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Ethyl Ferulate CAS 4046-02-0

Molecular Formula: C12H14O4

Formula Weight: 222.24

ZSpharmac: Ethyl Ferulate Supplement

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Product Name: Ethyl Ferulate
CAS No: 4046-02-0
Purity: 99%

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Basic Info

Product Name:Ethyl Ferulate
Other Names:Ethyl 4′-Hydroxy-3′-Methoxycinnamate
CAS:4046-02-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:223-745-5
Storage:Sealed in Dry,Room Temperature
Provide:Ethyl Ferulate MSDS;
Ethyl Ferulate COA

What is Ethyl Ferulate?

Active groups such as phenolic hydroxyl groups, carboxyl groups, olefinic bonds and aromatic rings are therefore recognized as one of the natural antioxidants and internationally recognized anti-cancer substances in recent years. The physiological functions of Ethyl Ferulate include scavenging free radicals, antithrombotic, anti-atherosclerosis, antibacterial and anti-inflammatory, preventing hypertension and heart disease, enhancing sperm motility, etc. Therefore, it is widely used in medicine, food, cosmetics and other fields.

However, due to the poor stability of Ethyl Ferulate, it is easily oxidized during storage and use, which limits the application and exertion of some important physiological functions of ferulic acid. Therefore, in recent years, ferulic acid molecules are often modified in a certain form to obtain ferulic acid derivatives with higher stability. Nyaradzo T. L. Chigorimbo-Murefu et al. studied lipase-catalyzed synthesis of esters from ferulic acid and natural compounds. It was found that Candida folds lipase is capable of transesterification of Ethyl Ferulate ethylene derivatives and steroids, and some synthetic compounds have higher antioxidant activity than the precursor Ethyl Ferulate. Xin Jiaying, Zheng Yan, Zhao Guanli, etc. first synthesized ethyl ferulate with ferulic acid and ethanol, and then used ethyl ferulic acid to react with Ve to obtain Ve ferulic acid ester. Ve ferulate, which is a compound formed by Ethyl Ferulate and the 6-position hydroxyl group of the β-chromone ring of a-tocopherol, has no antioxidant activity of VE due to the loss of free hydroxyl groups. It is relatively stable, because it can protect the 6-position hydroxyl group of a-tocopherol, which increases the stability of a-tocopherol during storage and transportation. Disadvantages of not being able to be used in the oil industry. Zhang Hui et al. modified Ethyl Ferulate with water-soluble chitosan, and found that chitosan could improve the activity of ferulic acid, and the cytotoxic activity of FA-COS was higher than that of Ethyl Ferulate.

The synthetic methods of Ethyl Ferulate ester derivatives include chemical synthesis method, microbial transformation method, and enzyme biocatalysis method. The biological enzyme catalysis method has become the most potential biotechnology because of its mild conditions, few by-products, simple process, mild environment, strong reaction selectivity and simple product purification. At present, Ethyl Ferulate sugar esters are mainly synthesized by chemical methods in China. Although the chemical method has a high conversion rate, the process is complicated, the product is not easy to separate, and there are many toxic by-products, so it is difficult to achieve continuous production in industry. However, the research on the enzymatic synthesis of Ethyl Ferulate sugar esters has not been reported yet.

Ethyl Ferulate ethyl ester is a ferulate ester derivative, which has greatly enhanced fat solubility compared to Ethyl Ferulate raw materials. In cosmetics, it has anti-free radical, anti-oxidation, promotion of blood microcirculation, bodybuilding and skin protection.

Ethyl Ferulate Property

Melting point 63-65 °C(lit.)
Boiling point 164-166 °C0.5 mm Hg(lit.)
density 1.0643 (rough estimate)
refractive index 1.4560 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka8.88±0.18(Predicted)
color White to Off-White

 

Ethyl Ferulate Uses

  1. Ethyl Ferulate is utilized for assay/identification/pharmacological experiments and so on. Pharmacological efficacy: the basic resources for the treatment of cardio and cerebrovascular conditions and leukopenia.
  2. Ethyl Ferulate is the fundamental raw material for the production of medications for the treatment of cardio as well as cerebrovascular illness and leukopenia.
  3. Ethyl Ferulate is 1. antioxidant, scavenging oxygen complimentary radicals, 2. advertising blood microcirculation, 3. sunlight security 5. Antibacterial has a great inhibitory effect on Staphylococcus aureus, and adding it to cosmetics can decrease the use of preservatives.

Redox Regulation of Human Skin by Ethyl Ferulate

The skin is among the primary targets of responsive oxygen varieties; hence, reactive oxygen species-induced damages as well as modification of proteins and lipids happen, and also the skin may struggle with a range of illness, from photosensitivity to cancer cells. In this research, human facial fibroblasts subjected to hydrogen peroxide (0-1000 micromol/L) showed significant rises in healthy protein carbonyls as well as 4-hydroxy-2-nonenal, which are healthy proteins and also lipids, respectively. indicators of oxidation. 25 μmol/ L Ethyl Ferulate is a well-known dietary anti-oxidant that significantly combats the oxidation of proteins and also lipids and minimizes the loss of cell viability caused by 500 μmol/ L hydrogen peroxide. A common method cells respond to oxidative stress and anxiety is to upregulate vitamins. The vitagene household belongs to the warm shock proteins hemeoxygenase-1 and also warmth shock protein 70, which are associated with cellular protection versus oxidative stress via different devices. Management of 25 μmol/ L Ethyl Ferulate substantially decreased hydrogen peroxide-induced protein and also lipid oxidation. Facial fibroblasts exposed to 25 μmol/ L ethyl ferulate in the presence of 500 μmol/ L hydrogen peroxide revealed heme oxygenase 1 compared to facial fibroblasts treated with hydrogen peroxide alone and enhanced degrees of heat shock protein 70. These findings give evidence for the safety duty of vitamins in skin damage caused by complimentary radicals and highlight the potential safety function of dietary antioxidants such as ferulic acid and its by-products. They are associated with mobile protection versus oxidative stress and anxiety with various systems. Management of 25 μmol/ L Ethyl Ferulate dramatically minimized hydrogen peroxide-induced protein as well as lipid oxidation. Dermal fibroblasts exposed to 25 μmol/ L ethyl ferulate in the presence of 500 μmol/ L hydrogen peroxide showed heme oxygenase 1 contrasted to dermal fibroblasts treated with hydrogen peroxide alone and raised degrees of warmth shock healthy protein 70. These findings provide proof for the safety function of vitamins in skin damage triggered by cost-free radicals and highlight the prospective protective role of nutritional anti-oxidants such as ferulic acid as well as its derivatives. They are involved in mobile protection against oxidative stress and anxiety through various systems. Management of 25 μmol/ L ethyl ferulate dramatically lowered hydrogen peroxide-induced healthy protein and also lipid oxidation. Facial fibroblasts revealed to 25 μmol/ L Ethyl Ferulate in the presence of 500 μmol/ L hydrogen peroxide revealed heme oxygenase 1 and also heat shock contrasted to facial fibroblasts treated with hydrogen peroxide alone Degrees of healthy protein 70 increased. These findings provide evidence for the safety function of vitamins in skin damage triggered by free radicals and highlight the potential protective duty of nutritional anti-oxidants such as ferulic acid and its derivatives. Administration of 25 μmol/ L ethyl ferulate dramatically reduced hydrogen peroxide-induced protein as well as lipid oxidation. Facial fibroblasts exposed to 25 μmol/ L Ethyl Ferulate in the existence of 500 μmol/ L hydrogen peroxide revealed heme oxygenase 1 as well as warmth shock contrasted to dermal fibroblasts treated with hydrogen peroxide alone Degrees of protein 70 boosted. These searchings for supply proof for the protective duty of vitamins in skin damages brought on by free radicals and also highlight the possible safety duty of dietary anti-oxidants such as ferulic acid and its derivatives. Management of 25 μmol/ L ethyl ferulate considerably decreased hydrogen peroxide-induced healthy protein and lipid oxidation. Facial fibroblasts subjected to 25 μmol/ L ethyl ferulate in the visibility of 500 μmol/ L hydrogen peroxide showed heme oxygenase 1 contrasted to dermal fibroblasts treated with hydrogen peroxide alone and enhanced degrees of warm shock healthy protein 70. These findings offer evidence for the protective duty of vitamins in skin damages caused by free radicals as well as highlight the potential protective role of dietary antioxidants such as ferulic acid and its derivatives. Facial fibroblasts revealed to 25 μmol/ L Ethyl Ferulate in the existence of 500 μmol/ L hydrogen peroxide showed heme oxygenase 1 and also warm shock compared to facial fibroblasts treated with hydrogen peroxide alone Levels of healthy protein 70 enhanced. These findings offer evidence for the safety duty of vitamins in skin damage triggered by free radicals and also highlight the prospective protective function of dietary anti-oxidants such as ferulic acid and its by-products. Facial fibroblasts subjected to 25 μmol/ L Ethyl Ferulate in the visibility of 500 μmol/ L hydrogen peroxide revealed heme oxygenase 1 as well as warmth shock compared to dermal fibroblasts treated with hydrogen peroxide alone Levels of healthy protein 70 enhanced. These searchings for provide proof for the safety function of vitamins in skin damage brought on by cost-free radicals as well as highlight the prospective safety duty of nutritional anti-oxidants such as ferulic acid and its derivatives.

Rapid Synthesis of Ethyl Ferulate by Biomimetic Radical Coupling Reaction

Dehydrodimerization of ferulate in grass cell walls provides a pathway for cross-linking of polysaccharide chains, limiting carbohydrate digestibility in ruminants and generally affecting the utilization of grasses as a renewable biological resource. Analysis of dehydrodifoliate (hereafter referred to as difoliate) in plant cell walls can be used to assess the quality of dairy forages used as animal feed. Therefore, there is a considerable demand for the number of dispersions as a standard for such analysis. Described here is the synthesis of diferulate from Ethyl Ferulate via a biomimetic radical coupling reaction using copper(II)-tetramethylethylenediamine [CuCl(OH)-TMEDA] complex as oxidant or catalyst. While CuCl(OH)-TMEDA oxidation of Ethyl Ferulate in acetonitrile yields a mixture consisting of 😯 – 4-, 8-5-, 8-8- (cyclic and acyclic) and 5-5-couplings Catalytic oxidation of diarylates using CuCl(OH)-TMEDA as catalyst and oxygen as oxidant led to such divergence in better overall yields. Flash chromatography allows separation of 8-8- and 5-5-coupled difluoro compounds. 8-5-Diferulate co-eluted with 8-O-4-diferulate, but was separated from it by crystallization; 8-O-4 diferulate remaining in the mother liquor was passed through after simple tetrabutylammonium fluoride treatment Re-chromatographed, this treatment converts 8-5-diferulate to another useful diferulate, 8-5-(acyclic) diferulate. So six of the nine (5-5, 8-O-4, 8-5-c, 8-5-nc, 8-5-dc, 8-8-c, 8-8-nc, 8 -8-Tetrahydrofuran, 4–O–5) Diferulic acid so far found in alkaline hydrolyzates of plant cell walls can be readily catalyzed by CuCl(OH)-TMEDA-catalyzed aerobic oxidative coupling reactions and subsequent Saponification reaction synthesis.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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