Zhishang Chemical

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Zhishang Chemical

Hinokitiol CAS 499-44-5

Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: Hinokitiol Raw Material Supplier

Product Name: Hinokitiol
CAS No: 499-44-5
Purity: 99%

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Basic Info

Product Name:Hinokitiol
Other Names:β-thujaplicin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Solid
EINECS No.:207-880-7
Storage:Room Temperature
Provide:Hinokitiol MSDS;
Hinokitiol COA

What is Hinokitiol?

Hinokitol, additionally called hinokitiol, is a monoterpene natural compound with a tropolone skeletal system drawn out from the trunk of Taiwanese cypress by the Japanese researcher Anderson in 1948. It originates from the tropolone family of substances and has fantastic anti-bacterial homes. It makes love, hydrating and pest repellent effects. It is a highly risk-free plant component that can be utilized as an anti-bacterial and insect repellent. It is the main part of Taiwanese cypress needed oil. It has a large array of biological jobs and has strong antiseptic capability. It is effective versus typical microorganisms. The minimal repressive concentration is 10-100ppm. It has a fragrant odor and outstanding effect. It can eliminate bacteria and bacteria in the air, prevent insects from getting into the body, and protect against human pathogenic microbes. It has really been utilized in the manufacturing of shower gel, cosmetics, medication and other products. It was revealed that hinokitiol has a great outcome on preventing Staphylococcus aureus (MRSA). This microorganism regularly exists in the skin and breathing tract of the body, creating skin infections such as blood poisoning, peritonitis, food poisoning, and sores, boils, and abscesses.

Hinokitiol Property

Melting point 50-52 °C(lit.)
Boiling point 140 °C10 mm Hg(lit.)
density 1.0041 (rough estimate)
refractive index 1.5190 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form solid
color White


Applications of Hinokitiol

Hinokitiol has excellent antibacterial, moisturizing and pest repellent results, and can be utilized as an antibacterial and bug spray. Hinoki alcohol is the primary element of Taiwanese cypress vital oil. It has a large range of biological activities and solid antiseptic capacity. The minimal inhibitory concentration for basic germs is 10 ~ 100ppm. It has a great smelling odor and great impact. It can eliminate bacteria and bacteria airborne. Germs can stop pests from attacking the human body and inhibit human pathogenic germs. Presently, hinokol is widely utilized in the production of shower gel, cosmetics, medication, agriculture and other products. For instance, some research has developed an anti-bacterial and antiperspirant containing hinokitiol. It makes use of hinokitiol as the major anti-bacterial representative and does not consist of annoying substances such as chlorine and iodine. It is worsened with ethanol, surfactants, water, and so on, and is developed right into a spray disinfectant. Anti-bacterial deodorant fluid for usage with devices. After being atomized by a sprayer, the antibacterial liquid can promptly engage with microorganisms in the automobile, inhibit their recreation, and get rid of odors in the auto. This accomplishes the objective of freshening the air in the vehicle. It has the advantages of being non-irritating to the skin, risk-free, and not contaminating the atmosphere. It can also be sprayed straight on hard surface areas or to sanitize hand skin. It has fantastic prospective for commercial manufacturing; there is additionally research and development of a vegetables and fruit stick movie with anti-bacterial function and its prep work method. By preparing a combined base product for cling film, extruding it with a screw extruder and blowing it right into a movie, splashing hinokitiol liquid on the surface of the film at the movie outlet, and after that stretching it in 2 directions, you can prepare a film with anti-bacterial feature. Fruit and vegetable cling wrap. The hinokitiol used in this approach has excellent antibacterial residential properties, hydrating homes, and is safe. It has great compatibility with low-density polyethylene movies and can be uniformly dispersed externally of the movie. It has high antibacterial rate and good moisturizing homes, and has long antibacterial maintenance time. It is long, can greatly enhance the storage space life of fruits and vegetables, has great handling security, is basic and easy to control the prep work process, has reduced power consumption, is eco-friendly, is low in price, and is suitable for massive production. Furthermore, Hinokitiol has a great impact on inhibiting Staphylococcus aureus. Additionally, cypressol has superior effects in the avoidance and treatment of soil-borne diseases.

Hinokitiol Preparation

Action 1: Synthesis of 1-isopropylcyclopentadiene
Under nitrogen protection, liquify metallic salt (14 g, 0.6 mol) in tetrahydrofuran (250 g), consist of cyclopentadiene (48 g, 0.72 mol), react at 30 ° C for 1 hour, and vaporize the tetrahydrofuran under lowered stress. Dimethyl sulfoxide (50 g) was consisted of in acquire an alternative of salt cyclopentadienyl in dimethyl sulfoxide. Include n-hexane (142 g) to this choice, incredible to 0 ° C, and include isopropyl bromide (148 g, 1.2 mol) dropwise within 50 mins. Keep the temperature at no more than 5 ° C throughout the enhancement, and no greater than 10 ° C after the enhancement; After that gradually add 1 N hydrochloric acid solution (62 g) and n-hexane (155 g), mix at 10 ° C for 5 minutes, and allow stand for 5 minutes. The natural layer and the liquid layer are separated to obtain isopropylcyclopentadiene-containing Service (420 g), the alternative was enabled to stand for 6 h at 20.0 ° C for isomerization. The proportion of isomers happened establishing 1: positioning 5: position 2 = 96.3: 1.7: 2.0, and the return was 95.2%.

Step 2: Synthesis of 7,7-dichloro-3-isopropyl-bicyclo [3,2,0] hept-2-en-6-one
Liquify isopropylcyclopentadiene (61.77 g, 0.571 mol) in n-hexane (500 mL), gradually include dichloroacetyl chloride (92.58 g, 0.658 mol) at 0 ° C, and later on add it at 0 ° C. Triethylamine (66.58 g, 0.658 mol) was added dropwise within 2 hours, after that 1 N hydrochloric acid was added to liquify the salt produced by the response, and the natural layer was divided to obtain the enone-containing adduct 7,7-dichloro-3- The n-hexane solution of isopropyl-bicyclo [3,2,0] hept-2-en-6-one was evaporated to do away with the solvent and later on distilled under lessened pressure to acquire 107 g of a fraction having ketene adduct, with a return of 85.8%., pureness 98%. The proportion of isomers examined by GC is first placement: 5th positioning: second positioning = 99.8:0:0.2.

Action 3: Synthesis of hinokitol
Liquify the ketene adduct (173.76 g, 0.761 mol) in a consolidated solvent of tert-butyl alcohol (1032 g), water (274 g) and acetic acid (274 g), and warm to reflux. Triethylamine (539.04 g, 5.327 mol) was included dropwise under reflux. The dropwise addition was completed in 2.5 h. After continuing to be to reflux for 1.5 h, it was cooled to space temperature level. Consist of water (1575 g), focused hydrochloric acid (119 g) and n-hexane (1000 mL) subsequently, and split the layers. The solvent was vaporized from the organic layer under lowered stress to get 130.09 g of unrefined hinokitiol (pureness 79.9%), with a return of 83.2%. The unrefined product was distilled under lowered pressure, and after distilling off the previous fraction at 45-90 ° C/1 mm Hg, the main portion at concerning 95 ° C/1 mm Hg was accumulated to obtain 106.64 g of hinokinol, with a purification recuperation rate of 97.5%. Liquify this section in n-hexane (500 mL) at 40 ° C and cool to 0 ° C at a rate of 1 to 2 ° C per minutes. The crystals were precipitated and filtered with suction. The filter cake was cleaned up with n-hexane cooled to 0 ° C and dried out to get 93.27 g (0.568 mol) hinokinol crystals with a pureness of 99.9% and a crystallization recovery rate of 92.1%.

Contact Us

About Products:
If you need Hinokitiol as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced Hinokitiol manufacturer and supplier, ZSpharmac will provide Hinokitiol raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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