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Guaiacol CAS 90-05-1

Molecular Formula: C7H8O2

Formula Weight: 124.14

ZSpharmac: Guaiacol Supplier

Product Name: Guaiacol
CAS No: 90-05-1
Purity: 99%

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Basic Info

Product Name:Guaiacol
Other Names:O-Methoxy-Phenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Light Yellow Liquid After Melting
EINECS No.:201-964-7
Provide:Guaiacol MSDS;
Guaiacol COA

What is Guaiacol?

Guaiacol (or guaiacol, called after the guaiac tree belonging to Latin America) is an all-natural organic compound with a molecular formula of C6H4(OH)(OCH3). This colorless aromatic oily substance is the major part of creosote, which can be prepared from guaiac wood resin, want oil, etc. Usual guaiacol tackles a dark shade when exposed to air or light. Due to the malfunction of lignin, the smoke produced when fire wood is burned consists of guaiacol. Numerous foods, such as baked coffee beans, have a distinctive scent due to the visibility of guaiacol. The unique flavor of smoked food is mainly because of the impact of guaiacol as well as syringol. Guaiacol turns blue when it meets ferric chloride.

Guaiacol Property

Melting point 

26-29 °C (lit.)

Boiling point 

205 °C (lit.)


1.129 g/mL at 25 °C (lit.)

vapor density 

4.27 (vs air)

vapor pressure 

0.11 mm Hg ( 25 °C)

refractive index 

n20/D 1.543(lit.)


180 °F

storage temp. 



H2O: insoluble


Liquid After Melting


9.98(at 25℃)


Clear colorless to light yellow


5.4 (10g/l, H2O, 20℃)


at 1.00 % in dipropylene glycol. phenolic smoke spice vanilla woody

Odor Type


Odor Threshold


Water Solubility 

17 g/

L (15 ºC)



Guaiacol Uses

  1. Guaiacol is commonly made use of in industry. Guaiacol is typically made use of to produce various fragrances such as eugenol, vanillin and also fabricated musk. Guaiacol is also commonly made use of in medicine, it can be utilized in the synthesis of guaiacol benzenesulfonate (potassium guaiacol sulfonate), made use of as an anesthetic or antibacterial, and also can likewise expectorant and treat acid indigestion. Due to its lowering residential or commercial properties, it is commonly included a small amount in cosmetics as an antioxidant and also commonly made use of together with synergists and steel ion chelating representatives. Guaiacol is also utilized as a dye since it reacts with oxygen to create dark colors. Guaiacol is likewise used as a raw material for natural synthesis and as a typical material for evaluation and determination.
  2. Guaiacol is a flavoring that is temporarily allowed in GB 2760-96. It is generally made use of in the prep work of tastes such as coffee, vanilla, smoke and cigarette.
  3. Guaiacol is utilized in medicine to make calcium guaiacol sulfonate, as well as in the perfume industry to make vanillin and also man-made musk. Test for copper, hydrocyanic acid and also nitrite.

Guaiacol Preparation Method

Method 1: Synthesis of guaiacol from methanol and catechol on Al—P—Ti—Si—O catalyst

In the aqueous solution containing a certain amount of aluminum source and under vigorous stirring, drop silicon source and titanium source, reflux after dropping phosphoric acid, and then reflux for several hours, heat and evaporate to dryness in a water bath, grind the obtained solid into powder, and dry at 393K for 12 h , Roasted in 673K air for 5 h, pressed into tablets and sieved to obtain 40~60 mesh catalysts. The XRD analysis of the catalyst was carried out on a DM ax-rA trans-target X-ray diffractometer, CuKα target, 40 kV x 150 mA. The specific surface area and pore structure tests were carried out on a Micrometrics A SA P2010 specific surface tester, with N2 as the adsorbate, which was adsorbed at the temperature of liquid nitrogen. The activity evaluation was carried out on a fixed-bed continuous flow reaction device: the reaction tube was a hard glass tube (Ø1.1 am), and the catalyst dosage was 14 g (40-60 mesh). Feed into N before the reaction: purge the reaction system, cut off Nz2 and adjust to the desired temperature, the reactant enters from the upper end of the reaction tube, and the product condenses at the bottom of the reaction tube and flows into the collection bottle, n(catechol)/n( Methanol)=1/5, feed rate 0.5 mL/h, reaction temperature 553K.

Method 2: Preparation of guaiacol by o-aminoanisole method

Include two steps: namely the diazotization of anthranil and the hydrolysis of diazonium salt, the former is a more common typical reaction in the diazotization reaction, as long as the appropriate acidity is controlled, avoid contact with harmful substances, and control the reaction at Carried out at low temperature, it is basically carried out quantitatively; and the latter is more complicated, which is also the key to the method.

During hydrolysis, the diazonium salt loses diazonium ions to generate phenyl carbocations. This step is a slow reaction step and is the controlling step of the hydrolysis reaction. The generated phenyl carbocations are quickly combined with nucleophile water molecules under the catalysis of copper ions. , a nucleophilic substitution reaction occurs to generate guaiacol, which is the main reaction, and the equation is as follows:

Method 3: using catechol as a raw material, and methylating reagents such as methanol and dimethyl carbonate to prepare guaiacol under the action of a catalyst.

The catechol method is still in its infancy, and is mainly studied in the laboratory, and no industrialization report has been seen. The reaction mechanism is that catechol first reacts with methylating reagents to generate guaiacol, which is the main reaction; the generated guaiacol can further react with methylating reagents to generate phthalic dimethyl ether, which is the main reaction. side effects. The general formula of the main and side reactions is as follows (CH3-X is a methylating reagent in the formula):

Guaiacol Extraction Method

The extraction of natural guaiacol is to make the natural guaiacol in the forest chemical creosote generate an insoluble salt, and then obtain natural guaiacol with a purity of more than 95% through filtration, acid precipitation, rectification and other processes, and extract rate of more than 60%.

The vanillin produced with natural guaiacol is of much better quality than the vanillin produced with synthetic guaiacol. Natural guaiacol is extracted from forest creosote, which is characterized by:

The first process is extraction. The creosote containing guaiacol is pumped into a stainless steel reaction kettle, and then 10% sodium hydroxide is added to make the two fully stirred evenly.

The second process is filtration. When the extract cools and crystallizes, the upper mother liquor is drawn out.

The third process is to wash with clean water and suck out the washing water.

The fourth process is acid analysis, put in sulfuric acid whose concentration is adjusted to 30%, and fully stir. After the acid analysis is completed, the sulfate wastewater is discharged from the bottom, and then the crude guaiac vinegar is washed with clean water. The above four processes are carried out in the same stainless steel reactor.

The fifth process is vacuum rectification. The washed crude guaiacol is pumped into a stainless steel rectification kettle, and the temperature of the rectification kettle is raised by heating equipment. The vacuum degree in the kettle is the same as the temperature at which natural guaiacol is collected. One to one correspondence.

About Products:
If you need Guaiacol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Guaiacol manufacturer and supplier, ZSpharmac will provide Guaiacol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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