Glutathion CAS 70-18-8

Molecular Formula: C10H17N3O6S

Formula Weight: 307.32

ZSpharmac: Glutathion Supplier

Product Name: Glutathion

CAS No: 70-18-8

Purity: 99%

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Basic Info

Product Name:	Glutathion
Other Names:	Glutathione
CAS:	70-18-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	200-725-4
Storage:	2-8°C
Provide:	Glutathion MSDS； Glutathion COA

What is Glutathion?

Glutathion is a tripeptide material established by the condensation of glutamic acid, cysteine and glycine through peptide bonds. It is simply one of the most important low-molecular-weight thiol in animal cells to stand up to oxidative anxiousness. It was revealed in 1921 as well as also its chemical structure was developed in 1930. Dr. Al Mindell, a widely known American sustenance and also in addition wellness professional, called Glutathion an anti-aging amino acid with 3 times the performance, furthermore called the anti-oxidation master of nature, along with its appearance is anemic as well as furthermore clear Elongated granular crystal, soluble in water, thin down alcohol, fluid ammonia, dimethylformamide, insoluble in ethanol, ether, acetone. When it is strong, its residences are steady, in addition to its fluid option is rapidly oxidized ideal right into oxidized glutathione air-borne. It is extensively found in baker’s yeast, wheat bacterium, animal liver, fowl blood, pig blood, tomato, pineapple, cucumber, amongst which wheat Bacterium as well as additionally animal liver are the best, the material is as high as 100 ~ 1000mg/100g.It has the attributes of anti-oxidation, scavenging totally free radicals, detoxing, boosting resistance, postponing aging, anti-cancer, and also anti-radiation threats. Also aids leukocyte kill germs, protects against oxidation of vitamins C in addition to E, stops stroke as well as also cataract advancement. Additionally, glutathione additionally binds health hazards as well as additionally secretes them with pee.

Glutathion Property

Melting point	192-195 °C (dec.) (lit.)
alpha	-16.5 º (c=2, H2O)
Boiling point	754.5±60.0 °C(Predicted)
density	1.4482 (rough estimate)
refractive index	-17 ° (C=2, H2O)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
pka	pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
color	White
PH	3 (10g/l, H2O, 20°C)
Odor	Odorless
Water Solubility	soluble

Glutathion Uses

Glutathion as an artificial additive
1. When included in flour items, it can play a reducing obligation. It not just lowers the minute for making bread to half or one-third of the preliminary time, however in addition considerably boosts the working problems, as well as additionally plays the responsibility of boosting food nutrition along with other features.
2. Include it to yogurt and infant food, which is equivalent to vitamin C and also can work as a stabilizer.
3. Stir it right into the fish cake to avoid the color from growing.
4. When included in food such as meat products as well as also cheese, it has the impact of strengthening the taste.

Glutathion as an antidote
Glutathion has a broad-spectrum cleaning impact, can incorporate with dangerous compounds going into the body such as acrylonitrile, fluoride, carbon monoxide, heavy metal ions or health hazards, and also promote their discharging, and also can be made use of for the therapy of poisoning of the above substances.

Glutathion as an anti-allergic agent
It has anti-allergic result as well as additionally can treat allergies brought on by the inequality of acetylcholine and also cholinesterase in the human body.

Glutathion as a hepatoprotector
It has the attribute of protecting the liver along with preventing the development of fatty liver. It can not only be used as a liver-protecting agent, but furthermore can be made use of as a feed additive. It has a liver-protecting impact on fish along with animals. Liver problem normally happens in fish and also milk cows as a result of over-density stocking as well as likewise dirty feed in breeding. Including glutathione can enhance liver function.

Glutathion as an Antioxidant
Numerous biochemical actions in the body are militarized by enzymes. Most of these enzymes use sulfhydryl groups as active teams. The state of sulfhydryl teams identifies the activation as well as additionally restriction of enzyme task. Glutathione is the natural activator of these enzymes in cells. The sulfhydryl group contained in it can decrease the H2O2 generated by the metabolic rate of human cells right into water, as well as remove absolutely complimentary radicals in the body. Free radicals can damage cell membrane layers, promote body aging, as well as likewise produce growths or arteriosclerosis. It has an anti-peroxidation influence on human cells, and can also boost the skin’s antioxidant capability as well as make the skin shiny. Human aging, infection, poisoning, exogenous toxins, oxidative tension as well as anxiety, as well as also electrophilic substance strike can all lower the degree of GSH in the cytoplasm. This phenomenon occurs in the truly onset of apoptosis as well as also can be observed in the beginning of apoptosis. To its damage process, so finding the level of glutathione can early review and also locate apoptosis. Glutathione has the feature of eliminating the formation of oxidized lipids, along with has the effect of anti-fat oxidation, as well as additionally it can additionally prevent the taste nucleotides (inosinic acid, guanylic acid) in foods (fish cakes, sausages, soy sauce, etc) Flavor nucleotides break down and also shed umami choice.

Production Method of Glutathion

A kind of production method of high-purity Glutathion is characterized in that the method comprises the following steps:

(1) centrifugation of the fermented liquid: centrifuging after the glutathione fermented liquid that the fermentation level reaches at least 1650mg/L is put into the tank, the centrifugal speed is 3000～5000rpm, and the time is 5～10min to obtain the wet yeast cell body;

(2) hot water wall breaking: 1 part of wet yeast cell body is added in the extraction tank of 6～10 parts of boiling water, stir, stirring speed is 300～350rpm, when extracting liquid temperature reaches 85～95 ℃ After being incubated for 10 to 15 minutes, stop the extraction, pour out the extract, and cool the extract to room temperature in a water bath;

(3) Centrifugation of the extract: the centrifugation of the extract, the centrifugal speed is 3000～5000rpm, and the time is 5～10min, the yeast residue is removed, and the extract containing GSH is obtained;

(4) adjust pH: add acid in the extract after centrifugation, make feed liquid system be in the acidic environment of pH 2.5～3.5, can precipitate some impurity, and make GSH be in steady state, prevent oxidation ;

(5) Microfiltration: Utilize the microfiltration equipment of 0.1～1 μ m aperture to filter the extract after pH adjustment, to remove suspended small particle impurities, obtain clear and transparent filtrate;

(6) Cationic resin separation: the feed liquid after microfiltration is adsorbed on the sulfonic acid group cationic resin in an acidic environment, GSH is adsorbed, and then analyzed with sodium chloride or hydrochloric acid solution to obtain a liquid rich in GSH;

(7) Adsorption resin separation: the GSH-rich liquid separated and purified by cation exchange resin is adsorbed again on styrene-based weakly polar macroporous adsorption resin, and then eluted with pure water to obtain GSH with high purity liquid;

(8) concentrating under reduced pressure: under the vacuum degree of-0.07～-0.098Mpa and 55～65 DEG C of temperature, concentrate the GSH solution under reduced pressure, make to reach GSH content more than 400mg/ml;

(9) Crystallization: add isopropanol or ethanol to the Glutathion concentrated solution to make the organic solvent content reach 60%~80%, adjust the pH value to 2.90~3.0, and carry out crystallization at 0~4°C environment;

(10) crystal washing: the crystals are washed with the acetone solution of 70% to 90% by volume percent concentration;

(11) Vacuum drying: dry under the vacuum degree of-0.07～-0.098Mpa, obtain the GSH of more than 98% purity.

The Role of Glutathion

Studies have shown (Sun Honggang, et al. Metabolism and Application of Glutathione. Health Professional Education. 2004, 10:1 Shen-127): Glutathione can be completely absorbed in the small intestine, and some epithelial cells can use it Exogenous glutathione detoxification, suggesting that dietary glutathione determines the extent to which cells in the body are protected from damage. In addition to being an anti-toxic agent, Glutathion also activates some sulfhydryl enzymes, can be used as an antioxidant to protect enzymes and other protein sulfhydryl groups, and plays a certain role in biological oxidation, amino acid transport, and protection of hemoglobin. In addition, glutathione also has the functions of inhibiting aging, preventing diabetes, and eliminating fatigue. Glutathion has a health care effect on the human body while enhancing the flavor of food. Its application prospect is obviously better than other types of antioxidants and preservatives. Recent studies have also found that glutathione has the effect of inhibiting AIDS. Therefore, the study of glutathione is of great significance to human health and life.

About Products:
If you need Glutathion, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Glutathion, ZSpharmac will provide Glutathion raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.