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Zhishang Chemical

Ethyl Formate CAS 109-94-4

Molecular Formula: C3H6O2

Formula Weight: 74.08

ZSpharmac: Ethyl Formate Raw Material Supplier

Product Name: Ethyl Formate
CAS No: 109-94-4
Purity: 99%

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Basic Info

Product Name:Ethyl Formate
Other Names:Ethyl Ester of Formic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Liquid
EINECS No.:203-721-0
Provide:Ethyl Formate MSDS;
Ethyl Formate COA

What is Ethyl Formate?

my nation’s GR2760-86 specifies that ethyl formate is a permitted edible flavoring, furthermore called ethyl formate. Its chemical framework has active carbonyl and ester group structures, is reducible, can undergo ester condensation feedbacks, and is miscible in ethanol, Ether, benzene and propylene glycol are a little soluble in mineral oil and water (gradually disintegrate in water), and are extremely easy to thaw. The vapor can develop an eruptive blend with air, with a surge limitation of 3.5% to 16.5% (quantity). Insoluble in glycerin, conveniently hydrolyzed into absolutely complimentary acid and ethanol in alkaline solution. It has a spicy and increasing taste, a fruity aroma like pineapple, and a strong rum-like fragrance with a rather bitter preference. Naturally situated in Boronia dentigeroides and Florida orange juice, honey, brandy, strawberries, raspberries, onions, apples, pears and rum. The fabricated synthesis method is to warmth and esterify ethanol and formic acid in the existence of sulfuric acid, and then dry out and treat it with phosphorus pentoxide or anhydrous calcium chloride. Food flavors are largely utilized in the prep work of fruity preferences such as cherries, apricots, peaches, strawberries, apples, pineapples, bananas, grapes, and so on. In a glass of a glass of wine flavors, it is usually made use of to prepare a glass of red wine tastes such as Rum, Sherry, Brandy, Scotch and White Grape. Used as aromatic flavor or flavor representative in medicines, food and cosmetics. Ethyl formate is recognized by FEMA as GRAS, FEMA number 2434, and licensed for usage by the FDA. The European Council has actually in addition included it in the listing of man-made tastes that can be used in food without harming human wellness. Its ADI well worth is 5mg/kg.

Ethyl Formate Property

Melting point 

-80 °C (lit.)

Boiling point 

52-54 °C (lit.)


0.921 g/mL at 20 °C (lit.)

vapor density 

2.5 (vs air)

vapor pressure 

15.16 psi ( 55 °C)

refractive index 

n20/D 1.359(lit.)


7 °F

storage temp. 



Miscible with alcohol, benzene, and ether (Hawley, 1981)






Characteristic; pleasant aromatic.

Odor Threshold


Odor Type


explosive limit


Water Solubility 

11 g/100 mL (18 ºC)


Ethyl Formate Uses

Ethyl formate is made use of as a solvent for nitrocellulose, cellulose acetate, and so on, in addition to a fungicide, larvicidal and fumigant for food, cigarettes, grains, dried out fruits, and so on. As a taste, ethyl formate can be used to blend the fragrances of peaches, bananas, apples, apricots, pineapples, berries, and more. It can additionally be made use of as a flavor for butter, brandy, liqueur, scotch, etc. Ethyl formate is furthermore an intermediate in natural synthesis. For example, in the pharmaceutical sector, it is made use of in the manufacturing of anti-tumor medicines Fulcedine and vitamin B1; ethyl formate and acetone are compressed in salt methoxide-xylene choice to get salt acetyl plastic alcohol, which is pressed with acetyl glycine ester and after that reacted with thiocyanate Cyclization with potassium can provide 2-mercaptoimidazole-4-carboxylic acid ethyl ester. Ethyl formate is utilized to generate medications such as Houttuynia cordata, Tongjingning, Anadrol, pyrantel, pyridine, Lixuesheng, and totally artificial anisodamine.

Preparation of Ethyl Formate

The here and now development is a technique for preparing ethyl formate that does not require a big amount of sulfuric acid and formic acid as drivers. In the response, the response liquid in the production procedure of 2-methyl-5-nitroimidazole and metronidazole is a good driver in the manufacturing of ethyl formate. Preparing ethyl formate by reacting the reactant of metronidazole with absolute ethanol makes full use waste, enriches item types, reduces manufacturing prices, decreases environmental pressure, and can additionally boost the return of ethyl formate.
In the above prep work technique, the metronidazole response service consists of metronidazole, 2-methyl-5-nitroimidazole, formic acid, and so on.
The here and now innovation is attained by embracing the complying with technological services:
A method for producing ethyl formate, consisting of the complying with actions:
( 1) Synthesis response: Put 100 to 120 parts by weight of the response basic material 2-methyl-5-nitroimidazole into the reaction tank, and put 100 parts by weight of formic acid with a concentration of 95% to 99% right into the response tank. After 2-methyl-5-nitroimidazole is totally liquified, maintain the temperature level for 10 to 20 minutes, then add 90 to 100 components by weight of ethylene oxide to get a metronidazole hydroxylation reaction option;
( 2) Take the metronidazole hydroxylation reaction service, include absolute ethanol, mix and warm to 65-70 ° C, reflux for 1.5-2 hours, boil down, gather the 65-100 ° C fraction, which is ethyl formate; where: The weight proportion of nitrozole response option to absolute ethanol is 3:8.
The existing preparation process of ethyl formate is as follows: place formic acid and acetic acid into a reaction kettle, control the temperature listed below 50 ° C, dropwise include focused sulfuric acid (1% of the quantity of formic acid), heat to reflux and afterwards distill, gather the fractions, and include Dry calcium chloride water, filter, fractionate the filtrate, collect 53-58 ° C, which is ethyl formate. In the original process of manufacturing ethyl formate, sulfuric acid is used as the driver and anhydrous calcium chloride is used as the desiccant. The function of today development is that in the present prep work procedure of metronidazole, the metronidazole hydroxylation reaction liquid is utilized as the driver. There is no need to include a huge amount of desiccant. This approach not only minimizes the price of basic materials however likewise increases the return of ethyl formate to more than 90%.
The method of the here and now creation is sensibly designed. In the process of preparing metronidazole, the hydroxylation reaction remedy of metronidazole is made use of to prepare ethyl formate, which not only boosts the financial benefits of the enterprise, but additionally minimizes the stress on environmental management.

Specific Implementation Methods of Ethyl Formate

Details embodiments of the present invention will certainly be explained thoroughly listed below.

An approach for generating ethyl formate, comprising the following actions:
( 1) Synthesis reaction: Place 100 components by weight of the reaction raw material 2-methyl-5-nitroimidazole right into the response tank, and put 100 parts by weight of formic acid with a concentration of 95% to 99% into the response storage tank, await 2- After methyl-5-nitroimidazole is completely dissolved, keep the temperature for 15 mins, then include 90 to 100 parts by weight of ethylene oxide to obtain the metronidazole hydroxylation response service;
( 2) Take the metronidazole hydroxylation response solution, include absolute ethanol, mix and warm to 70 ° C, reflux for 1.5 hours, boil down, accumulate the 65-100 ° C fraction, which is ethyl formate; amongst them: metronidazole reaction remedy The weight ratio to absolute ethanol is 3:8.

About Products:
If you need the cosmetic raw material Ethyl Formate, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Ethyl Formate manufacturer and supplier, our company, ZSpharmac will provide Ethyl Formate raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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