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Glycyrrhiza Fluid Extract CAS 68916-91-6

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Glycyrrhiza Fluid Extract Supplier

Product Name: Glycyrrhiza Fluid Extract
CAS No: 68916-91-6
Purity: 99%

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Basic Info

Product Name:Glycyrrhiza Fluid Extract
Other Names:Licorice Extract
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Brown Viscous Liquid
EINECS No.:272-837-1
Provide:Glycyrrhiza Fluid Extract MSDS;
Glycyrrhiza Fluid Extract COA

What is Glycyrrhiza Fluid Extract ?

Licorice is the dried root and root of licorice leguminous plant licorice, bulging licorice, or glabra. Modern pharmacological study has actually additionally verified that licorice has a wide variety of medicinal impacts, such as detoxification, antitussive, antispasmodic, analgesic, anti-inflammatory, anti-ulcer, anti-allergic, anti-tumor, reducing transaminase, protecting against liver cirrhosis, and also boosting resistance. Recently, licorice as a raw material of health food has actually been commonly utilized in formulas of organic food such as getting rid of the throat, enhancing resistance, and also securing liver function. These natural food might be taken in by people of every ages for a long time. The primary part of licorice is glycyrrhizic acid., Liquiritin, and so on. The chemical structure of licorice is extremely complicated. Until now, the substances separated from licorice include glycyrrhizin, glycyrrhetinic acid, glycyrrhizin, isoliquiritin, neoliquiritin, neoisoliquiritin, glycyrrhizin, isoliquiritigenin as well as licorice west Ding, glycyrrhizol, isoglycyrrhizol, 7-methylcoumarin, umbelliferolide as well as loads of compounds. Glycyrrhiza Liquid Essence, which is made from licorice, is used for anti-inflammation, detoxification, coughing alleviation and soothing intestinal smooth muscle spasm as well as deoxycorticosterone-like effects. Recently, it has actually additionally been used as industrial raw materials. And in the food as well as drink market as a flavor agent and sugar. The main energetic ingredients of licorice are triterpene saponins, commonly called glycyrrhizic acid. Generally, the process of extracting Glycyrrhiza Fluid Remove from licorice is as complies with: first crush or cut the raw material, essence with water under pressure or normal stress, and then warmth and evaporate to concentrate the remove into an extract. Since licorice has a tough texture and thick and also lengthy fibers, even if it is cut into flakes, it is still extremely difficult to draw out with water, and also the energetic components can not be completely removed. And if the approach of squashing is used, the dust is huge throughout work, the working environment is bad, the waste of basic materials is a lot, and the wood powder is extremely simple to obstruct the pipe throughout the removal procedure.

What is Glycyrrhiza Fluid Extract Used For?

Applications in the pharmaceutical market
1. Anti-acid: Glycyrrhiza Fluid Remove has a comparable result to adrenal cortex hormonal agent. It can hinder the hypersecretion of gastric acid triggered by histamine; it likewise has the impact of antacid and eliminating spasm of stomach smooth muscle.

2. Antitussive: licorice powder flavonoids, licorice powder essence and also glycyrrhiza liquid remove all have apparent antitussive result; expectorant effect is additionally a lot more substantial, and also the activity strength is licorice powder acid > licorice powder flavonoids > Glycyrrhiza Liquid Essence.

3. Anti-inflammatory and anti-allergic: Glycyrrhiza Liquid Remove also has anti-inflammatory and also anti-allergic effects, which can safeguard the swollen throat and tracheal mucosa. Licorice powder essence as well as licorice powder acid have cleansing effects comparable to glucuronic acid on particular toxins.

5. Prevention and also therapy of growths: The hypoacid consisted of in Glycyrrhiza Fluid Remove can obstruct the impact of carcinogens on generating lump growth.

Application in the healthcare market
Rejuvenate the spleen and also kidney: Glycyrrhiza Fluid Extract can likewise enhance the spleen and also kidney. Licorice powder can not only be used on the surface on the skin, yet also taken internally. For our inner body organs, licorice powder can control the health of our body organs, especially our kidneys When it comes to the tummy and also intestinal tracts, licorice powder can develop a safety film, eliminate physical pain, and also aid preserve the health of the organs and the equilibrium of the body.

Application in aesthetic market
Bleaching as well as freckle removal: Glycyrrhiza Liquid Essence can additionally lighten and also remove blemishes. For females that love elegance, licorice powder can lighten as well as eliminate freckles, which is very effective for smooth, tender and shiny skin. Consequently, many women pals like to consume some licorice powder. It has couple of negative effects as well as does not cause pain. It is a relatively all-natural elegance representative and is really suitable for females to eat.


Pharmacological Effects of Glycyrrhiza Fluid Extract

1) Protective effect of Glycyrrhiza Fluid Extract (Ⅰ) on paracetamol (Ⅱ) hepatotoxicity in mice. The effect of I on the lethality of mice poisoned by II, the effect on the decrease of liver glycogen in mice caused by I, and the liver damage in mice caused by II were observed. The results proved that pre-administering ig to mice by I could reduce the death rate of mice poisoned by II, and had a significant protective effect on the liver damage caused by II.

2) Experimental studies on the effects of glycyrrhizin on the levels of PGE2 and cAMP in the peritoneal cavity of rats and the regulation of certain immune functions showed that (Ⅰ) significantly inhibited the level of cAMP in rat peritoneal cells caused by zymosan and PGE2 (Ⅱ) rise. The Ⅰ compound reduces the release of Ⅱ from macrophages stimulated by zymosan, and has no obvious effect on the movement of mouse macrophages, but can weaken the movement of macrophages induced by phytohemagglutinin. Attenuates the inhibitory effect of macrophage migration inhibitory factor (MIF) induced by phytohemagglutinin on macrophage migration. Using 51Cr to label opsonized sheep erythrocytes, it was proved that low concentration I could stimulate macrophage phagocytosis. This product has no significant effect on the proliferation of spleen cells in mice.

Preparation of Glycyrrhiza Fluid Extract

Method 1: Glycyrrhiza Fluid Extract is prepared as follows:

1) Select Ural licorice from Inner Mongolia, its raw material is red in color, powdery, and of good quality;

2) After cutting the licorice into 0.3-0.6cm pieces, fry the licorice in a pan on the induction cooker, adjust the power of the induction cooker to 800w, stir-fry slowly on a low heat, and fry evenly until the red color of the licorice skin fades and the licorice is slightly yellow;

3) According to the weight ratio of fried licorice and water 1:5, add water to the fried licorice in step 1) and soak for 2 hours, then condense and reflux to extract two water extracts, each extraction for 2 hours, and concentrate the two water extracts to form The first concentrate, the density of the first concentrate relative to water is 1.0693±0.0080

4) Add 95% ethanol to the fried licorice in step 1) according to the weight ratio of 1:7 of fried licorice and 95% ethanol, then condense and reflux to extract the alcohol extract twice, each time for 2 hours, and mix the two alcohol extracts ;

5) Mix the first concentrated solution in step 3) with the two alcohol extractions in step 4), stir evenly and then alcohol precipitate for 24 hours, and the alcohol precipitation solution is filtered with a 0.8 μm filter membrane and enters the secondary concentration process to obtain The second concentrate, the density of the second concentrate relative to water is 1.290±0.0080;

6) Add propylene glycol for preservation to the second concentrated solution to prepare fried Glycyrrhiza Fluid Extract. The weight ratio of the second concentrated solution to propylene glycol is 1:0.04.

Method 2: A method for preparing Glycyrrhiza Fluid Extract from glycyrrhizic acid production waste, comprising the following steps:

I. Leaching: use licorice waste residue (1) [note: the licorice waste residue (1) of the present invention is glycyrrhizic acid preparation process, after licorice slices are leached with water at high temperature, filter the obtained filter residue] at 40-100 ° C. leaching with alcohol ammonia solution for 1 to 10 hours; and filtering the obtained leaching solution, and the filtrate is set aside;

II. Treatment of waste liquid (3) after acid precipitation of glycyrrhizic acid: waste liquid (3) after acid precipitation of glycyrrhizic acid After the solution is concentrated, add acid to precipitate glycyrrhizic acid, then filter the obtained filtrate] and add alkali to adjust the pH value of the solution to weak acid or neutral, and filter out the insoluble matter for later use;

III. Concentration: fully mix the liquid obtained in the above steps I and II, and concentrate at 40-100°C to a thick paste to obtain Glycyrrhiza Fluid Extract; it also includes plant protein, polysaccharide, amino acid, etc. (2) [Note: This The plant protein, polysaccharide, amino acid, etc. described in the invention (2) are in the preparation process of glycyrrhizic acid, after the licorice extract solution is concentrated, then the plant protein, polysaccharide, amino acid, etc. that are separated out through alcohol precipitation] heating water is dissolved, centrifuged Separate, take the supernatant and add it to step III, mix it with the liquid obtained in steps I and II, and then concentrate to a paste. The alcohol ammonia solution is an aqueous solution containing 5-50% ethanol and 5-10% ammonia.

Identification of Glycyrrhiza Fluid Extract

(1) Take regarding 1-2 mg of the great powder of this product, put it on a white porcelain plate, add a couple of declines of sulfuric acid option (4 → 5), it will appear yellow, and gradually change to orange-yellow to orange-red. (2) Take 1g of this product, add 10ml of water and also stir to liquify, divide into two equal parts. Take one component and also put it in an examination tube, shake vigorously to produce relentless foam; include thin down sulfuric acid to the other component to develop a large quantity of precipitate, then add excess ammonia examination option to redissolve the precipitate. (3) Take 1g of this product, add 40ml of water to liquify, shake and also extract 3 times with n-butanol, 20ml each time (centrifuge if required), combine n-butanol solution, wash with water 3 times, each time 20ml, n-butanol solution Placed it on a water bathroom as well as evaporate to dry skin, include 5ml of methanol to the residue to liquify it, as well as utilize it as the examination remedy. Take an additional glycoside ammonium oxalate recommendation material, include methanol to make an option containing 2mg per 1ml, and utilize it as the reference substance service. According to the thin-layer chromatography (Appendix VIB) examination, draw 5μl of each of the above 2 services, as well as direct them on the same 1% On the silica gel G thin-layer plate prepared by sodium hydroxide remedy, usage ethyl acetate-formic acid-glacial acetic acid-water (15:1:1:2) as the designer, create, take out, dry in the air, and spray with 10% sulfuric acid ethanol The service was heated up at 105 ° C up until the places were plainly colored, as well as checked under an ultraviolet light (365nm). In the chromatogram of the examination product, at the placement corresponding to the chromatogram of the recommendation product, the exact same orange-yellow fluorescent places appear.

About That Product:
If you need Glycyrrhiza Fluid Extract, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Glycyrrhiza Fluid Extract manufacturer and supplier, ZSpharmac will provide Glycyrrhiza Fluid Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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