Zhishang Chemical

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Zhishang Chemical

Glyoxylic Acid Sigma CAS 298-12-4

Molecular Formula: C2H2O3

Formula Weight: 74.04

ZSpharmac: Glyoxylic Acid Sigma Supplement

Product Name: Glyoxylic Acid Sigma
CAS No: 298-12-4
Purity: 99%

Basic Info

Product Name:Glyoxylic Acid Sigma
Other Names:Glyoxylic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Flavors and Fragrances
Appearance:Colorless Transparent Liquid
EINECS No.:206-058-5
Storage:Store Below +30°C.
Provide:Glyoxylic Acid Sigma MSDS;
Geranyl Glyoxylic Acid Sigma COA

What is Glyoxylic Acid Sigma?

Glyoxylic Acid Sigma is an organic acid substance that can be obtained as hemihydrate crystals from water and has an unpleasant odor. It is a strong corrosive acid and can corrode most metal products except some stainless steel alloys. Short-term exposure to air quickly deliquescence into syrup.

Glyoxylic Acid Sigma Properties:

Melting point -93°C
Boiling point 111°C
density 1.33 g/mL at 20 °C
refractive index n20/D 1.414
Fp 111°C
storage temp. Store below +30°C.
solubility Miscible with ethanol. Slightly miscible with ether and benzene. Immiscible with esters.
pka3.18(at 25℃)
Water Solubility miscible


Glyoxylic Acid Sigma Uses

  1. Glyoxylic Acid Sigma is the simplest keto acid (aldehyde acid) with both acid and also aldehyde residential or commercial properties. It is utilized as a resources for varnishes, intermediates for scents, pharmaceuticals, dyes, plastics and also home chemicals. Can be utilized to produce oral penicillin vanillin, ethyl vanillin and also allantoin (see 01320). Allantoin is an anti-ulcer medicine, as well as is likewise an intermediate of some pharmaceutical products and also everyday chemicals. It can be further refined right into a trace quantity of high-efficiency liquid fertilizer.
  2. Glyoxylic Acid Sigma is utilized as a fragrance as well as fixative in cosmetics and also in pharmaceuticals.

Prepared by Glyoxylic Acid Sigma

According to the different sources of raw materials, the synthesis methods of Glyoxylic Acid Sigma are roughly classified into the following four types.

1) Catalytic oxidation of glyoxal
Taking glyoxal as the starting material, the aqueous solution of glyoxal is obtained by oxygen (or air, or hydrogen peroxide) oxidation under catalyst and heating conditions. In the early stage of this method, nitric acid was used as a catalyst, which was difficult to control the reaction, and seriously corroded the equipment. The nitric oxide generated in the reaction polluted the air, and the product was purified by electrodialysis, which was not conducive to industrialization. At present, catalysts have been replaced by metal salts or metal oxides, and the hydrogen peroxide method has become the main method for the preparation of glyoxalic acid from glyoxal.

2) Condensation hydrolysis method of dichloroacetic acid or dibromoacetic acid
Dichloroacetic acid or dibromoacetic acid undergoes condensation and hydrolysis reaction with sodium methoxide in methanol solvent, and then removes the organic solvent through heating and cooling for crystallization, and finally separates by filtration to obtain Glyoxylic Acid Sigma.

3) Oxalic acid electrolytic reduction method
Under the action of direct current, oxalic acid obtains free electrons on the cathode, and a carbonyl group in the oxalic acid molecule is reduced to an aldehyde group to become Glyoxylic Acid Sigma. The method has mild reaction conditions, high yield, good product quality, low cost, and no three-waste pollution, and has become the main synthetic route for Glyoxylic Acid Sigma produced by domestic and foreign manufacturers.

Glyoxylic Acid Sigma Application

Glyoxylic Acid Sigma is the simplest aldehyde acid with aldehyde and carboxylic acid functional groups, and its derivatives have reached dozens of varieties. As an important fine chemical raw material, Glyoxylic Acid Sigma has been widely used in spices, medical paper, leather, plastics, coatings, coloring, pesticides, food additives, organic, biochemical and other fields. Typical are: vanillin, ethyl vanillin, jasmonaldehyde, allantoin, hydroxyphenylglycine, acetophenone and other chemical products.

1) Allantoin
A major use of Glyoxylic Acid Sigma is in the preparation of allantoin. Under certain temperature and catalyst, allantoin is formed by one-step condensation of glyoxylic acid and urea. The downstream products of allantoin include alcloxa, aldioxa, diazonium alkyl urea, polygalactonic acid and salicylic acid, ascorbic acid, glycine and other compounds of allantoin . Allantoin series products are widely used in medicine, daily use, agriculture and other industries, and the prospects are very promising. In medicine, it is a drug with various functions, which can be used directly or as an additive; in the field of light chemical industry, it can be used as an additive in cosmetics; in agriculture, it can be used as a regulator of plant growth. At present, allantoin in my country is mainly used in medicine and daily chemical industry, and the annual demand is about 200t. Due to the high price of allantoin, its use in agriculture has not been fully opened. With the large-scale production of Glyoxylic Acid Sigma acid in my country, the consumption of allantoin will increase significantly. In 2003, the production cost of allantoin was 30,000 yuan, the market price was 50,000 yuan, and the economic benefit was very high.

2) Vanillin and ethyl vanillin
Guaiacol and Glyoxylic Acid Sigma are condensed into 3-methoxy-4-hydroxyphenylglycolic acid in the presence of alkali, and then oxidized to remove CO2 under a catalyst to generate crude product, which is purified to make vanillin, that is, Friedel method. Vanillin is a broad-spectrum spice with elegant and refreshing aroma. It is directly used in cosmetics, soap, cigarettes, cakes, candies and baked goods. It is one of the most widely used spices. It is also used in the electroplating industry. Glazing agent, used as a ripening agent in agriculture, etc. In addition, vanillin is an important organic synthesis intermediate, which can produce such as 4,5-trimethoxybenzaldehyde (TMB), veratrol (3,4-dimethoxybenzaldehyde), catechin (3 , 4-dihydroxybenzoic acid) and many other products, the domestic prospects are very promising.

3) p-hydroxyphenylacetic acid
P-Hydroxyphenylacetic acid has developed rapidly in recent years, and its synthesis mainly adopts the route of phenol-glyoxylic acid. This method has simple process, less pollution and low cost, and is the main industrial production method at present. Phenol and glyoxylic acid first generate p-hydroxymandelate under alkaline conditions, then hydrolyze to p-hydroxymandelic acid, and finally reduce to p-hydroxyphenylacetic acid under catalyst. p-Hydroxyphenylacetic acid has a wide range of uses, and is currently mainly used in the synthesis of p-hydroxyphenylacetamide (intermediate of the antihypertensive drug atenolol), health care medicine soy isoflavones (daidzein, puerarin, etc.), p-methoxyphenylacetic acid Phenylacetic acid (an intermediate of the new antidepressant venlafaxine), dermatological drugs butylbenzene hydroxy acid, p-hydroxyphenethyl alcohol, etc., have very promising prospects. Atenolol is currently the best-selling antihypertensive drug in the world, and the demand at home and abroad is growing rapidly. p-Hydroxyphenethyl alcohol is prepared by the reduction of p-hydroxyphenylacetic acid, and is the raw material of cardiovascular drugs such as Metoprolol and Betaxolol.

4) Phenylglycine
Glyoxylic Acid Sigma can be used to synthesize phenylglycine, including dl-phenylglycine (DLPG), lev-phenylglycine (DPG), etc., usually referred to as DPG. In production, dl-dihydantoin is generally prepared first, and then DPG is prepared. DPG is currently mainly used to synthesize β-lactam antibiotics, polypeptide hormones and pesticides, and is mainly used to synthesize β-lactam antibiotics in China.

5) Mandelic acid
Mandelic acid, which has R- and S-structures, is prepared by the reaction of benzene and glyoxylic acid. The price of mandelic acid and its salts and esters is very high. Mandelic acid can be used to synthesize vasodilator cyclomandelic acid ester, ophthalmic drug oxybenzazole, central nervous system stimulant pimoline and benzodifuranone dye, in addition, mandelic acid can also synthesize acetophenone acid, which is a medicinal stomach. Changning and the raw materials of the highly effective and safe herbicide fenflumone currently on the market.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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