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Forskolin Forte CAS 66575-29-9

Molecular Formula: C22H34O7

Formula Weight: 410.5

ZSpharmac: Forskolin Forte Supplier

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Product Name: Forskolin Forte
CAS No: 66575-29-9
Purity: 99%

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Basic Info

Product Name:Forskolin Forte
Other Names:Forskolin
CAS:66575-29-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:266-410-9
Storage:Room Temp
Provide:Forskolin Forte MSDS;
Forskolin Forte COA

What is Forskolin Forte?

Coleusforskohlii (wild) Briq is a plant of the category Coleusforskohlii in the family Lamiaceae. Coleus is a category of about 90 types, mainly created in India and Yunnan in my country. Forskolin (FSK) as well as Isoferskolin (ISOF) are primarily monomeric substances removed, divided and fine-tuned from Coleus forskohlii. Forskolin was first acquired from abroad in the 1970s Diquat substances extracted from the roots of Coleus forskohlii, a plant of the Indian Labiatae household, have the effects of strengthening the heart, decreasing blood pressure, soothing asthma, anti-inflammatory, anti-platelet gathering, anti-tumor growth, and lowering intraocular stress (IOP). Researches recommend that FSK straight boosts adenylate cyclase (AIR CONDITIONER) to raise the concentration of cyclic adenosine monophosphate (cAMP) in different tissue cells, thereby participating in the law of different cell functions and also playing a vast array of regulatory duties in the body. In the 1980s, residential studies on the extraction and also task identification of FSK and its analogues started, specifically after the Kunming Institute of Ecology, Chinese Academy of Sciences extracted FSK analogues from the Coleus forskohlii plant in Yunnan, the study on FSK Maintain increasing as well as deepening.

Forskolin Forte Property

Melting point 282-232 °C
Boiling point 520℃
alpha D25 -26.19° (c = 1.68 in CHCl3)
density 1.23
refractive index 1.5300 (estimate)
Fp 172℃
storage temp. room temp
solubility DMSO: 5 mg/mL stable at least 6 months at room temperature
form powder
pka11.00±0.70(Predicted)
color off-white
Water Solubility Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.

 

Pharmacology of Forskolin Forte

cAMP is also known as the “second messenger”, which widely exists in various tissues of the body, affects various cell activities, and has the functions of promoting fat, glycogen decomposition, myocardial contraction, smooth muscle relaxation and inhibiting platelet aggregation. According to literature reports, Forskolin Forte and its analogues are Laudanane-type diterpenoids, both of which are direct agonists of adenylyl cyclase. It does not pass through receptors or inhibit phosphodiesterase, but directly Increasing the intracellular concentration produces physiological activity. Pharmacological studies have proved that forskolin is the only strongest adenylyl cyclase activator obtained from plants known so far. By directly stimulating adenylyl cyclase, it can increase the cyclic adenylase in various tissue cells. Nucleic acid is involved in the regulation of various cell functions in terms of concentration, and plays a wide range of regulatory roles in the body. The main functions of Forskolin Forte are lowering blood pressure, relieving pain, dilating bronchioles, dilating blood vessels, and strengthening the heart. The active ingredient FSK has important medical effects, including lowering blood pressure, relaxing smooth muscle, increasing the release of thyroid hormones, promoting secretion of the digestive tract, and lowering intraocular pressure. In India, it is used for digestive system disorders, such as dispelling wind, removing flatulence, and treating abdominal pain. It is used for circulatory system disorders, treating congestive heart failure, insufficient coronary blood flow, improving cerebral blood circulation, has pain relief, and treating asthma and bronchitis. At present, forskolin is clinically used to treat cardiovascular diseases, glaucoma, bronchial asthma, etc. At the same time, it can also regulate various tissues by activating adenylyl cyclase, and is an activator of other drugs.

Recent studies have shown that Forskolin Forte can more effectively help patients burn excess body fat, promote fat mobilization, and serve as a nutrient supply during the weight loss process. Increasing the body’s less fat mass will not stimulate the central nervous system, so it will not cause tachycardia, Seizures, strokes, nervousness, anxiety, depression, insomnia and a series of adverse side effects associated with the use of ephedra.

Application of Forskolin Forte

Abroad, Forskolin Forte has been successfully used in many clinical studies, including bronchial asthma, cardiovascular disease, glaucoma, male sexual dysfunction and skin diseases, and no adverse reactions of FSK were reported in these studies. FSK increases cAMP levels in the cardiovascular system, increases myocardial contractility, lowers blood pressure by relaxing arterial wall smooth muscle, dilates cerebral arteries, and inhibits platelet aggregation. For the treatment of congestive heart failure, high blood pressure can directly increase cAMP and inhibit PAF, can reduce the release of histamine and reduce tissue edema, for the treatment of asthma, eczema, psoriasis; at the same time, the increase of cAMP leads to smooth muscle relaxation, used for treatment Menstrual cramps, bladder spasms and other visceral irritant syndromes; Forskolin Forte can cause cAMP to increase to inhibit the growth of cancer cells, and it is expected to become a new and safe treatment for prostate cancer. In order to develop this valuable natural drug into a new drug for the benefit of mankind, many domestic experts and scholars have analyzed and studied it, and have developed a national six-category new drug, Coleus oral liquid, which is used for asthma, cough, Acute and chronic bronchitis.

Forskolin Forte Preparation

1) Weigh 180g of 100-200 mesh column chromatography silica gel, spread it on a plate, activate it at 110°C for 2 hours, put it in a 1000ml beaker, mix well with PE, remove the air bubbles, put it into a glass chromatography column by wet method, and then use Wash the column with PE.

2) Weigh 60g of 20% Coleus forskohlii extract, and add it into the chromatography column by wet method when the PE liquid level in the glass chromatography column is about 6cm higher than the surface of the silica gel, slowly add and remove the air bubbles, and then After elution with PE for 30 min, cover the sample with 2 cm thick chromatographic silica gel, and finally wash the column with PE.

3) After washing 600ml of the column with PE, wash the column with PE-ethyl acetate (10:1) directly; collect in conical flasks, 200ml per bottle, and recover the solvent in a water bath until dry. The solution that was washed first was darker and blacker, and there were a lot of impurity spots in it. When the solvent was recovered to a small volume, it was thicker and extremely black in color, but it could be dissolved in ethyl acetate, so it was discarded here. Continue to maintain the original gradient elution in this way, continuously remove the front lipophilic impurities, and recover as much solvent as possible from each bottle, so as to observe the phenomenon.

4) When a large number of crystals appear in the bottle, collect and combine them while opening. The phenomenon at this time is that a large number of crystals are precipitated, and the place washed by the hot solution is bright white, and the rest is brownish yellow. The precipitated crystals were carefully dissolved with ethyl acetate and all solutions from which crystals precipitated were combined. When combined to a certain volume, the water bath recovers the solvent to a small volume, equivalent to 1/3 of the original volume, allowing the crystals to precipitate naturally due to supersaturation when hot, and then separate the crystals from the mother liquor and wash them repeatedly with PE until When the color is lighter, dissolve it with ethyl acetate, collect it in another device, and combine it with the crystallization solution after washing. Use a straw to suck up the upper mother liquor, and the mother liquor and washing liquid continue to merge with the subsequent crystallization liquid. After repeated operations in this way, two parts are finally obtained: one part is the crystallization solution washed repeatedly with PE, the color is light brown and the other part is the mother liquor, the color is extremely dark and private. Identify again, find the spot of Forskolin Forte, but also can’t see that obvious crystal is separated out when solution is recovered to 1000, so this mother liquor abandons or uses when making another preparation.

5) Recover the solvent from the crystallization solution until crystals are about to precipitate when it is hot, take out the water bath, add 6 times the amount of PE, shake it slightly, and a large amount of white crystals will precipitate out in an instant, which is very obvious. When it was naturally cooled to room temperature, a large amount of white crystals could be seen at the bottom. Separate the crystallization and the mother liquor, and continue to concentrate the mother liquor until it is crystallized. Finally, two parts of crystals and a dark mother liquor are obtained. After recovering the solvent from the mother liquor to dryness, it is decolorized with PE, and the decolorized solid is dissolved with ethyl acetate and precipitated. After recrystallizing twice in this way, a large amount of white crystals were finally obtained, and finally 12.4g of the product was collected. After “testing, the content was 85%.

About Products:
If you need Forskolin Forte, the cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Forskolin Forte manufacturer and supplier, ZSpharmac will provide Forskolin Forte raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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