Zhishang Chemical

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Zhishang Chemical

Glycin CAS 56-40-6

Molecular Formula: C2H5NO2

Formula Weight: 75.07

ZSpharmac: Glycin Supplier

Product Name: Glycin
CAS No: 56-40-6
Purity: 99%

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Basic Info

Product Name:Glycin
Other Names:Glycine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:200-272-2
Provide:Glycin MSDS;
Glycin COA

What is Glycin?

Glycin is amongst the 20 participants of the amino acid collection with the most basic framework. It is in addition called glycine. It is a non-essential amino acid for the body. It has both acidic along with fundamental useful teams in the molecule. It is a strong electrolyte in liquid remedy in addition to a solid polar The solubility in the solvent is rather substantial, and likewise it is typically insoluble in non-polar solvents, and has a high boiling point and additionally melting point. Via the adjustment of the degree of acidity as well as alkalinity of the liquid solution, glycine can reveal numerous molecular types. The side bond to glycine is a hydrogen atom. Due to the fact that its alpha carbon additionally has a hydrogen atom, Glycin is not optically isomeric. Since Glycin’s side bonds are so tiny, it can occupy areas that other amino acids can not, for example as an amino acid within the collagen helix. It is white crystal or light yellow crystalline powder at area temperature level. It has a distinctive pleasant preference, which can soothe the acid along with alkali preference, mask the bitter preference of saccharin included food in addition to improve the sweetness. If the body absorbs way too much glycine, it will certainly not just be not able to be taken in as well as likewise utilized by the human body, but additionally will definitely break the body’s absorption balance of amino acids along with impact the absorption of numerous other amino acids, causing nutritional discrepancy in addition to influencing wellness. Milk-containing drinks generated with Glycin as the major sources are probably to have damaging effect on the normal development and growth of teenagers in addition to kids. Density 1.1607. Melting point 232 ~ 236 ℃ (decay). Soluble in water, insoluble in ethanol as well as additionally ether. It can respond with hydrochloric acid to form hydrochloride. Exist in the muscle mass of totally dry low-level transport. It can be acquired by the activity of monochloroacetic acid and likewise ammonium hydroxide, or by hydrolysis as well as refining of jelly.

Glycin Property

Melting point 

240 °C (dec.) (lit.)

Boiling point 




vapor pressure 

0.0000171 Pa (25 °C)

refractive index 

1.4264 (estimate)



storage temp. 



H2O: 100 mg/mL




2.35(at 25℃)


<5 (200 mg/mL)(APHA)



PH Range



4(0.2 molar aqueous solution)

Water Solubility 

25 g/100 mL (25 ºC)



Glycin Uses

  1. Glycin is used in the pharmaceutical sector, biochemical tests and organic synthesis.
  2. Glycin is made use of as a buffer for the preparation of cells culture media, for copper, gold and silver testing, and also medicinally for the therapy of myasthenia gravis and progressive muscle mass degeneration, hyperacidity, persistent enteritis, hyperprolinemia in children and also other diseases.
  3. Glycin is utilized in the treatment of myasthenia gravis and dynamic muscle mass atrophy; in the therapy of hyperlipidemia, persistent enteritis (often utilized in mix with antacids); in mix with pain killers, it can decrease its irritation to the belly; in the therapy of youngsters with hyperprolineemia Signs; as a nitrogen resource for the generation of non-essential amino acids, it is added to the mixed amino acid shot.
  4. Glycin is primarily used as a nutritional additive for chicken feed.
  5. Glycin has a particular inhibitory influence on the recreation of Bacillus subtilis as well as likewise Escherichia coli. For that reason, it can be utilized as a chemical for surimi items, peanut butter, etc, with an enhancement amount of 1% to 2%.
  6. Glycin is utilized in the production of pesticides to synthesize glycine ethyl ester hydrochloride, the intermediate of pyrethroid chemicals. Chemical, spices as well as other markets.
  7. Glycine enhances visible indications of aging, boosts hydration, boosts collagen production, as well as advertises skin repair service and regeneration. Glycine is likewise utilized as a barrier. Glycine is thought to assist sustain healthy and balanced collagen production and excitement.

Preparation of Glycin

290.91 g of ammonium carbonate with a purity of 99.0% and also 750 g of deionized water were contributed to a 1000 ml pressure-resistant zirconium-lined activator with a feeding and also stirring gadget, as well as the temperature level was raised to 65 ° C. to acquire an aqueous ammonium carbonate solution. From the feed port of the activator, 142.5 g of a preheated 40wt% hydroxyacetonitrile liquid service (50 ° C, pH=3.0) was injected with a pressure pump, and also the molar ratio of hydroxyacetonitrile, ammonium carbonate and also water was 1:3:46.4, Throughout the procedure of adding the hydroxyacetonitrile aqueous remedy, the activator was warmed to 100 ° C. for response, as well as the stirring rate was 120 r/min, the speed of including the hydroxyacetonitrile liquid solution was 8.0 g/min, and the liquid level of the reaction product was 96%. After the addition of the aqueous hydroxyacetonitrile remedy, the reactor was sealed, and also the temperature was promptly elevated to 150 ° C. The stress in the reactor was 4.2 MPa, and also the response was proceeded by mixing as well as keeping for 3 hrs.

After the response was finished, the temperature level was decreased to about 100 ° C., and then the stress was launched to regular pressure. The acquired reaction feed liquid was poured into a beaker and cooled down to space temperature to acquire 1152 g of an aqueous solution including Glycin and ammonium bicarbonate. The response feed liquid was brown yellow. The web content of glycine in the reaction option by ion chromatography was 6.484 wt%, and also no glycine dipeptide, hydantoin, diketopiperazine, glycine tripeptide, glycinamide, iminodiacetic acid (iminodiacetonitrile), The yield of glycine was 99.6% (determined as hydroxyacetonitrile) from pollutants such as nitrilotriacetic acid (aminotriacetonitrile), hydantoin and hydantoin amide.

The response feed fluid obtained above is warmed to 100 ° C on an electrical furnace, and also the metal zirconium powder audit for about 305ppm of the total mass of the response feed fluid is included, and after that gets in the stripping tower to focus and get rid of ammonia and also carbon dioxide by stripping till say goodbye to. Free ammonia was spotted, and afterwards deionized water was contributed to obtain a glycine liquid service. The content of Glycin in the glycine aqueous service by ion chromatography was 15.5 wt%, as well as glycine dipeptide, hydantoin, diketopiperazine, glycine tripeptide, glycine were not detected. Contaminations such as aminoamide, iminodiacetic acid (iminodiacetonitrile), nitrilotriacetic acid (aminotriacetonitrile), hydantoic acid, hydantoic acid amide, etc. Those Glycin aqueous option goes through membrane layer decolorization therapy to obtain a pale yellow service after decolorization, and afterwards focused under minimized pressure in a vacuum concentration pot lined with zirconium material to a glycine content of 40% by weight, entering into an unrefined product condensation kettle lined with zirconium material Cool to room temperature to accomplish formation, obtain unrefined product condensation mommy liquor and also solid product by suction filtering, as well as dry the gotten strong item to get 57.58 grams of light yellow crystals (glycin crude product) whose primary material of Glycin is 97.5%. The condensation price was 75%.

The unrefined item formation mommy alcohol obtained by suction filtration is 124.75 grams in total, wherein the material of glycine is 15wt%, and the content of ammonium sulfate is 5.2 wt%. Phase-membrane electrodialysis has 3 chambers, particularly, the fluid chamber, the liquid chamber (light chamber) as well as the receiving chamber (concentration chamber). Throughout the desalination process, ammonium sulfate moves to the focus chamber. When the ammonium sulfate material in the feed chamber is minimized to less than 0.5 wt%, the Glycin is 15.72 wt%, and also the overall mass of the fluid in the feed chamber is 118.89 grams. After desalination by electrodialysis, the retention rate of glycine reaches 99.5%, the salt elimination rate reached 90.4%. The desalted Glycin option is reused to those minimized stress concentration action to get unrefined glycine.

The Glycin unrefined product obtained over was dissolved in water, then 1wt% of turned on carbon was included for decolorization treatment, as well as the activated carbon was divided by suction purification. The crystals are suction filteringed system and also dried to acquire a recrystallized glycine item, the main material of glycine is ≥ 99.9%, and also the item high quality gets to the nationwide requirement for food grade Glycin (GB25542-2010). The Glycin recrystallization mommy liquor acquired by suction filtration is recycled to the following set of glycine unrefined item recrystallization step. After the mom alcohol was reused, the complete return of Glycin was 99.5% (computed in hydroxyacetonitrile).

About Products:
If you need Glycine, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Glycine manufacturer and supplier, ZSpharmac will provide Glycine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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