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Fluorometholone Price CAS 426-13-1

Molecular Formula: C22H29FO4

Formula Weight: 376.46

ZSpharmac: Fluorometholone Price Supplement

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Product Name: Fluorometholone Price
CAS No: 426-13-1  
Purity: 99%

Basic Info

Product Name:Fluorometholone Price
Other Names:Fluorometholone
CAS:426-13-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Powder
EINECS No.:207-041-5
Storage:Ventilated Dry 2-8°C
Provide:Fluorometholone Price MSDS;
Fluorometholone Price COA

What is Fluorometholone ?

Fluorometholone Price is a topical synthetic glucocorticoid, and its local anti-inflammatory effect is 40 times that of hydrocortisone, but the oral effects of the two are almost equal. Mainly used for topical treatment of skin allergy, itching, rash and other allergic-related diseases. It is also used orally to treat breast cancer, pediatric leukemia, connective tissue disease, etc.

Fluorometholone Price Properties:

Melting point 292-303°
alpha +52~+60°(c=1, pyridine) (D/20℃)
Boiling point 527.1±50.0 °C(Predicted)
density 1.0573 (rough estimate)
refractive index 55 ° (C=1, Pyridine)
storage temp. 2-8°C
form neat
pka12.50±0.70(Predicted)
Water Solubility 30mg/L(25 ºC)

 

Fluorometholone Price Uses

  1. Fluorometholone Price is mainly used locally to treat various skin diseases suitable for glucocorticoid therapy, allergic and inflammatory eye diseases, and can also be used to treat breast cancer and pediatric leukemia.
  2. Fluorometholone Price is a special drug for the treatment of glucocorticoid-sensitive inflammation of the eyelid conjunctiva, cornea and other anterior segment tissues; the anti-inflammatory effect of flumetholone is 40 times that of hydrocortisone. , vasoconstriction and antipruritic effect. Fluorometholone has a very good anti-inflammatory effect and can be used on the skin, eyes and other parts, and is widely used in dermatitis, eczema, and inflammatory eye diseases. The literature points out that clinical studies on the use of fluorometholone and dexamethasone in the eyes of patients show that fluorometholone The effect on intraocular pressure is smaller than that of dexamethasone. Flumetholone has a good anti-inflammatory effect and has important applications in medicine, especially in ophthalmology.
  3. Fluorometholone Price inhibits inflammation caused by mechanical, chemical or immune stimulators. There is no generally accepted explanation for this effect of glucocorticoids, and it is generally believed that corticosteroids act by inducing the inhibitory protein of phospholipase A2, which is called lipocorticoid. For inflammatory diseases of the outer eye and the anterior eye (blepharitis, conjunctivitis, keratitis, scleritis, episcleritis, iritis, iridocyclitis, uveitis, postoperative inflammation, etc.).

Fluorometholone Price Preparation

1.9,11-Epoxy reaction Add 10g of 6α-methyl-17α-hydroxy-1,4,9-triene-pregna-3,20-dione and 120ml of acetone into the reaction flask, stir, and cool down to 0°C, add NBS9g within 30 minutes, keep at 5-10°C to react for 2 hours, add 10% aqueous sodium carbonate solution to neutralize to PH=6.5, heat up to 20±2°C, add 10% hydroxide within 1 hour 15ml of sodium aqueous solution, temperature controlled at 20-25°C for 2 hours, neutralized with acetic acid to pH=7, concentrated under reduced pressure until there is no acetone smell, diluted into ice water, filtered and dried to obtain 11.2g of 9,11-epoxide. 2.9,11-Ring-opening reaction reaction flask, add 11.2g of 9,11-epoxide obtained by 9,11-epoxy reaction, 60ml DMF, stir, cool down to -5°C, feed hydrogen fluoride gas, keep at – Reaction at 5~0℃ for 1 hour, diluted in ice water, adjusted to pH=7 with ammonia water, filtered and dried to obtain 9.5g of fluorometholone, recrystallized in acetone to obtain 8.5g of fluorometholone, MP: 290-300 °C. Refining: Add 100 g of crude fluorometholone (97%) to 400 mL of N,N-dimethylformamide, stir and heat to 80-90 °C for 0.5 h, after complete dissolution, slowly add 1 L of anhydrous methanol, and add the whole The process temperature was kept in the range of 60-70 °C, after the addition was completed, kept for 0.5 h, cooled to 0-5 °C, kept at 0-5 °C for crystallization for 12 h, filtered to obtain off-white crystal fluorometholone fine product, and dried to obtain 30 g of fluorometholone fine product (99.55% purity, 0.14% known single impurities, 0.09% total impurities).

Precautions for the Use of Fluorometholone

As people spend more time using their eyes, more and more friends suffer from eye diseases. Eye drops have actually become the most frequently made use of medication in ophthalmology. Many illness require to be treated with eye decreases.Flumetholone eye drops is a common ophthalmic drug. In the process of medication, some friends still have misunderstandings in medication, which cause unnecessary side effects. Before taking medication, it is necessary for everyone to understand the relevant principles of medication, so as to avoid the situation of wrong medication.
1.the use of fluorometholone eye drops, correct medication is the key
Flumetholone eye drops is a conjunctivitis medication that needs to be used strictly in the correct dosage. When used for eye drops, 1~2 drops at a time is enough, 2~4 times a day, the number of drops should not be too many, and overdose may also have bad consequences. You need to shake the eye drops well before taking the medicine and drop them into the conjunctival sac. During the first 24 to 48 hours of treatment, it can be increased to 2 drops per hour as appropriate.
Some friends feel that their symptoms have improved, and they stop the drug without authorization, which is also not allowed. When using fluorometholone eye drops, be careful not to stop prematurely. If you need to stop the drug, you should ask your doctor for advice before deciding whether to stop the drug.
In addition, it is also necessary to pay attention to the use time of fluorometholone eye drops. Generally speaking, the normal use time of eye drops is less than three months after opening, some drugs are within one month, and fluorometholone drops The specific time of eye drops can follow the doctor’s advice, and long-term medication should not be used without authorization.

2. Before administration of fluorometholone eye drops, the administration steps need to be understood
Regardless of the type of eye drops, everyone should wash their hands before using them to avoid eye infections. When using fluorometholone eye drops, the method of administration should be correct. When we want to drop eye drops, it is recommended to hold the eye drops with the right hand first, while raising the head and looking up. Then use the left hand to separate the upper and lower eyelids, and drop the eye drops into the lower eyelid. One thing to watch out for is not to drip into the black eyeballs. After dripping, you can gently close your eyes and massage with your fingers.

3. When fluorometholone eye drops are used for a long time, it is necessary to be alert to adverse reactions
The main component of fluorometholone eye drops is fluorometholone, which belongs to hormone eye drops. Long-term use may cause some adverse reactions. Patients and friends must pay attention when taking them. When fluorometholone eye drops are used for a long time, individual sensitive patients may lead to increased intraocular pressure, and even induce glaucoma and damage the optic nerve, affecting vision and visual field. Therefore, you must use it under the guidance of a doctor, and do not buy it yourself.
In fact, eye drops are very common in our daily life, and many friends usually choose to buy eye drops by themselves. It is recommended that you look at the ingredient list before purchasing. If it is a hormonal eye drop, you need to follow the doctor’s advice when taking it.
Generally speaking, eye drops with the word “pine” as the main ingredient are mostly hormone eye drops, just like the fluorometholone eye drops we said is also one of them. This type of eye drops can improve the inflammation of the eyes, but improper use will also cause related adverse reactions. In severe cases, it may induce glaucoma and cause irreversible loss of visual function.
Eyes are very important to us. When using fluorometholone eye drops, everyone also needs to understand the relevant principles of medication to help them take reasonable medication. It is recommended that middle-aged and elderly people over 50 years old have regular eye examinations every year, so that eye diseases can be detected as early as possible and timely treatment measures can be taken.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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