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Zhishang Chemical

Glycyrrhetic Acid CAS 471-53-4

Molecular Formula: C30H46O4

Formula Weight: 470.69

ZSpharmac: Glycyrrhetic Acid Supplier

Product Name: Glycyrrhetic Acid
CAS No: 471-53-4
Purity: 99%

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Basic Info

Product Name:Glycyrrhetic Acid
Other Names:18β-Glycyrrhetinic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Powder
EINECS No.:207-444-6
Provide:Glycyrrhetic Acid MSDS;
Glycyrrhetic Acid COA

What is Glycyrrhetic Acid?

Glycyrrhetinic acid (or glycyrhetic acid, also called Enoxolone) is a pentacyclic triterpene material, which is called after the hydrolysis of glycyrrhizic acid in the herb Glycyrrhiza glabra. Glycyrrhetinic acid can be considered as a derivative of β-amyresinol (oleanane type), therefore functioning as the aglycone of glycyrrhizic acid. Glycyrrhetinic acid is often utilized as a scent as well as to mask the bitter taste of medicines such as aloe vera and also quinine.

Glycyrrhetic Acid Property

Melting point 292-295 °C(lit.)
alpha 165 º (c=1, CHCl3,on dry ba)
Boiling point 492.11°C (rough estimate)
density 0.9967 (rough estimate)
vapor pressure 10-220Pa at 20-50℃
refractive index 162 ° (C=1, MeOH)
storage temp. 2-8°C
solubility Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.
pkapKa 5.56±0.1 (Uncertain)
form Crystalline Powder
color White to off-white
optical activity[α]22/D +170.0°, c = 1 in chloroform


Glycyrrhetic Acid Uses

  1. Glycyrrhetinic acid is utilized as sweetener; wonderful taste improver; seasoning representative (used in combination with salt, the effect is specifically huge); flavor enhancer (for dairy products, chocolate items, egg products, mutton, and so on to get rid of mutton as well as boost taste). Our people are used to sauces and also sauce items, marinaded items, and so on.
  2. Glycyrrhetinic acid is made use of in anti-biotics for the therapy of Staphylococcus, Streptococcus, Escherichia coli, Helicobacter and various other infections.
  3. Glycyrrhetinic acid is a vital resources for medicine as well as top-quality cosmetics, which has the functions of anti-inflammatory, anti-allergic, as well as restraint of microbial recreation.
  4. Glycyrrhetinic acid is an anti-inflammatory medicine. For the therapy of adrenal deficiency, gastric and duodenal abscess and other illness.

What Does Glycyrrhetinic Acid Do

The major active ingredient of licorice is glycyrrhizic acid (Glycyrrhizic Acid), as well as the molecular structure of glycyrrhizic acid includes 1 molecule of glycyrrhetinic acid (Glycyrrhetinic Acid) as well as 2 molecules of glucuronic acid. In the last few years, pharmacological as well as professional researches have actually located that glycyrrhizic acid has the features of securing the liver, anti-inflammation, decreasing blood pressure, enhancing the body’s immunity, and enhancing physiological functions. Glycyrrhetinic acid has anti-inflammatory, anti-oxidation, anti-tumor, anti-bacterial, anti-viral and various other effects. Glycyrrhizinic acid as well as glycyrrhetinic acid have numerous resemblances in medicinal activity. In terms of anti-inflammation, glycyrrhetinic acid and also its by-products can straight inhibit the production of inflammatory cytokines and also inflammatory mediators via multiple targets, and also can also prevent the manufacturing of inflammatory mediators through multiple targets. Devices such as enhancing the activity of steroid hormones apply its anti-inflammatory feature indirectly.

Studies at home as well as abroad have actually revealed that the metabolic process of glycyrrhizic acid medicines in the body has actually been relatively clear. These medicines are hydrolyzed by gastric acid or metabolized right into 3-mono-glucosidase in liver cells by β-D-glucuronidase in lysosomes. Glycyrrhetinic acid, the latter can be additional metabolized in the liver, released right into the intestines with bile, metabolized right into glycyrrhetinic acid by intestinal tract bacteria, and then soaked up into the blood, so glycyrrhetinic acid drugs are basically glycyrrhetinic acid after getting in the body exert medicinal results.

Core pointer: It has a specific level of attention in the medical circles in the house as well as abroad, as well as it belongs to the medicine of adrenocortical hormonal agent and adrenocorticotropic hormone. Via experiments on computer mice, it is found that this drug has numerous results, such as anti-ulcer effect on pyloric ligation, can promote sodium and water retention, as well as boost potassium excretion. It has a deoxycorticosterone-like impact on healthy individuals and various animals. wait

With the adjustment of the moments as well as the progress of society, the rate of people’s life is obtaining quicker and much faster, the pressure of life is getting bigger and also larger, the living routines are getting worse, air contamination, extreme artificial additive, etc have led to the damage of lots of people’s figure. If you like to get ill or perhaps cancer cells, let me present a medicine that can hinder growth cells.

Glycyrrhetinic acid is a medicine for adrenocorticotropic hormonal agent as well as adrenocorticotropic hormonal agent, as well as has attracted attention in the medical circles in the house as well as abroad. Because glycyrrhetinic acid is the primary energetic metabolite of glycyrrhizin, it has a specific repressive impact on tumor cells originated from liver cancer cells, lung cancer cells and also various other tumors, and also its toxicity to regular somatic cells is relatively tiny.

Glycyrrhetinic acid can advertise salt, water retention, rise potassium excretion, and also has deoxycorticosterone-like impacts on healthy and balanced people as well as numerous animals. For patients with reciprocal adrenalectomy, everyday shots of hydrocortisone as well as glycyrrhetinic acid can have a collaborating impact and also maintain electrolyte balance. However you can not simply infuse glycyrrhetinic acid, or else there will be a loss of sodium storage space ability, which will certainly cause the threat of Addison’s.

Glycyrrhetinic acid can create sodium retention, antidiuretic and anti-inflammatory effects on animals with adrenal cortex and also pituitary gland got rid of. Via experiments on computer mice, it was discovered that glycyrrhetinic acid had an inhibitory impact on cotton round granuloma, formaldehyde foot swelling as well as subcutaneous granulomatous inflammation. And it can prevent the speculative joint inflammation brought on by carrageenan, and also inhibit the allergy of mice caused by steed lotion as well as egg white. By inhibiting capillary leaks in the structure, antihistamine or lowering the responsiveness of cells to stimulations may be the relationship between glycyrrhetinic acid’s anti-inflammatory as well as anti-allergic results. Glycyrrhetinic acid has inhibitory impacts on different acute swellings. Glycyrrhetinic acid plays an anti-inflammatory duty by preventing the generation of PgE2 in inflammatory cells, antagonizing inflammatory moderators such as histamine and serotonin, as opposed to relying on the pituitary-adrenal system.

Glycyrrhetinic acid can play a great anti-ulcer result on pylorus-ligated mice. It can decrease blood bilirubin in computer mice and raise urinary system bilirubin discharging, and also the healing index is still relatively high.

Via experiments, it is located that glycyrrhetinic acid can prevent the transplant of Oberling-gnerin myeloma in computer mice, and its sodium salt has a slight repressive result on the development of Ehrlich ascites carcinoma and also sarcoma-45 cells in mice at the maximum tolerated dosage.

Glycyrrhetinic acid as well as its salts have obvious antidiuretic impact. It can improve the reabsorption of sodium and also chloride by kidney tubules to achieve antidiuretic result, which may be a straight effect on renal tubules.

Glycyrrhetinic acid at a focus of 4 × 10-2mg/ ml has a considerable inhibitory result on acetylcholinesterase, and also the higher the medication focus in this dosage, the better the impact. Glycyrrhetinic acid has a non-competitive combined inhibitory impact on acetylcholinesterase.

Glycyrrhetinic acid has a scavenging result on the release of oxygen cost-free radicals from human polymorphonuclear leukocytes, as well as the impact is amazing. It has the feature of directly catching oxygen totally free radicals.

In the busy life, I hope that everybody can attempt their finest to preserve a good life schedule, try not to consume processed food, minimize bad habits, as well as proactively workout to enhance immunity as well as keep away from illness. It is wished that more medicines like glycyrrhetinic acid, or perhaps much better medicines than glycyrrhetinic acid, can be established immediately, to make sure that the majority of people can eliminate illness immediately.

Production Method of Glycyrrhetinic Acid

Glycyrrhizic acid extracted from the rhizome of leguminous plant Glycyrrhizauralen-sisfisch, made into ammonium salt and then hydrolyzed. Licorice is our annual herb, mainly produced in Inner Mongolia and Gansu. The roots and rhizomes of licorice mainly contain glycyrrhizin, which is the potassium and calcium salts of glycyrrhizic acid (Glycyrrhiz-icacid), which is the sweet component of licorice. The sweetness is about 50 times that of sucrose. Add water to the crushed licorice, heat it, extract it continuously in countercurrent, separate and remove the grass dregs and impurities, and obtain an aqueous solution. Evaporate, concentrate, add sulfuric acid pH2-3 under stirring. Let the pellet stand and remove the supernatant. The precipitate was washed with water to remove sulfate radicals, concentrated by heating, and boiled to make glycyrrhizic acid paste. Glycyrrhizic acid paste was crushed and extracted 2-3 times with 95% ethanol for 3 hours each time to obtain ethanol solution. After filtration, stir ammonia to pH 7-7.5. Then filter to obtain the crude product of triammonium glycyrrhizinate, which is refined with glacial acetic acid to obtain beige monoammonium glycyrrhizinate. Add monoammonium glycyrrhizinate into 5% sulfuric acid aqueous solution, stir and heat to near boiling, reflux and hydrolyze for 15 hours, filter and wash with water to obtain crude glycyrrhetinic acid. After recrystallization and decolorization, oxalenic acid with a content of more than 92% can be obtained. Based on licorice, the total yield is about 0.5%.

About Products:
If you need Glycyrrhetinic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Glycyrrhetinic Acid manufacturer and supplier, ZSpharmac will provide Glycyrrhetinic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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