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Honeysuckle Extract CAS 84603-62-3

Molecular Formula: C8H4N2O4

Formula Weight: 

ZSpharmac: Honeysuckle Extract Supplier

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Product Name: Honeysuckle Extract
CAS No: 84603-62-3
Purity: 99%

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Basic Info

Product Name:Honeysuckle Extract
Other Names:Honeysuckle, Lonicera caprifoliuM, ext.
CAS:84603-62-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Viscous Liquid
EINECS No.:283-263-6
Storage:2-8°C
Provide:Honeysuckle Extract MSDS;
Honeysuckle Extract COA

What is Honeysuckle Extract?

Honeysuckle is an usual conventional Chinese medication in my nation, which is the entirely dry blossom bud of Lonicera japonica Thunb.The honeysuckle essence obtained after extraction and also drying out of honeysuckle has been extensively utilized in Yinhuang oral liquid, Yinhuang pills, Yinhuang granules and other Chinese patent medicines. Chlorogenic acid, the primary active component in honeysuckle essence, has pharmacological impacts such as anti-virus, boosting resistance, and also reducing blood fat. Honeysuckle remove has actually been gradually applied in the fields of drug store, spices, cosmetics, natural food, health and wellness drink, etc, and also has a very wide possibility.

Chemical Composition of Honeysuckle Extract

1. Organic acids
The significant energetic component of honeysuckle significance is chlorogenic acid compounds. There are primarily chlorogenic acid (Chlorogcnicacid) in addition to isochlorogenic acid (Isochlorogenic acid). Chlorogenic acid (CGA), likewise referred to as coffee tannin, is a depsipolic acid established from caffeic acid in addition to quinic acid, as well as additionally comes from phenylpropanoid substances. Isochlorogenic acid is a mix, and its isomers are 4,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 1,3-dicaffeoylquinic acid, 3-feruloylquinic acid, 4-feruloylquinic acid, 5-feruloylquinic acid.
2. Flavonoids
The earliest flavonoid energised component extracted from honeysuckle is luteolin, followed by honeysuckle. In the 1990s, luteolin-3-O-α-D-glucoside, luteolin-7-O-β-D-galactoside, quercetin-7-O- β-D-glucoside as well as hyperin 4 flavonoids. 5-Hydroxy-3′, 4′, 7-trimethoxyflavone and Corymbosin were acquired from the chloroform remove of honeysuckle.
3. Unstable oils
There are bisporin and also linalool. Both made up 49.4% of the complete unstable oil. It still has eugenol, geraniol, α-terpineol, and more, along with 47 substances have actually been acknowledged.
4. Numerous other
Still consist of inositol, saponin, tannic acid etc. Chlorogenic acid (Chlorogenic acid): molecular formula C16H18O9, molecular weight 354.30. The hemihydrate is needle crystal (water), and additionally winds up being anhydrous substance at 110 ° C, mp.208 ° C, [α] D26-35.2 ° (C=2.8). The solubility in water at 25 ° C is 4%, as well as the solubility in hot water is even higher. It is conveniently soluble in ethanol and also acetone, as well as exceptionally slightly soluble in ethyl acetate. Honeysuckle leaves contain Loniceraflavone: molecular formula C15H10O5, Lonicein, Loganin in addition to tannins.

Pharmacological Actions of Honeysuckle Extract

1. Anti-inflammatory, antipyretic and anti-allergic effects
Honeysuckle remove can inhibit rat carrageenan foot swelling as well as lower the level of egg white foot swelling. It additionally has noticeable anti-exudation and anti-proliferation impacts on rat croton oily granulation sacs. Honeysuckle has obvious antipyretic impact on experimental animal high temperature models. Yinqiao powder has a considerable repressive result on various speculative inflammations, particularly sensitive inflammation, and also can dramatically inhibit 2,4-dinitrophenol-induced fever in rats.
2. Anti-fertility effect
The preparation extracted from honeysuckle by ethanol has noticeable anti-fertility impact via parenteral management. It is effective for early, center as well as late maternity in mice when infused intraperitoneally. It is likewise effective for early pregnancy in rabbits when carried out intravenously or intrauterinely. Honeysuckle can dramatically minimize plasma progesterone in early pregnant rats, the anti-early pregnancy impact of honeysuckle can be completely canceled by exogenous progesterone as well as chorionic gonadotropin (HCG), as well as honeysuckle can also significantly inhibit decidualoma in pseudopregnant mice The formation of, this impact can additionally be annoyed by progesterone.
3. Antioxidant impact
The liquid extract of honeysuckle has a straight removal effect on hydrogen peroxide (H2O2) artificial insemination, and it has a direct dose-effect partnership, yet whether it likewise has a result in vivo continues to be to be further studied. Furthermore, honeysuckle can enhance the release of H2O2 from neutrophils in scalded computer mice to a specific level, and also can lower the ability of neutrophils to synthesize and also release lysosomal enzymes in scalded mice, suggesting that it has an anti-oxidative effect. The experimental outcomes revealed that the crude extract of chlorogenic acid and also crude flavonoids had a considerable repressive effect on the peroxidation response of oil. Lonicera as well as chlorogenic acid are two phenolic acid compounds with high material in honeysuckle leaves. Phenolic acid is a regular type of compound with the result of scavenging cost-free radicals, while Lonicera is somewhat stronger than chlorogenic acid. The DPPH method was utilized to examine the antioxidative task of Lilyniacus japonica, and also the antioxidative activity was revealed by the inhibition price. The restraint price is 95.4% when the concentration is 5mg/ml, and also the restraint price is 94.3% when the extract is watered down 5 times to a focus of 1mg/ml, which reveals that Jasmine has a solid antioxidant capability.
4. Protect liver and gallbladder
The chlorogenic acid consisted of in the honeysuckle essence has a choleretic effect and can enhance bile secretion in rats. Subcutaneous shot of 200 mg/kg of total saponins of Lonicera tomentosa can dramatically withstand the rise of serum GPT and liver triglyceride material in computer mouse liver caused by CCl4, paracetamol as well as galactosamine, as well as substantially lower the intensity of liver pathological damages, making the liver The sum of the number of punctate death and also the event rate of death were substantially minimized.
5. Lower blood fat, boost immune feature
Gastrointestinal management of honeysuckle remove 2.5 g/kg to rats can decrease the absorption of cholesterol in the intestinal tract and also reduce the web content of cholesterol in plasma. In vitro tests additionally found that honeysuckle can be incorporated with cholesterol. The complete saponins of Lonicera tomentosa can substantially reduce the liver triglyceride content of typical mice, and also greatly reduce the liver triglyceride content of CCl4, paracetamol, and galactosamine infected mice. Honeysuckle water extract can promote the phagocytosis of outer blood leukocytes. The intraperitoneal shot of honeysuckle shot in computer mice can additionally significantly advertise the phagocytosis of inflammatory cells. 250mg/kg honeysuckle water remove can lower the ANAE positive percentage of T cells, suggesting that it may have an inhibitory result on mobile resistance. Furthermore, chlorogenic acid, as the major active component of ramie, has the impact of raising leukocyte.
6. Hemostatic effect
The chlorogenic acid and caffeic acid included in honeysuckle remove have substantial hemostatic result, which can reduce the coagulation time as well as bleeding time. Chlorogenic acid as well as caffeic acid are likewise the hemostatic active ingredients of ramie root. Chlorogenic acid is not resistant to heat, and also it will certainly be destroyed by heating for a long time as well as the efficacy will be reduced. The typical silver blossom charcoal made use of for hemostasis may be connected to this.
7. Central excitatory result
Dental administration of chlorogenic acid can trigger central nerves enjoyment in rats, mice and also various other pets, and also its stamina is 1/6 of that of high levels of caffeine, and the mix of the two has no additive or developing effect.
8. Antibacterial and also antiviral results
Honeysuckle remove has a large antibacterial array, and has repressive impacts on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus hemolyticus, Diplococcus pneumoniae, as well as Bordetella pertussis. Gram-negative bacteria such as Vibrio, Pseudomonas aeruginosa, Escherichia coli, human consumption, and meningococcus also have strong repressive effects, as well as are also effective versus Leptospira. The water preparation of this item has in vitro repressive impact on a selection of skin fungis such as Trichophyton violaceae, Pseudomonas schlensiella, Microsporum rust-colored, Epidermophyton rubrum, and Nocardia asteroides. Current studies have revealed that honeysuckle has antibacterial effects on typical pathogenic bacteria that trigger oral diseases, such as Streptococcus mutans, Myxobacter actinomycetes, Bacteroides gingivalis, and also Bacteroides melanogenes. Honeysuckle or its compound has inhibitory result on respiratory infections such as influenza An and orphan virus, and also can inhibit and also delay its cytopathic impact. On top of that, it additionally has a particular inhibitory impact on herpes virus. It is typically believed that its main energetic components are chlorogenic acid substances.
9. Other functions
In vitro tests, the water and also alcohol immersion remedy of honeysuckle had evident cytotoxic impact on computer mouse sarcoma S180 and Ehrlich ascites carcinoma. Oral administration of honeysuckle remove has a light preventative impact on pyloric-ligative gastric abscess in rats. Dental administration of huge doses of chlorogenic acid can improve intestinal mobility and also promote secretion of gastric juice and also bile. Chlorogenic acid and its decay products have excitatory results on the separated womb of rats. Chlorogenic acid contained in honeysuckle can create central nervous system exhilaration in rats as well as mice. Furthermore, chlorogenic acid can additionally a little improve the pressor result of epinephrine and norepinephrine on felines and rats, but has no result on cat’s nictitating membrane feedback.

Extraction Method of Honeysuckle Extract

1. Stone sulfur method
Take 1 kg of honeysuckle, add water to decoct twice, 2 hours each time, combine the decoction liquid, filter, add lime milk to the filtrate to adjust the pH value to 10-12, let it stand, filter out the precipitate, add appropriate amount of water, and adjust the pH value to 6-6 with sulfuric acid 7. Stir well, filter, concentrate the filtrate to a thick paste, and spray dry to obtain the honeysuckle extract.
2. Improved stone sulfur method
Take 1kg of honeysuckle, add (15, 10) times the amount of water, extract twice at 80-90°C for 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 2/5 of the original volume, add 20% milk of lime Adjust the pH value to 10-12, let it stand for 12 hours, filter out the precipitate, add 2 times the amount of 95% ethanol to suspend, add 50% sulfuric acid to adjust the pH value to 3-4, mix well, filter, and adjust the pH value of the filtrate with 40% NaOH 6-7, filter, concentrate to a thick paste, and spray dry to obtain the honeysuckle extract.
3. Ultrafiltration treatment
Take 1 kg of honeysuckle, add (15, 10) times the amount of water, decoct twice, 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 2/5 of the original volume, let it stand, filter, ultra-filter, The ultrafiltrate was collected, concentrated to the crude drug amount, allowed to stand, filtered, concentrated under reduced pressure, and vacuum-dried to obtain the honeysuckle extract.
4. Ethanol reflux extraction
Weigh 1 kg of honeysuckle, put it in a round bottom flask, add (10, 8) times the amount of 70% ethanol, heat and reflux for extraction twice, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure, and vacuum dry to obtain the honeysuckle extract.
5. Macroporous adsorption resin treatment
Take 1 kg of honeysuckle, add (15, 10) times the amount of water, extract twice at 90°C for 2 hours each time, filter, combine the filtrate, add the filtrate to the pretreated macroporous adsorption resin, add water to elute, collect and wash The liquid was removed, concentrated under reduced pressure, and dried in vacuum to obtain the honeysuckle extract.

About Products:
If you need Honeysuckle Extract, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Honeysuckle Extract manufacturer and supplier, ZSpharmac will provide Honeysuckle Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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