Zhishang Chemical

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Zhishang Chemical

Hesperetin Sigma CAS 520-33-2

Molecular Formula: C16H14O6

Formula Weight: 302.28

ZSpharmac: Hesperetin Sigma Supplier

Product Name: Hesperetin Sigma
CAS No: 520-33-2
Purity: 99%

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Basic Info

Product Name:Hesperetin Sigma
Other Names:Hesperetin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Pale Yellow Solid
EINECS No.:208-290-2
Storage:Room Temperature
Provide:Hesperetin Sigma MSDS;
Hesperetin Sigma COA

What is Hesperetin Sigma?

Hesperetin Sigma (hesperetin) is the primary active component in the fruit of the citrus genus CitrusL. in the family Rutaceae (Rutaceae). Hesperetin Sigma is the glycosyl ligand of hesperidin (hesperidin). team as well as multiple phenolic hydroxyl groups, to make sure that it has a large range of pharmacological impacts. Hesperetin will not build up in any organs, and it is secure to utilize without apparent negative effects. Very early research studies on the medicinal effects of hesperetin mostly focused on antibacterial, anti-inflammatory, anti-oxidant, anti-viral, anti-allergic, regulating blood lipids, enhancing immunity and anti-cancer. In the last few years, it has actually been reported that Hesperetin Sigma as well as its by-products likewise have anti-Alzheimer’s disease, anti-Parkinson’s disease, anti-hyperglycemia, anti-snake venom hemocoagulase, anti-lung, kidney, liver fibrosis as well as some new lumps. repressive result, and so on.

Hesperetin Sigma Property

Melting point 230-232°C
Boiling point 363.32°C (rough estimate)
density 1.2514 (rough estimate)
refractive index -4 ° (C=1.8, EtOH)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Pale Yellow
Water Solubility Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).


Pharmacological Action of Hesperetin Sigma

1. Impacts on main nerve system associated illness
Parkinson’s disease (PD) is a neurodegenerative illness caused by the loss of dopaminergic afferent neuron in the brain. PD inevitably brings about electric motor as well as cognitive impairment in people. The safety impact of Hesperetin Sigma on striatal 6-hydroxydopamine-injured rats was reviewed, as well as its feasible device of activity in apoptosis, swelling and also oxidative stress and anxiety was checked out.
2. Hypoglycemic effect
Diabetes is a group of metabolic illness that has come to be a major public health issue, enhancing the social and financial worry. Hyperglycemia and hyperlipidemia are common functions of diabetic issues, bring about modifications in sugar as well as lipid metabolism, as well as levels of liver enzymes. Persistent hyperglycemia, identified by persistent as well as unusually high postprandial blood glucose degrees, has become a crucial consider the beginning of diabetes. Rat studies have shown that hesperetin can successfully secure the typical histological morphology of STZ-induced rat liver, kidney and insulin-positive β-cells.
3. Antitoxin hemagglutinin impact
Poisonous snakebites are a global, overlooked public health issue. The Globe Health Company reported in 2017 that regarding 5.5 million individuals are attacked by poisonous serpents each year, concerning 400,000 individuals pass away from certain kinds of sequelae, such as amputation, and 20,000 to 125,000 individuals pass away from fatal injuries. Two serpent poison serine proteases 1 and also 2 (SVSP1, SVSP2) were separated from the poison of Simes rotus by gel filtering and also reverse chromatography (RP-HPLC), as well as their relative molecular masses were identified to be about 31300 and also 24600. Sequencing of SVSP1 as well as SVSP2 utilizing tandem mass spectrometry (Q-TOF) as well as in silico docking making use of a serine protease framework (PDB entrance: 4e7n) understood to be homologous to both target proteins showed that Hesperetin Sigma is the targeted preventions. The kinetic criteria of SVSPs were acquired via artificial insemination experiments on hesperetin. The outcomes showed that Hesperetin Sigma might be a non-competitive inhibitor of SVSP1 as well as SVSP2, and it can be used as an inexpensive inhibitor for the study of serpent poison proteases.
4. Anti-fibrosis impact
Cardiac improvement is a significant factor of cardiac arrest (heart failure), defined by cardiac hypertrophy, fibrosis, oxidative stress and anxiety, and myocyte apoptosis. Utilizing the mouse version of cardiac arrest generated by thoracic aortic banding (ABDOMINAL MUSCLE), through the monitoring of heart mass/body mass, lung mass/body mass, heart mass/tibia size, echocardiogram and hemodynamic parameters, and histology As well as information such as gene expression of hypertrophic and also fibrotic pens were assessed, it was discovered that Hesperetin Sigma prevented cardiac hypertrophy, fibrosis and also cardiac disorder in mice triggered by abdominal muscle, and also attenuated oxidative anxiety and also cardiomyocyte apoptosis. Refresher courses discovered that hesperetin inhibited cardiac remodeling by blocking PKCα/ βII-Akt, JNK as well as TGF-β1-Smad signaling paths. The research study discovered that a brand-new hesperetin derivative 7 [8-( N-methylpiperazinyl) hesperetin] can inhibit the induction of platelet-derived growth variable BB (PDGF-BB) through the Wnt/ β-catenin path. Activation as well as spreading of hepatic stellate cells.
5. Anti-tumor result
In human lung cancer cells H522 cells, hesperetin generated a cell signaling path independent of the p53 path, and also hesperetin up-regulated the expression of Fas, Fas-associated death domain name healthy protein (FADD) and caspase-8 proteins in H522 cells degrees, and also lowered the expression levels of caspase-3, caspase-9, p53 and Bax healthy proteins. The outcomes showed that hesperetin not only stimulated apoptosis through the path of p53 as well as Bax, however also activated the FADD/caspase -8 dependent apoptosis pathway composed of death receptors. Study of the result of Hesperetin Sigma on 7,12-dimethylphenylpropanthracene (DMBA)-generated buccal bag squamous cell cancer in hamsters by evaluating lipid peroxidation (LPO) byproducts, enzyme status, non-enzymatic anti-oxidants, remedy and other factors were reviewed for its chemopreventive result, and also the results revealed that hesperetin can hinder DMBA-induced hamster squamous cell carcinoma.

Market Outlook for Hesperetin Sigma

International market conditions:
( 1) Hesperetin Sigma is used in health care medications as well as healthcare products, such as Amway’s series of products are all added hesperetin. The main energetic component of Vigor 50, a hot-selling health item in the United States, is additionally hesperetin.
( 2) As an additive of some cosmetics, Hesperetin Sigma is consisted of in different night creams of CLARINS (Clarins).
( 3) It is also made use of in food in Japan as an additive with vitamin P function. In my country, hesperetin is mostly made use of as a medication basic material. The major curative impacts of relevant drugs are belly stimulating, expectorant, antitussive, carminative, diuretic, anti-influx and stomach discomfort relief.

Preparation of Hesperetin Sigma

A technique for drawing out high-purity Hesperetin Sigma from Citrus aurantium, is identified because, the method consists of the following steps:
Action 1, after squashing Fructus Citriifolia, remove 3 times with alcohol solvent reflux, the quantity of alcohol solvent utilized for the very first reflux extraction is 5 to 20 times of the quality of Fructus Fructus, the moment of reflux extraction is 1 hr to 2 hrs, as well as the quantity of alcohol solvent extracted by reflux for the second time The amount of alcohol solvent is 5-20 times of the high quality of Citrus aurantium, and the reflux extraction time is 1 hr to 2 hrs. After filtering system, the filtrates were integrated 3 times, and the mixed filtrates were concentrated under reduced stress to a concentrated remedy with a particular gravity of 1.0 to 1.06;
Step 2. Add mineral acid to the concentrated solution symphonious 1 to obtain a mixed option, hydrolyze the blended option at a temperature level of 90 ° C to 120 ° C for 3 hours to 10 hours, normally cool to area temperature level, as well as filter to get The filter deposit is cleaned with soft water at a temperature of 80 ° C to 100 ° C and afterwards centrifuged to get rid of the supernatant, and also the cleaning and centrifugation are duplicated 1 to 3 times to get the unrefined item of Hesperetin Sigma; the mass concentration of the not natural acid in the combined option is 3% to 5%.;.
Action 3, liquifying the Hesperetin Sigma crude item explained in step 2 with ethanol with a mass focus of 85% or even more, adding turned on carbon to the liquified service for reflux decolorization for 1 hr to 2 hours, and then decolorizing the option at a temperature level of 50 ° C Filtrate under the condition of ~ 80 ° C, concentrate the filtered filtrate to 1/4 of the quantity of the filtrate, after that position the focused filtrate at area temperature to take shape and after that filter, completely dry the filteringed system strong issue to get a mass purity of not less than 96 % Hesperetin Sigma crystalline.

About That Product:
If you need Hesperetin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Hesperetin, ZSpharmac will provide Hesperetin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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