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Hesperidin Methylchalcone CAS 24292-52-2

Molecular Formula: C29H36O15

Formula Weight: 624.59

ZSpharmac: Hesperidin Methylchalcone Supplement

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Product Name: Hesperidin Methylchalcone
CAS No: 24292-52-2
Purity: 99%

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Basic Info

Product Name:Hesperidin Methylchalcone
Other Names:Hesperidin Methyl Chalcone
CAS:24292-52-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Solid
EINECS No.:246-128-2
Storage:2-8°C
Provide:Hesperidin Methylchalcone MSDS;
Hesperidin Methylchalcone COA

What is Hesperidin Methylchalcone?

Hesperidin Methylchalcone (HMC) is a risk-free flavonoid for the therapy of chronic venous illness, however its effects and also devices on UVB irradiation-induced inflammation as well as oxidative anxiety have never been explained in vivo.

Hesperidin Methylchalcone Property

Melting point 120 °C (dec.)(lit.)
alpha -71 º (c=1 in ethanol)
Boiling point 583.81°C (rough estimate)
density 1.3090 (rough estimate)
refractive index 1.5940 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka6.71±0.40(Predicted)
form Solid
color Yellow

 

Hesperidin Methylchalcone Uses

Hesperidin Methylchalcone (HMC) is a ketone organic compound with the efficacy of vitamin C, which can be used in the production of whitening and freckle-removing products; used in prevention and red blood repair products.

Topical Formulation Containing Hesperidin Methylchalcone Inhibits UV-B Response

Recently, skin direct exposure to ultraviolet B (UVB) radiation, which is a significant root cause of several skin diseases, has actually increased considerably as a result of ozone depletion. Hesperidin Methylchalcone is a substance utilized to deal with vascular illness with shown anti-inflammatory activity in preclinical studies. Right here, we evaluated the antioxidant task of HMCs in cell-free systems and also in vivo. Effects of a supported topical formula having Hesperidin Methylchalcone on a computer mouse version of UVB irradiation-induced cutaneous oxidative tension as well as swelling. HMC has iron minimizing capability, reduces the effects of 2,2′-azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and also hydroxyl radicals, as well as prevents lipid peroxidation. In hairless mice, a topical formulation having Hesperidin Methylchalcone inhibited UVB radiation-induced skin edema, antioxidant ability (the capability to reduce iron as well as ABTS, as well as catalase activity), lipid peroxidation, superoxide anion manufacturing, and also mRNA expression of gp91phox (nicotinamide adenine dinucleotide phosphate [NADPH).] oxidase 2 subunit). Furthermore, HMC inhibited UVB irradiation-induced exhaustion of decreased glutathione degrees by keeping the expression of glutathione peroxidase-1 and also glutathione reductase mRNA, stopping the downregulation of nuclear element erythroid 2-related variable 2 (Nrf2) mRNA expression and enhanced soreness Oxygenase 1 mRNA expression. Ultimately, we show that topical application of HMC-containing formulas inhibits the manufacturing of cytokines (TNF-α, IL-1β, IL-6 and also IL-10) generated by UVB irradiation. Consequently, this topical formula consisting of Hesperidin Methylchalcone is an appealing new therapy to shield the skin from the dangerous results of UVB radiation.

Effects of Hesperidin Methylchalcone on Experimental Ulcerative Colitis

Neutrophil seepage, pro-inflammatory cytokines and also production of responsive oxygen species (ROS) have actually been linked in the development and also development of ulcerative colitis (UC), a sort of inflammatory digestive tract disease (IBD), It is characterized by ulcerative swelling of the mucosal layer normally constrained to the colon. Negative effects, security, as well as human intolerance are restrictions of presently approved therapies for UC. Hesperidin Methylchalcone (HMC), a flavonoid used to treat persistent venous condition, has actually shown anti-inflammatory, analgesic, and antioxidant homes in preclinical studies, however its impact on colitis has actually never been defined. As a result, we intended to examine the protective impact of HMC in a computer mouse design of acetic acid-induced colitis. Hesperidin Methylchalcone treatment substantially reduced neutrophil infiltration, edema, colon reducing, macroscopic and microscopic lesions induced by intracolonic acetic acid injection. The improvement in colitis after HMC therapy was associated with a boost in the antioxidant condition of the colon, in addition to restraint of the proinflammatory cytokines TNF-α, IL-6, IL-1β, and also IL-33 in the colon. In addition, we observed that HMC hindered NF-κB activation in the colon, which might describe the reduction in cytokines we observed. Ultimately, these results demonstrate a novel application of HMC to boost antioxidant responses and lower swelling throughout acetic acid-induced colitis, suggesting that it is an encouraging treatment for ulcerative colitis. The improvement in colitis after HMC therapy was related to a boost in the antioxidant status of the colon, along with inhibition of the proinflammatory cytokines TNF-α, IL-6, IL-1β, and also IL-33 in the colon. Moreover, we observed that HMC inhibited NF-κB activation in the colon, which may discuss the decrease in cytokines we observed. Finally, these results show an unique application of Hesperidin Methylchalcone to enhance antioxidant feedbacks as well as minimize swelling during acetic acid-induced colitis, suggesting that it is an appealing treatment for ulcerative colitis. The improvement in colitis after HMC treatment was associated with a boost in the antioxidant condition of the colon, in addition to restraint of the proinflammatory cytokines TNF-α, IL-6, IL-1β, as well as IL-33 in the colon. In addition, we observed that HMC hindered NF-κB activation in the colon, which may describe the decrease in cytokines we observed. Finally, these outcomes show a novel application of Hesperidin Methylchalcone to boost antioxidant responses as well as minimize swelling throughout acetic acid-induced colitis, suggesting that it is a promising treatment for ulcerative colitis.

Preparations Containing Hesperidin Methylchalcone Inhibit UV-B Skin Diseases

In recent years, skin exposure to ultraviolet B (UVB) radiation, which is a major cause of many skin diseases, has increased significantly due to ozone depletion. Hesperidin Methylchalcone is a compound used to treat vascular disease with demonstrated anti-inflammatory activity in preclinical studies. Here, we tested the antioxidant activity of HMCs in a cell-free system and the in vivo effects of stable topical formulations containing HMCs in a mouse model of UVB irradiation-induced skin oxidative stress and inflammation. HMC has iron-reducing ability, neutralizes 2,2′-azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and hydroxyl radicals, and inhibits lipid peroxidation. In hairless mice, topical formulations containing HMC inhibited UVB radiation-induced skin edema, antioxidant capacity (iron and ABTS reducing capacity and catalase activity), lipid peroxidation, superoxide anion production and gp91phox ( Depletion of mRNA expression of nicotinamide adenine dinucleotide phosphate [NADPH] oxidase 2 subunit). In addition, HMC inhibited UVB irradiation-induced depletion of glutathione levels by maintaining the expression of glutathione peroxidase 1 and glutathione reductase mRNA, preventing nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA Downregulation of expression and increase in heme oxygenase 1 mRNA expression. Finally, we demonstrate that topical application of a formulation containing Hesperidin Methylchalcone inhibits the production of cytokines (TNF-α, IL-1β, IL-6 and IL-10) induced by UVB irradiation.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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