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Gentamicin Sulfate 0 1 CAS 1405-41-0

Molecular Formula: C60H127N15O26S

Formula Weight: 1506.8

ZSpharmac: Gentamicin Sulfate 0 1 Supplement

Product Name: Gentamicin Sulfate 0 1
CAS No: 1405-41-0
Purity: 99%

Basic Info

Product Name:Gentamicin Sulfate 0 1
Other Names:Gentamycin Solution
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Crystalline Powder
EINECS No.:215-778-9
Storage:The Warehouse is Ventilated and Dry at 2-8°C
Provide:Gentamicin Sulfate 0 1 MSDS;
Gentamicin Sulfate 0 1 COA

What is Gentamicin Sulfate 0 1?

White or off-white crystalline powder, hygroscopic, soluble in water, insoluble in lipids, insoluble in organic solvents, chemically stable, stable to changes in temperature and pH, pH of 4% aqueous solution is 4.0 ~ 6.0 .

Gentamicin sulfate is an aminoglycoside antibiotic, which is a glycoside formed by aminocyclohexane polyol and amino sugar. There are five basic centers in the gentamicin molecule, which are basic compounds, and the drug is the sulfate of gentamicin. Gentamicin is a complex of C components, the main components are C1, C2, C1a and C2a.

Gentamicin Sulfate 0 1 Properties:

Melting point 218-237°C
alpha D25 +102°
density 1.000 g/cm3
storage temp. 2-8°C
solubility H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.
form powder
color colorless to light yellow
PH4.0-5.5 (0.1g/mL in H2O)
optical activity[α]20/D +110±8°, c = 1% in H2O
Water Solubility Soluble in water


Gentamicin Sulfate 0 1 Uses

  1. Gentamicin sulfate is used to treat sepsis, urinary tract infections, staphylococcal infections, endocarditis, and other diseases.
  2. Gentamicin sulfate is clinically used for septicemia, respiratory tract infection, biliary tract infection, purulent peritonitis, cranial tract infection caused by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella, Klebsiella, Proteus and other sensitive bacteria. Internal infections, urinary tract infections and bacillary dysentery.
  3. Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the transfer of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas depends on binding to the outer membrane part of the cell membrane, replacing the originally existing cations, making the membrane unstable, and forming voids on the cell surface. Antibacterial spectrum: Gram-negative bacteria, Staphylococcus and other Gram-positive bacteria.

Pharmacological Effects of Gentamicin Sulfate 0 1

Gentamicin sulfate is an aminoglycoside drug that acts on ribosomes in bacteria, inhibits bacterial protein synthesis, and destroys the integrity of bacterial cell membranes to play a bactericidal effect. The drug can first pass through the extracellular membrane porin by passive diffusion, and then enter the cell through the cell membrane through the transport system, and irreversibly bind to the isolated 30s subunit of the ribosome, resulting in the destruction of the A site, and then: (1) prevent Correct localization of aminoacyl tRNA at the A position, in particular, impedes the binding of methionyl tRNA, thereby interfering with the assembly of functional ribosomes and inhibiting the formation of the 70s initiation complex. (2) Induced mismatch between tRNA and mRNA code triplet, causing the 30s subunit of the intact ribosome to misread the genetic code, causing the wrong amino acid to be inserted into the protein structure, resulting in abnormal, nonfunctional protein synthesis. (3) Prevent the termination factor from binding to the A site, so that the synthesized peptide chain cannot be released, and prevent the dissociation of the 70s complete ribosome. (4) The process of depolymerization and assembly of polysomes is hindered, resulting in the depletion of ribosomes in bacteria.

Gentamicin Sulfate 0 1 Characteristics

1. It is a bactericidal antibiotic.
2. It is a broad-spectrum aminoglycoside.
3. There is obvious post-antibiotic effect (PAE) on Gram-negative bacteria and positive cocci, that is, it has a sustained bacteriostatic effect lower than the inhibitory concentration, completely eliminates the drug, or the drug concentration is lower than the minimum inhibitory concentration (MIC). ), the growth of bacteria continued to be inhibited for a certain period of time.
4. It is a concentration-dependent antimicrobial drug. Under the condition that the daily dose remains unchanged, a single administration can obtain a larger peak plasma concentration of multiple doses a day, making the peak concentration and the minimum inhibitory effect. The ratio of bacterial concentration increased, thereby significantly improving the antibacterial activity and clinical efficacy.
In addition, the post-antibiotic effect (PAE) of gentamicin on pathogenic bacteria is also concentration-dependent. A single daily dose can reduce the incidence of adaptive resistance and ear and nephrotoxicity. Stress reactions caused by injections and injections.
5. This product is rarely absorbed when taken orally, and the concentration in the intestine is relatively high. It can be used as a drug for intestinal infections to treat yellow and white diarrhea of ​​piglets and enteritis.
6. The product is absorbed rapidly and completely by injection. The peak blood concentration is generated within 0.5-1 hour after intramuscular injection, and the bioavailability can reach 90%. When the dose is increased, the blood concentration can be increased, and the duration can be appropriately extended.
7. This product is an alkaline compound, easily soluble in water, relatively stable, and has the strongest antibacterial activity in an alkaline environment.
8. Gentamicin has certain side effects if the dosage is too large or the medication time is too long.
9. Bacteria are also prone to resistance to this product, but the resistant strains are far less common than streptomycin and kanamycin. The occurrence can be reduced or prevented if the dose is adequate or in combination with other antibiotics and topical administration is avoided. Once it occurs, stop the drug immediately, and the bacteria can regain their sensitivity. There is incomplete cross-resistance among different varieties of aminoglycosides.

Clinical Application of Gentamicin Sulfate

This product is suitable for neonatal sepsis, sepsis and central nervous system infection caused by Pseudomonas aeruginosa, Proteus, Klebsiella, Enterobacter, Serratia, Citrobacter and Staphylococcus , respiratory tract infection, urinary tract infection, biliary tract infection, skin, bone, otitis media, sinusitis, soft tissue infection, etc.; Gentamicin sulfate is not suitable for simple urinary tract infection, and is ineffective against pneumococcus and anaerobic bacteria. Gentamicin sulfate is suitable for extra-central infection caused by sensitive bacteria. Simple urinary tract infection), skin and soft tissue infection, burn infection and neonatal sepsis, sepsis. 2, for the treatment of listeriosis. 3. Intramuscular injection in combination with clindamycin or metronidazole can be used to reduce the incidence of infection after colon surgery. 4. Intrathecal injection of gentamicin sulfate can be used as adjuvant therapy for severe central nervous system infections (meningitis, ventriculitis) caused by Pseudomonas aeruginosa or Staphylococcus. 5. Oral administration can be used to treat bacillary dysentery or other bacterial intestinal infections, and can also be used to prepare for colon surgery. 6. Eye drops are suitable for conjunctivitis, keratitis and dacryocystitis caused by coagulase-negative and positive Staphylococcus aeruginosa, Escherichia coli, Pneumonia bacillus, Influenza bacillus and other Gram-negative bacilli and Neisseria gonorrhoeae , blepharitis, stye, meibomian and corneal ulcers.

Gentamicin Sulfate Medication Instructions

1. Patients who are allergic to aminoglycosides are contraindicated.
2. Gentamicin sulfate has nephrotoxicity, ototoxicity (cochlea, vestibule) and neuromuscular blockade. Therefore, renal function (urine routine, blood urea nitrogen, serum creatinine) should be monitored during medication, and the patient’s hearing and vestibule should be closely observed. function, pay attention to the symptoms of neuromuscular blockade. Once the symptoms of the above-mentioned adverse reactions occur, the drug must be discontinued in time. It should be noted that the above-mentioned adverse reactions may also occur with topical administration.
3. Gentamicin sulfate can pass through the blood-fetal barrier, enter the fetal circulation, and endanger the fetal auditory nerve, so pregnant women should not use it; neonatal, infant, and elderly patients should try to avoid its use; when there are clear clinical indications for application, it should be used. Monitor the blood drug concentration and adjust the dosing regimen according to the monitoring results. 4. This product has poor antibacterial effect on Streptococcus pneumoniae and Hemolytic Streptococcus, the main pathogens of community-acquired upper and lower respiratory tract infections, and has obvious ear and nephrotoxicity. Use this product for treatment; because of its toxicity, it is not suitable for the treatment of simple upper and lower urinary tract infections.
5. It is not suitable for intravenous injection, because it is easy to cause respiratory depression; it cannot be used for intraocular or subconjunctival administration, because it may cause macular necrosis.
6. Do not mix with β-lactam antibiotics during intravenous infusion, so as not to reduce the efficacy. If there are indications for combined application, they can be injected separately.
7.It ought to not be made use of together with various other nephrotoxic medicines, ototoxic drugs, neuromuscular blockers or strong diuretics. May rise nephrotoxicity when co-administered with first-generation cephalosporins for shot.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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