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Zhishang Chemical

Hinoki Alcohol CAS 499-44-5

Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: Hinoki Alcohol Supplement

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Product Name: Hinoki Alcohol
CAS No: 499-44-5
Purity: 99%

Basic Info

Product Name:Hinoki Alcohol
Other Names:β-Thujaplicin
CAS:499-44-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:White Solid
EINECS No.:207-880-7
Storage:Sealed in Dry,Room Temperature
Provide:Hinoki Alcohol MSDS;
Hinoki Alcohol COA

What is Hinoki Alcohol?

Hinoki Alcohol, also referred to as hinokitiol, is a natural substance of monoterpenoids with tropolone skeleton removed by Japanese researcher Anderson in 1948 from the trunk of cypress in Taiwan. It belongs to the tropolone household as well as has good antibacterial properties., moisturizing and also bug repelling impact, is a high-safety plant component, can be utilized as antibacterial and also insect repellant, is the primary part of Taiwan Hinoki cypress vital oil, has a reasonably variety of organic tasks, has solid antiseptic capacity, and has the smallest impact on basic germs. The anti-bacterial concentration is 10-100ppm, the smell is fragrant and also the result is great. It can eliminate germs and microorganisms airborne, avoid insects from invading the body, and also hinder human pathogenic germs. It has been used in the manufacturing of shower gel, cosmetics, medication and other items. The surprising impact of Hinokitiol versus Staphylococcus aureus (MRSA) was introduced.

Hinoki Alcohol Properties:

Melting point 50-52 °C(lit.)
Boiling point 140 °C10 mm Hg(lit.)
density 1.0041 (rough estimate)
refractive index 1.5190 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka7.06±0.30(Predicted)
form solid
color White

 

Hinoki Alcohol App

Hinoki alcohol has excellent antibacterial, moisturizing and insect repellent effects, and can be used as an antibacterial and insect repellent. Hinoki alcohol is the main component of Taiwan juniper essential oil. It has a variety of biological activities and strong antiseptic ability. The minimum inhibitory concentration for general pathogens is 10-100ppm. It has a fragrant smell and packs an excellent punch. It kills microbes as well as microbes in the air. It can not only prevent insects from invading the human body, but also block human pathogenic bacteria.

For example, Hinoki Alcohol is used to develop disinfectant and deodorant, which uses juniper alcohol as the main antibacterial agent and does not contain irritating compounds such as chlorine and iodine. It can be mixed with ethanol, surfactant, water, etc. to make spray disinfectant. Antibacterial deodorant liquid used in the product. After the antibacterial liquid is atomized by the sprayer, it can quickly interact with the bacteria in the car, inhibit its reproduction, and eliminate the odor in the car. So as to achieve the purpose of freshening the air in the car. It has the advantages of no irritation to the skin, safety, and no environmental pollution. It can also be sprayed directly on hard surfaces or to disinfect the skin of the hands. Great potential for industrial production.

There is also research and development of a fruit and vegetable fresh-keeping film with antibacterial function and a preparation method thereof. The mixed base material of the fresh-keeping film is prepared, the film is extruded with a screw extruder, the hinokitiol liquid is sprayed on the film outlet, and then biaxially stretched, the fruits and vegetables with antibacterial function can be prepared. plastic wrap. The hinokitiol used in the method has good antibacterial and moisturizing properties, is non-toxic, has good compatibility with low-density polyethylene film, can be dispersed on the surface of the film, has high bacteriostatic rate, good moisturizing performance, and maintains antibacterial time for a long time. The storage life of fruits and vegetables can be greatly improved, the processing stability is good, the preparation process is simple and easy to control, the energy consumption is low, the environmental protection is good, the cost is low, and it is suitable for large-scale production. In addition, hinokitiol has a good inhibitory effect on Staphylococcus aureus. In addition, hinokitiol is effective in controlling soil-borne diseases.

Preparation of Hinoki Alcohol

Step 1: Synthesis of 1-isopropylcyclopentadiene

Under nitrogen protection, sodium metal (14 g, 0.6 mol) was dissolved in tetrahydrofuran (250 g), cyclopentadiene (48 g, 0.72 mol) was added, and the reaction was carried out at 30 °C for 1 h. After the tetrahydrofuran was evaporated under reduced pressure, Dimethyl sulfoxide (50 g) was added to give a solution of sodium cyclopentadienyl in dimethyl sulfoxide. To this solution, n-hexane (142 g) was added, cooled to 0 °C, and isopropyl bromide (148 g, 1.2 mol) was added dropwise within 50 min. During the addition, the temperature was maintained at not more than 5 °C, and the dropwise addition did not exceed 10 °C; Then 1 N hydrochloric acid solution (62 g) and n-hexane (155 g) were slowly added, stirred at 10 °C for 5 min, and after standing for 5 min, the organic layer and the aqueous layer were separated to obtain the isopropylcyclopentadiene-containing compound. solution (420 g), the solution was allowed to stand at 20.0 °C for 6 h for isomerization, the ratio of isomers became 1:5:2 = 96.3:1.7:2.0, and the yield was 95.2%.

Step 2: Synthesis of 7,7-dichloro-3-isopropyl-bicyclo[3,2,0]hept-2-en-6-one

Dissolve isopropylcyclopentadiene (61.77 g, 0.571 mol) in n-hexane (500 mL), at 0 °C, slowly add dichloroacetyl chloride (92.58 g, 0.658 mol), then at 0 °C, add Triethylamine (66.58 g, 0.658 mol) was added dropwise within 2 h, then 1 N hydrochloric acid was added to dissolve the salt generated by the reaction, and the organic layer was separated to obtain the enone adduct 7,7-dichloro-3- The n-hexane solution of isopropyl-bicyclo[3,2,0]hept-2-en-6-one was evaporated to remove the solvent and then distilled under reduced pressure to obtain 107 g of fractions containing ketene adduct with a yield of 85.8% , 98% purity. The ratio of isomers analyzed by GC was 1-position:5-position:2-position = 99.8:0:0.2.

Step 3: Synthesis of Hinoki Alcohol

The enone adduct (173.76 g, 0.761 mol) was dissolved in a mixed solvent of tert-butanol (1032 g), water (274 g) and acetic acid (274 g) and heated to reflux. Triethylamine (539.04 g, 5.327 mol) was added dropwise under reflux, the dropwise addition was completed for 2.5 h, and after refluxing was continued for 1.5 h, the mixture was cooled to room temperature. Water (1575 g), concentrated hydrochloric acid (119 g) and n-hexane (1000 mL) were added successively, and the layers were separated. The organic layer was evaporated to remove the solvent under reduced pressure to obtain 130.09 g (purity 79.9%) of crude juniper alcohol with a yield of 83.2%. The crude product was distilled under reduced pressure, and after distilling the front distillate at 45-90 °C/1 mm Hg, the main distillate of about 95 °C/1 mm Hg was collected to obtain 106.64 g Hinokitiol, and the distillation recovery rate was 97.5%. This fraction was dissolved in n-hexane (500 mL) at 40°C and cooled to 0°C at a rate of 1-2°C per minute. The crystals were precipitated, filtered with suction, and the filter cake was washed with n-hexane cooled to 0°C and dried to obtain 93.27 g (0.568 mol) of Hinokitiol crystals with a purity of 99.9% and a recovery rate of 92.1%.

Application of the Whitening Agent of Hinoki Alcohol

Tyrosinase is a key enzyme in the formation of melanin, which can catalyze the conversion of leptin and dopa into melanin and brown pigment through multiple pathways in the human body, thereby causing freckles, chloasma, and pregnancy spots. In vitro experiments showed that Hinokitiol had a strong inhibitory effect on tyrosinase bisphenolase, and the concentration of Hinoki Alcohol (IC50) was 0.3umol/l, which decreased the enzyme activity by 50% when dopa was used as the substrate. Its inhibitory effect is a reversible process, indicating that Hinoki Alcohol only inhibits the activity of tyrosinase without causing permanent inactivation of the enzyme. The good regulation mechanism of tyrosinase in melanocytes by hinokitiol is closely related to its structure. Tyrosinase is a ketone-containing oxidoreductase. The 2-position and 1-position ketone of cypressol cycloheptatriene The structure can combine with the copper atom in the active center of tyrosinase to form a tight complex, which leads to the decrease of the catalytic activity of tyrosinase, which is the main way to inhibit the activity of tyrosinase; Hydroxy and ketone structures can also combine with tyrosinase-substrate complex (ES) to form a ternary complex to regulate the formation of melanin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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