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Zhishang Chemical

Guaiacol Himedia CAS 90-05-1

Molecular Formula: C7H8O2

Formula Weight: 124.14

ZSpharmac: Guaiacol Himedia Supplement

Product Name: Guaiacol Himedia
CAS No: 90-05-1
Purity: 99%

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Basic Info

Product Name:Guaiacol Himedia
Other Names:Guaiacol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Light Yellow
EINECS No.:201-964-7
Provide:Guaiacol Himedia MSDS;
Guaiacol Himedia COA

What is Guaiacol Himedia?

Guaiacol Himedia (or guaiacol, named after the guaiac tree belonging to Latin America) is an all-natural organic compound with the molecular formula C6H4(OH)(OCH3). This anemic fragrant oily substance is the primary part of creosote, which can be gotten from guaiac material, pine oil, and so on. The usual guaiacol tackles a dark shade from exposure to air or light. The smoke from fire wood burning includes guaiacol due to the malfunction of lignin. Many foods, such as baked coffee beans, have a characteristic odor because of the presence of guaiacol. The unique flavor of smoked food is mostly due to the result of guaiacol and syringol. Guaiacol transforms blue when it comes across ferric chloride.

Guaiacol Himedia Properties

Melting point 

26-29 °C (lit.)

Boiling point 

205 °C (lit.)


1.129 g/mL at 25 °C (lit.)

vapor density 

4.27 (vs air)

vapor pressure 

0.11 mm Hg ( 25 °C)

refractive index 

n20/D 1.543(lit.)


180 °F

storage temp. 



H2O: insoluble


9.98(at 25℃)


Liquid After Melting


Clear colorless to light yellow


5.4 (10g/l, H2O, 20℃)

Odor Threshold


Water Solubility 

17 g/L (15 ºC)


Guaiacol Himedia Uses

  1. Guaiacol Himedia is usually added in a percentage as an antioxidant in cosmetics as well as is typically used together with synergists, metal ion chelating agents, and so on. Due to the fact that it responds with oxygen to give a dark shade, guaiacol is also utilized as a color. Guaiacol is also used as a basic material for organic synthesis and a standard material for analytical determination.
  2. Guaiacol Himedia is used in medicine to make calcium guaiacol sulfonate, and also in fragrance market to make vanillin as well as fabricated musk. Test for copper, hydrocyanic acid as well as nitrite.
  3. Guaiacol Himedia is a phenolic substance that functions as a scavenger for superoxide radicals.

Guaiacol Himedia Preparation Method

Method 1: Synthesis of Guaiacol Himedia from methanol and catechol over Al-P-Ti-Si-O catalyst

In an aqueous solution containing a certain amount of aluminum source and vigorously stirring, drop the silicon source and the titanium source. After refluxing the phosphoric acid, reflux for several hours, heat in a water bath and evaporate to dryness. The obtained solid is ground into powder and dried at 393K for 12 h. , calcined in air at 673K ​​for 5 h, pressed into tablets and sieved to obtain 40~60 mesh catalyst. The XRD analysis of the catalysts was carried out on a DM ax-rA type rotating target X-ray diffractometer, CuKα target, 40 kV x 150 mA. The specific surface area and pore structure test were carried out on a Micrometritics A SA P2010 specific surface area tester, and N2 was the adsorbate, which was adsorbed at the temperature of liquid nitrogen. The activity evaluation was carried out on a fixed-bed continuous flow reaction device: the reaction tube was a rigid glass tube (Ø1.1 am), and the amount of catalyst was 14 g (40-60 mesh). First pass into N before the reaction: purging reaction system, cut off Nz After adjusting to the required temperature, the reactant enters from the upper end of the reaction tube, and the product is condensed at the bottom of the reaction tube and flows into the collection bottle, n (catechol)/n ( Methanol) = 1/5, the feed rate is 0.5 mL/h, and the reaction temperature is 553K.

Method 2: Preparation of Guaiacol Himedia by o-anisole method

Include two steps: namely the diazotization of o-anisole and the hydrolysis of the diazonium salt, the former is a more common typical reaction in the diazotization reaction, as long as the appropriate acidity is controlled to avoid contact with harmful substances, and the control reaction is Performing at low temperature is basically quantitative; the latter is more complicated and is also the key to this method.

During hydrolysis, the diazonium salt loses the diazonium ion to generate phenyl carbocation. The slow reaction in this step is the control step of the hydrolysis reaction. The generated phenyl carbocation and the nucleophile water molecule are rapidly combined under the catalysis of copper ions. , a nucleophilic substitution reaction occurs to generate guaiacol, which is the main reaction, and the equation is as follows:

Method three: using catechol as raw material, and methylating reagents such as methanol and dimethyl carbonate under the action of catalyst to prepare guaiacol.

The catechol method is still in its infancy, and it is mainly studied in the laboratory, and there is no industrial report. The reaction mechanism is that catechol reacts with the methylating reagent first to form guaiacol, which is the main reaction; the generated guaiacol can further react with the methylating reagent to form phthalic ether, which is the main side reaction. . The general formula of the main and side reactions is as follows (in the formula CH3-X is a methylating reagent):

Extraction Method of Guaiacol Himedia

The extraction of all-natural Guaiacol Himedia is to make all-natural guaiacol in woodland creosote to create insoluble salt, and then via filtration, acid precipitation, rectification as well as other processes to obtain natural guaiacol with a purity of greater than 95%, the removal price of greater than 60%.

Vanillin created with natural guaiacol is far better quality than synthetic Guaiacol Himedia. Remove natural guaiacol from woodland creosote, which is defined by:

The very first process is removal. The woodland creosote containing guaiacol is pumped into the stainless-steel reaction pot, and after that sodium hydroxide with a focus of 10% is added to make the two fully stir evenly.

The second process is purification. When the essence is cooled down as well as crystallized, the upper mom liquor is drawn out.

The third procedure is to wash with clean water and suction out the washing water.

The 4th process is acid precipitation, put sulfuric acid whose concentration is gotten used to 30%, as well as stir well. After the acid precipitation is finished, the sulfate wastewater is released from all-time low, and afterwards the crude guaiac vinegar is washed with tidy water. The above 4 processes are carried out in the very same stainless steel reactor.

The fifth treatment is correction under minimized stress. The crude guaiacol after cleaning is pumped right into the stainless steel rectifying still, as well as the temperature level of the fixing still is heated by home heating tools, as well as the vacuum cleaner degree in the still corresponds to the temperature of collecting natural guaiacol one at a time.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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