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Ethylparaben CAS 120-47-8

Molecular Formula: C9H10O3

Formula Weight: 166.17

ZSpharmac: Ethylparaben Supplement

Product Name: Ethylparaben
CAS No: 120-47-8
Purity: 99%

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Basic Info

Product Name:Ethylparaben
Other Names:Ethyl 4-Hydroxybenzoate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:204-399-4
Provide:Ethylparaben MSDS;
Ethylparaben COA

What is Ethylparaben?

Ethyl p-hydroxybenzoate, also known as ethyl p-hydroxybenzoate, is a synthetic preservative obtained from the esterification of p-hydroxybenzoic acid and ethanol under the catalysis of sulfuric acid. Colorless fine crystal or white crystalline powder. Odorless, tasteless, slightly hemp. Melting point 116 ~ 118 ℃. Insoluble in water, soluble in ethanol, propylene glycol and peanut oil. It has strong antibacterial effect on mold and yeast, but weaker effect on bacteria, especially Gram-negative bacteria and lactic acid bacteria. Its antibacterial power is stronger than benzoic acid and sorbic acid, and has better antibacterial effect in the range of pH 4-8. Its antibacterial mechanism is to inhibit the activity of respiratory enzymes and electron transfer enzymes of microbial cells and destroy the cell membrane structure of microorganisms.

Since it is insoluble in water, it is generally used in combination with Ethylparaben, sodium ethyl paraben, etc., which not only improves the water solubility, but also has a certain synergistic effect. Quality standard: GB 8850-1988 (mandatory national standard), content (on dry basis) ≥ 99%; loss on drying ≤ 0.5%; ignition residue ≤ 0.05%; melting point 115 ~ 118 ℃; acidity: qualified; sulfated ash ≤0.024%; p-hydroxybenzoic acid and salicylic acid: qualified; aldehydes (calculated as propionaldehyde): qualified; arsenic≤0.0001%; ​​heavy metals≤0.001%. Ethylparaben is a paraben with good bacteriostatic effect over a wide pH range. Due to their low toxicity and non-irritant properties, they are widely used as preservatives in food, cosmetics and pharmaceuticals. It is one of the commonly used preservatives and bacteriostatic agents.

Therefore, the development of new green and efficient catalysts for the synthesis of Ethylparaben has great significance and broad application prospects. The traditional synthesis method uses sulfuric acid as a catalyst, an organic solvent as a water carrier, and p-hydroxybenzoic acid is reacted with the corresponding alcohol. Sulfuric acid as a catalyst has low price and high ester yield, but it has many side reactions, is difficult to separate, seriously corrodes equipment, and pollutes the environment. With the continuous improvement of environmental protection requirements in environmental regulations, the development of new catalysts that can replace sulfuric acid has become a common concern in industrial production.

Ethylparaben Properties:

Melting point 114-117 °C (lit.)
Boiling point 297-298 °C (lit.)
density 1.1708 (rough estimate)
vapor pressure 0.00012 hPa (25 °C)
refractive index 1.5286 (estimate)
Fp 297-298°C
storage temp. 2-8°C
solubility Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form Crystalline Powder
color White
PH4.5-5.5 (H2O, 20°C) (saturated solution)
Water Solubility Slightly soluble in water.


Ethylparaben Uses

  1. Ethylparaben has a solid inhibitory effect on mold and mildew and also yeast, as well as has an inadequate result on microorganisms, especially lactic acid germs and also gram-negative bacilli, yet its antibacterial ability is stronger than that of sorbic acid and benzoic acid, as well as the anti-bacterial impact is not impacted by pH. Large, the effect is good in the range of PH4-8. The longer the alkyl group of ethyl paraben, the stronger the antibacterial impact, followed by butyl ester > propyl ester > ethyl ester. Ethylparaben is one of the chemicals commonly used around the world. my country states that it is made use of for pastry dental fillings, as well as the optimum use is 0.5 g/kg (calculated as p-hydroxybenzoic acid, the very same below); the maximum usage in juice (flavored) beverages, jams (excluding tinned food), soy sauce, and sauces is 0.25 g/kg g/kg; optimum usage in carbonated drinks as well as egg yolk dental fillings is 0.2 g/kg; maximum useful usage in vinegar is 0.1 g/kg; optimum use in fruit and vegetable conservation is 0.012 g/kg.
  2. Ethylparaben is utilized as a chemical. Numerous countries utilize its ethyl ester and propyl ester, however Japan often utilizes its butyl ester. Due to the fact that it is insoluble in water, different esters are usually utilized in mix.
  3. Ethylparaben is an organic intermediate. Used as preservatives, bacteriostatic representatives, utilized in food, cosmetics, pharmaceuticals. It can additionally be made use of as a natural analytical reagent. The product has a wide range of anti-bacterial results on mold, yeast as well as bacteria, and also has a solid impact on mold and mildew and also yeast, yet has bad impact on microorganisms, especially Gram-negative bacilli as well as lactic acid microorganisms. It is a reliable antiseptic and bactericide for food and medicine.
  4. Ethylparaben is utilized as a food chemical, and also is also used in pharmaceutical, natural leather and also various other industries; it has a solid bacteriostatic impact on fungis, however a weaker bacteriostatic effect on bacteria. As a bacteriostatic chemical, it is commonly used in fluid preparations and also semi-solid prep work, and also can likewise be used in the conservation of food and cosmetics.
  5. Ethylparaben is used as a chemical (food, medicine). Bacteriostatic agent. Antifungal representative. Organic analysis establishes carbonyls as well as halides. The product has a large range of anti-bacterial results on mold, yeast and also germs, and also has a solid effect on mold and mildew and yeast, but has bad result on microorganisms, particularly Gram-negative bacilli and lactic acid bacteria. It is an effective antiseptic and also bactericide for food as well as medication. Calibration instruments and device; evaluation techniques; functioning standards; top quality assurance/quality control; various other.

Ethylparaben Preparation

1) S2O82-/ZrO2-Al2O3

The solid superacid catalyst S2O82-/ZrO2-Al2O3 was prepared by impregnation and precipitation method. The optimal conditions for catalyst preparation were determined by orthogonal experiment, namely ZrO12·8H2O and macroporous A1O, the mass ratio was 25.0:14.2, and the concentration of ammonium thiosulfate was 0.8 mol/L, the activation temperature was 650 °C, and the activation time was 3 h. Using solid superacid S2O82-/ZrO2-Al2O3 as catalyst, ethyl p-hydroxybenzoate was synthesized from p-hydroxybenzoic acid and absolute ethanol.

2) SO4-/TiO2-Attapulgite

Ethylparaben was synthesized using solid superacid SO4-/TiO2-attapulgite as catalyst, p-hydroxybenzoic acid and ethanol as raw materials, and the factors affecting the reaction were investigated. Under the optimal reaction conditions of acid-alcohol substance ratio of 1:4, catalyst dosage of 3%, and reaction time of 4 h, the product yield reached 93.2%. Compared with the single-component solid superacid SO4-/TiO2, the catalyst has the advantages of lower cost, easy separation from the product, reusability, and no environmental pollution. It is a green catalyst that is environmentally friendly and has application prospects.

3) Cerium improves solid superacid

Using p-hydroxybenzoic acid and ethanol as raw materials, a new type of solid superacid SO4-/Sb2O3/Ce4+ catalyst was prepared to catalyze the synthesis of ethyl paraben. The dosage of benzyl alcohol is 100 mL, and the dosage of acetic acid is 2.80 mL. The optimum process conditions are determined as: r/, (p-hydroxybenzoic acid): n (ethanol) = 1.0: 4.0, the temperature is about 350 °C, and the amount of catalyst is 0.6 g , the reaction time was 4 h, and the ester yield was 93.8%.

4) SO4/La2O3-TiO2

A new catalyst SO4/La2O3-TiO2 was prepared by loading lanthanum on SO4/TiO2. The esterification reaction of p-hydroxybenzoic acid and ethanol was used as a probe to investigate the effect of different preparation conditions on the performance of the catalyst. The results show that the highest esterification rate can reach 94.5%. And the catalyst has good reusability and regeneration ability, and is very suitable for synthesizing ethyl paraben.

Recently, it has been reported that copper methanesulfonate has a good catalytic effect on the esterification of organic acids. Considering the complicated synthesis conditions of methanesulfonic acid, copper p-toluenesulfonate was prepared from p-toluenesulfonic acid, which was used to catalyze the synthesis of ethyl p-hydroxybenzoate. Using p-hydroxybenzoic acid and ethanol as raw materials and copper p-toluenesulfonate as catalyst, ethyl p-hydroxybenzoate was synthesized, and the influencing factors of catalytic esterification were discussed. The optimized reaction conditions were as follows: the amount of p-hydroxybenzoic acid was 0.10 mol, the ratio of alkyd substances was 4:1, the amount of copper tosylate was 2.2 g, and the reaction was carried out at reflux temperature for 4.0 h. In this experiment, the esterification rate was acceptable. up to 94.3%. The product was characterized by Fourier transform infrared spectrometer and melting point meter, and it was confirmed that it was completely consistent with the target product.

Ionic liquid is a kind of salt, new reaction medium and green solvent that melts at room temperature. It has a wide liquid range, wide dissolution range, 0 vapor pressure, good stability, adjustable acidity and alkalinity, and easy separation of products. A series of unique properties such as recyclability and recyclability are considered to be another large class of reaction media and new green solvents with good application prospects in modern organic synthesis after water and supercritical carbon dioxide. At present, some ionic liquids have been successfully applied. for the synthesis of ethyl p-hydroxybenzoate.

1) 1,3-Dialkylimidazolium ionic liquid

Four kinds of 1,3-dialkylimidazole ionic liquids were used to catalyze the synthesis of ethyl p-hydroxybenzoate. The effects of reaction temperature, reaction time, catalyst dosage, and the ratio of acid-alcohol substances on the reaction yield and the reusability of ionic liquids were investigated. . The research results show that using [BMIm]BF as catalyst, its dosage is 3 mL, the ratio of acid to alcohol substance is 1.0:2.5, the reaction time is 2.5 h, the reaction temperature is 80 cI=, the yield is 79.7%, the highest yield is 79.7%. , and the product and the ionic liquid catalytic system are insoluble and layered, which is convenient for separation, and the ionic liquid can be used stably for 5 times. The ionic liquid can be used as a new type of green solvent to effectively catalyze the synthesis of ethyl p-hydroxybenzoate and reduce environmental pollution.

2) Acidic ionic liquid

Ethyl p-hydroxybenzoate was synthesized by using acidic ionic liquids [C, SO, Hmim]HSO4, [C4SO3Hmim]HSO4 and [C3SO3Hnhm]HSO4 instead of concentrated sulfuric acid as catalysts. The effects of reaction temperature, reaction time, catalyst dosage, acid-alcohol substance ratio on the reaction yield and the reusability of ionic liquids were investigated.

3) Reaction-controlled phase transfer ionic liquids

Using SO3H-functionalized 1-(3-sulfonic acid)propyl-3-methylimidazolium phosphomolybdic acid ionic liquid as catalyst to catalyze the synthesis of paraben, the performance of the catalyst and the green synthesis process of paraben were investigated. . Experiments show that the catalytic system can realize the reaction-controlled phase transfer of the catalyst, the product is easy to separate, and the catalyst is easy to recycle. Alcohols of different polarities have a significant effect on the realization of the reaction-controlled phase transfer of the catalyst. The optimized paraben reaction conditions are: (catalyst): (alcohol): where (paraben) = 0.03: 3: 1, When the reaction time is 8 h and the reaction temperature is 120 ℃, the yield of ethyl paraben can reach 97.6%. In the green esterification system, the catalyst can be reused 6 times, and the product yield is stable.

4) Br6nsted acidic ionic liquid [Hmim]C1

Using Br+nsted acidic ionic liquid [Hmim]cl as catalyst to catalyze the synthesis of parabens, the effects of reaction time, alkyd substance ratio and ionic liquid dosage on the reaction were investigated, and the optimal reaction conditions were determined: p-hydroxybenzene The amount of formic acid was 0.04 mol, the reaction time was 2.5 h, the ratio of alkyd substances was 2:1, the amount of ionic liquid was 3 mL, and the yield was more than 82%. The ionic liquid can be recycled for 5 times, and the catalytic activity is basically unchanged.

5) New ionic liquid 1-(4-sulfonic acid)butyl-3-methylimidazolesulfonic acid [BSmim]HSO

A novel ionic liquid, 1-(4-sulfonyl)butyl-3-methylimidazolesulfonic acid [BSmim]HSO, was studied for the catalytic synthesis of ethyl paraben. The reaction time, reaction temperature, alkyd substance ratio and ionic Effect of liquid dosage on the yield of ethyl paraben. The experimental results show that the optimal reaction conditions for ethyl paraben are as follows: when the reaction time is 2.5 h, the reaction temperature is the reflux temperature, the ratio of alkyd substances is 2.5:1, and the amount of ionic liquid is 3 mL. Using the ionic liquid as a catalyst for synthesizing parabens has the advantages of high yield, simple operation, reusability and good application prospect.

Under the condition of microwave irradiation, using p-hydroxybenzoic acid and ethanol as raw materials and SnCl/C as heterogeneous catalyst, ethyl p-hydroxybenzoate was synthesized efficiently and greenly. The effects of catalyst dosage, alkyd material ratio, reaction time, reaction temperature, microwave radiation power, etc. on the yield were studied respectively, and Fourier transform infrared spectroscopy (FT-IR), hydrogen nuclear magnetic resonance (H NMR) The structure of the product was determined by mass spectrometry (MS). The results showed that the optimal conditions for the synthesis of ethyl p-hydroxybenzoate were (p-hydroxybenzoic acid): n(ethanol)=4:4, the reaction time was 25 min, and the mass fraction of the catalyst was 10 %, the reaction temperature is 120 ℃, the microwave radiation power is 640w, and the product yield is 95%; after the SnCl/C catalyst is recycled for 4 times, it still shows good catalytic activity, and the yield can reach 89%.

The use of ultrasonic waves can improve the chemical reaction conditions and shorten the reaction time. Under ultrasonic radiation, using p-hydroxybenzoic acid and ethanol as raw materials, and using p-toluenesulfonic acid as a catalyst, ethyl p-hydroxybenzoate is synthesized, and the yield is affected. The optimal conditions were determined by orthogonal experiments: ultrasonic power 350 W, ultrasonic temperature 70-80 °C, ultrasonic time 70 min, the substance ratio of ethanol to p-hydroxybenzoic acid was 7:1, and the amount of catalyst was 8%. , the yield can reach 85.51%.

It has been reported in the literature as a solid Lewis acid to catalyze the synthesis of some esters. Using p-hydroxybenzoic acid and ethanol as raw materials and chitosan phosphotungstate as catalyst to synthesize Nijin ethyl ester, the optimal conditions of the reaction were determined: the ratio of alkyd substances was 5:1, the amount of catalyst was 0.9 g, and the reaction After 3 h, the product yield reached 87.1%. Experiments show that using chitosan phosphotungstate as catalyst not only has short reaction time, high activity and high esterification rate, but also the catalyst can be reused, which opens up a new field of ethyl paraben esterification catalyst.

Using methanesulfonic acid as a catalyst and adding triethyl orthoformate as a dehydrating agent in the reaction raw materials, ethyl paraben can effectively improve the reaction conversion rate and shorten the reaction time. Lai Yaping uses p-hydroxybenzoic acid and ethanol as the main raw materials, methanesulfonic acid as the catalyst, and adopts the dehydration method of adding triethyl orthoformate to the reaction system and heating to reflux to synthesize ethyl paraben. The reaction process is tracked by high performance liquid chromatography. The influence of various factors on product conversion was investigated. The experimental results show that the dehydration method of triethyl orthoformate can improve the conversion rate of the target product and reduce the reaction time compared with the traditional method.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

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*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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