Gardenia Extract CAS 92457-01-7

To study the choleretic effect of gardenia extract and the hepatoprotective effect on D-galactosamine (D-GLaN)-induced acute liver injury model mice, and found that gardenia extract may promote the biosynthesis of uridine phosphate in animals , Inhibit the combination of D-GLaN and uridine, promote the excretion of bile and protect the liver. Giving rats ig geniposide for 6 hours, it was found that geniposide could increase bile secretion in normal rats and rats with liver damage caused by isothiocyanate-1-naphthyl ester, indicating that it has choleretic effect.

C57BL/67 mice were fed high blood pressure for 4 weeks after a one-time injection of 90 mg/kg streptozotocin (STZ).

After 30 days of treatment with geniposide, the blood glucose level of the mice in the treatment group decreased, while the plasma insulin level increased, the oral glucose tolerance (OGTT) was improved, and the proliferation of pancreatic β cells was promoted. The mechanism of action was speculated It is related to promoting the proliferation of islet β cells and activating the Akt pathway downstream of the insulin receptor

Gardenia and its extracts have the effect of reducing pancreatic enzyme activity. Geniposide can significantly reduce pancreatic amylase, while its enzymatic hydrolysis product, genipin, has the strongest effect on increasing pancreaticobiliary flow, with a short duration. To investigate the effect of gardenia on the structure and function of pancreatic cells in severe acute pancreatitis and its relationship with nitric oxide (NO), endotoxin, and oxygen free radicals (OFR). , Lipid peroxide (LPO) was positively correlated with lysosome ACP release rate, and significantly negatively correlated with mitochondrial pancreatic cell mitochondrial succinate dehydrogenase (SDH) and microsomal cytochrome P450 levels, indicating that gardenia can reduce NO, Endotoxin, OFR damages the structure and function of pancreatic cells. It is suggested that Gardenia protects the normal structure and function of pancreatic subcellular organelles by eliminating oxygen free radicals of pancreatic subcellular organelles in severe acute pancreatitis, resisting lipid peroxidation.

To study the effect of geniposides (TGZ) on gastric ulcer in rats with pylorus ligation and preliminarily explore the mechanism of its anti-ulcer effect. amount, reduce the free acidity and total acidity in gastric juice, and effectively reduce the activity of pepsin in gastric juice. To study the protective effect of TGZ on the gastric mucosal injury induced by low-dose aspirin in rats, it was found that the gastric mucosal injury index of the rats after administration of TGZ was significantly lower than that of the model group, the local blood flow of the gastric mucosa was increased, and the infiltration of inflammatory cells in gastric tissue could be reduced at the same time. , significantly improved the histopathological changes of gastric mucosa, indicating that TGZ had a significant protective effect on gastric mucosal injury.

Gardenia decoction and alcohol extract have antihypertensive effect, which can be rapidly reduced by intravenous administration and last for a short time. The current research results show that the antihypertensive effect of gardenia is located in the center, mainly due to the enhancement of the excitability of the parasympathetic center in the medulla.

The effect of Zhizi Formula Granules on blood lipids and liver toxicity in normal Kunming mice was studied. The results showed that, compared with the blank group, the TG of each dose group of Zhizi Formula Granules was significantly reduced, and the body length of the mice in the 16g/kg Gardenia group was significantly reduced. increased, the Lee’s index decreased significantly, the liver index and AST content increased significantly, and the liver cells were significantly swollen and damaged

Dead, inflammatory cell infiltration, indicating that gardenia has a significant effect on reducing serum TG, but not on TC. Long-term low-dose administration of gardenia has no effect on the liver, but long-term high-dose administration can easily cause liver toxicity.

Geniposide can significantly improve the learning and memory ability of the simulated AD rat model injected with β-amyloid (Aβ) in the Y maze. Further, in the APPV717iAD transgenic mouse model, it was verified again that geniposide can increase APP/PSI small The density of dendritic spines in the AC1 area of ​​mice indicated that geniposide had an ameliorating effect on the pathological changes of dendritic spine loss in APP/PSI transgenic mice.