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Zhishang Chemical

Genivida Genistein CAS 446-72-0

Molecular Formula: C15H10O5

Formula Weight: 270.24

ZSpharmac: Genivida Genistein Supplement

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Product Name: Genivida Genistein
CAS No: 446-72-0
Purity: 99%

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Basic Info

Product Name:Genivida Genistein
Other Names:Genistein
CAS:446-72-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:207-174-9
Storage:-20°C
Provide:Genivida Genistein MSDS;
Genivida Genistein COA

What is Genivida Genistein?

Genivida Genistein is the ligand of sophora glucoside. Rectangular or hexagonal rod-shaped crystals (60% ethanol), or dendrites (ether). Melting point 297~298℃ (micro-decomposition), UVλmax262.5nm. Soluble in common organic solvents, insoluble in water, and soluble in dilute alkali, it turns yellow. Phloroglucinol and p-hydroxyphenylacetic acid are obtained under alkaline conditions. Preparation method: It is obtained by hydrolysis of sophora glucoside under the action of almond enzyme. purposes : as a dye.

The anticancer mechanisms of Genivida Genistein include inhibition of casein kinases, inhibition of hemangiogenesis, antioxidant effects, and competitive binding to estrogen receptor sites. Monoterpenoid phytochemicals may play a role by preventing dysregulation of cell proliferation. Anticancer effect.

Genivida Genistein Property

Melting point 297-298 °C
Boiling point 333.35°C (rough estimate)
density 1.2319 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. -20°C
solubility DMSO: soluble
form powder
pka6.51±0.20(Predicted)
color off-white
Water Solubility insoluble

 

Genivida Genistein Uses

  1. Genivida Genistein is used for anti-tumor, anti-fungal, hypochondriac, estrogenic activity.
  2. Genivida Genistein is used as a protein tyrosine kinase (PTK) inhibitor, a competitive inhibitor of ATP in other protein kinase reactions, inducing programmed cell death, improving anticancer efficacy, inhibiting angiogenesis, etc.
  3. Genivida Genistein (1) has estrogenic as well as antiestrogenic properties
    ( 2) In vivo can hinder colon cancer, bust cancer cells, skin cancer, prostate cancer cells, and so on( 3) It has repressive impact on a range of growth cell lines
    ( 4) has antioxidant effect
    ( 5) It can hinder the task of protein tyrosine kinase (PTK).
    ( 6) It can inhibit the activity of topoisopurchase II.
    ( 7) It can prevent postmenopausal weakening of bones.
    ( 8) It has the functions of generating set cell death, boosting anti-cancer effectiveness, as well as preventing angiogenesis. It is a prospective cancer cells chemopreventive agent, as well as its anti-cancer result as well as device have broad application potential customers.

 

Genivida Genistein Pharmacological Actions

1. Genivida Genistein and Cardiovascular Disease
Genivida Genistein plays a very important role in reducing the incidence of cardiovascular disease. Low-density lipoprotein cholesterol in the blood is high and easily oxidized, which can cause atherosclerosis. Genistein can effectively reduce cholesterol through its antioxidant effect, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), and make LDL in the blood. Maintain a low level, improve the abnormal state of peroxidation in the body caused by high fat, and relieve the peroxidative damage to the body. Genistein can up-regulate LDL receptors and increase LDL receptor activity, thereby promoting cholesterol clearance. Genistein also has the effect of inhibiting the proliferation of smooth muscle cells and angiogenesis and inhibiting cell adhesion, thereby reducing the incidence of cardiovascular disease.

2. The role of Genivida Genistein and cranial nerves
The latest literature reports that genistein has the effect of promoting brain nerve regeneration and cerebral coma. Modern medical theory holds that when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur, a series of pathophysiological changes such as ischemia, hypoxia, degeneration and necrosis of brain tissue cells are closely related to the influx of large amounts of extracellular calcium ions in brain tissue. relationship; the overload of calcium ions in brain cells is one of the main causes of degeneration and necrosis of brain cells. The latest research found that after changing the route of administration, genistein can pass through the blood-brain barrier, and by affecting the Ca++ receptors of the brain cell membrane, it can protect brain cells when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur.

3. Genivida Genistein and Cancer
Genivida Genistein has inhibitory and therapeutic effects on a variety of cancers through ①antioxidant effect ②inhibition of tyrosine kinase activity ③inhibition of topoisomerase activity ④estrogen and antiestrogen-like effect ⑤reduce tumor angiogenesis.

4. Genivida Genistein and Radiation Resistance
Genivida Genistein (genistein) is a potent inhibitor of protein tyrosine kinase activity, and also possesses antioxidant and estrogen-like effects, said landauer working in the laboratory of the United States Armed Forces Radiobiology Research Institute (AFRRI). et al demonstrated that it is a radioprotectant and that genistein significantly increased the dose of whole body radiation in patients with fatal traumatic brain injury, whether administered subcutaneously 24 hours before irradiation or by gavage 4 days before irradiation or 4 days after irradiation ( 30-day survival of mice at 9.5 Gy).

In the United States, some people use genistein for the prevention and treatment of side effects of tumor radiation therapy (Bio 300) using its anti-radiation effect. It is reported in the literature that genistein was taken before traumatic brain injury (7.75Gy) irradiation. Also reduces lung damage in long-lived animals.

5. Genivida Genistein and Women’s Menopause Syndrome
Genivida Genistein has weak estrogenic activity and has the effect of estrogen. Studies have shown that in women’s menopause, due to ovarian degeneration and the reduction of estrogen in the body, women will experience a series of symptoms of menopausal syndrome, while the intake of quantitative genistein during menopause It can supplement the lack of estrogen in the body and play a role in preventing and reducing women’s menopausal syndrome. Experiments suggest that estrogen-like effect may be the main mechanism of genistein to prevent osteoporosis.

Genivida Genistein Preparation

The method for extracting Genivida Genistein from plant Sophora japonica is characterized by comprising the following steps:

(1) Preparation of Genivida Genistein molecularly imprinted polymer:

1) Multi-step swelling polymerization:

a. First, add monodisperse microspheres to microemulsion A, and at room temperature, react with a rotating speed of 100-150 rpm in a constant temperature magnetic stirrer for 14-16 hours to obtain the first-step swelling solution;

The microemulsion A is configured by sodium dodecyl sulfonate, dibutyl phthalate and three distilled water, wherein each milliliter of microemulsion A contains 0.001-0.003 g of sodium dodecyl sulfonate, containing 0.03~0.05g of dibutyl phthalate, and the rest are three distilled water;

b. Add microemulsion B to the first-step swelling solution, and at room temperature, react with a rotating speed of 100-150rpm in a constant temperature magnetic stirrer for 1.5-2.5h to obtain the second-step swelling solution;

The microemulsion B is prepared from an initiator, chloroform, polyvinyl alcohol and three-distilled water, wherein each milliliter of the microemulsion B contains an initiator 0.01-0.02 g, chloroform 0.070-0.100 g and polyvinyl alcohol 0.018~0.025g, the rest are three distilled water;

c. Then add microemulsion C to the swelling solution in the second step, and at room temperature, in a constant temperature magnetic stirrer, react for 1.5-2.5 h at a rotational speed of 100-150 rpm to obtain the swelling solution in the third step;

The microemulsion C is made of genistein, functional monomer, cross-linking agent, cyclohexanol, sodium dodecyl sulfonate, polyvinyl alcohol and three distilled water, wherein each milliliter of microemulsion C contains genistein. 0.008g ~ 0.009g of elemental, functional monomer 0.022g ~ 0.024g, crosslinking agent 0.150 ~ 0.158g, cyclohexanol 0.105 ~ 0.110g, sodium dodecyl sulfonate 0.001 ~ 0.005g and polyvinyl alcohol 0.015 ~ 0.020g g, the rest are three distilled water;

d. Finally, thermally polymerizing the swelling liquid in the third step, specifically: under the protection of nitrogen flow, in a constant temperature magnetic stirrer at a temperature of 50° C. and a rotating speed of 180 rpm for 24 hours to obtain microspheres with a particle size of 1 to 15 μm, So as to complete the swelling polymerization;

2) After the multi-step swelling polymerization is completed, the obtained microspheres are subjected to six times of sedimentation, and the six times of sedimentation are: first, three times in methanol, then once in three-distilled water, and finally twice in tetrahydrofuran. The lower layer of sediment was taken out and filtered with a G4 funnel, and then the filter residue was dried at normal temperature and pressure to obtain genistein molecularly imprinted polymer;

(2) Preparation of Genivida Genistein molecularly imprinted solid phase extraction column:

The genistein molecularly imprinted polymer prepared in step (1) was packed into a column by the homogenization method, and then acetonitrile solution with a volume ratio of 20%, methanol-glacial acetic acid with a volume ratio of 4:1, and a volume ratio of 20% acetonitrile solution for elution to obtain a genistein molecularly imprinted solid phase extraction column;

(3) Genivida Genistein molecularly imprinted solid-phase extraction column to extract and separate genistein from the plant Sophora japonica.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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