European patent EP1294678 discloses a method for preparing Ethyl Lauroyl Arginate Hcl. The process includes two steps. The first step is to use L-arginine hydrochloride and ethanol as raw materials, apply esterification reagent, stir and heat, and the reaction formula is as follows As shown in the figure, arginine ethyl ester • 2HCl is mainly obtained.
In the second step, the reaction product of the previous step and lauroyl chloride are used as raw materials to react in an aqueous phase, and the reaction product is subjected to distillation under reduced pressure, filtration, etc. to obtain the final product Ethyl Lauroyl Arginate Hcl.
The water content of the white solid obtained by this method is between 11.5-18.6%, and the content of the active active ingredient (ie, lauroyl arginine ethyl ester hydrochloride) is between 71%-81%. After freeze-drying, the water content is less than 5%, and the active ingredient is between 85% and 95%. The patent was applied in Europe in 2001, and was also applied in the United States, Canada, Mexico, Japan and other places. At present, the patent has not been authorized.
At present, there are not many literatures on the preparation of Ethyl Lauroyl Arginate Hcl. This compound is difficult to prepare and has a high cost, which is not suitable for niche cosmetic manufacturers. Therefore, it is very necessary to develop a new low-cost process, which is also a cosmetic raw material manufacturer. R&D directions that companies can consider. The synthesis process of lauroyl arginine ethyl ester hydrochloride can adopt the acylation reaction process of fatty acid anhydride and amino acid salt, the hydrolysis acylation reaction process of fatty nitrile, the amide glycosylation reaction process, the reaction process of fatty acid chloride and amino acid, and the reaction process of fatty acid and amino acid. Amino acid salt reaction process, etc. In addition, enzymatic synthesis can also be used, and lipase is used to catalyze the amidation reaction between fatty acids and amino groups. These methods are still in the research stage, and no relevant industrial reports have been seen.