Zhishang Chemical

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Frolisin CAS 7061-54-3

Molecular Formula: C21H24O10

Formula Weight: 436.41

ZSpharmac: Frolisin Supplement

Product Name: Frolisin
CAS No: 7061-54-3
Purity: 99%

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Basic Info

Product Name:Frolisin
Other Names:Phlorizin Dihydrate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystal Powder
EINECS No.:628-113-6
Storage:Inert Atmosphere,2-8°C
Provide:Frolisin MSDS;
Frolisin COA

What is Frolisin?

Frolisin is also called phlorizin, yellow-colored needle-like crystals, soluble in hot water, ethanol, methanol, amyl alcohol, acetone, ethyl acetate, pyridine, glacial acetic acid, and so on, insoluble in ether, chloroform and also benzene. Phloridzin has been reported to have antitumor activity, has a therapeutic result on skin cancer cells, and is made use of in face products to hinder the development of melanin and lighten the shade of dark brown, gray areas and also blemishes.

Frolisin is a natural product discovered in numerous fruit trees, including the root bark, shoots, leaves, as well as ripe or immature fruits of vegetables and fruits. Research studies have actually shown that Frolisin make up 95% of the total web content of phenolic compounds in apple trees, and also its content is so high that its presence can affect the overall presence of identified substances. It is investigated utilizing apples, apple bark as well as leaves as basic materials. Phloridzin is a glycoside formed by integrating phloretin as well as a glycoside with glucoside, and the glycosyl hydrolysis to develop sugar, combined with high web content, is taken into consideration by several scholars to be a storage form of carbohydrates. Current professional research studies in the house and abroad have revealed that Frolisin has an excellent impact in the treatment of diabetes mellitus.

Frolisin Properties

Melting point 113-114 °C(lit.)
alpha -52 º (c=3, EtOH)
storage temp. Inert atmosphere,2-8°C
form neat


Frolisin Uses

  1. Frolisin is used to induce experimental diabetes.

Preparation of Frolisin

(1) Extract:
The raw material of apple root bark is pulverized to obtain a pulverized product, and the pulverized product is extracted with purified water in an amount of 3-10 times the mass of the raw material of apple root bark, wherein the purified water is added with 0.1%-2% of alkalinity by mass. Reagent, extract 1-3 times, the temperature is 20℃-70℃, and the extraction time is 1-3 hours. The alkaline reagent is sodium hydroxide, potassium hydroxide, sodium bicarbonate or sodium carbonate. The optimal extraction conditions were 8 times the amount, the temperature was 55°C, and the extraction time was 2h, twice. The best alkaline reagent is sodium carbonate, accounting for 1% of the purified water mass.

(2) Concentration:
The obtained extract is concentrated to obtain an extract, the specific gravity of the extract is 0.90-1.08, and filtered to obtain a filtrate. The optimum specific gravity is 1.03.

(3) Acid regulation
The obtained filtrate is adjusted to pH=2-7 with acid water, left standing, and centrifuged to obtain a precipitate and a supernatant, and the precipitate is a phlorizin product; the acid water is hydrochloric acid, sulfuric acid, formic acid or acetic acid; the best Using hydrochloric acid, the optimum pH is 4.

(4) Recrystallization
Dissolve the precipitate obtained in the third step with 1-10 times the amount of pure water, add 1%-20% of the weight of the precipitate to decolorize for 0.5h-4h, the decolorization temperature is 30-80 ℃, filter, place at room temperature for crystallization, suction filtration, Vacuum dry. The purity of the obtained product florixin is greater than 98%. The decolorizing agent is selected from activated carbon, activated clay, activated magnesium oxide or diatomaceous earth.

Inhibitory Activity of Frolisin Analogs

Plant-derived 7,8-dihydrochalcone phloretin as well as high molecular weight (less than 15,000) poly-Frolisin phosphate (PPP) polymers are iodothyronine monodeiodinase activity in rat liver microsomal prep work A potent inhibitor of Frolisin, 2′- O-glucoside phloretin, was inactive. Polymers with varying levels of phosphorylation-dependent polymerization showed concentration-dependent and ultimately total restraint of deiodinase task with IC50s between 0.2 as well as 0.5 μg PPP/ml. On the other hand, Frolisin restraint is cofactor (DTE) affordable with Ki = 0.75 microM. 2′,4′,6′,3,4- Pentahydroxychalcone, with the very same replacement pattern in the A ring as phloretin, is the just energetic inhibitor (IC50 = 8 microM) of a number of derivatives examined. Frolisin biodegradation products, phloric acid and also phloroglucinol and also their biosynthetic precursors, monomeric cinnamic acid and also cinnamic acid by-products, are inactive at concentrations approximately 100 microM. Evaluation of the X-ray crystal framework of Frolisin dihydrate revealed that the molecule is planar and totally prolonged, comparable to the conformation observed in the chalcone framework, characterized by the visibility of α, β-unsaturated bonds between the phenol rings. Contrast of planar Frosin crystal frameworks with oblique or anti-tilted thyroid hormonal agent conformations revealed that the β-D-glucose moiety did not share any type of thyroid hormone conformational space and also located the best structural homology with the 3′ anti-tilted conformation,5 ‘,3- Triiodothyronine,.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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