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Zhishang Chemical

Gardenia Extract CAS 92457-01-7

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Gardenia Extract Supplier

Product Name: Gardenia Extract
CAS No: 92457-01-7
Purity: 99%

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Basic Info

Product Name:Gardenia Extract
Other Names:Gardenia Jasminoides, Ext.
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
EINECS No.:296-280-9
Provide:Gardenia Extract MSDS;
Gardenia Extract COA

What is Gardenia Extract?

Gardenia remove is the fruit of Rubiaceae gardenia. Gardenia, also known as Mudan, Yuetao, Shanzhizi, Huangzhizi. It was first tape-recorded in “Shen Nong’s Materia Medica”. Harvest in autumn when the fruit is reddish-yellow, eliminate the stem contaminations, blanch in boiling water or vapor in a steamer until airy, obtain, and also dry in the sunlight or stove. It comes from the initial set of medical and also edible resources promoted by the Ministry of Health and wellness. It has the features of securing the liver, advertising gallbladder, reducing high blood pressure, soothing, stopping bleeding, and decreasing swelling. In conventional Chinese medicine, it is often used to deal with jaundice hepatitis, strains, hypertension, diabetic issues as well as other diseases.

Gardenia extract also contains high concentrations of flavonoids and ferulic acid (linked to ferulic acid), which act as antioxidants.

Chemical Constituents of Gardenia Extract

The fruit of Gardenia mainly contains iridoids, organic acids, pigments and triterpenes.
1. The iridoids mainly include: geniposide, hydroxygeniposide, and geniposide.
2. Organic acids are mainly: chlorogenic acid.
3. The main pigments are: saffron.
4. Triterpenes are mainly: ursolic acid.


Pharmacological Effects of Gardenia Extract

To study the choleretic effect of gardenia extract and the hepatoprotective effect on D-galactosamine (D-GLaN)-induced acute liver injury model mice, and found that gardenia extract may promote the biosynthesis of uridine phosphate in animals , Inhibit the combination of D-GLaN and uridine, promote the excretion of bile and protect the liver. Giving rats ig geniposide for 6 hours, it was found that geniposide could increase bile secretion in normal rats and rats with liver damage caused by isothiocyanate-1-naphthyl ester, indicating that it has choleretic effect.

C57BL/67 mice were fed high blood pressure for 4 weeks after a one-time injection of 90 mg/kg streptozotocin (STZ).

After 30 days of treatment with geniposide, the blood glucose level of the mice in the treatment group decreased, while the plasma insulin level increased, the oral glucose tolerance (OGTT) was improved, and the proliferation of pancreatic β cells was promoted. The mechanism of action was speculated It is related to promoting the proliferation of islet β cells and activating the Akt pathway downstream of the insulin receptor

Gardenia and its extracts have the effect of reducing pancreatic enzyme activity. Geniposide can significantly reduce pancreatic amylase, while its enzymatic hydrolysis product, genipin, has the strongest effect on increasing pancreaticobiliary flow, with a short duration. To investigate the effect of gardenia on the structure and function of pancreatic cells in severe acute pancreatitis and its relationship with nitric oxide (NO), endotoxin, and oxygen free radicals (OFR). , Lipid peroxide (LPO) was positively correlated with lysosome ACP release rate, and significantly negatively correlated with mitochondrial pancreatic cell mitochondrial succinate dehydrogenase (SDH) and microsomal cytochrome P450 levels, indicating that gardenia can reduce NO, Endotoxin, OFR damages the structure and function of pancreatic cells. It is suggested that Gardenia protects the normal structure and function of pancreatic subcellular organelles by eliminating oxygen free radicals of pancreatic subcellular organelles in severe acute pancreatitis, resisting lipid peroxidation.

To study the effect of geniposides (TGZ) on gastric ulcer in rats with pylorus ligation and preliminarily explore the mechanism of its anti-ulcer effect. amount, reduce the free acidity and total acidity in gastric juice, and effectively reduce the activity of pepsin in gastric juice. To study the protective effect of TGZ on the gastric mucosal injury induced by low-dose aspirin in rats, it was found that the gastric mucosal injury index of the rats after administration of TGZ was significantly lower than that of the model group, the local blood flow of the gastric mucosa was increased, and the infiltration of inflammatory cells in gastric tissue could be reduced at the same time. , significantly improved the histopathological changes of gastric mucosa, indicating that TGZ had a significant protective effect on gastric mucosal injury.

Gardenia decoction and alcohol extract have antihypertensive effect, which can be rapidly reduced by intravenous administration and last for a short time. The current research results show that the antihypertensive effect of gardenia is located in the center, mainly due to the enhancement of the excitability of the parasympathetic center in the medulla.

The effect of Zhizi Formula Granules on blood lipids and liver toxicity in normal Kunming mice was studied. The results showed that, compared with the blank group, the TG of each dose group of Zhizi Formula Granules was significantly reduced, and the body length of the mice in the 16g/kg Gardenia group was significantly reduced. increased, the Lee’s index decreased significantly, the liver index and AST content increased significantly, and the liver cells were significantly swollen and damaged

Dead, inflammatory cell infiltration, indicating that gardenia has a significant effect on reducing serum TG, but not on TC. Long-term low-dose administration of gardenia has no effect on the liver, but long-term high-dose administration can easily cause liver toxicity.

Geniposide can significantly improve the learning and memory ability of the simulated AD rat model injected with β-amyloid (Aβ) in the Y maze. Further, in the APPV717iAD transgenic mouse model, it was verified again that geniposide can increase APP/PSI small The density of dendritic spines in the AC1 area of ​​mice indicated that geniposide had an ameliorating effect on the pathological changes of dendritic spine loss in APP/PSI transgenic mice.

Clinical Research of Gardenia Extract

1. Antipyretic result: Gardenia preparation has antipyretic impact when taken by mouth. Its result is similar to that of Scutellaria baicalensis as well as Coptis chinensis, and it is mainly the result of preventing the fever facility.
2. Sedative impact: Pet experiments have proved that gardenia water extract as well as alcohol remove have substantial sedative effects when taken by mouth and also injected.
3. Antihypertensive effect: Gardenia water essence as well as alcoholic extract both have antihypertensive impact, and also their action time is longer.
4. Choleretic impact: Pet experiments have shown that gardenia water essence and alcoholic remove have significant choleretic impact. It can hinder the production of bilirubin in the blood. After ligation of the common bile air duct in rabbits, the remove of Gardenia jasminoides is taken by mouth, as well as the bilirubin in the blood will be significantly minimized. The greater the dosage, the extra significant the result.
5. Bacteriostasis: Artificial insemination tests have revealed that gardenia remove has inhibitory effects on Shigella, Staphylococcus aureus, and also Pseudomonas aeruginosa. It also has inhibitory result on some skin fungi.
6. Hemostatic result: Gardenia has the result of quiting blood loss. The hemostatic effect of raw gardenia is more powerful than that of burned gardenia, and it is mainly used for hemorrhaging because of heat syndrome.
7. Speed up wound healing: Apply the ointment made from gardenia extract and alcohol remove to the afflicted location, which can increase the recovery of soft tissue injuries.
8. Anti-cancer result: Pet experiments have actually confirmed that gardenia has the impact of inhibiting ascites cell growth.
9. Insecticidal effect: Gardenia decoction can eliminate adults of Schistosoma japonicum as well as Leptospira in vitro. Additionally, there are laxative, diuretic, anti-inflammatory and other effects.

Physical and Chemical Identification of Gardenia Extract

(1) Take 0.2 g of the powder of this product, add 5ml of water, warmth in a water bathroom for 3min, filter, take 5 decreases of the filtrate, evaporate to dry skin in an evaporating dish, include 1 decline of sulfuric acid, it will certainly appear blue-green, and quickly turn brown, and after that Transformed purple-brown.
( 2) Take 1 g of this item powder, include 10 ml of 75% ethanol, soak in a water bath for 2 hours, filter, and also the filtrate is made use of as the test remedy. Take one more Gardenia Extract referral material and include ethanol to make a 4mg/ml service as the recommendation compound service. Take 5 μl of each of the above two solutions and also detect them on the exact same silica gel G thin-layer plate respectively. Develop with ethyl acetate-acetone-formic acid-water (5:5:1:1), spray with sulfuric acid ethanol remedy (5 → 10), and also bake at 110 ° C for about 10min. The chromatogram of the examination item reveals spots of the exact same color at the setting representing the chromatogram of the recommendation product.

About Products:
If you need Gardenia Extract, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Gardenia Extract manufacturer and supplier, ZSpharmac will provide Gardenia Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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