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Gynostemma Extract CAS 15588-68-8

Molecular Formula: C4H11NO2

Formula Weight: 105.14

ZSpharmac: Gynostemma Extract

Product Name: Gynostemma Extract
CAS No: 15588-68-8
Purity: 99%

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Basic Info

Product Name:Gynostemma Extract
Other Names:Gynostemma Plant Extract
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:Gynostemma Extract MSDS;
Gynostemma Extract COA

What is Gynostemma Extract?

Basic source Gynostemma pentaphyllum (Thunb.) Makino
[alias] five-leaf ginseng, seven-leaf ginseng, wonderful tea creeping plant, seven-leaf gallbladder, Luoguodi, Gongluoguodi, lacquer yard, rooting anywhere.
Medicinal Parts Root or whole plant.
Environment circulation Grows in thick forests in valleys at an altitude of 100-3200 meters, under thin woodlands or bushes on hillsides. Like warm environment, wet atmosphere, prevent straight sunshine, inadequate drought resistance. The dirt issues are not strenuous, and likewise it is a great suggestion to select mountainous timberlands or suspicious incline valleys for planting, ideally abundant as well as loosened up sandy loam. It is dispersed in China, India, Nepal, Sikkim, Bangladesh, Southeast Asia, the Oriental Peninsula in addition to Japan.
[Origin] Our country is mainly generated in Shennongjia, Wushan, Wuxi, Chengkou, Enshi, Xiushan, Fengjie, Kaixian, Shizhu, Wulong. Nanchuan, Banan, Nan’an, Beibei, Jiangjin, Tongliang as well as also various other locations are furthermore dispersed.
[Resource Protection] Wild Gynostemma is rich in resources in the Three Gorges area. In the very early 1990s, pusher purchased Gynostemma pentaphyllum in large quantities, along with the masses welcomed the strategy of rooting out along with excavating in large amounts in order to obtain greater returns as well as higher profits, creating a sharp reduction in wild resources. Currently, wild Jiaogulan has really been listed as a second-class secured plant by the State Forestry Monitoring. The defense of wild Gynostemma pentaphyllum germplasm sources in the 3 Gorges location have to be enhanced, as well as likewise the coupon of Gynostemma pentaphyllum planting modern technology should be strongly achieved to fulfill market requirement.
Plant Kind Seasonal climbing up natural herb. Stems slim, glabrous or sparsely pubescent, much branched, with longitudinal ribs as well as grooves. The fallen leaves are alternative, the tendrils are slim, 2-pointed, as well as likewise sparsely solitary. The fallen leaves are bird-like, with 5-7 leaflets, ovate-oblong or oblong-lanceolate, the main leaflet is larger than the side sales brochures, the edges are curly or crenate, and also both sides are covered with brief setae. Dioecious, male blossoms in panicles, spikes slender as well as likewise branched, with subulate bracteoles at the base, calyx tube very short, 5-lobed, lobes triangular; corolla light environment-friendly, 5-parted; endurances 5, filaments short, unified Into the column. Females blooms are panicles, smaller sized than male flowers, calyx as well as also corolla similar to male blooms, ovary spherical, 3 designs, short as well as forked, prejudgment 2-lobed, with 5 quick staminodes. The fruit is round in addition to black when ripe.

Chemical Composition of Gynostemma Extract

Gynostemma pentaphyllum mostly has saponin, along with the remove the greatest web content is the fallen leave, adhered to by the stem and likewise the airborne element. Its standard structure is a dammarane tetracyclic triterpene. It additionally includes flavonoid glycosides, sugars, sterols, natural acids, pigments, cellulose, veggie protein, starch, and more 1. Saponins
The internet content of saponins in Gynostemma pentaphyllum is an essential index to take a look at the high quality of Gynostemma pentaphyllum, as well as there are countless ranges. Generally spread in the assimilative cells of vegetative body organs and also parenchyma cells of phloem, the internet material differs with varieties as well as environmental variables, normally 2% to 8% of completely dry weight. There are 4 kind of ginsenosides in the general saponins of Jiaogulan. Gypenosides III, IV, in addition to VIII are ginsenosides Rb1, Rb3, and also Rd, as well as panaxadiol, 2α, 19-dihydroxy-12 deoxypanaxadiol, as well as also gypelenone glycoside A, specifically. The complete saponin product is 3 times that of ginseng. Gynostemma pentaphyllum is the only plant consisting of ginseng saponin other than Araliaceae ginseng, and likewise the content of ginseng saponin in exceptional plants is additionally above that of ginseng.
2. Flavonoids
Higher than 10 kind of flavonoids such as SH-4, phytoglucoside, phytoglucoside, rutin, gypelenone 2A, pectin, malonic acid, and also malonic acid.
3. Polysaccharides
The stems along with leaves of Jiaogulan have fructose, sugar, galactose along with oligosaccharides, as well as also the hydrolyzate has rhamnose, xylose, arabinose, sugar as well as galactose.
4. Numerous other
Gynostemma likewise has 18 sort of amino acids, sugars, cellulose, sterols, pigments, 23 type of trace element and additionally various other parts.

Pharmacological Activity of Gynostemma Extract

Pharmacology of Conventional Chinese Medication
Nature and also taste: bitter in the mouth, cool in nature.
Effectiveness: removing cozy along with purifying, beneficial qi and advantageous yin.
Indicators: Cough with yellow phlegm, post-illness powerlessness, fatigue, anorexia, dry mouth, distressed along with sleeping problems and various other indicators.
medicinal effect
1. Immunomodulatory effect
( 1) Spleen-increasing outcome Gynostemma Essence can raise the spleen weight of computer system mice. Lymphocytes enhanced around the main splenic artery, as well as the makeover price of T lymphocytes was boosted. Monocytes multiplied and phagocytosis was energetic.
( 2) Whitening outcome Gypenoside can elevate the number of outer blood leukocytes, improve the phagocytosis of leukocytes, in addition to have an enhancing influence on the leukopenia caused by CTX.
( 3) Phagocytosis Gynostemma pentaphyllum polysaccharide can considerably improve the phagocytosis of peritoneal macrophages.
( 4) Regulating the result of DNA Gypenoside can advertise the DNA synthesis of lymphocytes in small dosages, while it can hinder the opposite impact in significant dosages.
2. Anti-aging outcome
Gypenosides can substantially prolong the ordinary life-span of Drosophila, significantly increase the SOD activity of the housefly and additionally computer system mouse mind and also liver, and likewise considerably lower the MDA content. Gynostemma Extract can decrease the web content of lipid peroxidation and also the material of mind lipofuscin in cream, heart, mind and liver of aged rats. Gynostemma polysaccharides also have anti-aging results.
3. Anti-tumor impact
Gynostemma Extract has significant repressive impacts on a series of growth cells.
4. Safety impact on coronary infarction along with myocardial anemia
Both in vivo as well as likewise in vitro experiments have verified that injection of gypenoside has apparent safety and security impact on heart attack as well as myocardial ischemia-reperfusion injury. Reduced the collection of coronary infarction, impede the boost of absolutely cost-free fatty acid in the blood after coronary infarction, minimize the MDA content in the myocardium of rats, secure the activity of myocardial lawn, and also at the same time stop the surge of lactate dehydrogenase in product.
5. Anti-platelet celebration result
Family pet experiments in vivo as well as artificial insemination have really revealed that GP has evident repressive results on platelet aggregation induced by ADP, arachidonic acid as well as collagen, as well as can similarly substantially hinder the launch of collagen-induced platelet 5-HT, as well as additionally increase the cAMP degree in platelet suspension. Family doctor has repressive influence on arterial apoplexy and also venous apoplexy. Its system may appear like that of aspirin.
6. Boost physical strength as well as anti-fatigue result
Gynostemma Remove, saponins, as well as likewise complete glycosides have in fact been confirmed to lengthen the swimming time, pole going up time as well as lots swimming time of computer mice. Gynostemma pentaphyllum essence of 200mg/kg by mouth carried out for 14 succeeding days can maintain long-time swimming rats with high blood sugar level degrees as well as also lower muscular tissue glycogen loss, which might be an essential factor for Gynostemma pentaphyllum anti-fatigue.
7. Blood lipid decreasing influence
0.25% ~ 0.5% Gynostemma Remove has a substantial outcome on decreasing product along with liver complete cholesterol and likewise triglyceride in rats. Giving overall saponins of Gynostemma pentaphyllum can impede the boost of lotion total up to cholesterol as well as additionally triglyceride in computer mice with hypercholesterolemia, and likewise reduced cholesterol, triglyceride as well as low-density lipoprotein in product of hyperlipidemia quail, as well as has a significant outcome on the liver of hyperlipidemia quail. Steatosis in addition to atherosclerosis development have a security effect
8. Hypoglycemic outcome.
Gynostemma Remove was administered to computer mice with alloxan diabetic issues mellitus for 3 successive days, and also it had a considerable hypoglycemic effect.
9. Increase sex-related function
Gynostemma Essence can substantially improve the testis as well as prostate of male computer system mice, and also the weight of womb of females computer system mice contrasted to the control group, showing that Gynostemma has a male and likewise female hormone-like impact.
10. Liver defense
( 1) Evasion as well as additionally therapy of severe liver injury Gypenoside has a therapy as well as also protective influence on alcohol-induced liver injury, can decrease the level of fatty degeneration of liver cells, prevent oxygen free radicals from lipid peroxidation damages to liver cell membranes as well as subcellular frameworks, in addition to shield liver cell membrane layers Stability, increase liver microcirculation, increase blood circulation, promote toxin discharge, subsequently minimizing liver damages.
( 2) Anti-hepatic fibrosis result Gypenoside can considerably lower the raised aspartate aminotransferase as well as alanine aminotransferase brought on by liver problems, as well as can increase the proportion of albumin/globulin; it can minimize collagen, and also pathological observation discloses that liver The collagen happens thinner, which shows that gypenoside has the result of securing the liver as well as anti-fibrosis of the liver.
( 3) Anti-nonalcoholic fatty liver Gynostemma pentaphyllum as well as its essences can considerably minimize liver as well as product lipids, as well as also have a therapeutic influence on nonalcoholic fatty liver problem.
( 4) Gypenosides 50mg/kg can considerably hinder the rise of serum transaminase task activated by carbon tetrachloride. Lower the web content of lipid peroxide in the liver tissue and additionally reduce the problems to the liver.
11. Numerous other
( 1) Result of improving coronary blood circulation Gynostemma pentaphyllum essence can raise the coronary circulation of the separated rabbit heart and likewise decrease the heart price; intravenous shot has antihypertensive effect.
( 2) Jiaogulan significance has sedative, analgesic as well as additionally hypnotic impacts.
( 3) Gypenoside has anti-oxidation, anti-injury, skin protection and likewise discount of abscess healing.

Gynostemma Extract Extraction Method

Optimization of the extraction method
At present, the extraction techniques of effective components of Gynostemma pentaphyllum are mainly alcohol extraction and water extraction. Comparing the microwave alcohol extraction method and the water extraction method, the total saponin purity extracted by the former is higher, and the bold material quality of the latter is higher; the purification process includes resin column chromatography and petroleum ether extraction method, etc., the former has high purification efficiency, The content of total saponin extracted by water extraction is higher, and the content of total saponin obtained by microwave alcohol extraction is higher. In addition, factors such as extraction temperature and extraction times are also obvious to the extraction of Gynostemma Extract, and are significantly greater than extraction methods such as ethanol concentration and solid-liquid ratio.

Gynostemma Extract Development Application

Gynostemma pentaphyllum has an extremely bitter taste as well as is not suitable for medicinal diet plan and dietotherapy, but it can be made use of as a health product. Gynostemma pentaphyllum has been become granules, granules, capsules and so on. However after a short time, it progressively went out, which might be connected to the imprecise positioning of Gynostemma pentaphyllum. Gynostemma is difficult to change ginseng, due to the fact that there is no lack of ginseng supply out there. Gynostemma pentaphyllum must be investigated and also created according to its very own features.
1. Healthcare items and food
Gynostemma pentaphyllum can also be utilized to make medicinal white wine, capsules as well as granules. It is used to reinforce the body, shield the liver, and avoid as well as treat illness. Gynostemma Medicinal Red wine: compound dish is better, Gynostemma 9g, raw sun-dried ginseng 9g, Ganoderma lucidum 30g, licorice 9g, red dates 30g, a percentage of rock sugar, honey and also other sugar can be contributed to taste. The elderly bring it for a long period of time to reinforce their bodies and also withstand aging. Gynostemma wellness tea, Gynostemma beverage, Gynostemma beer, Gynostemma sake, Gynostemma food additives, etc have actually been created and detailed.
2. Feed and also ingredients
In regards to animal husbandry, with the growth of animal husbandry and aquaculture, the troubles of drugs and feed additives have brought in people’s attention. Gynostemma pentaphyllum drugs and also food additives not just have a selection of micronutrient, yet also have the functions of invigorating the stomach, lowering inflammation, preventing microorganisms, boosting The role of immunity can control the nervous system and endocrine activities, aid to enhance the cravings of poultry, livestock, fish and shrimp, and so on, as well as improve feed application. It can be seen that Jiaogulan, as a plant-based feed additive, has a great growth prospect for improving the resistance of livestock and also poultry and also avoiding and managing transmittable diseases.
3. Cosmetics
As a result of its anti-aging, hair blackening and improving results, Gynostemma Extract has high advancement value in the cosmetics sector. As an example, blending Gynostemma saponin with stearic acid can be used to prepare cream, aesthetic lotion, soap, and so on. Although the application study of Gynostemma pentaphyllum has progressively end up being a hot spot, many functions of Gynostemma pentaphyllum have actually not been fully used, so Gynostemma pentaphyllum has excellent growth value and also potential.

About Products:
If you need Gynostemma Extract, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Gynostemma Extract manufacturer and supplier, ZSpharmac will provide Gynostemma Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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