The major active ingredient of licorice is glycyrrhizic acid (Glycyrrhizic Acid), as well as the molecular structure of glycyrrhizic acid includes 1 molecule of glycyrrhetinic acid (Glycyrrhetinic Acid) as well as 2 molecules of glucuronic acid. In the last few years, pharmacological as well as professional researches have actually located that glycyrrhizic acid has the features of securing the liver, anti-inflammation, decreasing blood pressure, enhancing the body’s immunity, and enhancing physiological functions. Glycyrrhetinic acid has anti-inflammatory, anti-oxidation, anti-tumor, anti-bacterial, anti-viral and various other effects. Glycyrrhizinic acid as well as glycyrrhetinic acid have numerous resemblances in medicinal activity. In terms of anti-inflammation, glycyrrhetinic acid and also its by-products can straight inhibit the production of inflammatory cytokines and also inflammatory mediators via multiple targets, and also can also prevent the manufacturing of inflammatory mediators through multiple targets. Devices such as enhancing the activity of steroid hormones apply its anti-inflammatory feature indirectly.
Studies at home as well as abroad have actually revealed that the metabolic process of glycyrrhizic acid medicines in the body has actually been relatively clear. These medicines are hydrolyzed by gastric acid or metabolized right into 3-mono-glucosidase in liver cells by β-D-glucuronidase in lysosomes. Glycyrrhetinic acid, the latter can be additional metabolized in the liver, released right into the intestines with bile, metabolized right into glycyrrhetinic acid by intestinal tract bacteria, and then soaked up into the blood, so glycyrrhetinic acid drugs are basically glycyrrhetinic acid after getting in the body exert medicinal results.
Core pointer: It has a specific level of attention in the medical circles in the house as well as abroad, as well as it belongs to the medicine of adrenocortical hormonal agent and adrenocorticotropic hormone. Via experiments on computer mice, it is found that this drug has numerous results, such as anti-ulcer effect on pyloric ligation, can promote sodium and water retention, as well as boost potassium excretion. It has a deoxycorticosterone-like impact on healthy individuals and various animals. wait
With the adjustment of the moments as well as the progress of society, the rate of people’s life is obtaining quicker and much faster, the pressure of life is getting bigger and also larger, the living routines are getting worse, air contamination, extreme artificial additive, etc have led to the damage of lots of people’s figure. If you like to get ill or perhaps cancer cells, let me present a medicine that can hinder growth cells.
Glycyrrhetinic acid is a medicine for adrenocorticotropic hormonal agent as well as adrenocorticotropic hormonal agent, as well as has attracted attention in the medical circles in the house as well as abroad. Because glycyrrhetinic acid is the primary energetic metabolite of glycyrrhizin, it has a specific repressive impact on tumor cells originated from liver cancer cells, lung cancer cells and also various other tumors, and also its toxicity to regular somatic cells is relatively tiny.
Glycyrrhetinic acid can advertise salt, water retention, rise potassium excretion, and also has deoxycorticosterone-like impacts on healthy and balanced people as well as numerous animals. For patients with reciprocal adrenalectomy, everyday shots of hydrocortisone as well as glycyrrhetinic acid can have a collaborating impact and also maintain electrolyte balance. However you can not simply infuse glycyrrhetinic acid, or else there will be a loss of sodium storage space ability, which will certainly cause the threat of Addison’s.
Glycyrrhetinic acid can create sodium retention, antidiuretic and anti-inflammatory effects on animals with adrenal cortex and also pituitary gland got rid of. Via experiments on computer mice, it was discovered that glycyrrhetinic acid had an inhibitory impact on cotton round granuloma, formaldehyde foot swelling as well as subcutaneous granulomatous inflammation. And it can prevent the speculative joint inflammation brought on by carrageenan, and also inhibit the allergy of mice caused by steed lotion as well as egg white. By inhibiting capillary leaks in the structure, antihistamine or lowering the responsiveness of cells to stimulations may be the relationship between glycyrrhetinic acid’s anti-inflammatory as well as anti-allergic results. Glycyrrhetinic acid has inhibitory impacts on different acute swellings. Glycyrrhetinic acid plays an anti-inflammatory duty by preventing the generation of PgE2 in inflammatory cells, antagonizing inflammatory moderators such as histamine and serotonin, as opposed to relying on the pituitary-adrenal system.
Glycyrrhetinic acid can play a great anti-ulcer result on pylorus-ligated mice. It can decrease blood bilirubin in computer mice and raise urinary system bilirubin discharging, and also the healing index is still relatively high.
Via experiments, it is located that glycyrrhetinic acid can prevent the transplant of Oberling-gnerin myeloma in computer mice, and its sodium salt has a slight repressive result on the development of Ehrlich ascites carcinoma and also sarcoma-45 cells in mice at the maximum tolerated dosage.
Glycyrrhetinic acid as well as its salts have obvious antidiuretic impact. It can improve the reabsorption of sodium and also chloride by kidney tubules to achieve antidiuretic result, which may be a straight effect on renal tubules.
Glycyrrhetinic acid at a focus of 4 × 10-2mg/ ml has a considerable inhibitory result on acetylcholinesterase, and also the higher the medication focus in this dosage, the better the impact. Glycyrrhetinic acid has a non-competitive combined inhibitory impact on acetylcholinesterase.
Glycyrrhetinic acid has a scavenging result on the release of oxygen cost-free radicals from human polymorphonuclear leukocytes, as well as the impact is amazing. It has the feature of directly catching oxygen totally free radicals.
In the busy life, I hope that everybody can attempt their finest to preserve a good life schedule, try not to consume processed food, minimize bad habits, as well as proactively workout to enhance immunity as well as keep away from illness. It is wished that more medicines like glycyrrhetinic acid, or perhaps much better medicines than glycyrrhetinic acid, can be established immediately, to make sure that the majority of people can eliminate illness immediately.
