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Zhishang Chemical

Gluconolactone CAS 90-80-2

Molecular Formula: C6H10O6

Formula Weight: 178.14

ZSpharmac: Gluconolactone Supplier

Product Name: Gluconolactone
CAS No: 90-80-2
Purity: 99%

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Basic Info

Product Name:Gluconolactone
Other Names:D-(+)-Glucono-1,5-lactone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Powder
EINECS No.:202-016-5
Storage:Sealed in Dry,Room Temperature
Provide:Gluconolactone MSDS;
Gluconolactone COA

What is Gluconolactone?

Gluconolactone is an ester formed by dehydration between the carboxyl group of gluconic acid and the hydroxyl group in the molecule, and the ester formed by dehydration between the hydroxyl group on the 5th (δ-position) carbon atom, called gluconic acid-δ- Lactone; the ester formed by dehydration with the hydroxyl group on the 4th (γ-position) carbon atom, called gluconic acid-γ-lactone. crystals. It has a sweet taste different from gluconic acid. It decomposes at 153°C, [α]D20+61.7°(C=1). It is easily soluble in water, hydrolyzed into gluconic acid in aqueous solution, and forms an equilibrium mixture with δ and γ lactones: its 6-phosphate is an intermediate in the oxidative decomposition of glucose in vivo (pentose phosphate pathway). In food processing, it is used as a coagulant for soybean protein or milk protein, a preservative for meat, a loosening agent for cakes and a stabilizer for pigments.

Gluconolactone Property

Melting point 160 °C (dec.)(lit.)
Boiling point 230.35°C (rough estimate)
alpha 65 º (c=1,H2O)
density 0.6
refractive index 63.5 ° (C=10, H2O)
storage temp. Sealed in dry,Room Temperature
solubility 590g/l Hydrolysis
form Crystalline Powder
color White to off-white
PH3.6 (10g/l, H2O, 20℃)
Water Solubility 500 g/L (20 ºC)


Gluconolactone Uses

  1. Gluconolactone as a coagulant: this product is hydrolyzed in aqueous solution to produce gluconic acid to coagulate protein, and the effect is better than calcium sulfate, calcium chloride and bittern. The tofu made with this product has good water retention, delicate texture, smooth and tender taste, and has antiseptic effect. When making tofu, add 2.5~2.6g of this product per kilogram of soymilk. This product can be dissolved in a small amount of water first, and then added to soy milk, or the soy milk with this product added canned, heated to 80°C with water isolation, protected for 15 minutes, and tofu can be coagulated.
  2. As a preservative, Gluconolactone has antiseptic effects on molds and common bacteria. It can be used for antiseptic preservation of fish, meat, poultry, shrimp, etc., making the appearance of the product shiny and not browning, while maintaining the elasticity of the meat. Adding 0.3% of this product to luncheon meat, sausage, red sausage, etc. can make the product bright in color, good in water holding capacity, elastic, antiseptic, and reduce the formation of nitrosamines in the product.
  3. Gluconolactone is used as a loosening agent. This product is compatible with sodium bicarbonate and mixed to make baking powder. When heated, gluconic acid reacts with sodium bicarbonate to produce carbon dioxide, which has good swelling effect and no peculiar smell. Especially suitable for pastry, fried food, etc. This product is mixed with sodium bicarbonate at a ratio of 2:1 to form baking powder, and its dosage can account for 50% to 70% of the sour agent. It can be used in biscuits, fried dough rolls and bread, etc., especially for cakes. The dosage is about 0.13% of wheat flour.
  4. As a chelating agent, Gluconolactone can be used in grape juice or other berry wines, adding this product can prevent tartar formation. Used in dairy products to prevent milk stone formation.
  5. As a sour agent, Gluconolactone can also be formulated into high-grade drinks with sodium bicarbonate. It not only has strong gas production power, but also can slowly hydrolyze gluconic acid, which is cool and delicious without stimulating the stomach.
  6. Gluconolactone dissolves dead skin cells, improves the appearance of fine lines and pigmentation, and helps remove excess oil from the skin. Because the molecules in gluconolactone are larger than other acids, they don’t penetrate as deeply into the skin, reducing the chance of redness and flaking after application.

Gluconolactone Production Method

Production of lactones from glucose
Microbial fermentation method Add nutrients such as magnesium sulfate, potassium dihydrogen phosphate and diammonium hydrogen phosphate to 15% to 35% glucose solution, inoculate Aspergillus niger strain NRRL3, and culture under aeration at 30°C and Ph6.5 for 40h . Filtrate the secluded liquid, and then post-process to obtain lactone crystals.
Glucose oxidase method: Under the conditions of 35-37°C and Ph6, in ethanol aqueous solution (such as 50%), glucose oxidase oxidizes glucose into a balanced solution of lactone and gluconic acid, and catalase is also added during the reaction , to decompose the hydrogen peroxide produced. The obtained gluconic acid solution can obtain lactone crystals through the above-mentioned post-treatment method, and the yield of this method can reach 98%. Catalytic oxidation method will 64mgPdCl. Dissolve in 1mL of concentrated hydrochloric acid, add appropriate amount of water and 3.8g of refined activated carbon (200 mesh), adjust Ph=5 with 10% NaOH solution, then stir the mixture at room temperature and add 67mg of NaOH. (dissolved in 2mL water) solution, the ionic palladium is reduced to metallic palladium, and adsorbed on activated carbon, filtered, washed with water, and dried to obtain 3.838g1% Pd-C catalyst. Add the above-mentioned catalyst to 300g of 8% glucose aqueous solution, feed air at 50°C, and add NaOH solution dropwise at the same time to keep Ph=9.0~9.5. The resin was processed to obtain 310 g of gluconic acid solution. Concentrate under reduced pressure at 70°C to a concentration of 80% to 85%, cool to below 40°C, add seed crystals, filter and dry to obtain 22.6g of lactone after crystallization, and then concentrate and crystallize the filtrate to obtain 5.3g of the product. The total yield is 93.3%.

Production of Lactone Using Calcium Gluconate as Raw Material
In this method, calcium gluconate is decomposed with inorganic acid or decalcified by ion exchange resin to obtain gluconic acid solution. For example, add 100 parts of concentrated sulfuric acid to 500 parts of water, then add calcium gluconate, keep warm at 60-85°C for 1.5h; let stand for 12h and then filter, add oxalic acid to the filtrate, and keep warm at 50°C for 1h; stand and filter to get Gluconic acid solution can be processed to obtain lactone. There are several post-processing methods.
The non-solvent crystallization method concentrates the gluconic acid solution under reduced pressure to a slurry state, adds low-level ketone non-solvents, slowly stirs and cools to precipitate crystals, and then separates, washes, and dries to obtain the finished product. This method is easy to operate and the yield is high.

Fractional crystallization
Concentrate the gluconic acid solution at 52-54°C to 78%-85%, cool to 47-48°C, add gluconolactone seed crystals, and continue to concentrate, and separate the first batch of lactone after the seed crystals grow up crystallization. The mother liquor continues to evaporate and concentrate in the same way. The crystallization is washed and dried to obtain the finished product, with a total yield of 75% to 78%. The advantage of this method is that no organic solvent is used, but the concentrated solution has a high viscosity and the operation of crystallization and separation is difficult.
The azeotropic dehydration crystallization method adds C3-C4 alkanols to the gluconic acid solution, and azeotropically dehydrates at 50°C and 16kPa. Then throw crystal seeds into the concentrated solution, cool down and crystallize, and then separate, wash and dry to obtain the finished product. The advantage of this method is that the viscosity of the system is low, the separation operation is easy, and the single-pass yield can reach more than 91%.

Determination of Gluconolactone Content

At present, the detection and analysis methods of Gluconolactone mainly include colorimetry, gas chromatography and high performance liquid chromatography. Colorimetry is complicated to operate and has low sensitivity. Gas chromatography is prone to interfering substances. High-performance liquid chromatography mainly includes normal phase chromatography and ion chromatography: normal phase chromatography mostly uses sugar columns and amino columns, and the separation is not ideal; ion chromatography generally uses alkaline mobile phases, and it is difficult to achieve equilibrium between Gluconolactone and gluconic acid. In view of the defects and deficiencies of the above-mentioned detection methods in actual detection, it is of great significance to develop a convenient, sensitive, and interference-free analysis method.

Using an organic acid column (4.6mm×250mm, 5μm), the mobile phase is 0.01mol/L potassium dihydrogen phosphate-phosphate buffer (ph=6.2), the flow rate: 0.8mL/min, using a differential detector with an internal temperature of 35°C . Meat and meat products, soy products, sports drinks and other foods were measured, and the results showed that the method had a good linear relationship, the detection limit was 7.5mg/kg, and the relative standard deviation of the determination results was 0.5%~1.9% (n=6). The rate is between 87% and 95%. The method has the advantages of high sensitivity and accurate qualitative, and is suitable for the detection of Gluconolactone in food.

About Products:
If you need the cosmetic raw material D-(+)-Glucono-1,5-lactone, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced D-(+)-Glucono-1,5-lactone manufacturer and supplier, ZSpharmac will provide D-(+)-Glucono-1,5-lactone raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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