Zhishang Chemical

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Zhishang Chemical

Glutathione Usp CAS 70-18-8

Molecular Formula: C10H17N3O6S

Formula Weight: 307.32

ZSpharmac: Glutathione Usp Supplement

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Product Name: Glutathione Usp
CAS No: 70-18-8
Purity: 99%

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Basic Info

Product Name:Glutathione Usp
Other Names:Glutathione;GSH
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:200-725-4
Provide:Glutathione Usp MSDS;
Glutathione Usp COA

What is Glutathione Usp?

Glutathione Usp is a tripeptide substance formed by the condensation of glutamic acid, cysteine as well as glycine through peptide bonds, as well as is one of the most vital low molecular weight thiol in animal cells against oxidative stress. It was uncovered in 1921 and also the chemical framework was figured out in 1930. Dr. Al Mindel, a well-known American nutrition and health care specialist, called Glutathione Usp an anti-aging amino acid with triple effectiveness, likewise referred to as nature’s anti-oxidant master, and also its look is colorless.Amongst them, wheat germ and The highest in pet liver, the content is as high as 100 ~ 1000mg/100g. It has the functions of anti-oxidation, scavenging complimentary radicals, cleansing, improving resistance, anti-aging, anti-cancer, and anti-radiation risk. Likewise helps leukocyte kill bacteria, protects against oxidation of vitamins C and also E, and avoids stroke as well as cataract formation. On top of that, glutathione additionally binds health hazards and also excretes them via pee.

The liver is the most vital detoxification organ in the body, and also the rich Glutathione Usp (GSH) in it plays a safety role in the synthesis, detoxing, as well as estrogen inactivation of the liver. It is the body’s primary antioxidant to combat the damages of free radicals, which are adding aspects to aging and illness. When the liver is harmed, such as experiencing numerous liver conditions, the body will certainly eat a big amount of GSH to help the hurt liver to fix and detoxify itself, causing a substantial decline in glutathione in the body. Right now, we require to take some Glutathione Usp drugs to help the damaged liver repair work itself. Consequently, Glutathione Usp medications appropriate for viral hepatitis (such as hepatitis A, liver disease B, etc), alcoholic liver illness, drug-induced liver disease, fatty liver and other liver illness, and also are great liver protection medications for people with liver conditions.

Glutathione Usp Properties:

Melting point 192-195 °C (dec.) (lit.)
alpha -16.5 º (c=2, H2O)
Boiling point 754.5±60.0 °C(Predicted)
density 1.4482 (rough estimate)
refractive index -17 ° (C=2, H2O)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
pkapK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
form powder
color White
PH3 (10g/l, H2O, 20°C)
Water Solubility soluble


Glutathione Usp Uses

  1. Glutathione Usp is a small-molecule peptide that exists in huge amounts in living organisms, specifically in liver cells. It can safeguard liver cell membranes, advertise liver enzyme task, and also combine with several toxic chemicals to cleanse. It has a great medicinal effect on liver injury, liver cirrhosis and also various other conditions caused by medication poisoning, alcoholism and other factors.
  2. Glutathione Usp has the functions of anti-oxidation, scavenging totally free radicals, detoxification, boosting resistance, anti-aging, anti-cancer, and also anti-radiation threat.
  3. Glutathione Usp has biochemical reagents as well as antidote, generally used for poisoning of heavy metals, acrylonitrile, fluoride, carbon monoxide gas and also natural solvents.
  4. Glutathione Usp is an endogenous antioxidant that plays an essential role in mobile metabolic rate and also decrease of responsive oxygen types created during burst respiration. Glutathione-S-transferases catalyze the formation of glutathione thioethers with xenobiotics, leukotrienes, as well as other particles with electrophilic facilities. Glutathione likewise creates disulfide bonds with cysteine residues in proteins. Via these systems, it may have the amazing impact of minimizing the efficiency of anticancer agents.

Glutathione Usp Depletion and Antioxidant


In the binding of Glutathione Usp, Glutathione Usp is catalyzed by glutathione-S-transferase to combine with exogenous chemicals or their metabolites, thereby reducing toxicity and increasing polarity, which is an important detoxification pathway in biotransformation . When the dose of exogenous chemical suitable for this reaction is large, glutathione may be depleted and metabolic saturation occurs, so that the amount of binding per unit time no longer increases with the dose of the exogenous chemical. Increase. Therefore, the toxicity of the corresponding exogenous chemical is greatly increased, and its dose-response curve is very different from that at low doses, and its toxicokinetics also show nonlinear kinetics. Glutathione depletion is not necessarily due to an overdose of one exogenous chemical alone, but may also be due to competition for this binding by another exogenous chemical, or to a reduced supply of Glutathione Usp due to nutritional deficiencies or tissue damage. Depletion of Glutathione Usp in either case can be toxic at otherwise tolerated doses.


Many biochemical responses in the human body are catalyzed by enzymes. Most of these enzymes make use of sulfhydryl teams as energetic teams. The state of sulfhydryl groups figures out the activation and restraint of enzyme activity. Glutathione Usp is an all-natural activator of these enzymes in cells. The sulfhydryl team consisted of in it can lower the H2O2 generated by the metabolic process of human cells to H2O and also remove cost-free radicals in the human body. Free radicals can damage cell membranes, advertise body aging, as well as cause growths or arteriosclerosis. It has anti-peroxidation result on human cells, and also can also enhance the antioxidant capacity of the skin, making the skin glossy. For that reason, detecting the degree of Glutathione Usp can evaluate as well as find apoptosis early. Glutathione Usp has the function of eliminating the generation of oxidized lipids, as well as has anti-oxidative effect of oil as well as fat, and can additionally avoid the taste nuclei of taste nucleotides (inosinic acid, guanylic acid) in foods (fish cakes, sausages, soy sauce, etc) Glycolic acid is decomposed and sheds its umami taste.

Effects of Glutathione Usp on Human and Animal Health

Glutathione Usp is just one of the toughest antioxidants produced in animal cells and is a tripeptide composed of glutamate, cysteine as well as glycine. The sulfhydryl group on cysteine is the energetic team of Glutathione Usp (so Glutathione Usp is frequently shortened as GSH), which makes it have solid electron giving away (or reducing) and metal chelating capability.
Glutathione Usp is offered in both reduced (GSH) and oxidized (GSSG) types, which form a high adverse redox (reduction/oxidation) potential distinction, making it a really powerful decreasing agent or anti-oxidant in body cells. Glutathione Usp can bind to heavy metals, certain medicines and contaminants, etc, as well as has an integrated detoxification effect. Therefore, Glutathione Usp (especially glutathione in liver cells) can join biotransformation, so as to convert damaging toxins in the body into safe substances as well as eliminate them out of the body. Glutathione Usp also aids keep typical body immune system feature. These characteristics of Glutathione Usp have significant effects on metabolic and physiological procedures, which subsequently influence human and animal health and wellness.

Glutathione Usp concentrations in human cells are connected with human wellness and aging. People who are literally and emotionally healthy as well as long-lived have higher degrees of glutathione in their blood cells, on the other hand, older grownups with joint inflammation, diabetic issues or cardiovascular disease have reduced levels of glutathione than those without condition, cancer cells as well as urinary system Glutathione focus are substantially reduced in persistent individuals with reproductive, intestinal, cardiovascular, and bone and joint problems.

Adjustments in the concentration of Glutathione Usp in body cells are associated with a series of inflammatory as well as neurodegenerative diseases as well as illness such as cancer cells. Glutathione shortage has been recorded in different lung conditions such as acute breathing distress disorder, asthma and also persistent obstructive pulmonary disease. Liver disease (fatty liver, intense and also chronic liver disease, cirrhosis) is also connected with decreased glutathione. Deficiency of glutathione artificial insemination prevents immune cell feature, as well as intracellular glutathione plays a central function in the regular feature of immune cells. As a result, glutathione supplements is recommended as a complement treatment.

There is proof that Glutathione Usp degrees in sheep are affected by measurable hereditary variant and solitary genetics, and also under the control of both sorts of genetics, inadequate wellness appears to be related to low glutathione focus. Pet private qualities did not differ with feed intake and disease standing (nematode infection), suggesting a feasible hereditary basis for tissue glutathione levels.

Raising degrees of glutathione in tissues can also boost meat quality in livestock. Oxymyoglobin and also lipid hydroperoxide have a significant effect on meat color and also inflammation, and glutathione, as an antioxidant, might play a vital duty in preserving the service life and high quality of meat products.

Glutathione Usp is a small peptide that can be absorbed in the small intestine into its constituent amino acids, nevertheless, some glutathione can be absorbed directly into the circulatory system. In rat experiments, oral management of glutathione in fluid and strong types can significantly increase plasma glutathione concentrations by 2-3 times, while oral management of equivalent amounts of constituent amino acids has no result. In the exact same experiment, plasma glutathione Changes in peptide focus appeared to be dose-dependent, with a maximum dosage of 375 mg/kg, oral 15 mg/kg in human subjects raised plasma glutathione levels 2-5-fold.

Glutathione synthesis can be boosted by supplementing with cysteine forerunners. Another food resource that enhances tissue glutathione levels is cold-processed whey protein. Whey healthy protein concentrate has actually been revealed to be an efficient and secure cysteine contributor for glutathione supplements during glutathione deficiency in immunodeficiency states. Pet (rat) experiments have actually shown that whey protein focuses additionally display anticancer as well as anticancer (colon cancer) activity.

In creatures, cysteine can be manufactured from methionine, and when methionine is catabolized, regarding fifty percent can be converted to cysteine via the reverse sulfidation pathway, which has been validated in lamb experiments as well as in the duodenum of lamb With daily shots of 0.88-2.25 g of methionine for 5 weeks, plasma cysteine focus and erythrocyte glutathione concentrations increased substantially during the infusion.

Glutathione Usp is commonly existing in animals as well as plants and also plays a crucial role in living organisms. Relatively high levels of glutathione are discovered in fresh meat, 20 mg/100g in beef, 9.5 mg/100g in hen breast (with skin), and modest in fruits and vegetables, while milk items, grains as well as lower glutathione concentrations in bread. Since glutathione is synthesized intracellularly and moved outside the cell, glutathione degrees seem greater in cells than in blood. As an example, glutathione in lamb liver tissue is 1200 to 2200 mg/kg, glutathione in muscle mass tissue is 180 to 540 mg/kg, and also glutathione in whole blood is 170 to 250 mg/L. Amongst cells, the liver has the highest possible concentration of glutathione, followed by the kidneys, lungs, intestinal tracts, brain, and then muscular tissue (heart). Research studies of glutathione degrees in mice have actually shown that adjustments in glutathione in the liver, kidneys, heart, spleen and also brain are alongside those in whole blood, so blood degrees can be made use of as a general physical indicator.

Enhancing tissue antioxidant ability with foods containing high concentrations of glutathione or cysteine and also glutamate may be a choice to prevent and/or deal with disease.

The application research study and professional practice of Glutathione Usp and various other antioxidants as nutraceuticals in the prevention or treatment of lots of chronic illness and aging have actually drawn in terrific attention of clinical employees. To stop persistent conditions, these dietary medicines need to be taken control of a long period of time or a life time, in which situation foods abundant in glutathione or various other anti-oxidants must be a more appropriate option. Glutathione focus seem of moderate heritability, as well as it is possible to apply modern-day hereditary breeding techniques to increase glutathione focus in tissues. Although there are couple of research studies on the organization between antioxidant degrees in tissues and animal health and wellness and performance, it is gotten out of the outcomes of human research studies that increasing degrees of natural anti-oxidants can improve the wellness of animals and their capability to handle tension and also contagious conditions, Expand the service life and high quality of meat items and also provide advantages to the wellness of consumers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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