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Ethyl Ferulate CAS 4046-02-0

Molecular Formula: C12H14O4

Formula Weight: 222.24

ZSpharmac: Ethyl Ferulate Supplier

Product Name: Ethyl Ferulate
CAS No: 4046-02-0
Purity: 99%

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Basic Info

Product Name:Ethyl Ferulate
Other Names:Ethyl 4′-Hydroxy-3′-Methoxycinnamate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:223-745-5
Storage:Sealed in Dry,Room Temperature
Provide:Ethyl Ferulate MSDS;
Ethyl Ferulate COA

What is Ethyl Ferulate?

Active groups such as phenolic hydroxyl group, carboxyl group, ethylenic bond and aromatic ring are therefore one of the recognized natural antioxidants, and also an internationally recognized anti-cancer substance in recent years. The physiological functions of ferulic acid include scavenging free radicals, anti-thrombosis, anti-atherosclerosis, antibacterial and anti-inflammatory, prevention of high blood pressure and heart disease, and enhancement of sperm motility. Therefore, it is widely used in medicine, food, cosmetics and other fields.

However, due to the poor stability of ferulic acid, it is easily oxidized during storage and use, which limits the application and exertion of some important physiological functions of ferulic acid. Therefore, ferulic acid molecules are often modified in some form in application in recent years to obtain ferulic acid derivatives with high stability. Nyaradzo T. L. Chigorimbo-Murefu et al. studied the synthesis of esters from ferulic acid and natural compounds catalyzed by lipase. It was found that Candida rugosa lipase is capable of transesterification of vinyl ferulic acid derivatives and steroids, and some synthetic compounds have higher antioxidant activity than the precursor ferulic acid. Xin Jiaying, Zheng Yan, Zhao Guanli, etc. first synthesized ethyl ferulate with ferulic acid and ethanol, and then reacted Ve ferulate with ethyl ferulate to obtain Ve ferulate. Ve ferulic acid ester, it is the compound formed by the esterification of ferulic acid and the 6-hydroxyl group of β-chromone ring of a-tocopherol. It does not have the antioxidant activity of VE due to the loss of free hydroxyl group. It is relatively stable in ferulic acid, because it can protect the 6-hydroxyl group of a-tocopherol, which increases the stability of a-tocopherol during storage and transportation. At the same time, it maintains many physiological activities of ferulic acid and overcomes the short alkane chain And the drawbacks that cannot be applied in the oil industry. Zhang Hui and others used water-soluble chitosan to modify ferulic acid, and found that chitosan has the function of improving the activity of ferulic acid, and the cytotoxic activity of FA-COS is higher than that of ferulic acid.

Ethyl Ferulate Property

Melting point 63-65 °C(lit.)
Boiling point 164-166 °C0.5 mm Hg(lit.)
density 1.0643 (rough estimate)
refractive index 1.4560 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color White to Off-White


Ethyl Ferulate Uses

1. Anti-oxidation, scavenging oxygen completely complimentary radicals,

2. Market blood microcirculation,

3. Sunlight protection

4. Whitening in addition to blemish elimination has an antagonistic effect on endothelin ET-1, competitively hinders the binding of ET-1 to its receptor, as well as also avoids the dispersing of endothelin on melanocytes;

5. Antibacterial has an exceptional repressive impact on Staphylococcus aureus, including it to cosmetics can decrease using chemicals.

Synthesis of Ethyl Ferulate

The synthesis methods of ferulic acid ester derivatives include chemical synthesis, microbial transformation and enzyme biocatalysis. Enzyme catalysis has become the most promising biotechnology because of its mild conditions, few by-products, simple process, mild environment, strong reaction selectivity, and easy purification of products. At present, sugar esters of ferulic acid are mainly synthesized by chemical methods in China. Although the chemical method has a high conversion rate, the process is complicated, the product is not easy to separate, and there are many toxic by-products, so it is difficult to realize continuous production in industry. However, there is no report on the enzymatic synthesis of sugar esters of ferulic acid.

About Products:
If you need Ethyl Ferulate as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Ethyl Ferulate manufacturer and supplier, ZSpharmac will provide Ethyl Ferulate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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