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Ethyl Acetoacetate CAS 141-97-9

Molecular Formula: C6H10O3

Formula Weight: 130.14

ZSpharmac: Ethyl Acetoacetate Supplier

Product Name: Ethyl Acetoacetate
CAS No: 141-97-9
Purity: 99%

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Basic Info

Product Name: Ethyl Acetoacetate
Other Names: 2-Ethyl-3-Oxobutanoate
CAS: 141-97-9
Place of Origin: Shandong, China
Brand Name: ZSpharmac
Type: Cosmetic Raw Materials
Appearance:  Colorless Liquid
EINECS No.: 205-516-1
Storage: Store Below +30°C.
Provide: Ethyl Acetoacetate MSDS;
Ethyl Acetoacetate COA

What is Ethyl Acetoacetate?

Ethyl acetoacetate is a vital basic material for organic synthesis. It is made use of in the synthesis of aminopyrroline, vitamin B, etc in medication. It is likewise made use of in the prep work of azo yellow dyes, and also is also made use of to blend apple tastes and also other fruity flavors. Ethyl acetoacetate can also be used in aesthetic scents such as gardenia, which can offer red wine fruity or stylish non-floral leading notes. It can provide ethanol a rounded feel in toilet water or lotion. Commonly used in food tastes, it can be utilized in several fruity or wine aromas.

Ethyl Acetoacetate Property

Melting point 

−43 °C(lit.)

Boiling point 

181 °C(lit.)


1.029 g/mL at 20 °C(lit.)

vapor density 

4.48 (vs air)

vapor pressure 

1 mm Hg ( 28.5 °C)

refractive index 

n20/D 1.419


185 °F

storage temp. 

Store below +30°C.


116 g/L (20°C)


11(at 25℃)




APHA: ≤15

Specific Gravity

1.027~1.035 (20/4℃)


4.0 (110g/l, H2O, 20℃)

Relative polarity



Agreeable, fruity.

Odor Type


explosive limit


Water Solubility 

116 g/L (20 ºC)


Ethyl Acetoacetate Uses

  1. Ethyl acetoacetate is sometimes utilized in aesthetic essences such as gardenia, which can present a glass of wine fruity or stylish non-floral top notes. It can give ethanol a rounded feel in toilet water or lotion. Commonly utilized in food tastes, can be utilized in several fruity or red wine flavors, such as apples, apricots, peaches, cherries, berries and rice white wine, brandy, gewurztraminer, scotch, rum and other food flavors and a glass of wine flavors.
  2. Ethyl acetoacetate is a crucial basic material for natural synthesis. On top of that, ethyl acetoacetate is also widely made use of in the sectors of medication, plastics, dyes, spices, varnishes and also ingredients.
  3. Ethyl acetoacetate is used in the pharmaceutical market to make aminopyrine, vitamin B, and so on. The color industry is used as a basic material for the synthesis of dyes as well as for dyeing movie substrates. The paint market is utilized to make paint. In the natural market, it is used as a solvent and also a material for the synthesis of natural substances.
  4. Ethyl acetoacetate is made use of for the determination of thallium as well as the decision of calcium oxide, calcium hydroxide and also copper; it is made use of as a complex indication for the resolution of high iron; Analysis of reduced hydrocarbon isomers, separation of regular as well as iso-1-butene and cis and also trans-2-butene.
  5. The unique structure of EAA figures out that it has both the residential or commercial properties of ketone and also the reaction characteristics of enol, as well as its chemical properties are very energetic. It is extensively made use of in medication, dyes, chemicals and also other areas, and also is additionally made use of in food additives and tastes as well as fragrances. It is additionally made use of in unsaturated polyester co-accelerators as well as artificial fragrances such as the prep work of linalool, ionone and macrocyclic fragrances abroad. Ethyl acetoacetate is also made use of in the synthesis of 4-hydroxycoumarin, which is utilized to make brand-new anticoagulant medications. Ethyl acetoacetate is cyclized with 1,3-bromochloropropane to provide 2-methyl-3-ethoxycarbonyl-5,6-dihydropyran. This is an intermediate of the vasodilator pentoxifylline. Ethyl acetoacetate is additionally utilized in the synthesis of dicloxacillin sodium, amoxicillin, selective coronary vasodilator Yantongxin and pyrimidine. Ethyl acetoacetate is compressed with aniline to offer 4-hydroxyquinaldine. It is used in the manufacturing of the anti-bacterial as well as disinfectant medication clindamyne. Pyrazolone by-products and also color intermediates created by the condensation of ethyl acetoacetate as well as phenylhydrazine. It likewise has essential applications in pesticides, seasonings, photochemicals, polymerization catalysts, etc. Ethyl acetoacetate is also used as a food flavor representative. Ethyl acetoacetate is also used as a solvent and as a reagent for the discovery of thallium, calcium oxide, calcium hydroxide, as well as copper.

Content Analysis of Ethyl Acetoacetate

Method 1 Precisely weigh regarding 0.8 g of the example, and also gauge it in technique 2 of pendulum aldehyde and ketone web content resolution technique (OT-7). The upkeep time is 15min. The equivalent aspect (e) in the calculation is 65.07.
Approach 2 Take 50ml of freshly distilled pyridine, placed it into a 250ml cone-shaped flask, and also include about 450mg of properly weighed sample. Cover the dropper and swirl up until entirely dissolved. Add a few decreases of thymol test service (TS-248) and also titrate with 0.1 mol/L sodium methoxide in pyridine up until blue water begins to appear. During titration, the nitrogen flow is sent out to bottle A through a 6mm glass tube, and also the short glass tube need to be set up near the lower end of the burette. Accomplish a blank examination as above. Each Ml0.1 mol/L sodium pyridine fluid stage blue is mixed with ethyl acetoacetate (C6H10O3) 13.01 mg. Method 3 is identified by the non-polar column method in GT-10-4.

Production Method of Ethyl Acetoacetate

The prep job technique typically taken advantage of in industry is to implement esterification of diketene and additionally outright ethanol under the catalysis of concentrated sulfuric acid to acquire the crude thing of ethyl acetoacetate, as well as afterwards obtain the ended up product by means of vacuum cleaner purification.

Include ethanol and additionally sulfuric acid into the esterification pot according to the proportion, mix in addition to warmth, when the temperature degree rises to 82 ° C, begin to include diketene dropwise, as well as likewise the esterification temperature level have to not exceed 130 ° C. Remain to reflux until the action temperature say goodbye to modifications in addition to the esterification service ends when there is no diketene. Decreased the temperature level of the feed fluid to within 120 ° C, remove the decreased boilers under the problem of controling the reflux proportion of 1:1, when the minimized main home heating central heating boilers no more distill, enhance the vacuum cleaner to 86.6 kPa, and also remain to get rid of the minimized boilers. When the leading temperature level rises above 100 ° C, boost the vacuum cleaner degree to 97.3 kPa to distill out the finished thing with an internet material over 97%.

Ethyl acetate can likewise be used for self-condensation response 2CH3COOC3H5 [Na] → CH3COCH2COOC2H5.

Include 250g of salt steel to 4240mL of ethyl acetate. The action starts really gradually and also needs to be warmed up on a water bath. Once the reaction begins, it is really horrible as well as likewise calls for to be cooled. Ethyl acetate was recuperated by purification after the reflux response. Include 1375mL of 56% acetic acid alternative, mix as well as reflux, add 250g of salt, different the oil, remove with ether, redeem ether from the eliminate, and also clean with 10% sodium bicarbonate choice up until it is acid-free. After drying out with calcium chloride, it is distilled under decreased stress, in addition to the part at 76-78 ° C/2.4 kPa is gathered as the completed item, in addition to the yield is close to 30%.

About Products:
If you need Ethyl Acetoacetate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Ethyl Acetoacetate manufacturer and supplier, ZSpharmac will provide Ethyl Acetoacetate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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