Zhishang Chemical

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Zhishang Chemical

Glabridin CAS 59870-68-7

Molecular Formula: C20H20O4

Formula Weight: 324.37

ZSpharmac: Glabridin

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Product Name: Genivida Genistein
CAS No: 59870-68-7
Purity: 99%

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Basic Info

Product Name:Glabridin
Other Names:Licorice Flavonoids
CAS:59870-68-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Brown Powder
EINECS No.:611-908-7
Storage:Room Temp
Provide:Glabridin MSDS;
Glabridin COA

What is Glabridin?

Glabridin is a natural lightening agent isolated from licorice flavonoids, as well as licorice flavonoids are drawn out from the rhizomes of particular varieties of licorice plants (such as Ural licorice, licorice, licorice, and so on), natural, pollution-free, It has no adverse effects on the body.
Glabridin is expectorant, emollient, anti-inflammatory, anti-filtering virus, anti-hepatotoxic as well as anti-bacterial. Due to these effects of licorice, it has actually been extensively examined in medicine and food. Licorice can be made use of in cosmetics. It has bleaching, anti-inflammatory, anti-bacterial and antioxidant results, and also is an extremely valuable cosmetic raw material.
Glabridin is referred to as “bleaching gold” because of its effective capacity to prevent reactive oxygen species and also melanin. First, it is commended for its bleaching impact. Second, the cost per gram of Glabridin approaches that of gold. Only a few brands risk to utilize it as a bleaching agent. Aspect.

Glabridin Property

Melting point 154~155℃
Boiling point 518.6±50.0 °C(Predicted)
density 1.257±0.06 g/cm3(Predicted)
Fp 267℃
storage temp. room temp
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
pka9.66±0.40(Predicted)
color white to light brown

 

Glabridin Uses

  1. Glabridin is a compound extracted from licorice (root) with cytotoxic, antibacterial, estrogenic and antiproliferative properties.
  2. Glabridin is used for content determination/identification/pharmacological experiments and other pharmacological effects: inhibition of reactive oxygen species production, inhibition of tyrosinase, anti-inflammatory, antioxidant effects.

Glabridin Benefits

Hinder tyrosinase
Human tyrosinase is a crucial enzyme that frequently creates melanin, which turns the skin or eyes from brown to black. We know that direct exposure of the skin to UV light can trigger some reactions (such as swelling), and also this histological modification is manifested as erythema and also coloring as a result of the damage of the phospholipid membrane of the skin cells by UV-induced responsive oxygen types. Energetic oxygen is a substance that can cause skin pigmentation, so inhibiting its manufacturing can prevent the manufacturing of melanin. Glabridin is one of the most costly and most efficient bleaching component among all bleaching ingredients. According to “Ben Cao Zhonghua”, the whitening result of Glabridin is 232 times that of regular vitamin C, 16 times greater than that of hydroquinone, and “arbutin”. 1164 times, so Glabridin is called “lightening gold”.

Anti-inflammatory effect
The anti-inflammatory activity of glabridin was verified by experiments. The test subject were irradiated with ultraviolet light to create coloring, and afterwards smeared with 0.5% glabridin solution. It was discovered that Glabridin alleviated skin inflammation brought on by ultraviolet stimulation. Erythema on the skin is stood for by a worth. The level of swelling reduction can be computed by recording the alpha value (colorimetric reading) of glabridin prior to and after irradiation. The scientists researched the task of glabridin to hinder cyclooxygenase. Cyclooxygenase is an enzyme that converts arachidonic acid into prostaglandins, which are pro-inflammatory elements. Glabridin was able to hinder cyclooxygenase compared to the control group (utilizing the present cyclooxygenase inhibitor, indenemethine). It is believed that glabridin impacts the manufacturing of arachidonic acid by hindering cyclooxygenase, thus lowering inflammation.

Anti-oxidize result
Glabridin has a solid scavenging effect on totally free radicals. Vitamin C, vitamin E and also β-carotene are acknowledged as the three kings of anti-oxidation and also anti-aging. Glabridin’s anti-aging capacity approaches that of vitamin E. It is an all-natural antioxidant. It is reported that the antioxidant effect of its antioxidants is significantly far better than that of BHA and also BHT. It has been reported in the literary works that licorice can be used to lower corticosteroids in infectious skin diseases as well as can improve the impact of steroids.

Aesthetic application
Glabridin has superb anti-inflammatory, anti-oxidative as well as anti-melanogenesis residential or commercial properties, so it is made use of as a component in various cosmetic and also medical care items such as lotions, lotions, body laundries, etc. It can be made right into a bleaching cream, a trademarked product of which is already on the marketplace.

Dosage: In cosmetics, in order to accomplish the bleaching effect, the suggested dose of the license is 0.001-3% of licorice, ideally 0.001-1%. With glycerol 1:10, reduced temperature level included. Topical licorice can inhibit the formation of melanin. It has outstanding tyrosinase inhibitory activity and also can avoid skin tanning, line places as well as sunburn. The recommended dose is 0.0007-0.05%. Research studies have revealed that as long as 0.05% of glabridin, 0.3% of aloe vera powder, 1% of niacinamide, as well as 1% of AA2G can hinder melanin tyrosinase by 98.97%, in order to hinder male hormones and also deal with acne, light The dose of licorice is 0.01-0.5%.

Chinese scientists have additionally researched the prep work and application of Glabridin liposomes in cosmetic products. The outcomes showed that glabridin liposomes could be effectively prepared by using liposome setting and also prep work technology. The phospholipid bilayer membrane of glabridin liposome is similar to organic membrane layer, and it is simple to fuse with microorganisms, which advertises the penetration of practical elements to biological membranes, and also makes the performance of useful components trans-skin obstacle and organic membrane transport higher. It has a favorable result on boosting its skin bleaching and also freckle-removing effect and other supporting effects.

Preparation of High-quality Glabridin Extract of Glycyrrhiza Glabra

Supercritical liquid extraction (SFE) making use of co-solvent changed supercritical carbon dioxide and a two-step separation/purification technique was explored as a method to improve the pureness of licorice, one of the many bioactive components of Glycyrrhiza glabra (Glycyrrhiza glabra). Enhance SFE specifications making use of an analytical grade SFE system over a temperature range of 40– 80 ° C as well as pressure variety of 10– 50 MPa. The removal was then scaled up 100-fold utilizing a preparative SFE system under the adhering to set of optimized problems: 40 ° C, 30 MPa, and also SCCO customized with ethanol equivalent to its 25% (v/v) focus. The purity of Glabridin acquired by the scaled-up SFE system was 6.2%, which is much more than that obtained by organic solvent extraction. The licorice extract acquired by scaling up the SFE system was separated and also cleansed by ethanol precipitation/filtration and also 80% ethanol liquid adsorption chromatography to acquire a purer item. Glabridin pureness of the final extract product was shown to be improved by approximately 37%, without any considerable loss of glabridin after two isolation/purification steps.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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