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Guaiacol CAS 90-05-1

Molecular Formula: C7H8O2

Formula Weight: 124.14

ZSpharmac: Guaiacol Supplier

Product Name: Guaiacol
CAS No: 90-05-1
Purity: 99%

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Basic Info

Product Name:Guaiacol
Other Names:O-Methoxy-Phenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Light Yellow Liquid After Melting
EINECS No.:201-964-7
Provide:Guaiacol MSDS;
Guaiacol COA

What is Guaiacol?

Guaiacol, chemically known as 2-methoxyphenol, is an organic compound naturally present in many plants and woods. Its molecular formula is C7H8O2, and it belongs to a class of phenolic compounds.

The guaiacol molecule contains a benzene ring and a methoxy group (-OCH3) attached to it. This structure gives it specific physical and chemical properties. It is a white to pale yellow crystal or powder, soluble in organic solvents such as ethanol and ether at room temperature, slightly soluble in water, and has a typical phenolic odor.

Guaiacol was originally named after being extracted from the resin of the Guaiacum officinale tree, but it can also be obtained through coal tar fractionation, chemical degradation of lignin, or certain microbial fermentation processes.

Guaiacol Property

Melting point 

26-29 °C (lit.)

Boiling point 

205 °C (lit.)


1.129 g/mL at 25 °C (lit.)

vapor density 

4.27 (vs air)

vapor pressure 

0.11 mm Hg ( 25 °C)

refractive index 

n20/D 1.543(lit.)


180 °F

storage temp. 



H2O: insoluble


Liquid After Melting


9.98(at 25℃)


Clear colorless to light yellow


5.4 (10g/l, H2O, 20℃)


at 1.00 % in dipropylene glycol. phenolic smoke spice vanilla woody

Odor Type


Odor Threshold


Water Solubility 

17 g/

L (15 ºC)



Guaiacol Uses

1. Medical field
Disinfection and preservation: Guaiacol has certain antibacterial properties and can be used in skin disinfectants, surgical disinfectants, etc. to fight against a variety of bacteria and fungi.
Drug synthesis: As a pharmaceutical intermediate, guaiacol is involved in the synthesis of a variety of drugs, such as analgesics, anti-inflammatory drugs and cardiovascular drugs, and its derivatives are also used to treat digestive system diseases.
Oral hygiene: Due to its antibacterial properties, guaiacol is added to oral care products such as toothpaste and mouthwash to help prevent gingivitis and oral ulcers.

2. Food industry
Anti-corrosion and antioxidant: Guaiacol, as a natural preservative and antioxidant, can extend the shelf life of food and prevent oil oxidation. It is widely used in meat products, baked goods and beverages.
Flavoring and flavoring: At low concentrations, guaiacol can provide a unique smoky aroma and is used as a food flavor to increase the flavor of foods such as barbecue and bacon.

3. Agriculture
Plant protection: Guaiacol and its derivatives are used as plant growth regulators to promote plant rooting and germination, enhance crop resistance, and as biological pesticides to combat fungal and bacterial diseases.
Feed additives: Adding guaiacol to animal feed can improve animal immunity and growth performance and reduce the occurrence of diseases.

4. Industrial manufacturing
Resin synthesis: Guaiacol reacts with formaldehyde to produce guaiacol formaldehyde resin, which has good heat resistance, water resistance and adhesion, and is widely used in the manufacture of adhesives, coatings and laminates.
Dyes and spices: As a precursor of dyes and spices, guaiacol can be chemically modified to obtain dyes of various colors and compounds with special fragrances, which are used in textile dyeing and cosmetics production.
Water treatment: In the water treatment industry, guaiacol derivatives are used as coagulants to help remove suspended matter and organic matter in water and purify water quality.

5. Environmentally friendly materials
Lignin modification: Guaiacol can participate in the modification process of lignin, improve the performance of biomass materials, and promote the efficient use of renewable resources, such as the production of biodegradable plastics and composite materials.

Guaiacol Prominent Applications in Cosmetics

1. Antioxidant
As a natural antioxidant, guaiacol can effectively remove free radicals, slow down the oxidative stress response during skin aging, and protect skin cells from damage, thereby delaying skin aging and reducing the formation of wrinkles and spots. In anti-aging skin care products, guaiacol is often used as an auxiliary ingredient to enhance the antioxidant capacity of the product.

2. Anti-inflammatory and soothing
Guaiacol has a mild anti-inflammatory effect and can reduce the redness, inflammation and discomfort caused by external stimuli (such as ultraviolet rays, pollutants, and allergic reactions). In skin care products for sensitive skin, guaiacol can be used as a mild soothing ingredient to help restore the health of the skin.

3. Antibacterial and skin cleansing
The antibacterial properties make guaiacol an effective ingredient in personal cleansing and care products such as facial cleansers, shampoos and shower gels. It can help inhibit the growth of bacteria on the skin surface, reduce the occurrence of acne and acne, and maintain the cleanliness and health of the skin.

4. Promote skin healing
Guaiacol can promote cell proliferation and repair, accelerate the healing process of skin wounds, and reduce scar formation. Therefore, it is used in restorative cosmetics such as scar repair cream, burn cream and anti-acne products to help the skin restore smoothness and fineness.

5. Fragrance and sensory experience
Guaiacol has a certain aromaticity and can provide a warm, woody or slightly smoky aroma. This property makes it a fragrance ingredient in perfumes and scented bath products to enhance the sensory experience of the product.


National Center for Biotechnology Information. “PubChem Compound Summary for CID 460, Guaiacol” PubChemhttps://pubchem.ncbi.nlm.nih.gov/compound/Guaiacol. Accessed 19 June, 2024.

As a company specializing in the production and supply of Guaiacol raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure the quality and stable supply of our products. No matter where you are, we can provide you with the Guaiacol raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relations with domestic and foreign customers and won their trust and praise.

If you have any needs or are interested in our products, please contact our service staff directly, and we will wholeheartedly provide you with the best service and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Guaiacol Quotation