its pharmacological task. Compared with stage I metabolism, comparable to ginkgo flavonoids, in vitro studies have actually shown that the metabolic rate of ginkgolides is additionally dominated by stage II metabolic rate. There were substantial induction impacts on tathione-S-transferase and also lipoamide dehydrogenase, while ginkgolides B and also C had no significant result on them at the exact same dose.

Fields of Application of Hovid Ginkgo Biloba Extract

1. Food and health items market
The flavonoids in Ginkgo biloba have antioxidant residential or commercial properties and also can be included in oils and cakes as anti-oxidants. The total flavonoids are mostly yellow as well as have vast solubility, both water-soluble and fat-soluble, so the complete flavonoids can contribute in coloring. agent impact. Ginkgo biloba is refined right into ultrafine powder and added to food. Ginkgo biloba leaves are superfinely grated as well as included in cakes, biscuits, noodles, sweet and ice cream at 5% to 10%, and after that they can be refined right into ginkgo biloba food with health-care results.
Hovid Ginkgo Biloba Remove is used as a preservative in Canada, and also has actually been approved as a non-prescription drug in Germany as well as France. Ginkgo biloba is provided in the United States Pharmacopoeia (24th Edition), and also Hovid Ginkgo Biloba Essence is available as a dietary supplement in the United States. There are greater than 30 kinds of ginkgo products on the planet, and the main dose types consist of: ginkgo fallen leave, ginkgo oral liquid, ginkgo lactone shot, ginkgo damole shot, ginkgo ketone ester dropping pills, substance ginkgo fallen leave granules, ginkgo fallen leave extract, etc. From 2009 to 2011, the sales as well as DDDs of Ginkgo biloba preparations placed among the leading 3 typically utilized typical Chinese medicines for cardiovascular diseases.
Ginkgo biloba consists of a small amount of proanthocyanidins and urushiolic acids, which are poisonous to the human body. When using ginkgo leaves as resources to refine food, special treatment is called for to reduce the material of proanthocyanidins as well as urushiolic acids. Nonetheless, within the currently utilized dose array, there is no intense as well as chronic poisoning and no teratogenic impacts. The Ministry of Health has actually accepted Hovid Ginkgo Biloba Extract as a brand-new preservative in 1992. In the last few years, the overall flavonoids of Ginkgo biloba have actually been extensively made use of in the food sector, as well as the research and development of Ginkgo biloba has wide leads.

2. Daily chemical market
The combination of Hovid Ginkgo Biloba Remove and skin absorption booster also stops irritation caused by adhesives made use of in topical lotions as well as patches, such as lotions, lotions, creams, sols and also plaster tapes. The skin care products containing GBE on the marketplace now mainly include anti-aging cleanser, body wash, lipstick, eye lotion, etc. GBE can likewise be utilized in the manufacturing of hair development as well as hair treatment items. Chen Yan and also others even added Hovid Ginkgo Biloba Extract to tooth paste. According to their research, it has a certain anti-caries impact.

Pharmacological Activity of Hovid Ginkgo Biloba Extract

1. Effects on the cardiovascular system
Hovid Ginkgo Biloba Remove can prevent the activity of angiotensin-converting enzyme (ACE) in normal human product, consequently inhibiting the constraint of tiny arteries, expanding capillary, and enhancing blood circulation. Ginkgolide is a very specific PAF receptor blocker, Hovid Ginkgo Biloba Remove or Ginkgolide can hinder platelet initiating element (PAF) as well as cyclooxygenase or lipoxygenase. Hovid Ginkgo Biloba Essence was well endured and annoyed platelet gathering by PAF, yet had no impact on ADP-induced gathering.

2. Impacts on the main nervous system
Hovid Ginkgo Biloba Remove influences the endocrine system as well as the interaction between the immune system and also the central nerves by inhibiting the result of PAF, which can advertise mind blood circulation as well as metabolic process as well as enhance memory feature. Along with boosting the hypoxia-induced memory impairment brought on by NaNO2, its anti-hypoxia impact might be linked to its increase of analytical blood circulation and improvement of mind basal metabolism throughout hypoxia. Ginkgolide B can be used for specialist therapy of stroke.

3. Effect on the digestive system
Hovid Ginkgo Biloba Essence can dramatically improve the gastric and digestion tract ulcers in rats caused by PAF as well as endotoxin, as well as also can partially prevent the damages to the stomach set off by ethanol. Possible healing result on liver cirrhosis. Ginkgolide B might have a function in the treatment of acute pancreatitis.

4. Outcomes on the breathing system
The ethanolic essence of Ginkgo biloba has a straight soothing result on tracheal smooth muscular tissue mass. The breathing of the aerosolized Hovid Ginkgo Biloba Extract not just impedes the bronchoconstriction outcome, but also inhibits the reduction of leukocyte along with eosinophils caused by PAF. Ginkgo Biloba Eliminate is of superb worth in preventing as well as taking care of bronchial hyperresponsiveness.

5. Anti-aging effect
Ginkgo biflavonoids, isoginkgo biflavonoids, ginkgol as well as quercetin in Ginkgo biloba fallen leave have inhibitory effects on lipid peroxidation, particularly quercetin has more powerful repressive job.

6. Function in transplant being rejected as well as various other immune actions
Hovid Ginkgo Biloba Extract lengthens the survival of skin grafts, ectopic heart xenografts, orthotopic liver xenografts. Ginkgo biloba extract can prevent the natural killer cell activity of the body on KC526 target cells, as well as can in addition stop the all-natural awesome cell task caused by interferon.

7. Anti-tumor result
The unrefined essence of eco-friendly leaves of Ginkgo biloba, the fat-soluble component, can inhibit EB infection, and also heptadecene salicylic acid and also Bilo-betin have solid inhibitory tasks; general flavonoids of Ginkgo biloba can enhance the weight of thymus in tumor-bearing mice And also SOD activity degree, turn on the body’s fundamental anti-tumor capability; quercetin along with myricetin can prevent the event of health hazards.

8. Antioxidant effect
Hovid Ginkgo Biloba Essence can straight remove lipid free radicals, lipid peroxidative totally free radicals as well as likewise alkyl radicals, and so on, and likewise terminate the domino effect chain of free radicals. At the same time, it can additionally join controling and likewise enhancing the activity of antioxidant enzymes such as superoxide dismutase as well as glutathione peroxidase. The antioxidant result of flavonoids in EGB likewise goes beyond that of vitamins, and also has anti-radical attack residential or industrial buildings artificial insemination.

Hovid Ginkgo Biloba Extract Extraction Method

According to insufficient statistics, the current global standard Hovid Ginkgo Biloba Essence is EGb761 generated according to the German Schwabe trademarked process. The look is brown powder with a mild ginkgo fallen leave fragrance. Hovid Ginkgo Biloba Extract is an item extracted from the leaves of Ginkgo biloba L. as basic material. The industrial extract is normally standard to include 24% of flavonoid glycosides as well as 6% of ginkgo terpene lactones.
There are lots of methods reported in the literary works on the manufacturing procedure of Ginkgo biloba extract, mainly including acetone extraction-lead salt rainfall technique, ethanol extraction-macroporous material adsorption splitting up approach, supercritical carbon dioxide extraction method, alcohol extraction-extraction-chromatographic splitting up approach, etc. The most commonly utilized method in China is the ethanol extraction-resin splitting up technique.
Presently, the most extensively used approach at home as well as abroad is the organic solvent removal technique. Since various other organic solvents are poisonous or unpredictable, ethanol is usually made use of as the extractant. Experiments by Zhang Yonghong and others revealed that the most effective problems for removing flavonoids from Ginkgo biloba leaves are 70% ethanol as the remove, the removal temperature is 90 ° C, the material-liquid proportion is 1:20, the removal times are 3 times, and each reflux is 1.5 h.
1. Ethanol extraction-macroporous resin adsorption separation method
Remove impurities and mildew leaves, wash, chop, extract with 70% ethanol reflux, separate the extract, filter, recover ethanol under reduced pressure, remove slag by high-speed centrifugation, add appropriate amount of pure water to dilute, add to macroporous adsorption Resin column, eluted with water until the eluent is clear and light in color, and then eluted with a certain concentration of ethanol, the eluent is collected, concentrated under reduced pressure, and dried in vacuo.
2. Acetone extraction-lead hydroxide precipitation method
Ginkgo biloba leaves were extracted with 60% acetone, filtered after cooling, the extract was extracted with carbon tetrachloride, butanone was added and mixed, the acetone-butanone phase was separated and separated out, and solid ammonia sulfate was added to the ketone phase and stirred, and the solid was filtered off. substance, evaporate the filtrate under reduced pressure to a concentration of 20%-60% solid content, and dilute with 50% denatured ethanol to a concentration of 10% solid content. The lead hydroxide suspension was added and the precipitate was filtered off. The filtrate is concentrated under reduced pressure to half the volume, then ammonium sulfate and butanone are added to the concentrated solution under stirring, and the butanone-ethanol phase is separated out after the stirring; the butanone-ethanol phase is separated from the water phase, and then in the water phase Add butanone, stir, separate out butanone-ethanol phase, and combine into the above-mentioned butanone-ethanol phase. Add ammonium sulfate under stirring, separate the precipitated water phase after mixing, dry the butanone-ethanol phase with sodium sulfate, evaporate to dryness under reduced pressure, dissolve the denatured viscous residue with denatured ethanol, stand for 12 hours to separate the precipitated precipitate, reduce Evaporate under pressure and dry under vacuum.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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