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Gynostemma Extract Powder CAS 15588-68-8

Molecular Formula: C80H126O44

Formula Weight: 1791.83

ZSpharmac: Gynostemma Extract Powder Supplement

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Product Name: Gynostemma Extract Powder
CAS No: 15588-68-8
Purity: 99%

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Basic Info

Product Name:Gynostemma Extract Powder
Other Names:Gipsoside
CAS:15588-68-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:0
Storage:-20°C
Provide:Gynostemma Extract Powder MSDS;
Gynostemma Extract Powder COA

What is Gynostemma Extract Powder?

Gynostemma Extract Powder, as a medicinal and edible homologous plant, has rich therapeutic effects and unique health care effects, and has broad prospects in development and utilization. In recent decades, a lot of work has been done on the species identification, planting and cultivation, chemical composition and pharmacological action of Gynostemma pentaphyllum at home and abroad. Market popularity is high, and these findings provide a scientific basis for the development of Gynostemma pentaphyllum. However, on the basis of the 2005 edition, the 2010 edition of “Chinese Pharmacopoeia” added a number of traditional Chinese medicine varieties, and Gynostemma pentaphyllum has not been included in the “Chinese Pharmacopoeia”, which may be due to the structure, mechanism of action and activity of Gynostemma pentaphyllum. The relationship between structure and conformation is unclear. At the same time, since technologies such as purifying Gynostemma saponins and polysaccharides cannot be applied to industrial production, it remains to be seen that Gynostemma Extract Powder can be used as a single drug in the treatment of human hypertension, hyperlipidemia, cancer and other major diseases. Research and explore. In terms of artificial planting, in recent years, technical difficulties such as domestication of wild species, breeding of fine varieties, high-yield cultivation mode, and pest control have been broken through, and 13 new varieties of triploid and tetraploid Gynostemma have been cultivated in 5 categories and established. The Gynostemma Germplasm Resource Garden and the CAP Gynostemma Demonstration Garden were established. However, the quality of the current Gynostemma strains in my country is significantly different, and the Gynostemma Gynostemma products are in a trend of miscellaneous, numerous and chaotic. It is necessary to establish a reliable quality evaluation system and brand system, strengthen the overall management of Gynostemma Extract Powder, and screen and cultivate excellent Gynostemma New varieties, deeply study the relevant factors affecting the content of Gynostemma Extract Powder, develop excellent extraction and purification processes, and provide scientific basis for the high-yield cultivation, timely harvesting, breeding and sustainable development and utilization of Gynostemma Extract Powder, thereby enhancing the Competitiveness among similar products.

Gynostemma Extract Powder Properties

density 1.62
pka2.62±0.70(Predicted)

 

Gynostemma Extract Powder Pharmacological Activity

(1) Spleen-enhancing effect Gynostemma Extract Powder can increase the spleen weight of mice. Lymphocytes increased around the central splenic artery, and the transformation rate of T lymphocytes was enhanced. Mononuclear cells proliferate and phagocytosis is active.
(2) Whitening effect Gynostemma saponins can increase the number of peripheral blood leukocytes, enhance the phagocytic ability of leukocytes, and have an increasing effect on leukopenia caused by CTX.
(3) Phagocytosis Gynostemma polysaccharide significantly enhanced the phagocytosis of peritoneal macrophages.
(4) Regulation of DNA effect Gynostemma saponins in small doses can promote DNA synthesis in lymphocytes, while large doses have the opposite inhibitory effect.

Gynostemma Gynostemma saponins can significantly prolong the average lifespan of Drosophila, significantly increase the SOD activity in the brain and liver of houseflies, mice, and significantly reduce the MDA content. Gynostemma Extract Powder can reduce the content of lipid peroxide in serum, heart, brain and liver and the content of cerebral lipofuscin in aged rats. Gynostemma polysaccharide also has anti-aging effect.

Gynostemma saponins have a significant inhibitory effect on a variety of tumor cells.

Both in vivo and in vitro experiments have confirmed that Gynostemma injection has obvious protective effect on myocardial infarction and myocardial ischemia-reperfusion injury. It can reduce the scope of myocardial infarction, inhibit the increase of free fatty acids in blood after myocardial infarction, reduce the content of MDA in rat myocardium, protect the activity of myocardial SOD, and inhibit the increase of lactate dehydrogenase in serum.

Animal in vivo and in vitro experiments showed that GP had obvious inhibitory effect on ADP, arachidonic acid and collagen-induced platelet aggregation, and also significantly inhibited collagen-induced platelet 5-HT release and increased cAMP level in platelet suspension. GP has inhibitory effects on arterial thrombosis and venous thrombosis. The mechanism may be similar to aspirin.

Gynostemma Extract Powder, saponins and total glycosides have been proved to prolong the swimming time, climbing time and load swimming time of mice. 200mg/kg of Gynostemma Extract Powder administered by gavage for 14 consecutive days can maintain a high blood sugar level in rats swimming for a long time and reduce the loss of muscle glycogen, which may be an important reason for the anti-fatigue of Gynostemma pentaphyllum.

0.25%~0.5% Gynostemma Extract Powder can significantly reduce serum and liver total cholesterol and triglyceride in rats. Oral administration of Gynostemma Gynostemma saponins can inhibit the increase of serum total cholesterol and triglyceride in hypercholesterolemic mice, and reduce serum cholesterol, triglyceride and low-density lipoprotein in hyperlipidemia quails, and have a diffuse effect on the liver of hyperlipidemia quails. Steatosis and atherosclerosis have protective effects.

Gynostemma Extract Powder was administered to alloxan diabetic mice by gavage for 3 days, and it had obvious hypoglycemic effect.

Gynostemma Extract Powder can significantly increase the testis and prostate of male mice and the weight of uterus of female mice compared with the control group, indicating that Gynostemma pentaphyllum has a male and female hormone-like effect.

(1) Prevention and treatment of acute liver injury Gynostemma saponin has an intervening and protective effect on alcohol-induced liver injury, can reduce the degree of steatosis in liver tissue, prevent lipid peroxidation damage to liver cell membrane and subcellular structure caused by oxygen free radicals, and protect liver cell membrane. Integrity, improve liver microcirculation, increase blood flow, promote the excretion of toxins, thereby reducing liver damage.
(2) The anti-hepatic fibrosis effect of Gynostemma saponin can significantly reduce aspartate aminotransferase and alanine aminotransferase, which are elevated in liver injury, and can increase the albumin/globulin ratio; it reduces collagen, and pathological observation found that liver Collagen is thinned, which confirms that Gynostemma saponins have liver-protecting and anti-fibrotic effects.
(3) Anti-Non-Alcoholic Fatty Liver Gynostemma Extract Powder has the effect of significantly reducing liver and serum lipids, and has a therapeutic effect on non-alcoholic fatty liver disease.
(4) Gynostemma Gynostemma saponins 50mg/kg can obviously inhibit the increase of serum transaminase activity caused by carbon tetrachloride. Reduce the lipid peroxide content in liver tissue and reduce the damage to the liver.

(1) The effect of increasing coronary flow Gynostemma Extract Powder can increase the coronary flow in isolated rabbit hearts and slow down the heart rate; intravenous injection has antihypertensive effect.
(2) Gynostemma Extract Powder has sedative, analgesic and hypnotic effects.
(3) Gynostemma saponins have anti-oxidation, anti-injury, skin protection and ulcer healing effects.

Gynostemma Extract Powder Clinical Applications

1. Application History
The record of Gynostemma pentaphyllum begins with Zhu Di’s “Materia Medica for Rescue the Famine” in the Ming Dynasty, which was called “Fairy Grass” in the Ming Dynasty. In ancient times, it was regarded as a miraculous “medicine of immortality and longevity”. It was known as “Gospel Herb” in Japan, and now it is known as “Southern Ginseng” and “Rookie against Cancer” in China. On March 5, 2002, the Ministry of Health included it in the list of health care products.

2. Modern applications
Gynostemma Extract Powder is used in the treatment of diseases such as leukopenia, hyperlipidemia, viral hepatitis, chronic gastroenteritis, chronic bronchitis, blood diseases, hyperlipidemia, hormonal side effects and abnormal sexual function. research value.
(1) Experiments have not confirmed whether Gynostemma Extract Powder has the effect of relieving cough and resolving phlegm in the treatment of chronic bronchitis and hepatitis. Its treatment of chronic bronchitis may be related to the enhancement of immune function, but this is an indirect effect. There are many clinical reports on the treatment of chronic hepatitis, and experiments have confirmed that Gynostemma pentaphyllum has hepatoprotective effects. Clinically, there are many traditional Chinese medicines for reducing transaminase, but few Chinese medicines for reducing bilirubin and inhibiting HBV-DNA. Gynostemma pentaphyllum has no effect in this regard.
(2) About anti-tumor and whitening Gynostemma pentaphyllum has anti-tumor effect. Although there are many anti-tumor Chinese medicines, most of them are weak. Gynostemma pentaphyllum has a broad anti-tumor spectrum, but the clinical effect is general, and it can be used in compound prescriptions to enhance efficacy. Gynostemma has a whitening effect and can treat leukopenia, especially after chemotherapy and radiotherapy. It has a certain effect on the clinical use of leukopenia.
(3) Regarding the syndrome of tonifying deficiency with Gynostemma, it may be related to the ginsenosides it contains, and it is also related to Gynostemma saponins. The content of panaxadiol glycosides in Gynostemma Extract Powder is very small, far less than the ginseng of Araliaceae. Tonic effect is very weak, very slow. Gynostemma has a heat-clearing effect. Taking it will only clear the fire, and will not get angry like ginseng.
(4) 1 pack of Gynostemma Extract Powder for the treatment of hyperlipidemia (equivalent to 2 g of crude drug, containing no less than 40 mg of total saponins), for 30 to 40 days, 23 cases of hypercholesterolemia were treated, and 5 cases were markedly effective. 7 cases were effective, 11 cases were invalid, the total effective rate was 68.17%.
(5) Other applications in the treatment of oral ulcers, psoriasis, physical weakness, poor appetite, fatigue, palpitations, dry mouth and other symptoms.

Gynostemma Extract Powder Extraction Method

Optimization of extraction methods Currently, the main extraction techniques of Gynostemma pentaphyllum are alcohol extraction and water extraction. Comparing the microwave alcohol extraction method and the water extraction method, the former has higher purity of total saponins, while the latter has higher crude substance quality; the purification processes include resin column chromatography and petroleum ether extraction, etc., the former has high purification efficiency, The content of total saponins extracted by water extraction was higher, and the content of total saponins obtained by microwave alcohol extraction was higher. In addition, factors such as extraction temperature and extraction times are also obvious to Gynostemma Extract Powder, and are significantly greater than those of extraction methods such as ethanol concentration and solid-liquid ratio.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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