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Zhishang Chemical

Forskolin Solgar CAS 66575-29-9

Molecular Formula: C22H34O7

Formula Weight: 410.5

ZSpharmac: Methylglyoxal Miel Supplement

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Product Name: Forskolin Solgar
CAS No: 66575-29-9
Purity: 99%

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Basic Info

Product Name:Forskolin Solgar
Other Names:Forskolin, 98%, From Coleus Forskohlii
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:Off-White Powder
EINECS No.:266-410-9
Storage:Room Temp
Provide:Forskolin Solgar MSDS;
Forskolin Solgar COA

What is Forskolin Solgar?

Coleusforskohlii (wild) Briq belongs to the genus Coleus of the Lamiaceae family. Coleus is a genus of about 90 species, mainly produced in India and Yunnan in my country. Forskolin Solgar (FSK) and Isofskolin (ISOF) are mainly monomeric compounds obtained from Coleus forskolin after extraction, separation and purification. The dicuminoid compounds extracted from the root of Coleus forskohlii have cardiotonic, antihypertensive, antiasthmatic, anti-inflammatory, antiplatelet aggregation, antitumor growth, and intraocular pressure (IOP) lowering effects. Studies have shown that FSK directly stimulates adenylate cyclase (AC ) to increase the concentration of cyclic adenosine monophosphate (cAMP ) in cells of various tissues, thereby participating in the regulation of various cellular functions and has a wide range of regulatory effects in vivo. In China, the extraction and activity identification of FSK and its analogs began in the 1980s, especially after the Kunming Institute of Botany of the Chinese Academy of Sciences extracted FSK analogs from the Coleus forskolin plant in Yunnan, the research on FSK. Continue to expand and deepen.

Forskolin Solgar Properties:

Melting point 282-232 °C
alpha D25 -26.19° (c = 1.68 in CHCl3)
Boiling point 520℃
density 1.23
refractive index 1.5300 (estimate)
Fp 172℃
storage temp. room temp
solubility DMSO: 5 mg/mL stable at least 6 months at room temperature
form powder
color off-white
Water Solubility Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.


Forskolin Solgar Pharmacology

Forskolin Solgar, also known as “second messenger”, is widely present in various tissues of the body and affects various cellular activities. It has the functions of promoting fat, glycogenolysis, myocardial contraction, smooth muscle relaxation and inhibiting platelet aggregation. According to literature reports, FSK and its analogs are laudanane-type diterpenoids, both of which are direct agonists of adenylate cyclase. It does not pass receptors or inhibit phosphodiesterase, but directly increases the The intracellular concentration produces physiological activity.

Pharmacological studies have proved that Forskolin Solgar is the only known strongest adenylate cyclase activator obtained from plants. At the concentration, it participates in the regulation of various cell functions and plays a wide range of regulatory roles in the body. The main effects of FSK are to lower blood pressure, relieve pain, dilate bronchioles, dilate blood vessels, and strengthen the heart. The active ingredient FSK has important medical effects, including lowering blood pressure, relaxing smooth muscle, increasing the release of thyroid hormones, promoting the secretion of digestive tract, and reducing intraocular pressure. It is used in India for digestive system disorders, such as expelling wind, eliminating flatulence, treating abdominal pain, treating circulatory system disorders, treating congestive heart failure, insufficient coronary blood flow, improving cerebral blood circulation, relieving pain, treating asthma, and bronchitis. At present, Forskolin Solgar is clinically used to treat cardiovascular diseases, glaucoma, bronchial asthma, etc. At the same time, it can also regulate various tissues by activating adenylate cyclase, and is an activator of other drugs.

Forskolin Solgar in Vitro Studies

Forskolin Solgar increases cAMP levels in membrane, cell or tissue preparations. Forskolin Solgar not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin Solgar is able to promote the activation of nine different independent AC forms, although somewhat less efficient for AC9, which could be used to provide a method to identify and quantify high-affinity binding sites of G protein (Gs)–AC complexes. Activation of G proteins by G protein-coupled receptors contributes to Forskolin Solgar-stimulated cAMP production in cells, as G protein-Forskolin has a potentiating effect on AC activity. Forskolin Solgar stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin Solgar promotes cAMP production in adipocytes and can inhibit basophil and mast cell degranulation and histamine release, reduce blood pressure, intraocular pressure, inhibit platelet aggregation, promote vasodilation, bronchodilation and thyroid hormone secretion, Stimulates lipolysis. Forskolin Solgar inhibits the binding of platelet activating factor (PAF), which is independent of cAMP formation, which may be achieved by Forskolin’s direct action on PAF or by interfering with the binding of PAF to its receptor. Forskolin also appears to have effects on various membrane transporters and can inhibit glucose transport in adipocytes, red blood cells, platelets, and other cells. Forskolin Solgar is also used to treat glaucoma.

Forskolin Solgar Preparation

1) Weigh 180g of 100-200 mesh column chromatography silica gel, spread it out on a plate, put it into a 1000ml beaker after activation at 110°C for 2h, mix it well with PE, remove air bubbles, and then wet it into a glass chromatography column, and then use PE wash the solid column.

2) Weigh 60 g of 20% Coleus forskohlii extract, when the PE liquid level in the glass column is about 6 cm higher than the silica surface, directly add it to the column by wet method, add it slowly and remove air bubbles, and then add it to the column. After eluting with PE for 30 min, the sample was covered with 2 cm thick chromatographic silica gel, and finally the column was washed with PE.

3) After washing 600ml of the column with PE, directly wash the column with PE-ethyl acetate (10:1); collect in a conical flask, 200ml per bottle, and recover the solvent in a water bath to dryness. The color of the solution washed first is dark and black, and there are many impurity spots in it. When the solvent is recovered to a small volume, it is thicker and darker in color, but it can be dissolved in ethyl acetate, which is discarded here. In this way, the original gradient elution was continued, and the previous strong lipophilic impurities were continuously removed, and the solvent was recovered as much as possible in each bottle, so as to observe the phenomenon.

4) When a large amount of crystals appear in the bottle, collect and combine when opening. The phenomenon at this time is that a large number of crystals are precipitated, and the place washed by the hot solution is bright white, and the rest is brown. The precipitated crystals were carefully dissolved in ethyl acetate, and all the precipitated crystals were combined. When combined to a certain volume, the solvent is recovered in a water bath to a small volume, which is equivalent to 1/3 of the original volume, and the crystals are naturally precipitated due to supersaturation during heat and are naturally precipitated when cooled. When the color is lighter, it is dissolved in ethyl acetate and collected in another device to be combined with the washed crystallization solution. The upper mother liquor was sucked up with a pipette, and the mother liquor and washing liquid continued to be combined with the subsequent crystallizing liquid. Repeated operations in this way, two parts are finally obtained: one part is the crystallization solution that has been repeatedly washed with PE, the color is light brownish yellow, and the other part is the mother liquor, which is very dark and private. After further identification, it was found that there were spots of FSK, but no obvious crystals could be seen when the solution was recovered to 1,000, so the mother liquor was discarded or used for another preparation.

5) Recover the solvent from the crystallization solution until the crystals will precipitate when it is hot, take out the water bath, add 6 times the amount of PE, shake it up a little, and instantly a large number of white crystals will precipitate out, which is very obvious. When it was naturally cooled to room temperature, a large number of white crystals could be seen at the bottom. The crystallization and the mother liquor are separated, and the mother liquor continues to be concentrated until it crystallizes. Finally, two parts of crystals and a dark-colored mother liquor were obtained. After recovering the solvent from the mother liquor to dryness, it was decolorized with PE, and the decolorized solid was dissolved in ethyl acetate and precipitated. After recrystallization twice in this way, a large amount of white crystals was finally obtained, and finally 12.4 g of the product was received. After “testing, the content was 85%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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