Zhishang Chemical

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Zhishang Chemical

Hexylresorcinol Cream CAS 136-77-6

Molecular Formula: C12H18O2

Formula Weight: 194.27

ZSpharmac: Hexylresorcinol Cream Supplier

Product Name: Hexylresorcinol Cream
CAS No: 136-77-6
Purity: 99%

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Basic Info

Product Name:Hexylresorcinol Cream
Other Names:Hexylresorcinol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-257-4
Provide:Hexylresorcinol Cream MSDS;
Hexylresorcinol Cream COA

Hexylresorcinol Lotion is a replaced phenol with bactericidal, anthelmintic as well as potential antitumor tasks. Hexylresorcinol is used as a chemical in mouth washes as well as skin injury cleansers. Hexylresorcinol can additionally inhibit oxidative DNA damages by enhancing the activity of antioxidant enzymes, consisting of glutathione peroxidase and glutathione reductase, which contribute to) to scavenge energetic oxygen molecules.

Hexylresorcinol Cream Property

Melting point 65-67 °C (lit.)
Boiling point 333-335 °C (lit.)
density 1.0010 (rough estimate)
vapor pressure 0.001Pa at 25℃
refractive index 1.5050 (estimate)
Fp >100°C
storage temp. 2-8°C
solubility chloroform: 50 mg/mL, clear
pkapKa 9.1 (Uncertain)
form Powder and/or Chunks
color White to pale orange or pale pink
PH7.7 (0.5g/l, H2O, 20℃)
Water Solubility 0.05 g/100 mL (18 ºC)


Hexylresorcinol Cream Uses

  1. Hexylresorcinol Cream is an encouraging molecule for cosmetic/aesthetic applications, including the therapy of hyperpigmentation and photoaging.
  2. Hexylresorcinol Cream is a new sort of antioxidant and also color-protecting agent that can prevent browning. It can be used to stop browning of shrimp. It ought to be used in an appropriate amount according to manufacturing needs, and the residual amount needs to not surpass 1mg/kg.
  3. Hexylresorcinol Cream is an anti-oxidant; a pigment stabilizer; an enzyme browning inhibitor; a processing help.

Hexylresorcinol Cream Production Method

Put 1/2 amount of hexanoic acid into the dissolution pot, add anhydrous zinc chloride, heat and stir to dissolve the mixture at about 120°C; put the other half of caproic acid into the condensation pot, add resorcinol, stir to dissolve ; Add the above zinc chloride/caproic acid solution dropwise at about 120°C, reduce the pressure to 93kPa, keep the temperature for 3 hours, and distill the water generated by the reaction at the same time; pot, dehydration under constant pressure, dehydration under reduced pressure, and recovery of unreacted hexanoic acid to obtain the condensation product hexanoyl resorcinol.
Add zinc amalgam to hexanoyl resorcinol, then add industrial hydrochloric acid, stir and raise the temperature to 75-80°C, then naturally raise the temperature to 104-110°C, and keep the temperature for 1.5-2.0h. Lower the temperature to 80°C and check the end point of the reaction; after the reaction is completed, lower the temperature to below 40°C, separate the reduced product, wash with water and distill off the water under reduced pressure, collect the fraction at 145-152°C (133-266Pa) to obtain the crude product of Hexylresorcinol Cream, the yield 90%; the crude product is recrystallized from petroleum ether to obtain the finished product.

Hexylresorcinol Cream Mechanism of Action

When used as a dental anesthetic for sore throat alleviation, it is generally thought that Hexylresorcinol Cream might have the ability to obstruct voltage-gated neuronal sodium channels, which consequently would hinder the initiation as well as conduction of nerve impulses to be picked up or transmitted in the city to which Hexylresorcinol Cream is applied discomfort signal. As a disinfectant, research studies have actually shown that hexylresorcinol has the capability to minimize or hinder bacterial biofilm development, disrupt microbial cell chain development, lower bacterial adhesion in the throat, prevent glycolytic enzymes as well as pH drop, and also change bacterial biofilm And so forth. Cell surface hydrophobicity. Sadly, there are either anti-biotics that are more efficient at officially treating bacterial growth, or there are various other plant-derived phenolic compounds comparable to hexylresorcinol that evoke a more powerful such device of action. Nevertheless, Hexylresorcinol Lotion has anesthetic and also some antiseptic homes and also is useful in the therapy of a variety of relatively self-limited scrapes and also aching throats that are dealt with by over-the-counter products having this compound. Very early studies in the 1930s as well as 1940s revealed that there were more powerful drugs than hexylresorcinol for deworming effects. As an anti-inflammatory as well as anti-aging agent, some research studies have shown that hexylresorcinol may prevent the phosphorylation of the immune action moderator NF-kappaB and also, as a result of its strong repressive impact on tyrosinase, likewise trigger substantial Famous skin lightening impact and also peroxidase along with on the synthesis of glutathione as well as E-cadherin. It is suggested that Hexylresorcinol Cream can directly bind to tyrosinase and inhibit its chemical activity. Literature data recommend that reduced glutathione levels are related to the deposition of melanin in the skin of humans as well as other animals, whereas high glutathione degrees prevent melanin production. Ultimately, glutathione depletion was reported to enhance tyrosinase task in human cancer malignancy cells, making the result of Hexylresorcinol Cream on tyrosinase preferable. Ultimately, continuous researches have actually shown that Hexylresorcinol Lotion is able to induce distinction of SCC-9 squamous cell line and also hinder the growth of squamous cell cancer SCC-9 cells by modulating E2F-mediated signaling paths. dose-dependent manner. Furthermore, such research studies have additionally revealed that Hexylresorcinol Lotion appears to be able to dose-dependently generate apoptosis in SCC-9 cells and inhibit transglutaminase-2 enzyme task, consequently advertising chemotherapy resistance.

Ecological information for Hexylresorcinol Cream

The manufacturing and also use of Hexylresorcinol Lotion as a topical antibacterial and insect repellant may lead to its release right into the environment through various waste streams. If launched to air, the approximated vapor stress at 25 ° C is 8.4X10-6 mm Hg, suggesting that Hexylresorcinol Lotion will exist in the ambient ambience in both vapor as well as particulate stages. Vapor-phase hexylresorcinol reacts with photochemically produced hydroxyl teams to break down cost-free radicals in the environment; the half-life of the response in air is approximated to be 2 hrs. The particle stage hexylresorcinol will certainly be removed from the environment by wet and completely dry deposition. Hexylresorcinol does not have chromophores that absorb at wavelengths > 290 nm and also is consequently anticipated to be less vulnerable to photolysis by direct sunlight. If launched to dirt, hexylresorcinol is expected to be much less mobile based on an estimated Koc of 1,800. Volatilization from moist soil surfaces is not anticipated to be a substantial fate process based upon an estimated Henry’s regulation constant of 2.6X10-10 atm-cu m/mole. If launched into water, Hexylresorcinol Cream is expected to adsorb to suspended solids and also debris based on the estimated Koc. Volatilization from the surface is not anticipated to be an important fate process based upon the approximated Henry’s law constant for this substance. An estimated BCF of 90 suggests a moderate bioconcentration potential in aquatic microorganisms. Hydrolysis is not expected to be a vital ecological destiny procedure because the substance lacks useful groups that hydrolyze under ambient problems. Work direct exposure to p-hexylresorcinol is restricted but may take place via breathing and dermal direct exposure to the substance in workplaces where hexylresorcinol is created. Usage information show that the basic populace might be subjected to Hexylresorcinol Lotion with inhalation and also dermal direct exposure to consumer products having hexylresorcinol. Exposure of the general populace to this medicine might be through intake and also intake of some over-the-counter throat lozenge prep work by people taking this drug (an anthelmintic).

About Products:
If you need Hexylresorcinol Cream, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Hexylresorcinol Cream manufacturer and supplier, ZSpharmac will provide Hexylresorcinol Cream raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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