Zhishang Chemical

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Zhishang Chemical

Hesperidin Solgar CAS 520-26-3

Molecular Formula: C28H34O15

Formula Weight: 610.56

ZSpharmac: Hesperidin Solgar Supplier

Product Name: Hesperidin Solgar
CAS No: 520-26-3
Purity: 99%

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Basic Info

Product Name:Hesperidin Solgar
Other Names:Hesperidin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:light Brown Powder
EINECS No.:208-288-1
Storage:Sealed in Dry,2-8°C
Provide:Hesperidin Solgar MSDS;
Hesperidin Solgar COA

What is Hesperidin Solgar?

Hesperidin Solgar is a flavonoid compound with a dihydroflavone oxyglycoside structure and is weakly acidic.

Hesperidin Solgar has a selection of biological residential or commercial properties. Modern research has actually found that hesperidin can withstand oxidation and also cancer cells, prevent mold, stand up to allergy, lower high blood pressure, hinder oral cancer as well as esophageal cancer cells, preserve osmotic pressure, boost capillary strength, Lower cholesterol and more. Relevant researches have revealed that hesperidin has a broad-spectrum anti-bacterial result on common food contamination microorganisms, as well as has substantial repressive results on Bacillus subtilis, Salmonella typhimurium, Shigella flexneri, hemolytic streptococcus as well as Vibrio cholerae, etc, so it is widely made use of in preservative as well as food processing.

Hesperidin Solgar Property

Melting point 250-255 °C (dec.)(lit.)
alpha -76 º (c=2,pyridine)
Boiling point 576.16°C (rough estimate)
density 1.3290 (rough estimate)
refractive index 1.5940 (estimate)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Pyridine (Slightly, Sonicated)
form Powder
color light brown
Water Solubility Insoluble in water. Soluble in organic solvents such as DMSO.


Hesperidin Solgar Uses

  1. Hesperidin Solgar has the features of maintaining osmotic pressure, enhancing capillary durability, shortening bleeding time, and also lowering cholesterol. It is medically made use of as an adjuvant therapy for cardiovascular system illness, and can cultivate a selection of medicines to avoid arteriosclerosis and also coronary infarction. It is a copyrighted medication” Among the major raw materials of “Main Tong”. It can be used as a natural anti-oxidant in the food industry. It can additionally be used in the cosmetic sector.
  2. Hesperidin Solgar is a crucial natural phenolic compound that is taken into consideration to be beneficial to health. It can reduce the fragility and also leaks in the structure of blood vessels, and also is used for the adjuvant therapy of high blood pressure and also capillary hemorrhagic diseases. It has the impact of enhancing capillary resistance (improving the impact of vitamin C), has anti-inflammatory, anti-virus, and also has the result of avoiding frostbite and also inhibiting the aldehyde reductase of rat eye lens.
  3. Hesperidin Solgar is a vitamin P substance abuse to boost the durability of capillaries. Methyl hesperidin, a derivative of hesperidin, is likewise a vitamin P medication, as well as it is a variety tape-recorded in Japan’s “Food Additives Public Procedure”.
  4. Hesperidin Solgar is a vitamin medicine. Can lower the brittleness and permeability of capillary.

Hesperidin Solgar Preparation

Research on Hesperidin Solgar

If we were to currently look at the human proof for oral hesperidin, it shows up to improve blood circulation (light to modest) and might have a weak impact on blood pressure. That claimed, in pet researches, dental hesperidin at dosages similar to those utilized in humans seems a very potent cardioprotective agent with equivalent brain protection against different stressors; the protection Antioxidant in nature yet shows up to resolve a presently unknown genomic antioxidant feedback. In addition to the safety results (most significantly in the heart and also brain, however expanding essentially to every body organ), hesperidin may be able to lower anorexia nervosa and have minor antiallergic homes.

0.1-1 mg/kg hesperidin (ip) shows up to have an antidepressant mechanism, metabolized by κ-opioid receptors and also not via δ opioids, μ opioids, or peripherally acting κ opioid antagonists or high levels of caffeine glands Hesperidin, caffeine, prevents signaling, perhaps also with opioid receptors, and also seems synergistic with morphine at a much less reliable dosage of hesperidin (10 μg/ kg ip).

In separated PC12 cells, reduced focus (100-1000 nM) of hesperidin were located to turn on neuronal growth aspects (Akt/ERK and CREB) and also antioxidant variables (seladin-1 and PGC-1α) in a fashion dependent on In TrkA receptor and also estrogen signaling. As a result of the neuroprotective effects of estrogen associated with Akt as well as selandin-1, selandin is thought to be an estrogen simulate with neuroprotective results, although all these effects are dependent on 2 elements (TrkA and estrogen signaling), selandin The boost in -1 is completely based on estrogen signaling.

Hesperidin appears to act through estrogen signaling and TrkA (BDNF receptor) to work with boosts in antioxidant defenses and pro-survival proteins, which are thought to be mechanisms to prevent cell death caused by oxidative toxins or stressors.

In irradiated rats (leading to decreased mitochondrial capacity of the brain and reduced natural chemical levels due to oxidative damages), dental intake of 50 mg/kg per day of hesperidin attenuated oxidative tension 10 days before and 2 weeks after irradiation (40% decrease in thiols) as well as changes in natural chemicals (49-60% depletion), while without radiation, hesperidin had no result. Mitochondrial capability is understood to be protected with a two week preload (50-100 mg/kg in computer mice) prior to immobilization stress and anxiety testing (which is known to increase NOS task).

In the mind, hesperidin shows up to have antioxidant effects, with hesperidin decreasing the increase in lipid peroxidation throughout cognitive problems, but this appears to be an indirect effect through nitric oxide signaling (inhibition), as opposed to straight Anti-oxidize effect.

Hesperidin shows up to have several neuroprotective impacts at relatively conventional oral doses, as well as these additionally show up to rely on preventing damaged nitric oxide signaling (causing antioxidant and anti-inflammatory defenses).

Shot of 0.1-1 mg/kg hesperidin (ip) right into mice based on the stress swim test had the ability to exert an antidepressant result, whereas 10 μg/ kg by itself was inadequate, and also this has been replicated in other places in the forced swim as well as tail hang tests Currently, it has the exact same effect as imipramine (15mg/kg injection) and also fluoxetine (32mg/kg injection), as well as the dose is 0.3-1mg/ kg.

In one research, it was discovered that intraperitoneal injection of hesperidin (0.1-1mg/ kg) could play an antidepressant impact, yet had no obvious anxiolytic effect, and also when dental intake of 20-100mg/ kg hesperidin, in little High-dose hesperidin injections (2-30mg/ kg) can generate forced anxiolytic effects in mice, which are thought to be connected to opioid receptor signaling. Hesperidin does not show up to have considerable however integral anxiolytic buildings unless injected in high dosages. It appears that under specific conditions where anxiety causes neurological damages resulting in anxiety, there may be anxiety-reducing residential or commercial properties due to the fact that the damages is blunted by hesperidin (and also anxiety is lowered due to less damage).

Oral administration of 5 mg/kg to rats in which cisplatin induced anorexia nervosa showed up to decrease the reduction in food consumption observed with cisplatin by 59%. Hesperidin has actually been revealed to positively reduce anorexia nervosa after dental administration in a manner thought to be mediated by serotonin signaling as well as depending on auxin action.

Hesperidin administered orally at 100 mg/kg for 90 days to young and also aged rats had the ability to partly turn around the deterioration of antioxidant enzymes seen in heart cells throughout aging, whereas changes in these enzymes were not substantial in young hearts; lipid attention deficit disorder Oxidation and also protein carbonylation, which is believed to result from enhanced Nrf2 expression in maturing hearts, decreased with aging (not raised in youth).

Hesperidin seems to protect the heart after dental administration of numerous stimulants and can work in a precautionary or rehabilitative way within a week. Although there are no human researches, it appears to be surprisingly effective at reducing markers of lipid peroxidation and cardiotoxicity.

In hyperlipidemia (baseline TG above 150 mg/dL) offered 500 mg G-hesperidin daily for 24 weeks, product triglycerides were substantially minimized (approximately 34%) after 4 weeks, which was kept at 24 weeks of supplements Repaired magnitude, stabilized to baseline worths after four weeks of cessation.

In computer mice subjected to frostbite (tibia) complied with by six-day injections of hesperidin at a dose of 50 mg/kg, muscle mass regeneration appeared to be substantially improved compared to controls.

A research study in healthy rats provided 0.5% hesperidin (55 mg/kg) in the diet plan for three months kept in mind that in teen rats, yet not older rats, hesperidin consumption Can lead to raised bone development.

In young rats, fairly sensible doses of hesperidin (discovered in supplements or orange peel) enhanced the price of bone development; this rise in bone development rate was not seen in older adults with fully created bones.

In male computer mice, administration of hesperidin (0.5%) or G-hesperidin (0.7% diet regimen) for 4 weeks decreased bone loss connected with androgen deficiency relative to controls.

Oral supplementation of 0.5% hesperidin (roughly 55 mg/kg) in ovariectomized rats (menopausal version) had the ability to partially undermine the bone loss seen from ovariectomy, with no evident impact on uterine weight, suggesting no pertinent Estrogenic results; these results were connected with plasma focus of 3.57 +/- 0.68 μM hesperidin.

About Products:
If you need Hesperidin Solgar, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Hesperidin Solgar manufacturer and supplier, ZSpharmac will provide Hesperidin Solgar raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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