Zhishang Chemical

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Zhishang Chemical

Genistein Supplement CAS 529-59-9

Molecular Formula: C21H20O10

Formula Weight: 432.38

ZSpharmac: Genistein Supplement Supplier

Product Name: Genistein Supplement
CAS No: 529-59-9
Purity: 99%

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Basic Info

Product Name:Genistein Supplement
Other Names:Genistin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Neat
EINECS No.:610-921-5
Provide:Genistein Supplement MSDS;
Genistein Supplement COA

What is Genistein Supplement?

Genistein Supplement is one of the energetic components in soybean isoflavones, as well as it is the 7-glucoside of genistin, the active component of soybean isoflavones.Genistin is used to reverse control homocytisine and other tyrosine kinase inhibitors, which have the ability to improve insulin resistance, anti-diabetic effects, the ability to inhibit the activity of cancer cells, inhibit prostate cancer and antioxidant activity, they Extraction provides new raw materials and functional additives for the food industry and pharmaceutical industry.

Genistein Supplement Property

Melting point 254°C
Boiling point 256 °C
alpha D21 -28° (c = 0.6 in 0.02N NaOH); D26 -21.4° (pyridine)
density 1.642±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/mL
form neat
color Off-white


Application of Genistein Supplement

1. For the preparation of compositions with anti-aging effects
CN201611046133.8 provides a composition with anti-aging effect, so as to increase the elasticity and luster of the skin under this combination, and treat benign prostatic hyperplasia, hypercholesterolemia, arteriosclerosis, erectile dysfunction and menopause, postmenopause Symptom purpose.

In order to achieve the above object, the present invention adopts the following technical solutions: Genistein Supplement has anti-aging effect composition, it is characterized in that, described anti-aging effect composition comprises daidzin, daidzein, Genistein Supplement, genistein and Puerarin, wherein the weight ratio of daidzein, daidzein, genistin, genistein and puerarin is (3*104-7*104):(6-10):(0.8*104-1.5*104) :(1-3):(80-110). The application of the composition of the present invention in the human body can increase the elasticity and luster of the skin. In addition, the composition can be used for skin care, breast care (including breast firming, breast enlargement, and breast wrinkle removal), and treatment of benign prostatic hyperplasia, hypercholesterolemia, arteriosclerosis, erectile dysfunction, and menopausal and postmenopausal symptoms. Used in the manufacture of cosmetics, cosmeceuticals, medicinal products and health care products, functional foods, beverages.

2. Pharmaceutical composition for treating hyperlipidemia and atherosclerosis
CN201710312895.6 provides a pharmaceutical composition for treating hyperlipidemia and atherosclerosis with clear ingredients, controllable quality and significant curative effect. The pharmaceutical composition comprises active components, and the active components are puerarin, daidzin, Genistein Supplement, daidzein, acteosin glucoside, astragaloside II, astragaloside IV, formononetin, mulberry bark Combination of two or more of glycoside A, morin, scopoletin, mulberry ketone C, 1-deoxynojirimycin, kudzu root polysaccharide, astragalus polysaccharide and Morus alba polysaccharide. The pharmaceutical composition can reduce the fat plaque area in the aorta of apoE-/-transgenic mice of atherosclerosis model, and has the effect of regulating hyperlipidemia in mice, and can treat hyperlipidemia and atherosclerosis.

Preparation of Genistein Supplement

The invention discloses a method for extracting Genistein Supplement from Daye Qianjinba; the method has abundant and easy-to-obtain raw materials, simple and feasible process, less pollution, short cycle time, high purity product and easy large-scale preparation. Include the following steps:

(1) Mince the raw material Daye Jiba, and reflux extract it with an aqueous ethanol solution with a concentration of 50-70% for 1.5-5 hours to obtain an extract;

(2) Go to the chromatographic column after the extract obtained in step (1) is concentrated, and the stationary phase in the chromatographic column is a macroporous adsorption resin; the ethanol-water solution with a volume ratio of 15~25:85~75 is the mobile phase for washing Take off, collect the eluate;

(3) Concentrate the eluate obtained in step (2) to a thick extract, add ethanol containing 2 to 3% glacial acetic acid, fully dissolve, let stand, filter to remove insoluble matter, recrystallize the filtrate, and wash the crystals with ethanol , vacuum-dried to obtain Genistein Supplement.

The method can obtain high-purity genistin; without multiple separations and purifications, high-purity genistin can be obtained only by one macroporous adsorption resin column chromatography, and the method is simple to operate and has good reproducibility; only water, Ethanol and a small amount of glacial acetic acid save reagents, are low in cost, are safe and environmentally friendly, and are very suitable for large-scale and industrial production.

Detection Method of Genistein Supplement

Genistein Supplement compounds include a variety of members with highly diverse chemical structures and biological functions, such as glycitein, mangiferin, daidzin, and genistin. The main ingredient of soy isoflavones extracted from soybeans is Genistein Supplement. Genistin is one of the active ingredients of soybean isoflavones, which belongs to phytoestrogens structurally. Studies have found that genistein cannot be directly absorbed by the body, but is absorbed in the form of genistein after being hydrolyzed by enzymes in intestinal bacteria to exert biological activity. Genistein is more active than daidzein in many aspects.

CN201711287750.1 provides a method for detecting genistin in honey vinegar black beans. The method adopts methanol ultrasonic-assisted extraction method to extract genistin in honey vinegar black beans, and uses ultra-high performance liquid chromatography to detect its content, through the preparation of honey vinegar black soybean extract, standard solution preparation, and sample solution preparation and ultra-high performance liquid chromatography detection steps to obtain the content of genistin in honey vinegar black beans. Include the following specific steps:

S1. Preparation of honey vinegar black soybean extract: crush the dried honey vinegar black soybeans, sieve to obtain honey vinegar black soybean powder, add methanol solution A for ultrasonication, take the supernatant after centrifugation, concentrate the supernatant, and use methanol Solution B was made to a constant volume to obtain a genistin extract;

S2. Preparation of genistein standard solution: the genistein standard product was constant volume with methanol solution C, and ultrasonically treated to make Genistein Supplement standard mother liquor, and the genistein standard mother liquor was constant volume with methanol solution C to make genistein standard solution;

S3. Preparation of the sample solution: the genistin extract obtained in step S1 is made into a dilution with methanol solution C, passed through the filter membrane, and stored for later use;

S4. Detection by ultra-high performance liquid chromatography: the content of the sample obtained in step S3 is detected, and the mobile phase is pure methanol, glacial acetic acid and water to detect the content of genistin in the honey vinegar black soybean product.

Figure 1 is the UHPLC detection spectrum of the standard solution of Genistein Supplement 12.50 μg/L.

About Products:
If you need Genistein Supplement, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Genistein Supplement manufacturer and supplier, ZSpharmac will provide Genistein Supplement raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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