Active groups such as phenolic hydroxyl groups, carboxyl groups, olefinic bonds and aromatic rings are therefore recognized as one of the natural antioxidants and internationally recognized anti-cancer substances in recent years. The physiological functions of Ethyl Ferulate include scavenging free radicals, antithrombotic, anti-atherosclerosis, antibacterial and anti-inflammatory, preventing hypertension and heart disease, enhancing sperm motility, etc. Therefore, it is widely used in medicine, food, cosmetics and other fields.
However, due to the poor stability of Ethyl Ferulate, it is easily oxidized during storage and use, which limits the application and exertion of some important physiological functions of ferulic acid. Therefore, in recent years, ferulic acid molecules are often modified in a certain form to obtain ferulic acid derivatives with higher stability. Nyaradzo T. L. Chigorimbo-Murefu et al. studied lipase-catalyzed synthesis of esters from ferulic acid and natural compounds. It was found that Candida folds lipase is capable of transesterification of Ethyl Ferulate ethylene derivatives and steroids, and some synthetic compounds have higher antioxidant activity than the precursor Ethyl Ferulate. Xin Jiaying, Zheng Yan, Zhao Guanli, etc. first synthesized ethyl ferulate with ferulic acid and ethanol, and then used ethyl ferulic acid to react with Ve to obtain Ve ferulic acid ester. Ve ferulate, which is a compound formed by Ethyl Ferulate and the 6-position hydroxyl group of the β-chromone ring of a-tocopherol, has no antioxidant activity of VE due to the loss of free hydroxyl groups. It is relatively stable, because it can protect the 6-position hydroxyl group of a-tocopherol, which increases the stability of a-tocopherol during storage and transportation. Disadvantages of not being able to be used in the oil industry. Zhang Hui et al. modified Ethyl Ferulate with water-soluble chitosan, and found that chitosan could improve the activity of ferulic acid, and the cytotoxic activity of FA-COS was higher than that of Ethyl Ferulate.
The synthetic methods of Ethyl Ferulate ester derivatives include chemical synthesis method, microbial transformation method, and enzyme biocatalysis method. The biological enzyme catalysis method has become the most potential biotechnology because of its mild conditions, few by-products, simple process, mild environment, strong reaction selectivity and simple product purification. At present, Ethyl Ferulate sugar esters are mainly synthesized by chemical methods in China. Although the chemical method has a high conversion rate, the process is complicated, the product is not easy to separate, and there are many toxic by-products, so it is difficult to achieve continuous production in industry. However, the research on the enzymatic synthesis of Ethyl Ferulate sugar esters has not been reported yet.
Ethyl Ferulate ethyl ester is a ferulate ester derivative, which has greatly enhanced fat solubility compared to Ethyl Ferulate raw materials. In cosmetics, it has anti-free radical, anti-oxidation, promotion of blood microcirculation, bodybuilding and skin protection.