Fucoxanthin CAS 3351-86-8

( 1) Skin cancer cells fucoxanthin can prevent the enhanced task of computer mouse skin ornithine decarboxylase induced by the strong skin cancer marketer tetradecanoylphorbol-13-acetate (TPA), while chocolate hinders TPA-induced activation of human herpesvirus, thus inhibiting TPA-induced skin tumors.
( 2) Colon cancer cells fucoxanthin has a repressive result on the formation of duodenal cancer cells caused by N-ethyl-N’- nitro-N-nitrosoguanidine. Fucoxanthin can dramatically hinder the growth of colon cancer cells cell lines, consisting of Caco-2, HT-29 and DLD-1. Generates DNA fragmentation in colon cancer cells, advertises cell apoptosis, and prevents the expression of apoptosis-related protein Bcl-2. Fucoxanthin can inhibit the expansion of human colon cancer cells cell line WiDr in a dose-dependent fashion, arrest the cell cycle in the G0/G1 phase, and induce apoptosis.
( 3) The effect of hematological growth fucoxanthin on severe myeloid leukemia HL-60 cell line. Fucoxanthin can significantly inhibit the expansion of HL-60 cells. Results of fucoxanthin on adult T lymphocyte leukemia. Fucoxanthin and its metabolite fucoxanthinol can prevent the survival of T cells contaminated by human T-celllymphotropic infection kind 1 (HTLV-1) and grown-up T-cell leukemia cells.
( 4) Prostate cancer cells fucoxanthin can dramatically lower the survival rate of prostate cancer cells and generate cell apoptosis. Both fucoxanthin and its metabolite fucoxanthinol can inhibit the proliferation of PC-3 cells, activate Caspase-3 and induce apoptosis.
( 5) Liver cancer fucoxanthin has a repressive result on the growth of human liver cancer cells HepG2 cells. It can obstruct the cells in the G0/G1 phase and prevent the phosphorylation of Rb protein Ser780 site.

Fucoxanthin has excellent antioxidant results, even far better than vitamin E and vitamin C. Fucoxanthin has a protective effect on human fiber cell damage caused by UV-B. The antioxidant result of fucoxanthin is mostly with managing the task of Na+- K+- ATPase, as well as the task of catalase and glutathione in tissues and molecules brought on by retinol shortage.

Fucoxanthin has a repressive impact on the infiltration of endotoxin-induced inflammatory mediators in a dose-dependent way. Its anti-inflammatory impact approaches that of prednisolone, indicating that fucoxanthin has a repressive result on endotoxin-induced swelling in mice., NO, PGE2 and lump death aspect have particular repressive results. Its anti-inflammatory effect is primarily through inhibiting the inflammatory reaction NO leak triggered by lipopolysaccharide-induced macrophages. RT-PCR evaluation showed that the mRNA of NO synthase and cyclooxygenase were inhibited by fucoxanthin, and, Growth death factor, leukocyte middlemans IL-1β and IL-6, and mRNA survivin expression were all inhibited by fucoxanthin in a dose-dependent fashion. These outcomes indicate that fucoxanthin might have various inflammatory feedbacks. plays a vital duty.

Fucoxanthin can remove fat build-up in two means. Fucoxanthin activates a protein called UCP1, which promotes lipolysis. It additionally stimulates the liver to produce DHA, which reduces cholesterol degrees.

Sea urchins eat algae and have fucoxanthin, which has a considerable effect on the phagocytosis capacity and ovulation of macrophages.