Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

Escin CAS 6805-41-0

Molecular Formula: C55H86O24

Formula Weight: 1131.26

ZSpharmac: Escin Supplier

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: Escin
CAS No: 6805-41-0
Purity: 99%

Navigation Bar

Basic Info

Product Name:Escin
Other Names:Aescine
CAS:6805-41-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:229-880-6
Storage:2-8°C
Provide:Escin MSDS;
Escin COA

What is Escin?

Escin, also known as aescinic acid, is the general name of total saponins, β-aescin or isoescin etc. extracted from the seeds of the genus Aescin, belonging to triterpenoid saponins. The water solubility of Escin is poor, in order to increase its solubility, it is often made into sodium salt. Aescin contains many kinds of saponin compounds. According to the national standards of our country, they are named aescin A, aescin B, aescin C and aescin D in sequence according to the liquid phase peak. They are isomers of each other. The sodium aescinate currently used clinically is a sodium salt mixture composed of aescin A, aescin B, aescin C, aescin D and other components.

Escin Property

Melting point 224.5°C
Boiling point 764.81°C (rough estimate)
density 1.1200 (rough estimate)
refractive index 1.6500 (estimate)
solubility Soluble in methanol.
form powder
color white

 

Pharmacological Action and Mechanism of Escin

Escin Invention Content

The objective of today innovation is to supply a certain prep work technique of aescin B with high pureness as well as high yield. The method has low equipment requirements, low purification price, reduced poisoning and less environmental pollution, and also is suitable for commercial production.

EscinB prep work method given by the invention consists of the following steps:
1) using saffron as resources, extracting with ethanol, gathering the remove and also focusing;
2) changing the pH of the concentrated remedy gotten in step 1) to 2 ~ 3, after that removing with n-butanol filled with water, dividing the organic layer as well as concentrating;

3) The focused solution acquired symphonious 2) is contributed to 2 to 5 times the volume of acetone/methyl tert-butyl ether mixed solution, heated up to reflux under stirring, then cooled to take shape and dried;

4) Dissolving the dried crystals in hot water, then cooling as well as taking shape again as well as drying;
5) Liquifying the strong after the additional formation in the organic solvent, then including 10-20% of the L-proline bookkeeping for the weight of the strong after the second condensation in the organic solvent, heating to reflux for 10-60min After that great to 40-50 ° C, add a percentage of aescin B as crystal seeds, continue to mix as well as cool to 0-20 ° C for formation, till white crystals no longer speed up, suction filter or centrifuge, completely dry the strong, Aescin B is obtained.

Ideally, the ethanol symphonious (1) is an aqueous ethanol option with a mass focus of 30-70%.

Ideally, in the acetone/methyl tert-butyl ether mixed remedy in step (3 ), the quantity ratio of acetone to methyl tert-butyl ether is 2-8:1.

Preferably, the organic solvent in step (5) is ethanol/n-hexane blended solvent, and also the volume ratio of ethanol to n-hexane is 10-30:1.

Ideally, symphonious (3 ), the L-proline accounts for 15% of the weight of the solid after secondary condensation.

The useful impacts of the here and now innovation are:
Aiming at the troubles in the prep work of EscinB monomer, today creation gives a certain approach for preparing high-purity aescin B. The technique embraces the chiral amino acid – L-proline to generate recrystallization, and can acquire high-purity as well as high-yield EscinB, avoiding making use of column chromatography, ion exchange resin as well as other techniques, easy procedure, reduced devices demands, as well as high purification effectiveness. The development has inexpensive, low toxicity, much less environmental pollution, great implementability and also is suitable for developed production.

Compared with aescin, the aescin B provided by the present invention has far better anti-inflammation, anti-edema medicinal activity and reduced muscle mass as well as mucous membrane inflammation, as well as can basically resolve the uniformity and safety of the existing Escin item high quality problems such as sex.

The Specific Implementation of Escin

1) Extraction: Get 1 kg of saffron powder and also essence twice, each use 1L mass focus of 70% ethanol aqueous solution, 45 ° (: mixing and also extracting 2h, filter, the filtrate of twice filtering is merged, under reduced pressure condition Spin to recoup solvent as well as concentrate to 2L.

2) Removal: the focused option obtained in step 1) was adjusted to pH 2 with 1mol/L hydrochloric acid, drawn out 3 times with 2L water-saturated n-butanol, and the natural layers were integrated as well as focused to 400mL;

3) Crystallization for the first time: the concentrated solution obtained in step 2) was included in 960 mL of acetone as well as 240 mL of methyl tert-butyl ether mixed solvent, warmed to reflux under mixing, then cooled down to 20 ° C to separate out a white precipitate, filteringed system, 45 ° C dried to offer 49g of white crystals;

4) Crystallization for the 2nd time: 49g crystals acquired by step 3) were liquified in 100 ° C of hot water of 200mL, mixed for 20min, then the remedy was cooled down to 0 ° C, a white strong was precipitated, suction filteringed system, as well as the solid was dissolved in Drying out under the condition of 45 DEG C, obtain β-escin 32g;

5) Preparation of aescin ended up item: Dissolve the 32g3-aescin acquired in step 4) in a mixed solvent of 300mL ethanol as well as 15mL n-hexane, add 4.8gL-proline to the above system, warmth and reflux for 30min, as well as dissolve the system Cool to 50 ° C, include 0.2 g of escin B with a pureness of 98% as seed crystals, continue to stir and cool down to 20 ° C, take shape up until white crystals no longer speed up, filter with suction, and dry the strong at 45 ° C After drying out, 12.5 g of white crystals of aescin B were obtained.

In this embodiment, the function of action I) is to remove and divide the total saponins from the seeds of sage, which is a standard process for drawing out the total saponins from the seeds, and also the removal approach can be reflux, soaking, leak, etc generally utilized in this field. method. Among them, the focus of ethanol will have an important influence on the pureness and also return of complete aescin. If the concentration of ethanol is also reduced, the removal of the product will certainly want, and also if the focus of ethanol is too expensive, the material of impurities will boost.

The removal of action 2) as well as the condensation functions of steps 3) and 4) are all to detoxify the essence to obtain high-purity β-escin. Amongst them, the purpose of readjusting pH is to boost the security and extraction efficiency of aescin. If the pH is expensive, the water solubility of aescin will enhance, and the removal performance of n-butanol will decrease; if the pH is too low, the security of aescin will be reduced. The ratio of acetone as well as methyl tert-butyl ether symphonious (3) will certainly influence the precipitation rate and also yield of aescin crystals.

The natural solvent symphonious 5) can also be picked from methanol, ethanol, isopropanol, acetone, tetrahydrofuran, methyl tert-butyl ether, n-hexane, n-heptane, and so on. Several arbitrary combinations, the objective is to make β-Aescin can dissolve well, as well as at the same time, it can much better separate out Aescin B13 in the generated recrystallization. The quantity of L-proline straight influences the splitting up as well as rainfall of Aescin B. Phylloside B can not just selectively as well as smoothly speed up crystals, yet also has high return and also pureness, and great crystal morphology.

Embrace high performance fluid phase approach to find aescin B in the product, particular condition is: chromatographic column is C18 message, as well as fragment diameter is 5um; Mobile phase is acetonitrile and also 0.5% phosphoric acid liquid service, and also the quantity proportion of acetonitrile as well as phosphoric acid water is 35:65, mobile stage PH= 2.,5; discovery wavelength is 220nm; circulation rate is 1.0 ml/min, shot volume is 10 μl;

The content of aescin B in the item was 99.7%, and the yield (the overall quantity of aescin B in the item accounted for the percent of the overall amount of aescin B in the feeding sage) was 61%.

About Products:
If you need Escin, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Escin manufacturer and supplier, ZSpharmac will provide Escin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Escin Quotation