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Glycyrrhizic Acid CAS 1405-86-3

Molecular Formula: C42H62O16

Formula Weight: 822.94

ZSpharmac: Glycyrrhizic Acid Supplement

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Product Name: Glycyrrhizic Acid
CAS No: 1405-86-3
Purity: 99%

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Basic Info

Product Name:Glycyrrhizic Acid
Other Names:Glycyrrhizin
CAS:1405-86-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:White to Light Yellow Solid
EINECS No.:215-785-7
Storage:Under Inert Gas (Nitrogen or Argon) at 2-8°C
Provide:Glycyrrhizic Acid MSDS;
Glycyrrhizic Acid COA

What is Glycyrrhizic Acid?

Glycyrrhizic acid originates from the origins and also roots of bean licorice, and also is the primary active component in licorice, with a material of regarding 10%. Glycyrrhizic acid, likewise known as glycyrrhizin and also glycyrrhizin, is a glycoside composed of glycyrrhetic acid and 2 particles of glucuronic acid. White to slightly yellow crystalline powder, odorless, with a particular sweetness, around 200 times sweeter than sucrose. Its sweetness is different from that of sugar such as sucrose, and also it takes a while to have a pleasant preference after entering it, however it lasts for a long time. A small amount of liquiritin and sucrose can utilize 20% less sucrose without altering the sweetness. Although it has no scent, it has a fragrance-enhancing result. The aqueous service is weakly acidic, as well as the pH of a 2% solution is 2.5 ~ 3.5. Insoluble in water as well as dilute ethanol. It is easily soluble in hot water and also becomes a viscous jelly after cooling. Glycyrrhizic acid is a triterpenoid saponin. Additionally, there are licorice glycosides, isoglycyrrhizin and so on. Bean licorice (Glycyrrhizasp.) is a crucial conventional Chinese medicine. It is made use of in 74 of the 110 prescriptions in Treatise on Febrile Diseases. Glycyrrhizic acid is prepared by extracting licorice root and has a special sweetness. It is mainly utilized in food, and additionally has applications in other sectors such as medication, cosmetics and cigarettes. Because the professional application of glycyrrhizic acid is frequently accompanied by pseudoaldosteronism, experts have actually carried out a lot of chemical synthesis and architectural alteration, as well as glycyrrhizic acid by-products have a wide variety of scientific applications.

Glycyrrhizic Acid Properties:

Melting point 220°C (rough estimate)
alpha D17 +46.2° (c = 1.5 in alc)
Boiling point 681.01°C (rough estimate)
density 1.1442 (rough estimate)
refractive index 61 ° (C=1.5, EtOH)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly)
pka2.76±0.70(Predicted)
form Solid
color White to Light Yellow

 

Glycyrrhizic Acid Uses

Licorice mostly contains glycyrrhizic acid and flavonoid glycyrrhizin (glycyrrhizin). Glycyrrhiza glabra extract is an additive with different functions such as anti-bacterial, anti-inflammatory, detoxing, deodorization, and so on. The major uses:

( 1) It is a health-care sugar with high sweet taste as well as reduced calorie value, and its sweet taste has to do with 250 times that of sucrose; it can be included in food, drink, as well as sweet industry as a sugar, and also can likewise be made use of in yellow or brownish food, It also serves as an all-natural pigment in beverages.

( 2) Drug market: used for antitussive and also expectorant, gastric abscess, severe and also chronic gastritis, dermatitis, pruritus, liver disease, hyperlipidemia, conjunctivitis, as well as for the treatment of cancer cells and avoidance and treatment of AIDS.

( 3) Cosmetics and cigarette sector; can avoid dermatitis, completely dry skin, sun exposure, rash, throat, etc( 4) Licorice extract can turn on corticosteroids (prevent metabolic enzymes) and indirectly improve the result of corticosteroids. It can be made use of in all cosmetics such as ointment, lotion, water, lotion, milk as well as honey. It can reduce the effects of or soothe or minimize the harmful substances of cosmetics, as well as can additionally prevent allergic reactions of some cosmetics. It is preferable for advanced hair or skin cosmetics.

( 5) Glycyrrhiza flavonoids have the effect of gently preventing tyrosinase, and also licorice extract has been confirmed to be the most reliable plant bleaching glycyrrhizic acid.

The Technological Process of Extracting Glycyrrhizic Acid From Licorice

1. Pulverization: Take the roots and stems of licorice, pulverize them in a pulverizer, and pass through a 20-mesh sieve for use.


2. Extraction: take 200kg of the above-mentioned licorice coarse powder, put it into a 2000L enamel reaction kettle, add 1200kg of water, slowly heat to 85-100°C, stir and extract for 2h, filter, add 1000kg of water to the filter residue, and extract twice according to the above method , and combined the 3 filtrates.


3. Concentration: pump the extract into an enamel evaporator for concentration, and filter it while hot when it is concentrated to 1/5 of the original volume.


4. Separation: The filtrate is cooled to room temperature and 95% ethanol is added to make the ethanol content in the extract reach 65%, and it is allowed to stand for 24 hours, and then filtered to remove vegetable protein and polysaccharide.


5. Precipitation: Take licorice filtrate, put it into a sedimentation tank, add concentrated sulfuric acid to adjust pH=3, and glycyrrhizic acid will precipitate out, filter, wash twice with deionized water, and then vacuum dry.


6. Refining: add 3 times the amount of acetone to the glycyrrhizic acid precipitation, heat and reflux for extraction for 3 hours, filter and reflux the residue for 2 times, combine the 3 reflux extracts, filter, and recover acetone to obtain a wet product of glycyrrhizic acid.


7. Drying: Put the dry oxalic acid wet product into the drying room to dry, control the temperature at 45 °C, dry for 1 hour, slowly heat up to 85-95 °C, when it is nearly drying, heat up to 100 °C, and finally bake at 105 °C for 5 minutes .


8. Pulverization: put the dried glycyrrhizic acid in a pulverizer and pulverize, and pass through a 60-80 mesh sieve to obtain glycyrrhizic acid powder.

Clinical Application of Glycyrrhizic Acid Preparation in The Treatment of Liver Disease

The treatment of chronic hepatitis B (CHB) and chronic hepatitis C (CHC) in viral hepatitis should focus on the antiviral treatment for the cause, but for patients whose cause has not been completely controlled or is temporarily unsuitable for antiviral treatment In the case of liver inflammation, anti-inflammatory and hepatoprotective drugs are appropriately selected.

Recommendation 1: Glycyrrhizic acid preparations can be used for patients with viral hepatitis with abnormal liver function, and can also be used in combination with antiviral drugs for CHB and CHC patients with abnormal liver function (A1). Those with severe inflammation can be switched to oral dosage form for sequential treatment for 4-12 weeks after treatment with injection dosage form (C1).

n recent years, with the increase of drug types and the continuous emergence of new drugs, the incidence of drug-induced liver injury (DILI) has increased significantly. In developed countries such as the United States and Western Europe, acetaminophen is the main cause of acute liver failure. A retrospective Meta-analysis of the causes of DILI in my country from 1999 to 2012 showed that the main causes of DILI in my country after 2006 evolved into Chinese herbal medicine (30.38%), anti-tuberculosis drugs (20.57%), antibacterial drugs (11.49%) and anti-tumor drugs (10.26%). Timely discontinuation of suspicious drugs is the most important treatment for DILI, and hepatoprotective drugs can be appropriately selected for patients with severe inflammation.

Recommendation 2: For patients with drug-induced liver injury, it is recommended to use glycyrrhizic acid preparations for liver protection and anti-inflammatory treatment on the basis of timely discontinuation of drugs that cause liver injury (A1).

The pathogenesis of alcoholic liver disease (ALD) is related to free radical damage, lipid metabolism disorder and oxidative stress. The main treatment is etiological treatment (alcohol abstinence). On this basis, the application of glycyrrhizic acid can improve the liver Biochemical Indicators.

Recommendation 3: For patients with alcoholic liver disease, the etiological treatment (abstinence) should be emphasized. On this basis, there are still repeated abnormal liver function, liver tissue examination confirmed obvious inflammation and fibrosis, or the disease has progressed significantly, glycyrrhizic acid can be used. Preparation for anti-inflammatory liver protection therapy (B2).

Although Chinese guidelines currently do not recommend the routine use of hepatoprotective drugs for NAFLD/NASH patients, it points out that under the premise of basic treatment, hepatoprotective drugs such as glycyrrhizic acid can be used as adjuvant therapy for: ① NASH patients diagnosed by liver histology; ② Clinical and experimental Laboratory examinations suggest that there may be obvious liver damage and/or progressive liver fibrosis; ③ Those who intend to use other drugs that may or have caused liver damage will affect the implementation of the basic treatment plan; ④ Combined with hepatotropic virus infection or other liver disease. The course of treatment usually takes more than 6-12 months.

Recommendation 4: For patients with non-alcoholic fatty liver disease, basic treatments such as lifestyle changes, weight control, improvement of insulin resistance, and correction of metabolic disorders should be emphasized, but ALT, AST, and GGT are still elevated, and liver tissue examination confirms that the course of the disease is chronic. For those who progress, glycyrrhizic acid preparations can be used for anti-inflammatory and hepatoprotective treatment (B2).

Glycyrrhizic acid preparation has a certain value in the treatment of autoimmune hepatitis (AIH) in addition to its general hepatoprotective effect in the treatment of autoimmune liver disease. AIH is an inflammatory lesion of the liver characterized by hyperglobulinemia, multiple autoantibodies, and pathologically with debris-like necrosis in the portal area. At present, the relevant guidelines recommend that the standard treatment regimen for AIH is glucocorticoid ± immunosuppressive agents, but clinically, a considerable number of AIH patients are not suitable for the use of glucocorticoids and Immunosuppressants. Glycyrrhizic acid preparations have certain value in the treatment of such AIH patients due to their anti-inflammatory, regulation of excessive immunity in the liver and steroid-like effects.

Recommendation 5: Glycyrrhizic acid preparations can be used for the adjuvant treatment of AIH patients, especially for patients with contraindications to hormones ± immunosuppressants, the application of glycyrrhizic acid preparations as much as possible can be considered to improve the biochemical indicators of patients (B2).

Glycyrrhizic acid preparations can alleviate liver fibrosis by improving liver inflammation through its anti-inflammatory effect. A number of in vitro experiments and animal model studies have shown that glycyrrhizic acid preparations can act on signaling pathways such as TGF-β1/Smad to inhibit liver fibrosis.

Recommendation 6: Patients with liver cirrhosis and liver cancer with abnormal liver function can be treated with glycyrrhizic acid preparations for liver protection and anti-inflammatory treatment (B2). During the treatment, attention should be paid to the monitoring of adverse reactions such as electrolyte disturbance (C2).

Liver failure is a serious liver damage caused by a variety of factors, resulting in severe impairment or decompensation of liver synthesis, detoxification, excretion, and biotransformation, mainly including coagulation dysfunction, jaundice, hepatic encephalopathy, and ascites. A group of clinical syndromes manifested, divided into four types: acute, subacute, acute-on-chronic and chronic liver failure. At present, there is still a lack of specific drugs and means for medical treatment. Corresponding etiological treatment and comprehensive treatment measures are mainly adopted for different etiologies. Basic research has confirmed that compound glycyrrhizin can reduce hepatocyte apoptosis, restore degenerated hepatocytes, and protect uninjured hepatocytes in mice with fulminant liver failure, thereby reducing the mortality rate.

Recommendation 7: Glycyrrhizic acid preparations have anti-inflammatory and improve liver function. It is recommended that patients with liver failure should use glycyrrhizic acid preparations on the basis of etiological treatment and comprehensive supportive treatment (B1).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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