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Zhishang Chemical

Gamma Valerolactone CAS 108-29-2

Molecular Formula: C5H8O2

Formula Weight: 100.12

ZSpharmac: Gamma Valerolactone Supplement

Product Name: Gamma Valerolactone
CAS No: 108-29-2
Purity: 99%

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Basic Info

Product Name:Gamma Valerolactone
Other Names:Y-Valerolactone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:203-569-5
Storage:Sealed in Dry,Room Temperature
Provide:Gamma Valerolactone MSDS;
Gamma Valerolactone COA

What is Gamma Valerolactone?

Gamma Valerolactone is frequently known as octadecanal, coconut aldehyde, as well as its chemical name is γ-nonolactone. It is a light yellow or anemic oily liquid. It has coconut scent when it is thick, as well as almond or peach bloom scent when thinned down. It can be used basically that need oily odor as well as lots of flavor essences, such as coconut and almond significances. It is the main lactone scent made use of in food and also state-of-the-art cosmetics. It is refined as well as prepared from heptanal acquired by fracturing castor oil at home and abroad. The raw products of this technique are pricey, the manufacturing procedure is complicated, and also the expense is high. With the growth of petrochemical industry, the new route of synthesizing alkylγ-lactones from olefins is increasingly remarkable, which not just might reduce manufacturing expenses, however additionally may change imported seasonings with domestic items. Saturated lactones are an extremely important course of edible tastes, which naturally exist in various fruits, and are currently widely made use of in the formula of edible tastes such as different beverages and also baked goods. γ-Lactones are a class of lactone substances obtained by the lactonization of γ-hydroxycarboxylic acids. They are abundant in milky and also fruity fragrances, and have the features of durable fragrance and also rounded aroma. Gamma Valerolactone is a common substance in γ-lactone, with coconut scent and also oily scent, which can be made use of in flavors and flavors (such as coconut as well as almond flavors) that call for oily fragrance.

Gamma Valerolactone Property

Melting point 

−31 °C(lit.)

Boiling point 

207-208 °C(lit.)


1.05 g/mL at 25 °C(lit.)

vapor density 

3.45 (vs air)

refractive index 

n20/D 1.432(lit.)


204.8 °F

storage temp. 

Sealed in dry,Room Temperature


Chloroform, Methanol




Clear colorless


7 (H2O, 20℃)

Water Solubility 



Gamma Valerolactone Uses

  1. Gamma Valerolactone is a naturally occurring chemical in fruit that is often used as a food additive. It can be converted into liquid olefins, which can be used as transportation fuel.
  2. Gamma Valerolactone is GB 2760–1996 stipulates that the edible spice is allowed to be used. Mainly used to prepare peach, coconut, vanilla and other flavors.
  3. Gamma Valerolactone has strong reactivity and can be used as a resin solvent and an intermediate for various related compounds. Also used as lubricants, plasticizers, gelling agents for non-ionic surfactants, lactone additives for leaded gasoline, and for dyeing cellulose esters and synthetic fibers. Gamma-valerolactone has vanillin and coconut aromas.

Preparation Method of Gamma Valerolactone

For a long time, the synthesis of Gamma Valerolactone at home and abroad has adopted the condensation reaction of heptanal and malonic acid to generate noneenoic acid, which is then prepared by heating cyclization with HY molecular sieve or sulfuric acid as the lactating agent. This method is synthesized in two steps, the yield of next nonolactone is only about 52%, there are many side reactions, the product quality is unstable, and the energy consumption is large. In recent years, solid strong bases can make such reactions carry out highly active catalytic reactions under mild conditions, which not only saves energy, but also reduces environmental pollution, which is in line with the research direction of green chemistry. of attention.

(1) A new process for the one-step catalytic synthesis of gamma nonolactone using a solid strong base supported by organic barium phosphate as a condensation catalyst

In a 50mL dry three-necked flask equipped with a stirrer, a thermometer, a reflux condenser and a dropping funnel, add 1.4-dioxane, malonic acid and a solid strong base (barium polyvinylpolyaminoethylphosphonate- KOH-K), stir slowly to dissolve malonic acid completely, and add freshly distilled heptanal dropwise within 30 min at 40-50 °C. Start heating to make the reaction temperature between 75-85 ℃, and react for about 1 h until no more carbon dioxide is released. Then it was raised to a constant temperature for reaction, and the reaction was continued for a period of time. After the completion of the reaction, suction filtration while hot to recover the catalyst, the filtrate is naturally cooled to room temperature, and 100 ml of 10% KOH solution is added to the reactant under stirring. After separating the organic layer, the aqueous phase was extracted twice with 50 mL of 1.4-dioxane, the 1.4-dioxane extract was combined with the organic layer, washed with water until neutral, and dried with anhydrous sodium sulfate. Atmospheric distillation recovered 1.4-dioxane, then vacuum distillation, collected Gamma Valerolactone at 123-128℃(800pa).


2) There are four main methods for synthesizing alkyl γ-lactones from α-olefins:

1. α-heptene reacts with sodium hypochlorite in the presence of chlorourea to obtain amyl chloroethanol, which is then reacted with calcium hydroxide to obtain amyl oxirane, which is reacted with sodium malonate and then hydrolyzed , heating to generate gamma non-lactone.

2. Using high-valent acetate such as cerium and vanadium or manganese acetate as oxidant, it is prepared by the reaction of α-heptene and acetic acid

3. Using bromoacetic acid and α-olefin as raw materials, using benzoyl peroxide as catalyst, through free radical reaction, it is prepared under mild conditions. This method has a higher yield.

4. Slowly add octene to the acetic acid heterogeneous mixture of potassium peroxodisulfate, fatty acid potassium and basic ferric acetate at 120-140 ° C, to obtain lactone with a yield of 65% after the reaction, and the olefin conversion rate is 49 % .

Summarize above 4 kinds of routes in the 1st method reaction process is complicated, the raw material consumption is more, and some are not easy to obtain; The shortcoming of the 3rd method is that bromoacetic acid is difficult to prepare and the price is higher; The shortcoming of the 4th method is the potassium peroxodisulfate value high and complex. Therefore, the second route is adopted. The advantages of this method are that the raw materials are cheap and easy to obtain, the reaction steps are few, and the industrialization is possible.

Product Identification of Gamma Valerolactone

Determination of Gamma Valerolactone in Coconut Milk by Dispersive Solid Phase Extraction-HPLC- MS/MS

As a general extraction solvent, acetonitrile has been widely used in residue detection. Because it is difficult to extract sugar and protein compounds, it has a higher recovery rate for gamma nonolactone. Acetonitrile is used as the extraction reagent, and the maximum Minimize the extraction of Gamma Valerolactone from coconut water and make the extract less interfering.

The samples to be tested were directly extracted with acetonitrile, dispersive solid-phase extraction with PSA, scanned in positive ion mode with electrospray ionization (ESI) and multiple reaction monitoring, and selected m/z 157.1/139.1 and m/z 157.1/121.1 as the internal Qualitative and quantitative transitions of esters, quantitative external standard method. In the range of 0.025 μg/m L~0.50 μg/m L, there was a good linear relationship between the concentration and the peak area. The detection limit of the instrument was 0.025 μg/m L, and the detection limit of the method was 0.10 mg/kg. The limit of quantification was 0.40 mg/kg, and the average recoveries of propyl-nononolactone at dosage levels of 0.10, 0.20, and 0.40 mg/kg ranged from 92.4 % to 98.4 %, respectively, with the relative standard deviations of 6.8 % to 7.6 % (n= 10).

The method for the determination of Gamma Valerolactone content is simple, fast, easy to operate, accurate, high sensitivity, good reproducibility, low detection limit, and has strong practicability.


Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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