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Hemin CAS 16009-13-5

Molecular Formula: C34H31ClFeN4O4-

Formula Weight: 650.94

ZSpharmac: Hemin Supplier

Product Name: Hemin
CAS No: 16009-13-5
Purity: 99%

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Basic Info

Product Name:Hemin
Other Names:Chloroprotoferrihem
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Black Crystal
EINECS No.:240-140-1
Provide:Hemin MSDS;
Hemin COA

What is Hemin?

Hemin (hemin) is a metalloporphyrin compound with a reasonably fundamental framework. It is developed by complexing a molecule of ferrous iron and additionally protoporphyrin. It is an artificial insemination team substitute for natural heme (heme). Its chemical buildings resemble those of heme. comparable. As an indispensable tiny particle compound in living microorganisms, heme exists generally in different family pets, plants, microorganisms, algae as well as various other organisms. Wayen Biotech extracts hemin from the blood of animals in addition to chicken with its very own trademarked innovation. It has actually been found via research study and additionally method that hemin has a considerable impact on minimizing the abiotic stress and anxiety of plants.

Hemin Property

Melting point 300 °C
storage temp. 2-8°C
solubility 1.4 M NaOH: soluble25mg/mL
form crystal
color black
Water Solubility practically insoluble


Hemin Uses

1. Hemin In the food industry, heme can change the tinting representative nitrite and made pigments in meat items. In the pharmaceutical market, heme can be used as a semi-synthetic bilirubin resources, in addition to can similarly be utilized to prepare anticancer drugs. It can furthermore be utilized as a blood restorative.

2. Hemin is made use of as a food pigment, as an iron fortifier in addition to anti-anemia drug in medication, and also as a semi-synthetic bilirubin sources.

Hemin Pharmacology

Hemin Chloride, also known as hemin and hemin, is an oxidized form of heme (Heme), which can inhibit eukaryotic translation initiation factor 2c kinase 1 (elF2aK1), eIF -2a
a suppressor of . This property alters the initiation of mRNA translation, activating – a cascade of cellular effects. Hemin is used to induce the expression of heme oxygenase (HO-1) in cell and animal experiments. ferrous iron from blood
Heme is usually oxidized to hemin. In porphyria, a disorder caused by an increase in porphyrins, hemin is used to activate an inhibitory feedback of δ-aminolevulinic acid synthase, thereby reducing heme biosynthesis.

The Production Method of Hemin

The preparation methods of heme include base matter-organic solvent method, glacial acetic acid method, acetone method, methanol or methanol-ethanol method, ion exchange cellulose method.
Method 1. Basic substance-organic solvent method
Add 60L of methanol and 1kg of diethylamine into the reaction tank, stir evenly, add 5kg of fresh bovine blood powder, stir and extract at 45°C for 1 hour, cool, filter, concentrate the filtrate to 5L, add 10L of glacial acetic acid, 200g of strontium chloride, and heat and distill Remove residual methanol, heat up to 100-102°C for 1 h, cool, filter, and collect hemin crystals. The hemin crystals were successively washed with glacial acetic acid, water and acetone, and dried to obtain 85 g of hemin.
Bovine blood meal [methanol, diethylamine]→[45℃, 1h][filter]→filtrate [ice Hac, SrCl2]→[100-102℃,1h][filter, wash, dry]→hemin
Take 60L of methanol and 5kg of spray-dried bovine erythrocytes into the reaction tank, stir evenly, extract at 40°C for 30 minutes, cool, filter, concentrate the filtrate to 5L, add 10L of glacial acetic acid, 100g of sodium chloride, add 2L of water to dissolve, heat and distill Remove residual methanol, heat up to 100°C for 1 h, cool, filter, and collect hemin crystals. The hemin crystals were washed successively with glacial acetic acid and water, and dried to obtain 65 g of hemin.
Bovine erythrocytes [methanol]→[40℃, 30min][filter]→filtrate [ice Hac, NaCl,H2O]→[100℃,1h][filter, wash, dry]→hemin
Preparation of heme: Take 300kg of fresh blood powder, add 1200L of methanol, add 30kg of dichloroacetic acid, stir well, stir and extract at 45°C for 1h, cool, filter, and concentrate the filtrate to dryness to obtain 45kg of heme.
Fresh blood meal [methanol, dichloroacetic acid] → [45°C, 1h] [filtered, concentrated] → heme
Preparation of hemin: Take 45 kg of hemin, add 100 L of glacial acetic acid containing 2 kg of NaCl, boil and reflux for extraction for 1 hour, cool and filter to obtain hemin, wash with glacial acetic acid and water in turn, and dry to obtain hemin 4.8kg.
Heme [mixed solvent of NaCl and glacial acetic acid]→[boiling for 1h][washing and drying]→hemin
Method two, methanol-ethanol mixed solvent extraction
Preparation of acidic blood meal: Take 100 kg of blood meal, add 100 kg of 0.6 mol/L HCl solution, stir for hemolysis, and spray dry to obtain 40 kg of acidic blood meal.
Blood meal [HCl] → acidic blood meal
Preparation of heme Take 40kg of acidic blood meal, extract 3 times with a mixed solvent composed of 90% ethanol, 6% methanol and 4% water, the amount of mixed solvent is 800L, 300L and 200L respectively, combine the supernatant, distill and concentrate to obtain heme.
Acid blood meal [mixed solvent] → [extract 3 times] supernatant [concentrate] → heme.

About Products:
If you need Hemin, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Hemin manufacturer and supplier, ZSpharmac will provide Hemin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Hemin Quotation