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Ethylparaben CAS 120-47-8

Molecular Formula: C9H10O3

Formula Weight: 166.17

ZSpharmac: Ethylparaben Supplier

Product Name: Ethylparaben
CAS No: 120-47-8
Purity: 99%

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Basic Info

Product Name:Ethylparaben
Other Names:Ethyl Paraben
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:204-399-4
Provide:Ethylparaben MSDS;
Ethylparaben COA

What is Ethylparaben?

Ethyl p-hydroxybenzoate, also known as Ethylparaben, is a synthetic preservative obtained by esterification of p-hydroxybenzoic acid and ethanol under the catalysis of sulfuric acid. Colorless fine crystals or white crystalline powder. Odorless and tasteless, slightly numb tongue. The melting point is 116-118°C. Insoluble in water, easily soluble in ethanol, propylene glycol, peanut oil. It has strong antibacterial effect on mold and yeast, and weak effect on bacteria, especially Gram-negative bacteria and lactic acid bacteria. Its antibacterial ability is stronger than that of benzoic acid and sorbic acid, and it has good effect in the range of pH 4-8. Its antibacterial mechanism is to inhibit the activity of respiratory enzymes and electron transfer enzymes of microbial cells, and to destroy the cell membrane structure of microorganisms.

Because it is difficult to dissolve in water, it is generally mixed with propyl p-hydroxybenzoate, sodium ethyl p-hydroxybenzoate, etc., which not only improves the water solubility, but also has a certain synergistic effect. Quality standard: GB 8850-1988 (mandatory national standard), content (on a dry basis) ≥ 99%; loss on drying ≤ 0.5%; residue on ignition ≤ 0.05%; melting point 115-118°C; acidity: qualified; sulfate ash ≤0.024%; p-hydroxybenzoic acid and salicylic acid: qualified; aldehydes (calculated as propionaldehyde): qualified; arsenic ≤0.0001%; heavy metals ≤0.001%. Ethylparaben is paraben, which has good antibacterial effect in a wide pH range. Due to its low toxicity and non-irritating advantages, it is widely used as a preservative in food, cosmetics, and pharmaceuticals. It is commonly used at home and abroad. One of preservatives and bacteriostats.

Ethylparaben Property

Melting point 114-117 °C (lit.)
Boiling point 297-298 °C (lit.)
density 1.1708 (rough estimate)
vapor pressure 0.00012 hPa (25 °C)
refractive index 1.5286 (estimate)
Fp 297-298°C
storage temp. 2-8°C
solubility Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form Crystalline Powder
color White
PH4.5-5.5 (H2O, 20°C) (saturated solution)
Water Solubility Slightly soluble in water.


Ethylparaben Uses

Ethylparaben has a solid inhibitory effect on mold and mildew and also yeast, and also has an inadequate result on germs, particularly lactic acid germs and also Gram-negative bacilli, yet its antibacterial capacity is stronger than that of sorbic acid as well as benzoic acid, and its antibacterial impact is not affected much by pH worth. The effect is great in the series of pH value 4-8. The longer the alkyl team of parabens, the stronger the antibacterial effect, in order of butyl > propyl > ethyl. Ethylparaben is among the chemicals frequently made use of in countries all over the world. my country states that it is made use of for pastry dental filling, the maximum use amount is 0.5 g/kg (computed as p-hydroxybenzoic acid, the very same listed below); the maximum use quantity in fruit juice (flavored) beverages, jams (excluding canned food), soy sauce, and sauces is 0.25 g/kg; the optimum quantity utilized in carbonated drinks and egg yolk stuffing is 0.2 g/kg; the optimum quantity used in vinegar is 0.1 g/kg; the maximum amount made use of in fruit and vegetable preservation is 0.012 g/kg. It can be made use of as preservative (food, medicine), bacteriostatic representative, antifungal agent, natural analysis as well as decision of carbonyl as well as halide. This product has a variety of antibacterial results on mold, yeast and also bacteria, as well as has a solid effect on mold and also yeast, however has an inadequate impact on bacteria, particularly Gram-negative bacilli and also lactic acid microorganisms. It is an efficient disinfectant and also fungicide for food and medicine.

Preparation of Ethylparaben

1. Solid super acid

1) S2O82-/ZrO2-Al2O3

Prepare the solid superacid catalyst S2O82-/ZrO2-Al2O3 by impregnation and precipitation methods. The optimum conditions for catalyst preparation are determined by orthogonal experiments, that is, the mass ratio of ZrO12 8H2O and macroporous A1O is 25.0:14.2, and the concentration of ammonium thiosulfate is 0.8 mol/L, the activation temperature is 650°C, and the activation time is 3 h. Using solid superacid S2O82-/ZrO2-Al2O3 as catalyst, p-Ethylparaben was synthesized from p-hydroxybenzoic acid and absolute ethanol.

2) SO4-/TiO2-attapulgite

Ethylparaben was synthesized with solid superacid SO4-/TiO2-attapulgite as catalyst, p-hydroxybenzoic acid and ethanol as raw materials, and the factors affecting the reaction were investigated. Under the optimal reaction conditions, the molar ratio of acid to alcohol is 1:4, the amount of catalyst is 3%, and the reaction time is 4 h, the product yield is 93.2%. Compared with the single-component solid superacid SO4-/TiO2, the catalyst has the advantages of lower cost, easy separation from products, reusability, and no environmental pollution. It is an environmentally friendly and green catalyst with application prospects.

3) Cerium-improved solid superacid

Using p-hydroxybenzoic acid and ethanol as raw materials, a new type of solid superacid SO4-/Sb2O3/Ce4+ catalyst was used to catalyze the synthesis of ethylparaben. The amount of benzyl alcohol added is 100 mL, the amount of acetic acid added is 2.80 mL, and the optimal process conditions are determined as: r/, (p-hydroxybenzoic acid): n (ethanol) = 1.0: 4.0, the temperature is about 350 ° C, and the catalyst dosage is 0.6 g , the reaction time was 4 h, and the ester yield was 93.8%.

4) SO4/La2O3-TiO2

A new catalyst SO4/La2O3-TiO2 was prepared by loading lanthanum on SO4/TiO2, and the effect of different preparation conditions on the performance of the catalyst was investigated using the esterification reaction of p-hydroxybenzoic acid and ethanol as a probe. The results show that the highest esterification rate can reach 94.5%. Moreover, the catalyst has good reusability and regeneration ability, and is very suitable for synthesizing Ethylparaben.

2. Copper p-toluenesulfonate

It has been reported recently that copper methanesulfonate has a good catalytic effect on the esterification of organic acids. Considering the complicated synthesis conditions of methanesulfonic acid, copper p-toluenesulfonate was prepared from p-toluenesulfonic acid, which was used to catalyze the synthesis of ethyl p-hydroxybenzoate. Ethyl p-hydroxybenzoate was synthesized with p-hydroxybenzoic acid and ethanol as raw materials and copper p-toluenesulfonate as catalyst, and the influencing factors of catalytic esterification were discussed. The optimized reaction conditions were as follows: the amount of p-hydroxybenzoic acid was 0.10 mol, the molar ratio of alkyd to acid was 4:1, the amount of copper toluenesulfonate was 2.2 g, and the reaction time was 4.0 h at reflux temperature. In this experiment, the esterification rate could reach Up to 94.3%. The product was characterized by a Fourier transform infrared spectrometer and a melting point instrument, and it was confirmed that it was completely consistent with the target product.

3. Ionic liquid: As a salt that melts at room temperature, a new type of reaction medium and a green solvent, ionic liquid has a wide range of liquid state, a wide range of dissolution, zero vapor pressure, good stability, adjustable acidity and alkalinity, and easy separation of products A series of unique properties such as recyclability and recyclability are considered to be another large class of reaction media and new green solvents with good application prospects in modern organic synthesis after water and supercritical carbon dioxide. At present, some ionic liquids have been successfully applied. In the synthesis of Ethylparaben.

1) 1,3-dialkylimidazolium ionic liquid

Four kinds of 1,3-dialkylimidazolium ionic liquids catalyzed the synthesis of ethyl p-hydroxybenzoate, and investigated the effects of reaction temperature, reaction time, catalyst dosage, and acid-alcohol ratio on the reaction yield and the reusability of ionic liquids . The research results show that [BMIm]BF is used as catalyst, the dosage is 3 mL, the ratio of acid to alcohol is 1.0:2.5, the reaction time is 2.5 h, the reaction temperature is 80 cI=, and the yield is 79.7%, which is the highest. , and the product is insoluble and separated from the ionic liquid catalytic system, which is easy to separate, and the ionic liquid can be stably reused 5 times. Ionic liquid can be used as a new type of green solvent to effectively catalyze the synthesis of Ethylparaben reaction and reduce environmental pollution.

2) Acidic ionic liquid

Ethyl p-hydroxybenzoate was synthesized using acidic ionic liquids [C, SO, Hmim]HSO4, [C4SO3Hmim]HSO4 and [C3SO3Hnhm]HSO4 instead of concentrated sulfuric acid. The effects of reaction temperature, reaction time, catalyst dosage, acid-alcohol ratio on the reaction yield and the reusability of ionic liquids were investigated.

3) Reaction controlled phase transfer ionic liquids

Using SO3H-functionalized 1-(3-sulfonic acid)propyl-3-methylimidazolium phosphomolybdic acid ionic liquid as a catalyst to catalyze the synthesis of paraben ester, the performance of the catalyst and the green synthesis process of paraben ester were investigated . Experiments show that the catalytic system can realize the reaction-controlled phase transfer of the catalyst, the product is easy to separate, and the catalyst is easy to recycle. Alcohols with different polarities have a significant impact on the realization of the reaction-controlled phase transfer of the catalyst. The optimized reaction conditions for paraben esters are: (catalyst): (alcohol): where (paraben acid) = 0.03: 3: 1, When the reaction time was 8 h and the reaction temperature was 120°C, the yield of ethyl paraben could reach 97.6%. In the green esterification system, the catalyst can be reused 6 times, and the product yield is stable.

4) Br6nsted acidic ionic liquid [Hmim] C1

Using Br+nsted acidic ionic liquid [Hmim]cl as a catalyst to catalyze the synthesis of paraben ester, the influence of reaction time, the ratio of alkyd substances and the amount of ionic liquid on the reaction was investigated, and the optimal reaction condition was determined: p-hydroxybenzene The amount of formic acid was 0.04 mol, the reaction time was 2.5 h, the molar ratio of alkyd to acid was 2:1, the amount of ionic liquid was 3 mL, and the yield was more than 82%. The ionic liquid can be recycled 5 times, and the catalytic activity remains basically unchanged.

5) Novel ionic liquid 1-(4-sulfonic acid) butyl-3-methylimidazole sulfonic acid [BSmim] HSO

Study on the synthesis of ethylparaben catalyzed by a new type of ionic liquid 1-(4-sulfo)butyl-3-methylimidazolesulfonic acid [BSmim]HSO, investigate the reaction time, reaction temperature, molar ratio of alkyd and acid species and ion Effect of liquid dosage on yield of ethylparaben. The experimental results showed that the optimal reaction conditions for ethylparaben were as follows: when the reaction time was 2.5 h, the reaction temperature was reflux temperature, the molar ratio of alkyd to acid was 2.5:1, and the amount of ionic liquid was 3 mL. Using the ionic liquid as a catalyst for synthesizing parabens has high yield, is easy to operate, can be used repeatedly, and has good application prospects.

4. Microwave radiation catalytic synthesis

Ethyl p-hydroxybenzoate was efficiently and greenly synthesized under microwave irradiation conditions using p-hydroxybenzoic acid and ethanol as raw materials and SnC1/C as a heterogeneous catalyst. The effects of catalyst dosage, alkyd ratio, reaction time, reaction temperature, microwave radiation power, etc. on the yield were studied respectively, and Fourier transform infrared spectroscopy (FT-IR) and hydrogen nuclear magnetic resonance (H NMR) and mass spectrometry (MS) to determine the structure of the product. The results show that the best conditions for the synthesis of Ethylparaben are (p-hydroxybenzoic acid): n (ethanol) = 4: 4, the reaction time is 25 min, the mass fraction of the catalyst is 10%, and the reaction temperature is 120 ℃, microwave radiation power 640w, the product yield is 95%; SnC1/C catalyst still shows good catalytic activity after being recycled 4 times, and the yield can reach 89%.

5. Ultrasonic Catalytic Synthesis

The use of ultrasonic waves can improve chemical reaction conditions and shorten the reaction time. Under ultrasonic radiation, p-hydroxybenzoic acid and ethanol are used as raw materials, and p-toluenesulfonic acid is used as a catalyst to synthesize ethyl p-hydroxybenzoate, and affect the yield. The optimal conditions were determined by orthogonal experiments: ultrasonic power 350 W, ultrasonic temperature 70-80 °C, ultrasonic time 70 min, the ratio of ethanol to p-hydroxybenzoic acid was 7:1, and the amount of catalyst was 8%. , the yield can reach 85.51%.

6. Chitosan Phosphotungstate

It has been reported in the literature that it can act as a solid Lewis acid to catalyze the synthesis of some esters. Ethylparaben was synthesized by using p-hydroxybenzoic acid and ethanol as raw materials and chitosan phosphotungstate as a catalyst. The optimal conditions for the reaction were determined: the molar ratio of alkyd to acid was 5:1, the amount of catalyst was 0.9 g, and the reaction time was 3 h , the product yield reaches 87.1%. Experiments have shown that the use of chitosan phosphotungstate as a catalyst not only has short reaction time, high activity, and high esterification rate, but also the catalyst can be reused, opening up a new field of ethyl paraben esterification catalysts.

7. Synthesis by Dehydration of Triethyl Orthoformate

Using methanesulfonic acid as a catalyst, adding triethyl orthoformate as a dehydrating agent to the reaction raw materials, ethylparaben can effectively improve the reaction conversion rate and shorten the reaction time. Lai Yaping used p-hydroxybenzoic acid and ethanol as the main raw materials and methanesulfonic acid as the catalyst to synthesize ethyl paraben by adding triethyl orthoformate to the reaction system and heating to reflux for dehydration. The reaction process was tracked by high-performance liquid chromatography. The influence of various factors on the product conversion rate was investigated. The experimental results show that the dehydration method of triethyl orthoformate can improve the conversion rate of the target product and reduce the reaction time compared with the traditional method.

Study on the Adsorption Characteristics of Ethyl Paraben by Straw Biochar

In order to promote the resource utilization of straw, bagasse, eggplant straw, and corn cob were used as materials in this study, and bagasse biochar (SBC), eggplant straw biochar (EBC), Corn cob biochar (CBC) was tested for the removal of ethylparaben from water.

The results show:

(1) The raw materials for the preparation of biochar significantly affected its adsorption effect on ethyl paraben, and the adsorption capacity of biochar prepared from three kinds of straws to ethyl paraben was in the order of SBC>EBC>CBC.

In addition, factors such as the initial concentration of ethylparaben in water, adsorption temperature and time can all affect the adsorption effect.

(2) The removal efficiencies of three kinds of biochars to ethyl paraben decreased with the increase of the initial concentration of ethyl paraben, and high temperature was beneficial to the adsorption.

When the initial ethylparaben concentration was 30 mg·L-1 at 45 ℃, bagasse biochar (SBC) had the highest removal rate of ethylparaben, reaching 99.7%.

The reaction increased rapidly in the first 120 min and reached adsorption equilibrium after 270 min.

(3) The adsorption isotherm of biochar to ethylparaben conforms to Langmuir model and Freundlich model.

This provides a theoretical basis for the application of agricultural straw waste to the removal of organic pollutants such as ethyl paraben.

About Products:
If you need Ethylparaben, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Ethylparaben manufacturer and supplier, ZSpharmac will provide Ethylparaben raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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