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Gallic Acid Sigma CAS 149-91-7

Molecular Formula: C7H6O5

Formula Weight: 170.12

ZSpharmac: Gallic Acid Sigma Supplement

Product Name: Gallic Acid Sigma
CAS No: 149-91-7
Purity: 99%

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Basic Info

Product Name:Gallic Acid Sigma
Other Names:Gallic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:Off-White Powder
EINECS No.:205-749-9
Provide:Gallic Acid Sigma MSDS;
Gallic Acid Sigma COA

What is Gallic Acid Sigma ?

Gallic Acid Sigma itself has a substantial antioxidant effect, and in addition has great deals of influences such as anti-tumor, eliminating trypanosomes, securing the liver and also anti-hepatitis B infection; current studies have actually pointed out that Gallic Acid Sigma may be Pu-erh tea to hinder the synthesis of cholesterol in HepG2 cell lines. one of the active components. On the basic level, the content of gallic acid (9.01 mg/g) in Pu-erh tea is more than that of other herbal medications. In this feeling, gallic acid is among the essential physiologically active components of Pu-erh tea.

Gallic Acid Sigma Properties:

Melting point 251 °C (dec.) (lit.)
Boiling point 259.73°C (rough estimate)
density 1.694
refractive index 1.5690 (estimate)
storage temp. 2-8°C
solubility Methanol (Slightly), Water (Slightly, Heated)
pka4.41(at 25℃)
form Powder
color Off-white
PH3.75(1 mM solution);3.22(10 mM solution);2.71(100 mM solution)
Water Solubility 12 g/L cold water


Gallic Acid Sigma Uses

  1. Gallic Acid Sigma is antibacterial and also treats bacillary dysentery. Has astringent, hemostasis and also antidiarrheal impacts. Can be utilized as a preservative. It can prepare pyrogallic acid, medication, ink, mordant color and explosion-proof agent, and so on. It is additionally used as a designer and an analytical reagent for the discovery of free inorganic acids, dihydroxyacetone, alkaloids as well as metals.
  2. Gallic Acid Sigma can be utilized as a chemical, can prepare mordant and anti-explosion agent, and so on.
  3. Gallic Acid Sigma was utilized as chemical reagent.
  4. Gallic Acid Sigma is primarily made use of as a coupler for blue-black inks. In the pharmaceutical industry, it is utilized for the preparation of sulfa synergist TMP and as an intensifying agent for sulfa drugs such as SMZ and also SD B. The food market is used to prepare the preservative propyl gallate. The protection industry is used to prepare explosion-proof representatives. Additionally, it can likewise be used for the production of mordant dyes and also as a designer.
  5. Gallic Acid Sigma is made use of as a depolarizer in electrochemical analysis; for the decrease of phosphomolybdic acid; for the resolution of antimony, barium, bismuth, calcium, cerium and also copper, etc; for the determination of phosphorus, nitrite, silver, thorium and titanium Wait.
  6. Gallic Acid Sigma is a water-soluble phenolic acid located in grapes and the leaves of many plants and is a powerful in vitro anti-oxidant.

Gallic Acid Sigma Production Method

The production of gallic acid by acid method and alkali hydrolysis is the two most commonly used production methods at present. The acid method is to directly hydrolyze the tannins in gallnut with sulfuric acid. Good, but the product contains a small amount of sulfate ions, the production is difficult to control, and it is prone to excessive hydrolysis. The hydrolyzed Gallic Acid Sigma acts to generate pyrogallic acid and other substances, resulting in an increase in the solubility of Gallic Acid Sigma, a darker color, and a decrease in yield. .

Alkaline method: It uses sodium hydroxide to act on the tannins in Galla japonica. The product has low purity, weak Gallic Acid Sigma activity, easily contains unhydrolyzed tannins, and has many auxiliary equipment and a long production cycle. SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a Gallic Acid Sigma production technology which can improve the production quality of Gallic Acid Sigma, increase the yield, and solve the defect of unstable product performance in the prior art.

The technical scheme that the present invention solves its technical problem adopts: a kind of buffer solution hydrolysis Gallic Acid Sigma production technique, it is characterized in that: comprise the following steps:

5) pulverize the gall;

6) in the enamel reaction kettle, add NaH PO Solution;

7) Add gall powder under stirring and stir well;

8) slowly add H SO Make pH value 1-2; Add steam 0.15MPA and be warming up to 120 DEG C, regulate and keep the pH=1-2 of mixture. Reaction times 2-4 hours, after reaction finishes cooling crystallization: filter, Dehydration, decolorization, filtration, crystallization, dehydration, and drying are performed to obtain the finished product.

The reaction conditions of the present invention are mild, and can effectively solve the improper control in the hydrolysis process using pure concentrated sulfuric acid, which is prone to excessive hydrolysis, and the problems of carbonization and other impurities. cycle, reduce the loss of gallic acid caused by excessive solid hydrolysis and activated carbon adsorption, improve the yield of Gallic Acid Sigma, and reduce production costs.

Active Factors in Pu'er Tea - Gallic Acid Sigma

In the 35 Yunnan Pu-erh tea samples tested, the content of gallic acid ranged from 1.608 mg/g to 20.72 mg/g, with an average content of 9.01 mg/g. The average content of Gallic Acid Sigma in Pu-erh tea is relatively high, with 16 samples (accounting for 45.71% of the total samples) containing more than 10 mg/g; 1.608=12.88).
During the piling process, the fermentation of microorganisms played a decisive role in the formation of the quality of Yunnan Pu-erh tea, and produced some aromatic compounds that affected the quality and flavor of Pu-erh tea. Studies have found that some microorganisms can effectively degrade hydrolyzed tannins and promote the formation of Gallic Acid Sigma. Therefore, the content of gallic acid in Pu-erh tea has a certain relationship with the ability of the microbial population to degrade hydrolyzed tannins. Due to the differences in microbial population and quantity in the post-fermentation process, in addition, the activity of microorganisms will be affected by many factors such as the climatic conditions of the production area, the temperature and humidity of the heap, and the turning time, resulting in many problems in the post-fermentation process of Pu-erh tea. All factors may lead to differences in the chemical composition of Gallic Acid Sigma and other inclusions among Pu-erh tea samples.

The Gallic Acid Sigma content changed obviously during the piling process of sun-dried green tea. The gallic content in the raw materials of sun-dried tea from four different origins is not much different (about 5 mg/g). Compared with the raw materials of sun-dried tea, the content of gallic acid in the finished products of Baoshan and Lincang’s Chudui Pu’er teas increased significantly, which is consistent with the research reports in the literature; while the content of gallic acid in the finished products of Wenshan and Dali’s Chudui Pu’er teas was different from that of the raw materials. Not much. Although the increase of gallic acid was the most obvious after the first doubling of the sun-dried green tea raw materials from the four origins, it was found in the test that the raw materials of the sun-dried hair tea from Baoshan and Lincang could still increase by 60.97% and 16.67% respectively after the second doubling. The possible reason for the increase of Gallic Acid Sigma content in the early stage of the piling process is that, on the one hand, the gallic tannin contained in the sun-dried green tea is decomposed under the action of tannase secreted by microorganisms, resulting in the production of gallic acid. On the other hand, although most catechins undergo oxidative polymerization, a small number of ester catechins (such as EGCG) may also undergo hydrolysis to produce Gallic Acid Sigma; the combined effect of these two aspects may lead to an increase in the content of gallic acid. high.

Gallic Acid Sigma itself has a significant antioxidant effect, and also has many effects such as anti-tumor, killing trypanosomes, protecting the liver and anti-hepatitis B virus. Recent studies have pointed out that gallic acid may be an effective effect of Pu-erh tea in inhibiting the synthesis of cholesterol in HepG2 cell lines. one of the ingredients. On the general level, the content of gallic acid (9.01 mg/g) in Pu-erh tea is higher than that of other herbal medicines. In this sense, Gallic Acid Sigma is one of the important physiologically active components of Pu-erh tea.
However, in cell experiments, there are some components with strong antioxidant activity (such as PE8 component) that do not contain Gallic Acid Sigma. Therefore, there may be some potential unidentified special components in Pu-erh tea, such as derivatives of gallic acid and secondary metabolites of microorganisms, which play a more important role than Gallic Acid Sigma. Proving the existence of these components and isolating and identifying the structures of these compounds are urgent problems to be solved at present.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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