Zhishang Chemical

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Zhishang Chemical

Hematoporphyrin CAS 16009-13-5

Molecular Formula: C34H31ClFeN4O4-

Formula Weight: 650.94

ZSpharmac: Hematoporphyrin Supplier

Product Name: Hematoporphyrin
CAS No: 16009-13-5
Purity: 99%

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Basic Info

Product Name:Hematoporphyrin
Other Names:Hemin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Black Crystal
EINECS No.:240-140-1
Provide:Hematoporphyrin MSDS;
Hematoporphyrin COA

What is Hematoporphyrin?

Hematoporphyrin (hemin) is a metalloporphyrin compound with a relatively straightforward framework.It is an in vitro team replacement of all-natural heme (heme), as well as its chemical properties resemble heme. Hematoporphyrin, as an important small particle substance in organisms, commonly exists in various animals, plants, microorganisms, algae and various other organisms. Wayen Biotech essences hemin from the blood of livestock and fowl with its own copyrighted innovation. It has been located via research study as well as method that Hematoporphyrin has a considerable effect on easing the abiotic anxiety of plants.

Hematoporphyrin Property

Melting point 300 °C
storage temp. 2-8°C
solubility 1.4 M NaOH: soluble25mg/mL
form crystal
color black
Water Solubility practically insoluble


Hematoporphyrin Uses

  1. Hematoporphyrin In the food industry, heme can change the chromogen nitrite and fabricated pigments in meat products; in the pharmaceutical market, Hematoporphyrin can be made use of as a semi-synthetic bilirubin raw material, and can be made use of to prepare anticancer drugs; Clinically, heme can be made right into heme iron supplement.
  2. Hematoporphyrin dietary supplement (iron fortifier) is removed from pig blood. It is recognized by contemporary medicine to prevent and also deal with iron-deficiency anemia. It has high absorption price as well as great result. It is a biological iron source without any iron smell and does not stimulate the stomach. It is the front runner raw material for the production of natural iron-supplementing foods, medicines, healthcare products as well as cosmetics.

Hematoporphyrin Production Method

The preparation techniques of Hematoporphyrin consist of base matter-organic solvent approach, antarctic acetic acid technique, acetone approach, methanol or methanol-ethanol technique, ion exchange cellulose approach
Technique 1. Basic substance-organic solvent approach.
Include 60L of methanol as well as 1kg of diethylamine right into the response storage tank, mix evenly, include 5kg of fresh bovine blood powder, mix as well as extract at 45 ° C for 1 hour, cool, filter, concentrate the filtrate to 5L, include 10L of antarctic acetic acid, 200g of strontium chloride, and warmth as well as boil down Get rid of recurring methanol, warm up to 100-102 ° C for 1 h, cool, filter, and also accumulate hemin crystals. Hematoporphyrin crystals were cleaned together with glacial acetic acid, water and acetone, and dried out to get 85 g of Hematoporphyrin.
Bovine blood dish [methanol, diethylamine] → [45 ℃, 1h] [filter] → filtrate [ice Hac, SrCl2] → [100-102 ℃,1 h] [filter, laundry, completely dry] → hemin.
Take 60L of methanol and also 5kg of spray-dried bovine erythrocytes into the response tank, mix evenly, essence at 40 ° C for half an hour, trendy, filter, concentrate the filtrate to 5L, include 10L of antarctic acetic acid, 100g of sodium chloride, add 2L of water to dissolve, heat and distill Get rid of recurring methanol, warm up to 100 ° C for 1 h, cool, filter, as well as collect Hematoporphyrin crystals. The hemin crystals were washed successively with glacial acetic acid as well as water, and dried out to acquire 65 g of hemin.
Bovine erythrocytes [methanol] → [40 ℃, 30min] [filter] → filtrate [ice Hac, NaCl, H2O] → [100 ℃,1 h] [filter, clean, completely dry] → hemin.
Prep work of heme Take 300kg of fresh blood meal, include methanol 1200L, add 30kg of dichloroacetic acid, stir well, stir and remove at 45 ° C for 1h, cool, filter, and focus the filtrate to dryness to obtain 45kg of Hematoporphyrin.
New blood meal [methanol, dichloroacetic acid] → [45 ° C, 1h] [filteringed system, concentrated] → heme.
Preparation of Hematoporphyrin Take 45kg of Hematoporphyrin, add 100L of glacial acetic acid having 2kg of NaCl, boil and also reflux for extraction for 1 hr, cool and also filter to obtain hemin, clean with glacial acetic acid and also water in turn, and dry to get 4.8 kg of hemin.
Heme [blended solvent of NaCl and also antarctic acetic acid] → [steaming for 1h] [washing as well as drying] → hemin.
Method 2, methanol-ethanol mixed solvent removal.
Preparation of acidic blood dish: Take 100 kg of blood dish, include 100 kg of 0.6 mol/L HCl option, mix for hemolysis, and spray completely dry to get 40 kg of acidic blood dish.
Blood dish [HCl] → acidic blood dish.
Preparation of Hematoporphyrin Take 40kg of acidic blood dish, remove 3 times with a mixed solvent made up of 90% ethanol, 6% methanol and also 4% water, the combined solvent dose is 800L, 300L as well as 200L respectively, integrate the supernatant, distill as well as concentrate to prepare Hematoporphyrin. Acid blood dish [mixed solvent] → [essence 3 times] supernatant [concentrate] → Hematoporphyrin.

Hematoporphyrin Application

Water-soluble Hematoporphyrin is a natural pigment in animal blood, has important physiological functions and practical value, and has applications in chemical, food, medicine and cosmetic industries.

In the pharmaceutical industry, water-soluble Hematoporphyrin can be used as a raw material for semi-synthetic bilirubin, and bilirubin can be used to prepare artificial bezoar; Hematoporphyrin can also be used to synthesize hematoporphyrin derivatives, which have been proven to have anti-cancer effects. In 1998 my country has formally approved hematoporphyrin derivatives synthesized from hemin as raw materials to be used as antitumor drugs. In addition, Hematoporphyrin has been clinically used as an iron supplement to treat anemia caused by iron deficiency. Although non-hemin iron supplements are commonly used at present, such as ferrous gluconate, ferrous sulfate, ferric fumarate, etc., the absorption rate of these substances in the human body is very low, and there are certain toxic and side effects; As an iron supplement, water-soluble hemin not only has few side effects, but can also be directly absorbed by the villous cells on the intestinal mucosa, with an absorption rate of over 20%, and will not cause damage to the gastrointestinal tract. It is expected to replace the current commonly used supplements. Iron preparations have become a popular generation product. Hemin (Hemin), also known as hemin or hemin (HaeminorFerricChlorideHeme). Hemin is a porphyrin compound containing ferric ions. Hematoporphyrin can be oxidized from natural heme, the chemical properties of the former and the latter are similar. Heme is ubiquitous in animal blood, muscle and some plant tissues. It is the key prosthetic group of many bioactive macromolecules (such as hemoglobin, muscle protein, cytochrome and peroxidase, etc.), so Hematoporphyrin is a One of the most important compounds.

In clinical treatment, Hematoporphyrin is most widely used as an iron fortifier in the treatment of iron deficiency anemia. In contrast to inorganic iron (non-heme iron), which is mainly released from vegetables and plant foods, heme iron exists in molecular form in the body. Therefore, heme iron can be directly absorbed by the intestinal mucosa, and its absorption rate is 50%-87% higher than that of non-heme iron, and its bioavailability is also higher. In addition, hemin also has the advantages of no iron odor, no gastrointestinal irritation, and no iron accumulation poisoning in the body, so it is the first choice for pure natural biological iron supplements. Secondly, hemin is also used as a correction agent for porphyrin metabolism in the clinical treatment of acute porphyria. Porphyria, which can be hereditary or acquired, is characterized pathologically by deficiency of specific enzymes involved in heme biosynthesis, with reduced heme synthesis leading to compensatory induction of beta-aminolevulinic acid (ALA) synthetase , the accumulation and excretion of intermediates of porphyrin synthesis are increased. Hemin supplementation can inhibit the induction of ALA synthase, reduce the formation and accumulation of potentially harmful intermediates or metabolites in the porphyrin synthesis process, and correct the heme deficiency in the body to a certain extent. There are currently two Hematoporphyrin products on the market for the treatment of porphyria. There is a preparation of heme in lyophilized form (trade name Panhematin). The other is Hematoporphyrin and arginine complex freeze-dried powder (trade name), with ethanol: propylene glycol: water as a mixed solvent, intravenous injection for the treatment of intermittent protoporphyria.

In the food industry, Hematoporphyrin also has broad prospects for development. For example, nitrite is often used to develop color in traditional meat product processing, which will have a certain risk of carcinogenicity, and the use of artificial synthetic pigments also has certain toxic and side effects. Hematoporphyrin can replace the artificial pigments such as nitrite in meat products that are harmful to human health. It can not only maintain the inherent natural color of the meat, the color is uniform, the taste is strong, and the nutritional value is also increased.

About Products:
If you need Hemin, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Hemin manufacturer and supplier, ZSpharmac will provide Hemin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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