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Zhishang Chemical

Heptaldehyde CAS 111-71-7

Molecular Formula: C7H14O

Formula Weight: 114.19

ZSpharmac: Heptaldehyde Supplier

Product Name: Heptaldehyde
CAS No: 111-71-7
Purity: 99%

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Basic Info

Product Name:Heptaldehyde
Other Names:Heptanal
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Yellow-Beige Powder
EINECS No.:203-898-4
Storage:Flammables Area
Provide:Heptaldehyde MSDS;
Heptaldehyde COA

What is Heptaldehyde?

Heptaldehyde, also known as Heptaldehyde, is miscible with ethanol and ether, soluble in 60% ethanol, and slightly soluble in water. It can be reduced to n-heptanol and oxidized to n-heptanoic acid, which exists in castor oil. N-heptanal can be used as a raw material for organic synthesis, such as the synthesis of δ-laurolactone. Lactone is an important organic compound and intermediate, and has broad application prospects in the fields of fragrance, flavor and drug synthesis.

For example, γ- and δ-lactones have been used in high-grade cosmetics, food and tobacco industries, etc., and because lactones are the main components of natural cream flavor, and natural cream contains a lot of animal fat, excessive inhalation can easily cause cardiovascular disease, In some developed countries, vegetable oil is used to add cream flavors as margarine in the food industry, and the flavor is almost the same as natural cream. The use of this new type of high-quality cream essence can reduce the amount of cream in food, which plays an important role in ensuring people’s health.

Therefore, it is of great significance to explore the chemical synthesis of δ-lactone. The synthetic method of using Heptaldehyde to synthesize δ-lactone is aldol condensation of cyclopentanone and Heptaldehyde under alkaline conditions, and reflux dehydration through a heatable reactor equipped with a water separator, and then vacuum distillation to obtain 2-heptene Cyclopentanone; then hydrogenation under normal pressure under the action of palladium catalyst supported on ion exchange resin to obtain 2-heptylcyclopentanone; finally, hydrogen peroxide was used as oxidant and Baeyer-Villiger rearrangement reaction was adopted to obtain crude product δ-dodecanolide. The crude product is then refined by a molecular distillation device to obtain the target product with higher purity.

Heptaldehyde Property

Melting point 

-43 °C (lit.)

Boiling point 

153 °C (lit.)


0.817 g/mL at 25 °C (lit.)

vapor pressure 

3 hPa (20 °C)

refractive index 

n20/D 1.413(lit.)


95 °F

storage temp. 

Flammables area


1.25g/l insoluble


Powder, Crystals or Chunks


White to light yellow-beige

explosive limit


Odor Threshold


Water Solubility 




Heptaldehyde Uses

  1. Heptaldehyde is a food seasoning that is momentarily admitted GB 2760-96. Mostly utilized in the preparation of citrus, veggie and melon flavors.
  2. Heptanal as well as benzaldehyde can be condensed in water and alcohol remedy to acquire jasmonal. Heptanal reacts with triethyl orthoformate in the existence of an acidic driver to create heptanal diethyl acetal ([ 688-82-4]. Both jasminal and also heptanal diethyl acetal are fragrances as well as are used in the preparation of perfume significances. It is additionally a resources for drugs, organic synthesis and also rubber products.

Heptaldehyde Application

Heptaldehyde can be used in the preparation of orange essence and rose essence, and it can also be used in the preparation of Heptaldehyde as a raw material for organic synthesis. Its application examples are as follows:

1. Preparation of 2-heptylidenecyclopentanone.

Under the action of sodium hydroxide catalyst, react cyclopentanone, Heptaldehyde and phase transfer catalyst at 50-80°C for 8-10 hours, adjust the pH value to 6-7, add toluene, and stir at 100-120°C until no Water is generated again, and finally the finished product is obtained by washing and drying, and the molar ratio of cyclopentanone to n-heptanal is (1~1.3):1. Using β-cyclodextrin as a phase transfer catalyst can speed up the reaction rate and promote the cross-condensation.

2. Preparation of δ-Lauryl Lactone.

Include the following steps:

(1) Condensation and dehydration: Add sodium hydroxide solution with a mass fraction of 0.5% to 20%, cyclopentanone and a phase transfer catalyst into a three-necked flask, and after heating up to 10-50°C, add n-heptanal dropwise for 1-4 hours Dropping is completed (the molar ratio of cyclopentanone to n-heptanal is 1:1 to 5:1). Because the activity of condensation reaction between aldehyde and aldehyde is greater than the activity of condensation reaction between aldehyde and ketone, in order to avoid excessive side reactions, ketone must be excessive.

Then react at a constant temperature of 10-50°C for 1-3 hours, cool down, and neutralize with acetic acid to make the pH of the mixture = 5-6. Stand to separate the layers, extract the water layer with the extractant, combine the organic phases, wash with 5% NaHCO3 and saturated NaCl aqueous solution, transfer to a device with a water separator for heating, and dehydrate. Wash after cooling, dry with anhydrous Na2SO4, evaporate the extractant under normal pressure at 105Pa, distill under reduced pressure at 350-450Pa, and collect 2-heptenylcyclopentanone at 90-100°C/350-450Pa fraction.

(2) Hydrogenation: Add 2-heptenylcyclopentanone into a reactor in N2 atmosphere, then add ion exchange resin-supported palladium catalyst and solvent, and feed H2 under normal pressure at 10-50°C until the reaction stops absorbing Hydrogen stops. The ion-exchange resin-supported palladium catalyst is washed with a solvent. The solvent in the reaction was removed by rotary evaporation, the pressure was reduced to 250Pa-270Pa for distillation, and the fraction 2-heptylcyclopentanone at 75-85°C/250-270Pa was collected.

(3) Oxidation: Add methanol as a solvent to a three-necked flask, then add 2-heptylcyclopentanone and an acid accelerator, and add the oxidant dropwise while stirring at 20-60°C. Commonly used oxidants are hydrogen peroxide and oxygen, which are mainly easy to protect the environment. However, the reaction selectivity and conversion rate of oxygen as the oxidant are usually low, so the utilization of hydrogen peroxide is particularly important. After the dropwise addition, keep the temperature at 20-60°C, follow the end of the reaction by TLC, add water to continue stirring, wash with water, neutralize with 5% NaHCO3, wash the water layer with toluene, combine the organic phases, and distill to remove the toluene in the organic layer under normal pressure 105Pa , the control temperature should not exceed 60°C, and the residue is the crude product δ-laurolactone.

(4) Refining of the crude product: Distill the above crude product with a molecular distillation device, control the temperature at 120-130° C., and the pressure at 300 Pa, and collect the distilled product, which is δ-laurolactone.

Synthesis of Heptaldehyde

1. Heptaldehyde is contained in rose oil as well as perilla oil. It was first manufactured by pyrolysis of castor oil in 1845. Castor oil includes ricinoleic acid glyceride, and also in the presence of solid caustic potassium, it is alcoholylated with methanol at area temperature to obtain ricinoleic acid methyl ester. The response item was acidified with sulfuric acid, the methanol was distilled off, the glycerin layer was divided and also washed with water to get methyl ricinoleic acid. Split it in a pyrolysis heater at 450-500 ° C and 0.05-0.07 MPa to obtain methyl undecylenate and also Heptaldehyde. Separate the pyrolysis item from the material, and carry out vacuum correction to get methyl undecylenate (the raw product of undecylenic acid, a vital intermediate of fragrances) and heptanal. Heptaldehyde was cleansed with sodium bisulfite and also sodium carbonate to obtain a pure product with a content ≥ 88%, and also regarding 5.5 t of castor oil was eaten per ton of Heptaldehyde.

2. Acquired by oxidation of heptanol or cracking of castor oil.

3. Prep work technique:

Include 500mL of anhydrous pyridine ① right into a completely dry reaction flask furnished with a stirrer, a thermostat, as well as a drying tube, cool in an ice-water bathroom to 15 ° C, include 68 g (0.56 mol) of anhydrous chromium trichloride ② in batches over 15 minutes while mixing, Keep in mind that the temperature level of the response solution does not go beyond 20 ° C when adding. A dark yellow flocculent precipitate sped up out during the addition, as well as the viscosity of the combination increased. After the addition, continue to mix and also rise to room temperature, the viscosity decreases within 1h, and the yellow product is dark red crystal. Let stand, pour off pyridine, as well as wash 3 times with anhydrous oil. Filtrate with suction, laundry with petroleum ether, and also dry in vacuo to acquire 150-160 g of chromium trioxide-pyridine, which is stored in a brownish bottle at 0 ° C. Heptaldehyde (1 ): In a reaction flask outfitted with a stirrer, add 650 mL of anhydrous dichloromethane, add 77.5 g (0.3 mol) of chromium trioxide-pyridine facility at space temperature level under stirring, and then include n-heptanol (2) each time 5.8 g (0.05 mol), after regarding 20min, pour out the supernatant from the insoluble brown jelly, and also wash the insoluble deposit three times with ether. The dichloromethane as well as ether layers were combined, cleaned successively with 5% salt hydroxide, 5% hydrochloric acid, saturated sodium carbonate, and also saturated brine, as well as dried out over anhydrous magnesium sulfate. After distilling off the solvent, distill under lowered stress, accumulate the fraction at 80-84 ° C/8.65 kPa, and also get 4-4.8 g of Heptaldehyde ③( 1 ), with a return of 70% -84%.

Note: ① Dry with solid potassium hydroxide as well as re-steam as soon as before usage. ② Dry chromium trioxide in a vacuum desiccator full of phosphorus pentoxide before usage. ③ This is just one of the techniques for preparing aldehydes from alcohols. The general approach for preparing aldehydes from alcohols using chromium trioxide-pyridine facilities as an oxidant is as adheres to: initial prepare 5% chromium trioxide-pyridine in anhydrous dichloromethane service (dark red), to ensure that the molar proportion of the complex to alcohol is 6:1. The excess of the oxidizing agent is to totally oxidize the alcohol to the aldehyde. Add the alcohol to the above dark red solution at once under stirring at area temperature level, and also the key or additional alcohol without steric limitation can be completely reacted within 5-15 mins at 25 ° C, as well as the brown-black chromium trioxide-pyridine decrease product is sped up at the same time. The supernatant was decanted, and also the precipitate was completely cleaned with dichloromethane. Incorporate the dichloromethane option, laundry with water down hydrochloric acid, sodium bicarbonate, water, etc in order to remove pyridine as well as chromium salts, or straight filter with filter aid, or separate with a chromatographic column, and distill off the solvent to obtain the corresponding item.

4. Prep work method:

In a reaction flask outfitted with a stirrer and also a thermometer, add a solution of 11g of silver p-toluenesulfonate ① liquified in 100mL of acetonitrile, trendy to 0-5 ° C, add 7.0 g (31mmol) of 1-iodoheptane (2 ), and stirred overnight at space temperature in the dark. The catalyst was poured into ice water and extracted with ether. The ether layer was dried as well as solvent gotten rid of to provide an oil. Include 20 g of sodium bicarbonate as well as 150 mL of DMSO into an additional reaction flask, and impact nitrogen into it to maintain bubbling. Include the above oil and also warmth to 150 ° C (often smoking cigarettes). After 3 minutes, it was quickly cooled down to space temperature. The resulting aldehyde was reacted with 2,4-dinitrophenylhydrazine to generate the matching phenylhydrazone, and also 6.9 g of phenylhydrazone was gotten, with a yield of 70%, mp106 ~ 107 ℃. The typical samples are mixed, and also the melting point of the combination continues to be unchanged.

Keep in mind: ① Its preparation approach is: include equimolar silver oxide and p-toluenesulfonic acid monohydrate right into acetonitrile, mix for half an hour at night, and also filter. Acetonitrile was vaporized, dried at 65 ° C and also set aside.

About Products:
If you need Heptaldehyde, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Heptaldehyde manufacturer and supplier, ZSpharmac will provide Heptaldehyde raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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