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Fucoxanthin CAS 3351-86-8

Molecular Formula: C42H58O6

Formula Weight: 658.91

ZSpharmac: Fucoxanthin Cosmetic Raw Material Suppliers

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Product Name: Fucoxanthin
CAS No: 3351-86-8
Purity: 99%

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Basic Info

Product Name:Fucoxanthin
Other Names:Fucoxanthin solution
CAS:3351-86-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Crystalline Neat
EINECS No.:200-486-6
Storage:-20°C
Provide:Fucoxanthin MSDS;
Fucoxanthin COA

What is Fucoxanthin?

Fucoxanthin, also known as fucoxanthin and fucoxanthin, is an all-natural pigment of the lutein class among carotenoids, representing more than 10% of the complete amount of approximately 700 naturally taking place carotenoids.It has pharmacological outcomes such as anti-tumor, anti-inflammatory, antioxidant, weight-loss, nerve cell defense, increasing the web material of ARA (arachidonic acid) and DHA (docosahexaenoic acid) in computer mice, and is made use of as a medication, skin therapy and allure item It is extensively utilized in products and healthcare products market.

Fucoxanthin Property

Melting point 166-168°C
alpha D18 +72.5 ±9° (chloroform)
Boiling point 590.43°C (rough estimate)
density 1.09
refractive index n20/D1.360-1.362
Fp 14℃
storage temp. -20°C
solubility Ethanol,
pka14.47±0.60(Predicted)
form neat
color Crystalline

 

Fucoxanthin Application

1. Along with being used as a weight loss health item, it can additionally be applied to numerous foods, such as butter, pies, eco-friendly tea cakes and various other baked items, to boost the shade and capability of the product.
2. Made use of as egg yolk colorant.
3. Skin care and charm items.
4. As medicine, used for the treatment of skin cancer cells, colon cancer cells, prostate cancer cells, liver cancer cells and various other cancers cells.

Fucoxanthin Pharmacological Effects

( 1) Skin cancer cells fucoxanthin can prevent the enhanced task of computer mouse skin ornithine decarboxylase induced by the strong skin cancer marketer tetradecanoylphorbol-13-acetate (TPA), while chocolate hinders TPA-induced activation of human herpesvirus, thus inhibiting TPA-induced skin tumors.
( 2) Colon cancer cells fucoxanthin has a repressive result on the formation of duodenal cancer cells caused by N-ethyl-N’- nitro-N-nitrosoguanidine. Fucoxanthin can dramatically hinder the growth of colon cancer cells cell lines, consisting of Caco-2, HT-29 and DLD-1. Generates DNA fragmentation in colon cancer cells, advertises cell apoptosis, and prevents the expression of apoptosis-related protein Bcl-2. Fucoxanthin can inhibit the expansion of human colon cancer cells cell line WiDr in a dose-dependent fashion, arrest the cell cycle in the G0/G1 phase, and induce apoptosis.
( 3) The effect of hematological growth fucoxanthin on severe myeloid leukemia HL-60 cell line. Fucoxanthin can significantly inhibit the expansion of HL-60 cells. Results of fucoxanthin on adult T lymphocyte leukemia. Fucoxanthin and its metabolite fucoxanthinol can prevent the survival of T cells contaminated by human T-celllymphotropic infection kind 1 (HTLV-1) and grown-up T-cell leukemia cells.
( 4) Prostate cancer cells fucoxanthin can dramatically lower the survival rate of prostate cancer cells and generate cell apoptosis. Both fucoxanthin and its metabolite fucoxanthinol can inhibit the proliferation of PC-3 cells, activate Caspase-3 and induce apoptosis.
( 5) Liver cancer fucoxanthin has a repressive result on the growth of human liver cancer cells HepG2 cells. It can obstruct the cells in the G0/G1 phase and prevent the phosphorylation of Rb protein Ser780 site.

Fucoxanthin has excellent antioxidant results, even far better than vitamin E and vitamin C. Fucoxanthin has a protective effect on human fiber cell damage caused by UV-B. The antioxidant result of fucoxanthin is mostly with managing the task of Na+- K+- ATPase, as well as the task of catalase and glutathione in tissues and molecules brought on by retinol shortage.

Fucoxanthin has a repressive impact on the infiltration of endotoxin-induced inflammatory mediators in a dose-dependent way. Its anti-inflammatory impact approaches that of prednisolone, indicating that fucoxanthin has a repressive result on endotoxin-induced swelling in mice., NO, PGE2 and lump death aspect have particular repressive results. Its anti-inflammatory effect is primarily through inhibiting the inflammatory reaction NO leak triggered by lipopolysaccharide-induced macrophages. RT-PCR evaluation showed that the mRNA of NO synthase and cyclooxygenase were inhibited by fucoxanthin, and, Growth death factor, leukocyte middlemans IL-1β and IL-6, and mRNA survivin expression were all inhibited by fucoxanthin in a dose-dependent fashion. These outcomes indicate that fucoxanthin might have various inflammatory feedbacks. plays a vital duty.

Fucoxanthin can remove fat build-up in two means. Fucoxanthin activates a protein called UCP1, which promotes lipolysis. It additionally stimulates the liver to produce DHA, which reduces cholesterol degrees.

Sea urchins eat algae and have fucoxanthin, which has a considerable effect on the phagocytosis capacity and ovulation of macrophages.

Fucoxanthin Extraction and Isolation Method

Fucoxanthin is an all-natural carotenoid. It is insoluble in very polar solvents such as water under neutral conditions and is easily soluble in non-polar organic solvents. It is a fat-soluble pigment. To draw out pigments from dry powder, a percentage of little polar solvent is contributed to a non-polar solvent.
1. Removal process of fucoxanthin in kelp: use anhydrous ethanol-acetone-petroleum ether (4:1:1) composite solvent as the extraction agent, essence two times at a material-to-liquid proportion of 40:1 and 40 ° C, each time times 1h. After the removed essence is saponified, fucoxanthin and fucosterol are divided and detoxified making use of silica gel column chromatography to obtain a high-purity item with a pureness of 91.6%.
2. The extraction procedure of fucoxanthin in hijiki: 90% ethanol-acetone (3:1) composite solvent is made use of as the extraction agent, and the liquid-to-material proportion is 40:1, and the ultrasonic temperature is 65 ° C. The water bathroom is oscillated and extracted two times, each time 80min, the removal rate got to 1.067 mg · g-1.
3. The extraction procedure of fucoxanthin in Un-dariapinnatifida: 3% methanol is made use of as the entrainer, the pressure is 200dN/mm2, and the temperature is 323K. Or make use of ethanol as the entraining agent and usage supercritical CO2 to remove fucoxanthin from kelp origins, and acquire an unrefined extract with a purity of 5%.

About Products:
If you need Fucoxanthin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced Fucoxanthin manufacturer and supplier, ZSpharmac will provide Fucoxanthin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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