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Glycyrrhetinic Acid CAS 471-53-4

Molecular Formula: C30H46O4

Formula Weight: 470.69

ZSpharmac: Glycyrrhetinic Acid Raw Material Supplier

Product Name: Glycyrrhetinic Acid
CAS No: 471-53-4
Purity: 99%

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Basic Info

Product Name:Glycyrrhetinic Acid
Other Names:18β-Glycyrrhetinic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Powder
EINECS No.:207-444-6
Provide:Glycyrrhetinic Acid MSDS;
Glycyrrhetinic Acid COA

What is Glycyrrhetinic Acid?

The molecular framework of glycyrrhizic acid consists of 1 particle of glycyrrhetinic acid and also 2 molecules of glucuronic acid. Recently, pharmacological and also professional studies have actually found that glycyrrhizic acid has hepatoprotective, anti-inflammatory, antihypertensive, improved body immunity, as well as improved physical features. Glycyrrhetinic acid has various results such as anti-inflammatory, antioxidant, anti-tumor, antibacterial, and antiviral. Glycyrrhetinic acid and glycyrrhetinic acid have many similarities in medicinal activities. In regards to anti-inflammation, glycyrrhetinic acid and its by-products can straight hinder the production of inflammatory cytokines and inflammatory mediators via several targets, as well as can also Systems such as improving the task of steroid hormonal agents indirectly exert their anti-inflammatory features.

Glycyrrhetinic Acid Property

Melting point 292-295 °C(lit.)
alpha 165 º (c=1, CHCl3,on dry ba)
Boiling point 492.11°C (rough estimate)
density 0.9967 (rough estimate)
vapor pressure 10-220Pa at 20-50℃
refractive index 162 ° (C=1, MeOH)
storage temp. 2-8°C
solubility Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.
pkapKa 5.56±0.1 (Uncertain)
form Crystalline Powder
color White to off-white
optical activity[α]22/D +170.0°, c = 1 in chloroform


Glycyrrhetinic Acid Uses

  1. Glycyrrhetinic acid is utilized as sugar; sweetness improver; flavoring agent (especially effective when utilized in combination with salt); flavor enhancer (used to remove smell as well as boost taste of milk items, cocoa products, egg products, mutton, and so on). Chinese individual usually use it in sauces, sauce products, pickled items, and so on.
  2. Glycyrrhetinic acid is used in prescription antibiotics to deal with infections brought on by Staphylococcus, Streptococcus, Escherichia coli, Helicobacter, etc.
  3. Glycyrrhetinic acid is a crucial raw material for medicine and also premium cosmetics. It has anti-inflammatory and also anti-allergic impacts, preventing bacterial recreation, etc.
  4. Glycyrrhetinic acid is an anti-inflammatory medicine. Made use of to deal with adrenal lack, stomach and also duodenal abscess as well as other conditions.

What Does Glycyrrhetinic Acid do?

Glycyrrhetinic acid is a medicine for adrenocortical hormone as well as adrenocorticotropic hormone, and also has brought in much focus in the medical community in your home as well as abroad. Since glycyrrhetinic acid is the major active metabolite of glycyrrhizin, it has a specific inhibitory impact on lump cells originated from various lumps such as liver cancer and lung cancer cells, as well as has reasonably little poisoning to regular somatic cells.

Glycyrrhetinic acid can advertise salt and water retention and increase potassium excretion, which has a deoxycorticosterone-like effect on healthy and balanced people as well as various pets. For individuals that have actually had both adrenal glands eliminated, everyday injections of hydrocortisone and glycyrrhetinic acid can have a collaborating effect in keeping electrolyte equilibrium. But you can not just infuse glycyrrhetinic acid, otherwise you will shed your salt storage ability as well as threat Addison’s condition.

Glycyrrhetinic acid can produce salt retention, anti-diuretic as well as anti-inflammatory effects on pets that have actually had their adrenal cortex and also pituitary gland eliminated. Via experiments on computer mice, it was found that glycyrrhetinic acid has an inhibitory result on cotton ball granuloma, formaldehyde foot swelling and subcutaneous granulomatous inflammation. It likewise has an inhibitory impact on experimental joint inflammation caused by carrageenan, and also has an inhibitory effect on allergies in mice triggered by horse lotion as well as egg albumen. By hindering capillary permeability, antihistamine or lowering cell responsiveness to stimuli, glycyrrhetinic acid might be accountable for its anti-inflammatory and also anti-allergic impacts. Glycyrrhetinic acid has a repressive effect on a selection of intense swellings. Glycyrrhetinic acid plays an anti-inflammatory result by hindering the production of PgE2 in inflammatory tissues as well as annoying the inflammatory moderators histamine and also serotonin, rather than relying upon the pituitary-adrenocortical system.

Glycyrrhetinic acid has a great anti-ulcer impact on pyloric ligated mice. It can minimize blood bilirubin in computer mice and also boost urinary system bilirubin discharging, so the healing index is still reasonably high.

With experiments, it was found that glycyrrhetinic acid has a repressive effect on hair transplanted Oberling-gnerin myeloma in computer mice, and also its sodium salt has a mild repressive effect on the development of Ehrlich ascites cancer as well as sarcoma-45 cells in mice at the optimum tolerated dosage.

Glycyrrhetinic acid as well as its salts have considerable antidiuretic results. It can boost the reabsorption of sodium and chloride by the renal tubules to accomplish antidiuretic impact, which might be a straight result on the kidney tubules.

Glycyrrhetinic acid at a focus of 4 × 10-2mg/ ml has a substantial inhibitory impact on acetylcholinesterase. The higher the medicine concentration within this dose, the far better the result. Glycyrrhetinic acid has a non-competitive blended inhibitory impact on acetylcholinesterase.

Glycyrrhetinic acid has a considerable result on scavenging oxygen free radicals released by human polymorphonuclear leukocytes. It has the function of directly catching oxygen complimentary radicals.

Glycyrrhetinic Acid Production Method

It is acquired by hydrolyzing glycyrrhizic acid drawn out from the root of the leguminous plant Glycyrrhizauralen-sisfisch as well as making ammonium salt. Licorice is a yearly natural herb in China, mainly produced in Inner Mongolia and also Gansu. The roots and roots of licorice mostly have glycyrrhizin, which is the potassium and also calcium salt of glycyrrhizic acid (Glycyrrhiz-icacid) as well as is the wonderful component of licorice. It has to do with 50 times sweeter than sucrose. Add water to the crushed licorice, warm it, continuously extract it under countercurrent, separate and also eliminate contaminations from the grass deposit, and also obtain a liquid option. Vaporize, concentrate, and include sulfuric acid to pH 2-3 with mixing. Entrust to settle and get rid of the supernatant. The precipitate is cleaned with water to eliminate the sulfate radicals, heated and focused, as well as steamed to make glycyrrhizic acid paste. Squash the glycyrrhizic acid paste and also remove it 2-3 times with 95% ethanol for 3 hours each time to acquire an ethanol solution. After filtration, stir and also pass ammonia until the pH is 7-7.5. Filter once again to acquire the unrefined triammonium glycyrrhizinate salt, which is refined with glacial acetic acid to acquire beige monoammonium glycyrrhizinate salt. Add glycyrrhizic acid monoammonium salt to 5% sulfuric acid liquid remedy, stir and also warmth to almost boiling, reflux and also hydrolyze for 15 hrs, filter as well as clean with water to get crude glycyrrhetinic acid. After recrystallization and also decolorization, base oxalic acid with a web content of more than 92% is gotten. Based on licorice, the total return has to do with 0.5%.

Contact Us

About Products:
If you need Glycyrrhetinic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Glycyrrhetinic Acid manufacturer and supplier, our company, ZSpharmac will provide Glycyrrhetinic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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