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Ethyl Cellulose CAS 9004-57-3

Molecular Formula: C23H24N6O4

Formula Weight: 448.47446

ZSpharmac: Ethyl Cellulose Supplier

Product Name: Ethyl Cellulose
CAS No: 9004-57-3
Purity: 99%

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Basic Info

Product Name:Ethyl Cellulose
Other Names:Ethylcellulose M9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Slightly Yellow Powder
EINECS No.:618-384-9
Provide:Ethyl Cellulose MSDS;
Ethyl Cellulose COA

What is Ethyl Cellulose?

The chemical formula is (C12H22O5)n, odorless and tasteless, white or light brown powder, glass transition temperature: 129-133°C, safe for food. Ethyl cellulose hardly absorbs moisture from humid air, and even if it absorbs a small amount of moisture, it evaporates easily. Solubility: Insoluble in glycerin, polyethylene glycol and water. Ethyl cellulose containing less than 46.5% ethoxy is easily soluble in chloroform, methyl acetate, tetrahydrofuran and mixtures of aromatic hydrocarbons and 95% ethanol. Ethyl cellulose with less than 46.5% ethoxy is easily soluble in chloroform, 95% ethanol, ethyl acetate, methanol and toluene. Depending on n, there are large differences in molecular weight. Ethyl cellulose is the ethyl ether of cellulose, a long-chain polymer linked by acetal with β-anhydroglucose as the unit, and is one of the most widely used water-insoluble cellulose derivatives.

Ethyl Cellulose Property

Melting point 240-255 °C
density 1.14 g/mL at 25 °C (lit.)
refractive index n20/D 1.47(lit.)
storage temp. 2-8°C
solubility esters, aromatic hydrocarbons, alcohols and ketones: soluble
form powder
Specific Gravity1.14
color White to slightly yellow
Water Solubility insoluble


Ethyl Cellulose Uses

Ethyl Cellulose is thoroughly utilized in paints. It can additionally be made use of as the raw item of solid lubricating substances for stamping steel workpieces. In microcircuit printing, ethyl cellulose is used as an auto. In the radio industry, it is used as an innovative shielding material, and also as a distinct movie in safety finishings, such as the cladding layer of rocket propellants. It can be made use of as hot-melt adhesives along with finishings for cables, paper, textiles, and so forth, in addition to insulation for extruded cables and furthermore strength boosters for plastics. It can also be capitalized on in pigment grinding bases, publishing inks, formed plastic powders, explosive fuzes, as well as formulas of vitamins, and so forth. Utilized as a peelable surface to protect steel parts from deterioration in addition to ruining before utilize, as well as also as a peelable layer to protect prone glasses. There are great deals of uses in adhesives, textile in addition to fiber, medication together with food, along with various other markets.Industrial superior quality ethyl cellulose is taken advantage of in treatments (gel finishes, hot-melt finishings), inks (screen printing inks, gravure printing inks), adhesives, pigment pastes, and so on.

Preparation Application of Ethyl Cellulose

Ethylcellulose is extensively used in dental as well as topical solutions. Ethyl cellulose in dental preparations is mostly used as a hydrophobic covering material and also sustained-release matrix material for tablets and also granules. The major function of coating with ethyl cellulose is to readjust the release rate of the medicine, mask the poor smell as well as increase the security of the prep work. For instance, granules are covered with ethyl cellulose to prevent oxidation, and also sustained-release tablets can utilize ethyl cellulose as a matrix product

1. Finishing product.
Ethyl cellulose is an insoluble movie layer material, which has the functions of moisture-proof, light-shielding, taste-masking, slow-release and also improving fluidness. Ethyl cellulose has excellent film-forming residential or commercial properties, good tensile toughness as well as flexibility, and has the capacity to modify medication release, so it has actually been commonly studied as a layer agent.

When making use of ethyl cellulose layer, usually concerning 6% weight gain of the tablet computer size can get a better continual release impact (the weight gain of the finish is substantially affected by the size of the tablet core, if the tablet computer core or round core is bigger Small, then the surface is relatively huge, as well as a huge finish weight gain can be attained to satisfy the demand). Ethylcellulose-coated pellets and also granules can stand up to a certain stress, which can shield the coating layer from breaking during the tableting procedure.

2. Topical administration
Some topical prep work, such as sensory preparations as well as transdermal prep work, can make use of ethyl cellulose for continual release. Ocular drug distribution is a requiring dose form in pharmaceutical technology. In order to enhance eye bioavailability, researchers have designed sustained-release medicine dosage forms, such as hydrogels or microtablets. Ethyl cellulose alone or in mix with hydrophilic excipients can be utilized as a sustained-release matrix product for drugs. By readjusting the percentage of ethyl cellulose in the prescription, the release rate of the medicine can be controlled. With the boost of its dosage, the release rate of the drug decreases.

3. Slow-release matrix
Ethyl cellulose has the result of reducing the dissolution of medications. This is because the water-insoluble skeletal system made up of ethyl cellulose is not easily moistened by water, which can reduce the dissolution of drugs; as well as the medicine particles are uniformly spread in the skeletal system structure, as well as the dissolution medium can just travel through. The micropores in the framework infiltrate, as well as gradually dissolve the drug and also scattered outward to attain a sustained release result.

4. Microcapsules or Nanocapsules
Microcapsules or nanocapsules are a typical technique for altering medicine launch. Enveloping drugs in polymers can not only attain sustained medication launch, yet additionally enhance drug bioavailability, minimize side effects, as well as improve medication stability. High thickness ethyl cellulose can be utilized for medicine microencapsulation. The drug launch procedure from ethylcellulose-coated microcapsules is related to the microcapsule wall surface thickness and area.

5. Bioadhesive preparations
Bioadhesive prep work, that is, a pharmaceutical preparation in which the substance abuse hydrogel polymer as a service provider and also follows the mucous membrane layer for a long period of time through bioadhesion to exert its alleviative result. People have created bioadhesive powders, tablet computers, gels, liposomes and also microspheres and other preparations at present, and also there are hormone-containing oral abscess glue movies and tablets abroad. The application of bioadhesive prep work has accomplished extremely significant results in prolonging medication action time, minimizing damaging drug reactions, and also enhancing medication bioavailability. When creating bioadhesive formulations, the option of ideal polymers with sticky properties is vital. Polymers that are bioadhesive and also do not liquify up until the medication is released are well matched for sustained medication launch dose types.

Ethyl cellulose, as a water-insoluble polymer, is typically made use of as a support film due to its film-forming residential properties, low water leaks in the structure, drug impermeability, and also moderate versatility. It is bioadhesive, however less than carbomer and chitosan. When the solution enters into contact with water, ethylcellulose creates a hydrophobic network, allowing continual release of the medicine. The drug-loaded ethylcellulose membrane has good bond, mechanical toughness and sustained release characteristics. Its performance can be adjusted by the amount of porogen, film thickness as well as molecular weight of ethyl cellulose.

6. Provider
Ethyl cellulose can be made use of as a drug service provider to prepare microspheres or strong diffusions by emulsification-solvent dissipation technique, phase coagulation technique, solvent technique or spray drying out technique. Unlike the usual fast-acting and bioavailability-enhancing effects of strong dispersions, ethyl cellulose can reduce the dissolution rate of drugs. In a strong dispersion system, medication bits are integrated right into an ethyl cellulose service provider for controlled medicine release.

7. Adhesive
Ethyl cellulose has good attachment buildings and can be used as a binder. In tablets, ethylcellulose can be made use of as a binder dry-process or wet-blended with 95% ethanol as a solvent. And also its hydrophobicity additionally makes high-viscosity ethyl cellulose have obvious delayed medication release efficiency when used as a binder. Therefore, the plain tablets made from ethyl cellulose are hard as well as low in brittleness, but the dissolution is fairly poor.

8 Application in typical Chinese medication preparations
Because of the complex energetic ingredients of traditional Chinese medication as well as conventional Chinese medication compound, the application of ethyl cellulose in standard Chinese medication prep work [8] is still in the study phase, mainly concentrating on slow-moving and also regulated launch film covering products, matrix adhesive products, solid dispersion service providers, etc. The supreme research objective of ethyl cellulose is to enhance the alleviative result of conventional Chinese medicine by managing the medication launch price, lower the number of times of taking medicine, solve the issues of solid hygroscopicity and very easy mildew of Chinese medicine, as well as attain the needs of high effectiveness, lasting impact, and also low poisonous as well as negative effects.

Production Method of Ethyl Cellulose

Alkaline cellulose is made from fine-tuned pulp or cotton linters as well as also sodium hydroxide. Afterwards react alkaline cellulose with ethyl chloride in an autoclave to change all or part of the 3 hydroxyl teams in the sugar with ethoxy teams. The response product is cleaned up with hot water as well as dried to obtain ethyl cellulose.

About Products:
If you need Ethyl Cellulose as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Ethyl Cellulose manufacturer and supplier, ZSpharmac will provide Ethyl Cellulose raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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