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Glycin CAS 56-40-6

Molecular Formula: C2H5NO2

Formula Weight: 75.07

ZSpharmac: Glycin Supplier

Product Name: Glycin
CAS No: 56-40-6
Purity: 99%

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Basic Info

Product Name:Glycin
Other Names:Glycine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:200-272-2
Provide:Glycin MSDS;
Glycin COA

What is Glycin?

Glycine is one of the most basic one amongst the 20 participants of the amino acid collection. It is also called aminoacetic acid. It is an amino acid not needed for the body. It has high solubility in solvents, is essentially insoluble in non-polar solvents, and additionally has high steaming and also melting elements. Glycine can show numerous molecular kinds by changing the acidity as well as alkalinity of the aqueous treatment. Considered that its alpha carbon additionally has a hydrogen atom, glycine is not optically isomerizable. As a result of the truly little side bonds of glycine, it can live in spaces that other amino acids can not, as an instance as an amino acid within the collagen helix. It is white crystal or light yellow crystalline powder at area temperature level. It has a distinct fantastic taste, which can relieve the acid and also alkali choice, cover the bitter preference of saccharin included food along with improve the remarkable choice. If the human body takes in way too much glycine, not just will it not be absorbed and also made use of by the body, nonetheless it will likewise break the body’s absorption balance of amino acids as well as likewise influence the absorption of various other amino acids, creating nutritional imbalance as well as affecting health. Milk-containing drinks created with glycine as the primary resources are likely to have negative impacts on the typical development as well as growth of teenagers in addition to kids. Density 1.1607. Melting point 232 ~ 236 ° C (disintegration). Soluble in water, insoluble in ethanol as well as additionally ether. It can react with hydrochloric acid to form hydrochloride. It exists in the ligaments of completely dry low-grade freight. It can be developed by the task of monochloroacetic acid as well as ammonium hydroxide, in addition to can furthermore be managed hydrolyzing along with refining jelly.

Glycin Property

Melting point 

240 °C (dec.) (lit.)

Boiling point 




vapor pressure 

0.0000171 Pa (25 °C)

refractive index 

1.4264 (estimate)



storage temp. 



H2O: 100 mg/mL




2.35(at 25℃)


<5 (200 mg/mL)(APHA)


4(0.2 molar aqueous solution)



PH Range


Odor Type


Water Solubility 

25 g/100 mL (25 ºC)


Glycin Uses

  1. Glycin is made use of as a buffer, for the preparation of cells society tool, for the discovery of copper, silver and gold, as well as utilized in medicine for the treatment of myasthenia gravis as well as dynamic muscle mass atrophy, hyperacidity, persistent enteritis, hyperprolineemia in kids as well as other diseases.
  2. Glycin is made use of for the treatment of myasthenia gravis as well as modern muscular tissue atrophy; therapy of hyperesteridemia, chronic enteritis (combined with antacids); incorporated with pain killers, it can reduce its inflammation to the tummy; therapy of hyperprolineemia in youngsters syndrome; as a nitrogen resource for the development of non-essential amino acids, it was contributed to the mixed amino acid shot.
  3. Glycin is mostly utilized in seasoning and other aspects.Seasoning and also alanine are made use of in alcoholic beverages
    It has a certain inhibitory effect on the reproduction of Bacillus subtilis and Escherichia coli. Therefore, it can be made use of as a chemical for surimi items, peanut butter, etc, as well as the addition amount is 1% to 2%.
    In medication, it is made use of as an antacid (hyperacidity), a restorative agent for muscle dystrophy, and a remedy. It is additionally a raw material for the synthesis of amino acids such as threonine.
  4. Glycin is made use of as a solvent for eliminating carbon dioxide in the fertilizer industry. In the pharmaceutical market, it can be utilized as an amino acid preparation, a barrier for chlortetracycline, and also as a resources for the synthesis of L-dopa, an anti-Parkinson’s illness drug. It is additionally an intermediate of ethyl imidazolate, and also it is also a complementary therapy Medication, can deal with nervous hyperacidity, and also is additionally effective in subduing hyperacidity of stomach abscess. In the food market, it is made use of as a formula for artificial red wine, developing items, meat handling as well as rejuvenating beverages, and also as a saccharin devalue agent. As an artificial additive, glycine can be made use of alone as a flavoring, or it can be made use of with sodium glutamate and DL-alanine Acid, citric acid, etc made use of with each other.

Glycin Production Method

1. The Strecker technique responds formaldehyde with sodium cyanide (or potassium cyanide) as well as ammonium chloride, and also includes antarctic acetic acid at the same time, and also the condensation of methylene aminoacetonitrile is precipitated. The product is filtered, and also ethanol is added in the presence of sulfuric acid for decay to obtain aminoacetonitrile sulfate. After that include barium hydroxide to decay to get the barium salt of glycine. Finally, a specific amount of sulfuric acid was added to speed up the barium quantitatively and also filtered off. Concentrate the filtrate, location it for cooling down, as well as speed up glycine crystals.
2. Chloroacetic acid technique Mix ammonia water and also ammonium bicarbonate and also warmth to 55 ° C, include a chloroacetic acid liquid option, and react at 55 ° C for 2h. Heated to 80 ° C to eliminate residual ammonia, as well as decolorized with activated carbon. Filter, include 95% ethanol to the decolorizing solution to precipitate glycine crystals, filter, laundry with ethanol, and completely dry to acquire the crude item. The unrefined product is dissolved in hot water and also recrystallized with ethanol to get the ended up item. The return is about 42%.
3. Extract from silk hydrolyzate Include 25kg of waste silk to 75L of 6N commercial hydrochloric acid, warm and also reflux at 110-120 ° C for 22h, fully hydrolyze up until the biuret response does not turn purple. After hydrolysis, include dual quantity of water, include 30-40g powdered turned on carbon per litre, as well as stir at 60 ° C for 30min. Usage polyester fabric to remove impurities in the filter storage tank to acquire concerning 150L of brown hydrolyzate. Initial usage triggered carbon to soak up tyrosine in the hydrolyzate, and then use an ion exchange column to separate glycine, and also at the same time, alanine as well as serine can also be separated. Amongst those production methods, the monochloroacetic acid method is reasonably basic. As a matter of fact, monochloroacetic acid is included the ammonia tank, and also glycine can be generated at room temperature level for a very long time. In commercial manufacturing, making use of urotropine solution as a medium, responding monochloroacetic acid and also high-concentration ammonia at 70 ° C for 2 hrs, speeding up with methanol (or ethanol), and also refining therapy can obtain white crystal glycine. The yield of this approach is 92- 94%, product content 99%. Raw material consumption quota: monochloroacetic acid (95%) 1600kg/t, liquid ammonia 880kg/t, urotropine 350kg/t, methanol (95%) 1100kg/t. Furthermore, making use of gelatin as basic material, glycine can additionally be obtained via hydrolysis, refining, purification, as well as drying.

Production of Glycine by Glycin Biosynthesis

In the late 1980s, Mitsubishi Firm of Japan added the screened cardiovascular Agrobacterium, Brevibacterium, Corynebacterium along with other microbial category to the medium having carbon source, nitrogen resource along with not natural nutrient alternative for cultivation, and then the This sort of microorganisms adjustments ethanolamine into glycine at 25-45 ° C as well as pH value of 4-9, and also gets glycine by concentration neutralization ion exchange treatment. After getting in the 1990s, the advancement of producing glycine abroad has actually made brand-new development. Nitto Chemical Field Co., Ltd. of Japan utilized 0.5% (mass part, (entirely dry weight) was added to the matrix including glycine amine, as well as reacted for 45 hours at 30 ° C and likewise pH 7.9-8.1, mostly all of the glycine amine was hydrolyzed to Glycine, and the conversion price got to 99%. Although the natural method is still in the research study stage, it has high selectivity as well as no pollution, so it will certainly be a synthetic path with terrific advancement opportunity.

About Products:
If you need Glycine, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Glycine manufacturer and supplier, ZSpharmac will provide Glycine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Glycin Quotation